Different regulatory effects of pentoxifylline on human T cell activation pathways

Journal of Clinical Immunology

Volumn 17, Issue 3, 1997, Pages 247-252

  Dong, Rui Ping ^a   Umezawa, Yoshimi ^b   Ikushima, Hideto ^a   Munakata, Yasuhiko ^a   Schlossman, Stuart F ^a   Morimoto, Chikao ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b JUNTENDO UNIVERSITY   (Japan)

Author keywords

CD26; CD28; CD3; cytokine; Pentoxifylline

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CYTOKINE; DIPEPTIDYL PEPTIDASE IV; INTERLEUKIN 2; INTERLEUKIN 4; OKT 3; PENTOXIFYLLINE; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; DRUG EFFECT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

CELL SURVIVAL; CYTOKINES; HUMANS; LYMPHOCYTE ACTIVATION; PENTOXIFYLLINE; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0031004829     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027362629161     Document Type: Article

References (31)

1. Dezube BJ, Lederman MM: Pentoxifylline for the treatment of HIV infection and its complications. J Cardiovasc Pharmacol 25:139-142, 1995
2. Graninger W, Wenisch C: Pentoxifylline in severe inflammatory response syndrome. J Cardiovasc Pharmacol 25:134-138, 1995
3. Eugene-Jolchine I, Milpied N: Prevention studies with pentoxifylline: New clinical projects. J Cardiovasc Pharmacol 25:143-146, 1995
4. Gillings DB: Pentoxifylline and intermittent claudication: Review of clinical trials and cost-effectiveness analyses. J Cardiovasc Pharmacol 25:44-50, 1995
5. Robey E, Allison JP: T-cell activation: Integration of signals from the antigen receptor and costimulatory molecules. Immunol Today 16:306-309, 1995
6. Green JM, Noel PJ, Sperling AI, Walunas TL, Gray SG, Bluestone JA, Thompson CB: Absence of B-7 dependent responses in CD28-deficient mice. Immunity 1:501-508, 1994
7. Freeman GJ, Borriello F, Hodes RJ, Reiser H, Hathcock KS, Laszlo G, McKnight AJ, Kim J, Du L, Lombard DB, Gray GS, Nadler LM, Sharpe AH: Uncovering of functional alternative CTLA-4 counter-receptor in B-7 deficient mice. Science 262:907-909, 1993
8. Linsley PS, Ledbetter JA: The role of the CD28 receptor during T cell response to antigen. Annu Rev Immunol 11:191-212, 1993
9. Bierer BE, Barbosa J, Herrmann S, Burakoff SJ: Interation of CD2 with its ligand, LFA-3, in human T cell proliferation. J Immunol 140:3358-3363, 1988
10. van Noesel C, Miedema F, Brouwer M, de Rie MA, Aarden LA, van Lier RAW: Regulatory properties of LFA-1 α and β chains in human T-lymphocyte activation. Nature 333:850-852, 1988
11. Morimoto C, Torimoto Y, Levinson G, Rudd CE, Schrieber M, Dang NH, Letvin NL, Schlossman SF: IF7, a novel cell surface molecule involved in helper function of CD4 cells. J Immunol 143:3430-3439, 1989
12. Strieter RM, Emick DG, Ward PA, Spengler RN: Cellular and molecular regulation of tumor necrosis factor a production by pentoxifylline. Biochem Biomed Res Commun 155:1230-1236, 1988
13. Thanhauser A, Reiling N, Bohle, et al.: Pentoxifylline: A potent inhibitor of IL-2 and IFN-γ biosynthesis and BCG-induced cytotoxicity. Immunology 80:151-156, 1993
14. Neuner P, Klosner G, Pourmojib M, et al.: Pentoxifylline in vivo down-regulates the release of IL-1β, IL-6, IL-8 and tumor necrosis factor-α by human peripheral blood mononuclear cells. Immunology 83:262-267, 1994
15. Gimmi CD, Freeman GJ, Gribben JG, Sugita K, Freedman AS, Morimoto C, Nadler LM: B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci USA 88:6575-6579, 1991
16. Dang NH, Torimoto Y, Deusch K, Schlossman SF, Morimoto C: Comitogenic effect of solid-phase immobilized anti-IF7 on human CD4 T cell activation via CD3 and CD2 pathway. J Immunol 144:4092-4100, 1990
17. Bienvenu J, Doche C, Gutowski M-C, Lenoble M, Lepape A, Perdrix J-P: Production of proinflammatory cytokines and cytokines involved in the TH1/TH2 balance is modulated by pentoxifylline. J Cardiovasc Pharmacol 25:80-84, 1995
18. Benbernou N, Esnault S, Potron G, Guenounou M: Regulatory effects of pentoxifylline on T helper cell-derived cytokine production in human blood cells. J Cardiovasc Pharmacol 25:75-79, 1995
19. Bessler H, Gilgal R, Djaldetti M, Zahavi I: Effects of pentoxifylline on the phagocytic activity, cAMP levels, and superoxide anion production by monocytes and polymorphornuclear cells. J Leukocyte Biol 40:747-750, 1986
20. Taffet SM, Singhel KJ, Overholtzer JF, Shurtleff SA: Regulation of tumor necrosis factor expression in a macrophage-like cell line by lipopolysaccharide and cyclic AMP. Cell Immunol 120:291-300, 1989
21. Doherty GM, Jensen JC, Alexander HR, Buresh CM, Norton JA: Pentoxifylline suppression of tumor necrosis factor gene transcription. Surgery 110:192-198, 1991
22. Novak TJ, Rothenberg EV: cAMP inhibits induction of interleukin 2 but not interleukin 4 in T cells. Proc Natl Acad Aci USA 87:9353-9357, 1990
23. + T cells from aged mice. Int Immunol 5:1167-1176, 1993
24. Borger P, Kauffman HF, Postma DS, Vellenga E: Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 87:691-698, 1996
25. Perras JP, Ramos R, Sevin BU: Demonstration of an S phose population of cells without DNA synthesis generated by cisplatin and pentoxifylline. Cytometry 14:441-448, 1993
26. Biswas DK, Dezube BJ, Ahlers CM, Pardee AB: Pentoxifylline inhibits HIV-1 LTR-driven gene expression by blocking NF-kB action. J Acquir Immune Syndr 6:778-786, 1993
27. Rudd CE, Janssen O, Cai YC, da Silva AJ, Raab M, Prasad KVS: Two-step TcRζ/CD3-CD4 and CD28 signaling in T cells: SH2/ SH3 domains, protein tyrosine and lipid kinases. Immunol Today 15:225-234, 1994
28. Masuyama J, Berman JS, Cruikshank WW, Morimoto C, Center DM: Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol 148:1367-1374, 1992
29. Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL: In vitro activation T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med 312:1405-1411, 1985
30. Eguchi K, Ueki Y, Shimomura C, Otsubo T, Nakao N, Migita K, Kawakami A, Mastsunaga M, Tezuka H, Ishikawa N, Ito K, Nagataki S: Increment in the Ta1+ cells in the peripheral blood and thyroid tissue of patients with Graves' disease. J Immunol 142:4233-4240, 1989
31. Nakao H, Eguchi K, Kawakami A, Migita K, Otsubo T, Ueki Y, Shimomura C, Tezuka H, Matsunaga M, Maeda K, Nagataki S: Increment of Ta1 positive cells in peripheral blood from patients with rheumatoid arthritis. J Rheumatol 16:904-910, 1989