Abnormal renal vascular reactivity to acetylcholine and nitroprusside in aging rats

General Pharmacology

Volumn 28, Issue 1, 1997, Pages 133-137

  Vargas, Félix ^a   Osuna, Antonio ^b   Fernández Rivas, Antonio ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Servicio de Nefrologia   (Spain)

Author keywords

endothelium; vasoconstriction; vasodilation

Indexed keywords

ACETYLCHOLINE; CALCIUM CHLORIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE;

AGE; AGED; AGING; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; KIDNEY PERFUSION; MALE; MEMBRANE STABILIZATION; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; RESISTANCE BLOOD VESSEL; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; AGING; ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; KIDNEY; MALE; MUSCLE CONTRACTION; MUSCLE RELAXATION; NITROPRUSSIDE; RATS; RATS, WISTAR; VASOCONSTRICTION; VASODILATION; VASODILATOR AGENTS;

EID: 0031022503     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00176-0     Document Type: Article

References (19)

1. Atkinson J., Rabelais T. and Capdeville C. (1994) Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat. Br. J. Pharmacol. 111, 1184-1188.
2. Bohr F. and Webb R. C. (1988) Vascular smooth muscle membrane in hypertension. Annu. Rev. Pharmacol. Toxicol. 28, 389-409.
3. Doherty J. R. (1986) Aging and the cardiovascular system. J Autom. Pharmacol. 6, 77-84.
4. Furchgott R. F. (1988) Studies on relaxation of rabbit aorta by sodium nitrate: basis for the proposal that the acid activable component of the inhibitory factor from retractor penis is inorganic nitrate and the endothelium-derived relaxing factor is nitric oxide. In Mechanisms of Vasodilation. (Edited by Vanhoute, P. M.) pp. 401-414. New York, Raven Press.
5. Furchott R. F. and Zawadzki J. V. (1980) The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288, 373-376.
6. Fleish J. H., Maling H. M. and Brodie B. B. (1970) β-Receptor activity in aorta. Variations with age and species. Circ. Res. 26, 151-162.
7. Guerra R. J. R., Brotherton A. F. A, Goodwin P. J., Clark C. R., Armstrong M. L. and Harrison D. G. (1989) Mechanisms of abnormal endothelium-dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF. Blood Vessels 26, 300-314.
8. Hongo K., Nakagomi T., Kassell N. F., Sasaki T., Lehman M., Vollmer D. G., Tsukahara T., Ogawa H. and Torner J. (1988) Effects of aging and hypertension on endothelium-dependent vascular relaxation in rat carotid artery. Stroke 19, 892-897.
9. Hynes M. R. and Duckles S. P. (1987) Effect of increasing age on the endothelium-mediated relaxation of rat blood vessels in vitro. J. Pharm. Exp. Ther. 241, 387-392.
10. Koga T., Takata Y., Kobayashi K., Takishita S., Yamashita S. and Fujishima M. (1989) Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension 14, 542-548.
11. 2-Purinergic receptors in vascular smooth muscle and endothelium. Hypertension 19, 286-289.
12. Kowalnk E. A., Seth P. and Fung H. L. (1992) Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J. Pharm. Exp. Ther. 262, 916-922.
13. Lüscher T. F. (1990) The endothelium. Target and promoter of hypertension? Hypertension 15, 482-485.
14. Moritoki H., Hosoki E. and Ishida Y. (1986) Age-related decrease in endothelium-dependent dilator response to histamine in rat mesenteric artery. Eur. J. Pharmacol. 126, 61-67.
15. Olah M. E. and Rahwan R. G. (1987) Age-related changes in responsiveness of the rat aorta to depolarizing and receptor-mediated contractile stimuli and to calcium antagonism. Pharmacology 35, 163-173.
16. Oyama Y., Kawasaki H., Hattori Y., and Kanno M. (1986) Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur. J. Pharmacol. 131, 75-78.
17. Vanhoutte P. M. (1989) Endothelium and control of vascular function. Hypertension 13, 658-667.
18. Vargas F., Fernández-Rivas A., García-Estañ J., García del Río C. (1995) Endothelium-dependent and endothelium-independent vasodilation in hyperthyroid and hypothyroid rats. Pharmacology 51, 308-314.
19. Webb R. C. and Bohr D. F. (1980) Vascular reactivity in hypertension: altered effect of ouabain. Experentia 36, 220-222.