Rates of glucagon activation and deactivation of hepatic glucose production in conscious dogs

Metabolism: Clinical and Experimental

Volumn 47, Issue 2, 1998, Pages 135-142

  Dobbins, Robert L ^b   Davis, Stephen N ^b   Neal, Doss ^b   Caumo, Andrea ^b   Cobelli, Claudio ^b   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; INSULIN; SOMATOSTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DOG; FEMALE; GLUCAGON RELEASE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL;

EID: 0031882591     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90209-8     Document Type: Article

References (52)

1. Cherrington AD, Diamond MP, Green DR, et al: Evidence for an intrahepatic contribution to the waning effect of glucagon on hepatic glucose production in the conscious dog. Diabetes 31:917-922, 1982
2. Cherrington AD, Williams PE, Shulman GT, et al: Differential time course of glucagon's effects on glycogenolysis and gluconeogenesis in the dog. Diabetes 30:180-187, 1981
3. Wada M, Connolly CC, Tarumi C, et al: Hepatic denervation does not significantly change the response of the liver to glucagon in conscious dogs. Am J Physiol 268:E194-E203, 1995
4. Ferrannini E, DeFronzo R, Sherwin R: Transient hepatic response to glucagon in man: Role of insulin and hyperglycemia. Am J Physiol 242:E73-E81, 1982
5. Fradkin J, Shamoon H, Felig P: Evidence for an important role of changes in rather than absolute concentrations of glucagon in the regulation of glucose production in humans. J Clin Endocrinol Metab 50:698-703, 1980
6. 125I-labelled glucagon and glucagon-stimulated accumulation of adenosine 3′:5′-monophosphate in isolated, intact rat hepatocytes. J Biol Chem 253:3203-3210, 1978
7. Steele R, Wall J, DeBodo R, et al: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
8. Plas C, Nunez J: Glycogenolytic response to glucagon of cultured fetal hepatocytes. Refractoriness following exposure to glucagon. J Biol Chem 249:3615-3621, 1975
9. Shiota M, Green R, Colburn CA, et al: Inability of hyperglycemia to counter the ability of glucagon to increase net glucose output and activate glycogen phosphorylase in the perfused rat liver. Metabolism 45:481-485, 1996
10. Finegood D, Bergman R, Vranic M: Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034, 1988
11. 14C]glucose during hyperinsulinemia in humans. Diabetes 38:97-107, 1989
12. Wall JS, Steele RG, DeBodo RC, et al: Effect of insulin on utilization and production of circulating glucose. Am J Physiol 189:43-50, 1957
13. Cobelli C, Man A, Ferrannini E: Non-steady state error analysis of Steele's model and developments for glucose kinetics. Am J Physiol 252:E679-E689, 1985
14. Caumo A, Cobelli C: Hepatic glucose production during the labeled IVGTT: Estimation by deconvolution with a new minimal model. Am J Physiol 264:E829-E841, 1993
15. Dobbins RL, Davis SN, Neal DW, et al: Pulsatility does not alter the response to a physiologic increment in glucagon in conscious dogs. Am J Physiol 266:E467-E478, 1994
16. Ferrannini E, Smith JD, Cobelli C, et al: Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest 76:357-364, 1985
17. Katz H, Butler P, Homan M, et al: Hepatic and extrahepatic insulin action in humans: Measurement in the absence of nonsteady-state error. Am J Physiol 264:E561-E566, 1993
18. Adkins BA, Myers SR, Hendrick GK, et al: Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest 79:557-565, 1987
19. Iversen J: Inhibition of pancreatic glucagon release by somatostatin in vitro. Scand J Lab Invest 33:125-129, 1974
20. Frizzell RT, Hendrick GK, Brown LL, et al: Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes 37:1531-1541, 1989
21. Wasserman DH, Spalding JA, Bracy D, et al: Exercise-induced rise in glucagon and ketogenesis during prolonged muscular work. Diabetes 38:799-807, 1989
22. Cherrington AD, Chiasson JE, Liljenquist JE, et al: The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest 58:1407-1408, 1976
23. Kadish AH, Little RL, Sternberg JC: A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clin Chem 14:116-131, 1968
24. Nelson N: A photometric adaptation of the Somogyi method for the determination of glucose. J Biol Chem 153:375-380, 1944
25. Somogyi M: Determination of blood sugar. J Biol Chem 154:69-73, 1975
26. Morgan CR, Laxarow AL: Immunoassay of insulin: Two antibody system. Plasma insulin of normal, subdiabetic, and diabetic rats. Diabetes 12:115-126, 1963
27. Aguilar-Parada E, Eisentraut EM, Unger RH: Pancreatic glucagon secretion in normal and diabetic subjects. Am J Med Sci 257:415-419, 1969
28. Berman M: Compartmental analysis in kinetics, in Stacy RW, Waxman BD (eds): Computers in Biomedical Research. New York, NY, Academic, 1965, p 173
29. Twomey S: The application of numerical filtering to the solution of integral equations in direct sensing measurements. J Franklin Inst 279:95-109, 1965
30. Phillips DL: A technique for the numerical solution of certain integral equations of the first kind. J Assoc Comput Machin 9:97-101, 1962
31. Weigle DS, Suret IR, Goodner CJ: A kinetic analysis of hepatocyte responses to a glucagon pulse: Mechanism and metabolic consequences of differences in response decay times. Endocrinology 121:732-737, 1987
32. Weigle DS, Koerker DJ, Goodner CJ: A model for augmentation of hepatocyte response to pulsatile glucagon stimuli. Am J Physiol 248:E681-E686, 1985
33. Dobbins RL, Davis SN, Neal DW, et al: Compartmental modeling of glucagon kinetics in the conscious dog. Metabolism 44:452-459, 1995
34. Jaspan JB, Polonsky KS, Rubenstein AH: The metabolic clearance rate of glucagon, in Lefebvre PJ (ed): Handbook of Experimental Pharmacology. Glucagon II. New York, NY, Springer-Verlag, 1983, pp 353-359
35. Komjati M, Bratusch-Marrain P, Waldhausl W: Superior efficacy of pulsatile vs. continuous hormone exposure on hepatic glucose production in vitro. Endocrinology 118:312-318, 1986
36. Youn JH, Bergman RN: Enhancement of hepatic glycogen by gluconeogenic precursors: Substrate flux or metabolic control? Am J Physiol 258:E899-E906, 1990
37. Goodner CJ, Hom FG, Koerker DJ: Hepatic glucose production oscillates in synchrony with the islet secretory cycle in fasting rhesus monkeys. Science 215:1257-1260, 1982
38. Paolisso G, Scheen AJ, Albert A: Effects of pulsatile insulin and glucagon in humans. Am J Physiol 257:E686-E696, 1989
39. Paolisso G, Scheen AJ, Luyckx AS, et al: Pulsatile hyperglucagonemia fails to increase hepatic glucose production in normal man. Am J Physiol 252:E1-E7, 1987
40. Komjati M, Breitenecker F, Bratusch-Marrain PJ, et al: Contribution by the glycogen pool and adenosine 3′,5′-monophosphate release to the evanescent effect of glucagon on hepatic glucose production in vitro. Endocrinology 116:978-986, 1985
41. Liljenquist J, Bomboy JD, Lewis SB, et al: Effect of glucagon on net splanchnic cyclic AMP production in normal and diabetic men. J Clin Invest 53:198-204, 1974
42. Premont RT, Iyengar R: Glucagon-induced desensitization of adenylyl cyclase in primary cultures of chick hepatocytes. J Biol Chem 263:16087-16095, 1988
43. Soman V, Felig P: Glucagon receptor: Regulation by physiologic hyperglucagonemia. Nature 272:829-832, 1978
44. Srikant CB, Freeman D, McKorkle K, et al: Binding and biologic activity of glucagon in liver cell membranes of chronically hyperglucagonemic rats. J Biol Chem 252:7434-7438, 1977
45. m phosphodiesterase of adipocytes by addition of cAMP-dependent protein kinase. J Biol Chem 263:10359-10363, 1988
46. Gettys TW, Blackmore PF, Redmon JB, et al: Short-term feedback regulation of cAMP by accelerated degradation in rat tissues. J Biol Chem 262:333-339, 1987
47. Pagliassotti MJ, Holste LC, Moore MC, et al: Comparison of the time courses of insulin and portal activation on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97:81-91, 1996
48. Holste LC, Connolly CC, Cherrington AD: Glucagon can alter net hepatic glucose uptake during intraportal glucose delivery in the conscious dog. Diabetes 42:243A, 1993 (abstr)
49. Butler C, Caumo A, Zerman A, et al: Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 264:E548-E560, 1993
50. Sindelar DK, Balcom JH, Chu CA, et al: A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45:1594-1604, 1996
51. Sindelar DK, Chang CA, Neal DW, et al: Basal hepatic glucose production is controlled by the portal vein insulin concentration. Diabetes 46:48A, 1997 (abstr)
52. Flattern N, Venson P, Snead W, et al: Glucagon secretion sensitively increases in response to mild non-insulin induced hypoglycemia in the dog. Diabetes 46:17A, 1997 (abstr)