Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice

Journal of General Virology

Volumn 78, Issue 1, 1997, Pages 31-37

  Holzmann, Heidemarie ^a   Stiasny, Karin ^a   Ecker, Michael ^a   Kunz, Christian ^a   Heinz, Franz X ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN; VIRUS ENVELOPE PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE SENSITIVE MUTANT; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VIRUS INFECTION; VIRUS MUTANT; VIRUS REPLICATION; VIRUS VIRULENCE;

ACARI; ANIMALIA; FLAVIVIRUS; TICK-BORNE ENCEPHALITIS VIRUS; VERTEBRATA;

EID: 0031014304     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-78-1-31     Document Type: Article

References (46)

1. Allison, S. L., Schalich, J., Stiasny, K., Mandl, C. W., Kunz C. & Heinz, F. X. (1995). Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. Journal of Virology 69, 695-700.
2. Blondel, B., Crainic, R., Fichot, O., Dufraisse, G., Candrea, A., Diamond, D., Girard, M. & Horaud, F. (1986). Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site. Journal of Virology 57, 81-90.
3. Buckley, A & Gould, E. A. (1985). Neutralization of yellow fever virus studied using monoclonal and polyclonal antibodies. Journal of General Virology 66, 2523-2531.
4. Cahour, A., Pletnev, A., Vazeille-Falcoz, M., Rosen, L. & Lai, C.-J. (1995). Growth-restricted dengue virus mutants containing deletions in the 5′ noncoding region of the RNA genome. Virology 207, 68-76.
5. Cecilia, D. & Gould, E. A. (1991). Nucleotide changes responsible for loss of neuroinvasiveness in Japanese encephalitis virus neutralization-resistant mutants. Virology 181, 70-77.
6. Chen, W., Kawano, H., Men, R., Clark, D. & Lai, C.-J. (1995). Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for mice. Journal of Virology 69, 5186-5190.
7. Colman, P. M., Varghese, J. N. & Laver, W. G. (1983). Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature 303, 41-44.
8. Diamond, D. C., Jameson, B. A., Brown, J., Kohara, M., Abe, S., Itoh, H., Komatsu, T., Arita, M., Kuge, S., Osterhaus, A. D. M. E., Crainic, R., Nomoto, A. & Wimmer, E. (1985). Antigenic variation and resistance to neutralization in poliovirus type 1. Science 229, 1090-1093.
9. Gao, G. F., Hussain, M. H., Reid, H. W. & Gould, E. A. (1994). Identification of naturally occurring monoclonal antibody escape variants of louping ill virus. Journal of General Virology 75, 609-614.
10. Gritsun, T. S., Holmes, E. C. & Gould, E. A. (1995). Analysis of flavivirus envelope proteins reveals variable domains that reflect their antigenicity and may determine their pathogenesis. Virus Research 35, 307-321.
11. Guirakhoo, F., Heinz, F. X. & Kunz, C. (1989). Epitope model of tickborne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain and conformational changes occurring at acidic pH. Virology 169, 90-99.
12. Guirakhoo, F., Hunt, A. R., Lewis, J. G. & Roehrig, J. T. (1993). Selection and partial characterization of dengue 2 virus mutants that induce fusion at elevated pH. Virology 194, 219-223.
13. Hasegawa, H., Yoshida, M., Shiosaka, T., Fujita, S. & Kobayashi, Y. (1992). Mutations in the envelope protein of Japanese encephalitis virus affect entry into cultured cells and virulence in mice. Virology 191, 158-165.
14. Heinz, F. X. & Kunz, C. (1981). Homogeneity of the structural glycoprotein from European isolates of tick-borne encephalitis virus: comparison with other flaviviruses. Journal of General Virology 57, 263-274.
15. Heinz, F. X., Berger, R., Tuma, W. & Kunz, C. (1983). A topological and functional model of epitopes on the structural glycoprotein of tick-borne encephalitis virus defined by monoclonal antibodies. Virology 126, 525-537.
16. Heinz, F. X., Tuma, W., Guirakhoo, F. & Kunz, C. (1986). A model study of the use of monoclonal antibodies in capture enzyme immuno assays for antigen quantification exploiting the epitope map of tick-borne encephalitis virus. Journal of Biological Standardization 14, 133-141.
17. Heinz, F. X., Stiasny, K., Püschner-Auer, G., Holzmann, H., Allison, S. L., Mandl, C. W. & Kunz, C. (1994). Structural changes and functional control of tick-borne encephalitis virus glycoprotein E by heterodimeric association with protein prM. Virology 198, 109-117.
18. Hogle, J. M., Chow, M. & Filman, D. J. (1985). Three dimensional structure of poliovirus at 2·9 Å resolution. Science 229, 1358-1365.
19. Holzmann, H., Mandl, C. W., Guirakhoo, F., Heinz, F. X. & Kunz, C. (1989). Characterization of antigenic variants of tick-borne encephalitis virus selected with neutralizing monoclonal antibodies. Journal of General Virology 70, 219-222.
20. Holzmann, H., Heinz, F. X., Mandl, C. W., Guirakhoo, F. & Kunz, C. (1990). A single amino acid substitution in the envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model. Journal of Virology 64, 5156-5159.
