Gene therapy in sports medicine

Sports Medicine

Volumn 25, Issue 2, 1998, Pages 73-77

  Lamsam, Chanin ^a   Fu, Freddie H ^a   Robbins, Paul D ^a   Evans, Christopher H ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GROWTH FACTOR;

CARTILAGE CELL; DRUG DELIVERY SYSTEM; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HEALING; HUMAN; LIGAMENT; MARKER GENE; REVIEW; SPORT INJURY; SYNOVIUM;

ANIMALS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; MUSCULOSKELETAL SYSTEM; WOUND HEALING;

EID: 0031889376     PISSN: 01121642     EISSN: None     Source Type: Journal    
DOI: 10.2165/00007256-199825020-00001     Document Type: Review

References (33)

1. Trippel SB, Coutts Rd, Einhorn TA, et al. Growth factors as therapeutic agents. J Bone Joint Surg Am 1996; 78: 1272-86
2. Frank CB, Bray RC, Hart DA, et al. Soft tissue healing. In: Fu FH, Harner CD, Vince KG, editors. Knee surgery. Baltimore: Williams & Wilkins, 1944: 189-230
3. Evans CH, Bandara G, Robbins PD, et al. Gene therapy for ligament healing. In: Jackson DW, editor. The anterior cruciate ligament: current and future concepts. New York: Raven Press, 1993: 419-21
4. Evans CH, Robbins PD. Gene therapy for arthritis. In: Wolff JA, editor. Gene therapeutics: methods and applications of direct gene transfer. Boston: Birkhauser, 1994: 320-43
5. Latchman DS. Germline gene therapy? [editorial]. Gene Ther 1994; 1: 277-9
6. Robbins PD, Tahara H, Mueller G, et al. Retroviral vectors for use in human gene therapy for cancer. Gaucher disease, and arthritis. Ann NY Acad Sci 1994; 716: 72-89
7. Miller DG, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 1990; 10: 4239-42
8. Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cell by a lentiviral vector. Science 1996; 272: 263-7
9. Crystal RG. Transfer of genes to humans: early lessons and obstacles to success. Science 1995; 270: 404-10
10. Stratford-Perricaudet LD, Perricaudet M. Gene therapy: the advent of adenovirus. In: Wolff JA, editor. Gene therapeutics: methods and applications of direct gene transfer. Boston: Birkhauser, 1994: 344-62
11. Yang Y, Nunes FA, Berencsi K, et al. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 1994; 91: 4407-11
12. Evans CH, Robbins PD. Possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 1995; 77: 1103-14
13. Whalen RG. Promoters, enhancers, and inducible elements for gene therapy. In: Wolff JA, editor. Gene therapeutics: methods and applications of direct gene transfer. Boston: Birkhauser, 1994: 60-79
14. Robson MC, Phillips LG, Thomason A, et al. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 1992; 339: 23-5
15. Mazue G, Bertolero F, Jacob C, et al. Preclinical and clinical studies with recombinant human basic fibroblast growth factor. N Engl J Med 1989; 326: 76
16. Falanga V, Eaglstein WH, Bucalo B, et al. Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers. J Dermatol Surg Oncol 1992; 18: 604-6
17. Robson MC, Phillip LG, Cooper DM, et al. Safety and effect of transforming growth factor-beta2 for treatment of venous stasis ulcers. Wound Repair Regeneration 1995; 3: 157
18. Cuevas P, Burgos J, Baird A. Basic fibroblast growth factor (FGF) promotes cartilage repair in vivo. Biochem Biophys Res Commun 1988; 156: 611-8
19. Hunziker EB, Rosenberg LC. Repair of partial-thickness detects in articular cartilage: cell recruitment from the synovial membrane. J Bone Joint Surg Am 1996; 78: 721-33
20. Arnoczky SP, Warren RF, Kaplan N. Meniscal remodeling following partial meniscectomy: an experimental study in the dog. Arthroscopy 1985; 1: 247-52
21. Webber RJ, Harris MG, Hough AJ. Cell culture of rabbit meniscal fibrochondrocytes: proliferative and synthetic response to growth factors and ascorbate. J Orthop Res 1985; 3: 36-42
22. Collier S, Ghosh P. Effects of transforming growth factor beta on proteoglycan synthesis by cell and explant cultures derived from the knee joint meniscus. Osteoarthritis Cartilage 1995; 3: 127-38
23. Hashimoto J, Kurosaka M, Yearout KM, et al. Meniscal repair using fibrin sealant and endothelial cell growth factor: an experimental study in dogs. Am J Sports Med 1992; 20: 537-41
24. Arnoczky SP, Warren RF, Spivak JM. Meniscal repair using an exogenous fibrin clot: an experimental study in dogs. J Bone Joint Surg Am 1988; 70: 1209-17
25. Spindler KP, Imro AK, Mayes CE, et al. Patellar tendon and anterior cruciate ligament have different mitogenic responses to platelet-derived growth factor and transforming growth factor beta. J Orthop Res 1996; 14: 542-6
26. Lee J, Green MH, Amiel D. Synergistic effect of growth factors on cell outgrowth from explants of rabbit anterior cruciate and medial collateral ligaments. J Orthop Res 1995; 13: 435-41
27. Schmidt CC, Georgescu HI, Kwoh CK, et al. Effect of growth factors on the proliferation of fibroblasts from the medial collateral and anterior cruciate ligaments. J Orthop Res 1995; 13: 184-90
28. DesRosiers EA, Yahia L, Rivard CH. Proliferative and matrix synthesis response of canine anterior cruciate ligament fibroblasts submitted to combined growth factors. J Orthop Res 1996; 14: 200-8
29. Gerich TG, Kang R, Georgescu HI, et al. Comparison of viral vectors of potential use for gene transfer to ligaments and menisci. Trans Orthop Res Soc 1996; 21: 285
30. Bandara G, Robbins RD, Georgescu HI, et al. Gene transfer to synoviocytes: prospects for gene treatment for arthritis. DNA Cell Biol 1992; 11: 227-31
31. Kang R, Marui T, Ghivizzani SC, et al. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study. Osteoarthritis Cartilage 1997; 5: 139-43
32. Gerich TG, Kang R, Fu FH, et al. Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing. Gene Therapy 1996; 3: 1089-93
33. Lou JP, Manske PR, Aoki M, et al. Adenovirus-mediated gene-transfer into tendon and tendon sheath. J Orthop Res 1996; 14: 513-7