Emergence of syncytium-inducing human immunodeficiency virus type 1 variants coincides with a transient increase in viral rna level and is an independent predictor for progression to aids

Journal of Infectious Diseases

Volumn 178, Issue 2, 1998, Pages 397-403

  Spijkerman, Ingrid ^a   De Wolf, Frank ^b   Langendam, