Persistent antibody responses but declining cytotoxic T-lymphocyte responses to multiple human immunodeficiency virus type 1 antigens in a long- term nonprogressing individual with a defective p17 proviral sequence and no detectable viral RNA expression

Journal of Virology

Volumn 72, Issue 4, 1998, Pages 3472-3474

  Binley, James M ^a   Jin, Xia ^a   Huang, Yaoxing ^a   Zhang, Linqi ^a   Cao, Yunzhen ^a   Hu, David ^a   Moore, John P ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGICAL MEMORY; MALE; PRIORITY JOURNAL; VIRUS GENOME;

EID: 0031900150     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.4.3472-3474.1998     Document Type: Article

References (34)

1. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54-60.
2. Bachmann, M. F., T. M. Kündig, B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1994. Free recirculation of memory B cells versus antigen-dependent differentiation to antibody forming cells. J. Immunol. 153:3386-3397.
3. Binley, J. M., P. J. Klasse, Y. Cao, I. Jones, M. Markowitz, D. D. Ho, and J. P. Moore. 1997. Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J. Virol. 71:2799-2809.
4. Binley, J. M., M. Markowitz, Y. Cao, A. Hurley, D. D. Ho, and J. P. Moore. 1997. Differential regulation of the antibody responses to gag and env proteins of HIV-1; effects of combination antiviral therapy, abstr. 384. In Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections.
5. Bonhoeffer, S., R. M. May, G. M. Shaw, and M. A. Nowak. 1997. Virus dynamics and drug therapy. Proc. Natl. Acad. Sci. USA 94:6971-6976.
6. Cao, Y., L. Qin, L. Zhang, J. Safrit, and D. D. Ho. 1995. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type-1 infection. N. Engl. J. Med. 332:201-208.
7. Cavert, W., D. W. Notermans, K. Staskus, S. W. Weitgrefe, M. Zupancic, K. Gebhard, K. Henry, Z. Zhang, R. Mills, H. McDade, J. Goudsmit, S. A. Danner, and A. T. Haase. 1997. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 276:960-964.
8. Connor, R. I., K. E. Sheridan, C. Lai, L. Zhang, and D. D. Ho. 1996. Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 70: 5306-5311.
9. Deacon, N. J., A. Tyskin, A. Solomon, K. Smith, M. Ludford-Menting, D. J. Hooker, D. A. McPhee, A. L. Greenaway, A. Ellet, C. Chatfield, V. A. Lawson, S. Crowe, A. Maerz, S. Sonza, J. Learmont, J. S. Sullivan, A. Cunningham, D. Dwyer, D. Dowton, and J. Mills. 1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270:988-991.
10. Greenway, A. L., J. Mills, D. Rhodes, N. J. Deacon, and D. A. McPhee. Serologic detection of attenuated HIV-1 variants with nef gene deletions. AIDS, in press.
11. Haase, A. T., K. Henry, M. Zupancic, G. A. Sedgewick, R. A. Faust, H. Melroe, W. Cavert, K. Gebhard, K. Staskus, Z. Zhang, P. J. Dailey, H. H. Balfour, Jr., A. Erice, and A. S. Perelson. 1996. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 274:985-989.
12. Harrer, T., E. Harrer, S. A. Kalams, T. Elbeik, S. I. Staprans, M. B. Feinberg, Y. Cao, D. D. Ho, T. Yilma, A. M. Caliendo, R. P. Johnson, S. P. Buchbinder, and B. D. Walker. 1996. Strong cytotoxic T cells and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection. AIDS Res. Hum. Retroviruses 12:585-592.
13. Huang, Y., L. Zhang, and D. D. Ho. 1995. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 69:93-100.
14. Huang, Y., L. Zhang, and D. D. Ho. 1995. Biological characterization of nef in long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 69:8142-8146.
15. Hung, Y., L. Zhang, and D. D. Ho. 1998. Characterization of gag and pol sequences from long-term survivors of human immunodeficiency type 1 infection. Virology 240:36-49.
16. Jin, X., C. G. P. Roberts, D. F. Nixon, Y. Cao, D. D. Ho, B. D. Walker, M. Muldoon, B. T. Korber, R. A. Koup, and the ARIEL Project Investigators. Submitted for publication.
17. Kirchhof, F., T. C. Greenough, D. B. Brettler, J. L. Sullivan, and R. C. Desrosiers. 1995. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332:228-232.
18. Klenerman, P., R. E. Phillips, C. R. Rinaldo, L. M. Wahl, G. Ogg, R. M. May, A. J. McMichael, and M. A. Nowak. 1996. Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc. Natl. Acad. Sci. USA 93:15323-15328.
19. Koup, R. A., J. T. Safrit, Y. Cao, C. A. Andrews, G. McLeod, W. Borkowsky, C. Farthing, and D. D. Ho. 1994. Temporal association of cellular immune response with the initial control of viremia in primary HIV-1 syndrome. J. Virol. 68:4650-4655.
20. Mariani, R., F. Kirchhoff, T. C. Greenough, J. L. Sullivan, R. C. Desrosiers, and J. Skowronski. 1996. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 70:7752-7764.
21. Markowitz, M., M. Vesanen, K. Tenner-Racz, Y. Cao, J. M. Binley, A. Talal, A. Hurley, X. Jin, M. Rashid Chaudhdry, M. Health-Chiozzi, J. M. Leonard, J. P. Moore, P. Racz, D. F. Nixon, and D. D. Ho. The impact of commencing combination antiretroviral therapy soon after HIV-1 infection on virus replication and antiviral immune responses. Submitted for publication.
22. Michael, N. L., G. Chang, L. A. d'Arcy, C. J. Tseng, P. K. Ehrenberg, R. Mariani, M. P. Busch, D. L. Birx, and D. H. Schwartz. 1995. Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus. J. Virol. 69:4228-4236.
23. Montefiori, D. C., G. Pantaleo, L. M. Fink, J. T. Zhou, M. Bilska, G. D. Miralles, and A. S. Fauci. 1996. Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term non-progressors. J. Infect. Dis. 173:60-67.
24. Moore, J. P., Y. Cao, D. D. Ho, and R. A. Koup. 1994. Development of the antibody response during seroconversion to human immunodeficiency virus type 1. J. Virol. 68:5142-5155.
25. Nowak, M. A., and C. R. Bangham. 1996. Population dynamics of immune responses to persistent viruses. Science 272:74-79.
26. Ogg, G. S., X. Jin, S. Bonhoeffer, P. R. Dunbar, M. A. Nowak, S. Monard, J. Segal, Y. Cao, S. L. Rowland-Jones, V. Cerundolo, A. Hurley, M. Markowitz, D. D. Ho, D. F. Nixon, and A. J. McMichael. The number of circulating HIV-1 specific cytotoxic T lymphocytes is inversely correlated with plasma viral load. Science, in press.
27. Ortiz, G., P. J. Kuebler, X. Jin, S. Bonhoeffer, W. M. Kakimoto, Y. Cao, D. D. Ho, M. Markowitz, and D. F. Nixon. Unpublished data.
28. Premkumar, D. R. D., X.-Z. Ma, R. K. Maitra, B. K. Chakrabarti, J. Salkowitz, B. Yen-Lieberman, M. S. Hirsch, and H. W. Kestler. 1996. The nef gene from a long-term HIV type 1 nonprogressor. AIDS Res. Hum. Retroviruses 12:337-345.
29. Rinaldo, C., X. L. Huang, Z. F. Fan, M. Ding, L. Beltz, A. Logar, D. Panicali, G. Mazzara, J. Liebermann, M. Cottrill, and P. Gupta. 1995. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J. Virol. 69:5838-5842.
30. Tenner-Racz, K., H.-J. Stellbrink, J. van Lunzen, C. Schneider, J.-P. Jacobs, B. Raschodorff, G. Großschupff, R. S. Steinman, and P. Racz. The unenlarged lymph nodes of HIV-1 infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of antiretroviral therapy. J. Exp. Med., in press.
31. Wang, B., Y.-C. Ge, P. Palasanthiran, S.-H. Xiang, J. Zeigler, D. E. Dwyer, C. Randle, D. Dowton, A. Cunningham, and N. K. Saksena. 1996. Gene defects clustered at the C terminus of the vpr gene of HIV-1 in long-term nonprogressing mother and child pair: in vivo evolution of vpr quasispecies in blood and plasma. Virology 223:224-232.
32. Wills, M. R., A. J. Carmichael, K. Mynard, X. Jin, M. P. Weekes, B. Plachter, and J. G. P. Sissons. 1996. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70:7569-7579.
33. Zhang, L. Q., Y. X. Huang, H. Yuan, S. Tuttleton, and D. D. Ho. 1997. Genetic characterization of vif, vpr, and vpu sequences from long-term survivors of human immunodeficiency virus type 1 infection. Virology 228: 340-349.
34. Zhang, L. Q., Y. X. Huang, H. Yuan, B. K. Chen, J. Ip, and D. D. Ho. 1997. Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 71:5608-5613.