Immunohistochemical study of desmosomes in oral squamous cell carcinoma: Correlation with cytokeratin and E-cadherin staining, and with tumour behaviour

Journal of Pathology

Volumn 184, Issue 4, 1998, Pages 369-381

  Shinohara, Masanori ^a   Hiraki, Akimitsu ^a   Ikebe, Tetsuro ^a   Nakamura, Seiji ^a   Kurahara, Shin Ichi ^a   Shirasuna, Kanemitsu ^a   Garrod, David R ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Cytokeratin; Desmosomes; E cadherin; Oral squamous cell carcinoma

Indexed keywords

CYTOKERATIN; DESMOCOLLIN; DESMOPLAKIN; UVOMORULIN;

ARTICLE; CANCER INVASION; CELL ADHESION; CELL JUNCTION; DESMOSOME; EPITHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METASTASIS; MOUTH CARCINOMA; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; CADHERINS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CYTOSKELETAL PROTEINS; DESMOCOLLINS; DESMOGLEINS; DESMOPLAKINS; DESMOSOMES; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINS; LYMPHATIC METASTASIS; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031893469     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199804)184:4<369::AID-PATH1236>3.0.CO;2-L     Document Type: Article

References (45)

1. Coman DR. Decreased mutual adhesiveness: a property of cells from squamous cell carcinoma. Cancer Res 1944; 4: 625-629.
2. Hart J, Hogg N. (eds). Cell Adhesion and Cancer. Cancer Surveys 1995; 24: 1-1-55.
3. Garrod DR. Desmosomes and hemidesmosomes. Curr Opin Cell Biol 1993; 5: 30-40.
4. Garrod DR. Desmosomes and cancer. In: Hart J, Hogg N, eds. Cell Adhesion and Cancer. Cancer Surveys 1995; 24: 97-111.
5. Schmidt A, Heid HW, Schäfer S, Nuber UA, Zimbelmann R, Franke WW. Desmosomes and cytoskeletal architecture in epithelial differentiation: cell-type specific plaque components and intermediate filament anchorage. Eur J Cell Biol 1994; 65: 229-245.
6. Kowalczyk AP, Stappenback TS, Parry DAD, et al. Structure and function of desmosomal transmembrane core and plaque molecules. Biophys Chem 1994; 50: 97-112.
7. Collins JE, Garrod DR (eds). The Molecular Biology of Desmosomes and Hemidesmosomes. Austin: RG Landes, 1994.
8. Green KJ, Jones JCR. Desmosomes and hemidesmosomes: structure and function of the molecular component. FASEB J 1996; 10: 871-881.
9. Garrod DR. Epithelial development and differentiation: the role of desmosomes. J R Coll Physicians London 1996; 30: 366-373.
10. Parrish EP, Marston JE, Mattey DL, Measures HR, Venning R, Garrod DR. Size heterogeneity, phosphorylation and transmembrane organization of desmosomal glycoproteins 2 and 3 (desmocollins) in MDCK cells. J Cell Sci 1990; 96: 239-248.
11. Parrish EP, Steart PV, Garrod DR, Weler RO. Antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours. J Pathol 1987; 153: 265-273.
12. Buxton RS, Cowin P, Franke WW, et al. Nomenclature of desmosomal cadherins. J Cell Biol 1993; 121: 481-483.
13. Legan PK, Yue KKM, Chidgey MAJ, Holton JL, Wilkinson R, Garrod DR. The bovine desmocollin family: a new gene and expression patterns reflecting epithelial proliferation and differentiation. J Cell Biol 1994; 126: 507-518.
14. Schäfer S, Koch PJ, Franke WW. Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res 1994; 211: 391-399.
15. Nuber UA, Schäfer S, Schmidt A, Koch PJ, Franke WW. The widespread human desmocollin Dsc2 and tissue-specific patterns of synthesis of various desmocollin subtypes. Eur J Cell Biol 1995; 66: 69-74.
16. Yue KKM, Holton JL, Clarke JP, et al. Characterization of a desmocollin isoform (bovine Dsc3) exclusively expressed in lower layers of stratified epithelia. J Cell Sci 1995; 108: 2163-2173.
17. Amagai M, Karpeti S, Klaus-Kovtun V, Udey MC, Stanley JR. Extra-cellular domains of pemphigus vulgaris antigen (desmoglein 3) mediates weak homophilic adhesion. J Invest Dermatol 1994; 102: 402-408.
18. Chidgey MAJ, Clarke JP, Garrod DR. Expression of full length desmosomal glycoproteins (desmocollins) is not sufficient to confer strong adhesion on transfected L929 cells. J Invest Dermatol 1996; 106: 689-695.
19. Garrod DR, Collins JE. Intercellular junctions and cell adhesion in epithelial cells. In: Fleming TP, ed. Epithelial Organization and Development. London: Chapman & Hall, 1992; 1-52.
20. Cowin P. Plakoglobin. In: Collins JE, Garrod DR, eds. The Molecular Biology of Desmosomes and Hemidesmosomes. Austin: RG Landes, 1994; 53-68.
21. Bornslaeger E, Corcoran CM, Stappenbeck TS, Green KJ. Breaking the connection displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly. J Cell Biol 1996; 134: 985-1001.
22. Kouklis PD, Hutton E, Fuchs E. Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol 1994; 127: 1049-1060.
23. Alroy J, Pauli BU, Weinstein RS. Correlations between numbers of desmosomes and aggressiveness of transitional cell carcinoma in human urinary bladder. Cancer 1981; 47: 104-112.
24. Burkhadt A. Oral Cancer and Precancer: Ultrastructural and Immuno-pathological Aspects. Stuttgart: G Fischer, 1980.
25. Schindler AM, Amaudruz MA, Kocher O, Riotten G, Gabbiana G. Desmosomes and gap junctions in various epidermoid preneoplastic and neoplastic lesions of the cervix uteri. Acta Cytol 1981; 26: 466-470.
26. Osborne M, Weber K. A monoclonal antibody recognizing desmosomes: use in human pathology. J Invest Dermatol 1995; 85: 385-388.
27. Moll R, Cowin P, Kaprell HP, Franke WV. Desmosomal proteins: new markers for identification and classification of tumours. Lab Invest 1986; 54: 4-25.
28. Vilela MJ, Parrish EP, Wright DH, Garrod DR. Monoclonal antibody to desmosomal glycoprotein l - a new epithelial marker for diagnostic pathology. J Pathol 1987; 153: 365-375.
29. Conn IG, Vilela MJ, Garrod DR, Crocker J, Wallace DMA. Immunohistochemical staining with monoclonal antibody 32-2B to desmosomal glycoprotein l. Its role in the histological assessment of urothelial carcinomas. Br J Urol 1990; 65: 176-180.
30. Krunic ALJ, Garrod DR, Smith NP, Orchard GS, Svijetic OB. Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis. Acta Derm Venereol (Stockholm) 1996; 76: 394-498.
31. Collins JE, Taylor I, Garrod DR. A study of desmosomes in colorectal carcinoma. Br J Cancer 1990; 62: 796-805.
32. Garrod DR, Chidgey MAJ, North AJ. Desmosomes: differentiation, development and disease. Curr Opin Cell Biol 1996; 8: 670-678.
33. Harada T, Shinohara M, Nakamura S, Shimada M, Oka M. Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: correlation with differentiation, mode of invasion, and metastatic potential. Int J Oral Maxillofac Surg 1992; 21: 346-349.
34. Hiraki A, Shinohara M, Ikebe T, Nakamura S, Kurahara S, Garrod DR. Immunohistochemical staining of desmosomal components in oral squamous cell carcinomas and its association with tumour behaviour. Br J Cancer 1996; 73: 1491-1497.
35. Schipper JH, Frixen UH, Behrens J, Unger A, Jahuke K, Birchmeier W. E-cadherin expression in squamous cell carcinoma of the head and neck: inverse correlation with tumour differentiation and lymph node metastasis. Cancer Res 1990; 51: 6328-6337.
36. Willen R, Nathanson A, Mobergen G, Enneroth G. Squamous cell carcinoma of the gingiva. Histological classification and grading of malignancy. Acta Otolaryngol 1975; 79: 146-154.
37. Yamamoto E, Miyakawa A, Kohama G. Mode of invasion and lymph node metastasis in squamous cell carcinoma of the oral cavity. Head Neck Surg 1984; 6: 938-947.
38. Murakami Y, Yasuda N, Saito Y, Nin H, Nakai S. Immunohistochemical investigation on expression of cytokeratins in normal epithelium, precancerous lesions and carcinoma of hypopharynx. J Otolaryngol Jpn 1991; 94: 183-191.
39. Collins JE, Legan PK, Kenny TP, MacGarvie J, Holten JL, Garrod DR. Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains. J Cell Biol 1991; 113: 381-391.
40. Pauli BU, Cohen SM, Alroy J, Weinstein JR. Desmosome ultrastructure and the biological behaviour of chemical carcinogen-induced urinary bladder carcinomas. Cancer Res 1978; 38: 3276-3285.
41. Aberle H, Bierkamp C, Torchard D, et al. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Proc Natl Acad Sci USA 1995; 92: 6384-6388.
42. Simcha I, Geiger B, Yehuda-Levenberg S, Salomon D, Ben-Ze'ev A. Suppression of tumorigenicity by plakoglobin: an augmenting effect of N-cadherin. J Cell Biol 1996; 133: 199-209.
43. Cowin P, Kapprell H-P, Franke WW, Tamkun J, Hynes RO. Plakoglobin: a protein common to different kinds of intercellular junctions. Cell 1986; 46: 1063-1073.
44. Cowin P, Burke B. Cytoskeleton-membrane interactions. Curr Opin Cell Biol 1996; 8: 56-65.
45. Shiozaki H, Tahara H, Oka H, et al. Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol 1991; 139: 17-23.