21. Holzmann, H., Utter, G., Norrby, E., Mandl, C. W., Kunz, C. & Heinz, F. X. (1993). Assessment of the antigenic structure of tick-borne encephalitis virus by the use of synthetic peptides. Journal of General Virology, 74, 2031-2035.
22. Holzmann, H., Stiasny, K., York, H., Dorner, F., Kunz, C. & Heinz, F. X. (1995). Tick-borne encephalitis virus envelope protein E-specific monoclonal antibodies for the study of low pH-induced conformational changes and immature virions. Archives of Virology 140, 213-222.
23. Iorio, R. M. & Bratt, M. A. (1985). Selection of unique antigenic variants of Newcastle disease virus with neutralizing monoclonal antibodies and anti-immunoglobulin. Proceedings of the National Academy of Sciences, 82, 7106-7110.
24. Jiang, W. R., Lowe, A., Higgs, S., Reid, H. & Gould, E. A. (1993). Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence. Journal of General Virology 74, 931-935.
25. Kawano, H., Rostapshov, V., Rosen, L. & Lai, C.-J. (1993). Genetic determinants of dengue type 4 virus neurovirulence for mice. Journal of Virology 67, 6567-6576.
26. Lai, C.-J., Men, R., Pethel, M. & Bray, M. (1992). Infectious RNA transcribed from stably cloned dengue virus cDNA: construction of growth-restricted dengue virus mutants. In Vaccines 92. Modern Approaches to New Vaccines Including Prevention of AIDS, pp. 265-270. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
27. Lin, B., Parrish, C. R., Murray, J. M. & Wright, P. J. (1994). Localization of a neutralizing epitope on the envelope protein of Dengue virus type 2. Virology 202, 885-890.
28. Lobigs, M., Usha, R., Nestorowicz, A., Marshall, I. D., Weir, R. C. & Dalgarno, L. (1990). Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence. Virology 176, 587-595.
29. McMinn, P. C., Lee, E., Hartley, S., Roehrig, J. T., Dalgarno, L. & Weir, R. C. (1995). Murray Valley encephalitis virus envelope protein antigenic variants with altered hemagglutination properties and reduced neuroinvasiveness in mice. Virology 211, 10-20.
30. Mandl, C. W., Heinz, F. X. & Kunz, C. (1988). Sequence of the structural proteins of tick-borne encephalitis virus (Western subtype) and comparative analysis with other flaviviruses. Virology 166, 197-205.
31. Mandl, C. W., Guirakhoo, F., Holzmann, H., Heinz, F. X. & Kunz, C. (1989). Antigenic structure of the flavivirus envelope protein E at the molecular level, using tick-borne encephalitis virus as a model. Journal of Virology 63, 564-571.
32. Marin, M. S., De A. Zanotto, P. M., Gritsun, T. S. & Gould, E. A. (1995). Phylogeny of TYU, SRE, and CFA virus: different evolutionary rates in the genus Flavivirus. Virology 206, 1133-1139.
33. Monath, T. P. & Heinz, F. X. (1996). Flaviviruses. In Fields Virology, 3rd edn, pp. 961-1034. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia & New York: Lippincott-Raven Publishers.
34. Nowak, T. & Wengler, G. (1987). Analysis of disulfides present in the membrane proteins of West Nile flavivirus. Virology 156, 127-137.
35. Page, G. S., Mosser, A. G., Hogle, J. M., Filman, D. J., Rueckert, R. R. & Chow, M. (1988). Three-dimensional structure of poliovirus serotype 1 neutralizing determinants. Journal of Virology 62, 1781-1794.
36. Pletnev, A. G., Bray, M. & Lai, C.-J. (1993). Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice. Journal of Virology 67, 4956-4963.
37. 4 variants with monoclonal antibodies results in attenuation. Journal of General Virology 68, 865-869.
38. Rey, F. A., Heinz, F. X., Mandl, C., Kunz, C. & Harrison, S. C. (1995). The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution. Nature 375, 291-298.
39. Rice, C. M. (1996). Flaviviridae: the viruses and their replication. In Fields Virology, 3rd edn, pp. 931-959. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia & New York: Lippincott-Raven Publishers.
40. Rossmann, M. G., (1989). Neutralization of small RNA viruses by antibodies and antiviral agents. FASEB Journal 3, 2335-2343.
41. Saito, T., Taylor, G., Laver, W. G., Kawaoka, Y. & Webster, R. G. (1994). Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase. Journal of Virology 68, 1790-1796.
42. Sherry, B., Mosser, A. G., Colonno, R. J. & Rueckert, R. R. (1986). Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14. Journal of Virology 57, 246-257.
43. Sil, B. K., Dunster, L. M., Ledger, T. N., Wills, M. R., Minor, P. D. & Barrett, A. D. T. (1992). Identification of envelope protein epitopes that are important in the attenuation process of wild-type Yellow fever virus. Journal of Virology 66, 4265-4270.
44. Sumiyoshi, H., Tignor, G. H. & Shope, R. E. (1995). Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA. Journal of Infectious Disease 171, 1144-1151.
45. Tulip, W. R., Varghese, J. N., Baker, A. T., Van Donkelaar, A., Laver, W. G., Webster, R. G. & Colman, P. M. (1991). Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants. Journal of Molecular Biology 221, 487-497.
46. Wiley, D. C. & Wilson, I. A., Skehel, J. J. (1981). Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289, 373-378.