Exposure to oxidized low-density lipoprotein in vivo enhances intimal thickening and selectively impairs endothelium-dependent dilation in the rabbit

Cardiovascular Research

Volumn 37, Issue 1, 1998, Pages 239-246

  Matthys, Katelijne E ^a   Van Hove, Cor E ^a   Kockx, Mark M ^b   Andries, Luc J ^a   Van Osselaer, Nancy ^a   Herman, Arnold G ^a   Bult, Hidde ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b MIDDELHEIM HOSPITAL   (Belgium)

Author keywords

Atherosclerosis; Endothelium; Intima; Low density lipoprotein; Nitric oxide; Rabbit; Vasodilation

Indexed keywords

ACETYLCHOLINE; CALCIMYCIN; CALCIUM IONOPHORE; GLYCERYL TRINITRATE; MALONALDEHYDE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE DONOR; OXIDIZED LOW DENSITY LIPOPROTEIN; PHENYLEPHRINE; SEROTONIN; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CONTROLLED STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACETYLCHOLINE; ANIMALS; CALCIMYCIN; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; IONOPHORES; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; NITROGLYCERIN; PENICILLAMINE; PHENYLEPHRINE; RABBITS; S-NITROSO-N-ACETYLPENICILLAMINE; TUNICA INTIMA; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 0031889321     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(97)00202-2     Document Type: Article

References (33)

1. Stary H.C. Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children. Atherosclerosis. 64:1987;91-108.
2. Stary H.C., Blankenhorn D.H., Chandler A.B.et al. A definition of the intima of human arteries and of its atherosclerosis-prone regions. Circulation. 85:1992;391-405.
3. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
4. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 88:1991;1785-1792.
5. Holvoet P., Collen D. Oxidized lipoproteins in atherosclerosis and thrombosis. FASEB J. 8:1994;1279-1284.
6. Meredith IT, Yeung AC, Weidinger FF et al. Role of impaired endothelium-dependent vasodilation in ischemic manifestations of coronary artery disease. Circulation 1993;87 suppl V:V-56-V-66.
7. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
8. Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA. 84:1987;9265-9269.
9. Flavahan N.A. Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity. Circulation. 85:1992;1927-1938.
10. Cox D.A., Cohen M.L. Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: clinical and pharmacological implications in atherosclerosis. Pharmacol Rev. 48:1996;3-19.
11. Kockx M.M., De Meyer G.R.Y., Jacob W.A., Bult H., Herman A.G. Triphasic sequence of neointimal formation in the cuffed carotid artery of the rabbit. Arterioscler Thromb. 12:1992;1447-1457.
12. Van Put D.J.M., Van Hove C.E., De Meyer G.R.Y., Wuyts F., Herman A.G., Bult H. Dexamethasone influences intimal thickening and vascular reactivity in the rabbit collared carotid artery. Eur J Pharmacol. 294:1995;753-761.
13. Smith C.C.T., Betteridge D.J. Reduced platelet serotonin content and release in familial hypercholesterolaemia. Atherosclerosis. 130:1997;87-92.
14. Barradas M.A., Gill D.S., Fonseca V.A., Mikhailidis D.P., Dandona P. Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. Eur J Clin Invest. 18:1988;399-404.
15. De Meyer GRY, Van Put DJM, Kockx MM, et al. Possible mechanisms of collar-induced intimal thickening. Arterioscler Thromb Vasc Biol 1997;17:1924-1930.
16. De Meyer G.R.Y., Bult H., Martin J.F., Van Hoydonck A.-E., Herman A.G. The effect of a developing neo-intima on serotonergic and adrenergic contractions. Eur J Pharmacol. 187:1990;519-524.
17. Wines P.A., Schmitz J.M., Pfister S.L.et al. Augmented vasoconstrictor responses to serotonin precede development of atherosclerosis in aorta of WHHL rabbit. Arteriosclerosis. 9:1989;195-202.
18. Matthys KE, Van Hove CE, Kockx MM, et al. Local application of low-density lipoprotein promotes intimal thickening in the collared carotid artery of the rabbit. Arterioscler Thromb Vasc Biol 1997; in press.
19. Ameli S., Hultgardh-Nilsson A., Regnström J.et al. Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 16:1996;1074-1079.
20. Kolodgie F.D., Virmani R., Rice H.E., Mergner W.J. Vascular reactivity during the progression of atherosclerotic plaque. A study in Watanabe heritable hyperlipidemic rabbits. Circ Res. 66:1990;1112-1126.
21. 2-receptor-mediated vasoconstrictions in atherosclerotic rabbit common carotid arteries. J Cardiovasc Pharmacol. 26:1995;503-510.
22. Verbeuren T.J., Jordaens F.H., Zonnekeyn L.L., Van Hove C.E., Coene M.-C., Herman A.G. Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circ Res. 58:1986;552-564.
23. Kawachi Y., Tomoike H., Maruoka Y.et al. Selective hypercontraction caused by ergonovine in the canine coronary artery under conditions of induced atherosclerosis. Circulation. 69:1984;441-450.
24. Heistad D.D., Armstrong M.L., Marcus M.L., Piegors D.J., Mark A.L. Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys. Circ Res. 54:1984;711-718.
25. Golino P., Piscione F., Willerson J.T.et al. Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. New Engl J Med. 324:1991;641-648.
26. Vita J.A., Treasure C.B., Yeung A.C.et al. Patients with evidence of coronary endothelial dysfunction as assessed by acetylcholine infusion demonstrate marked increase in sensitivity to constrictor effects of catecholamines. Circulation. 85:1992;1390-1397.
27. Vanhoutte P.M., Shimokawa H. Endothelium-derived relaxing factor and coronary vasospasm. Circulation. 80:1989;1-9.
28. Moncada S., Rees D.D., Schulz R., Palmer R.M. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA. 88:1991;2166-2170.
29. 2 receptors. J Pharm Pharmacol. 41:1989;868-876.
30. 2+ mobilization causes supersensitivity of contractile response to serotonin in atherosclerotic arteries. Circ Res. 75:1994;1096-1102.
31. Matthys K.E., Bult H. Nitric oxide function in atherosclerosis. Mediators Inflamm. 6:1997;1-18.
32. Harrison D.G., Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol. 75:1995;75B-81B.
33. Münzel T., Sayegh H., Freeman B.A., Tarpey M.M., Harrison D.G. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. J Clin Invest. 95:1995;187-194.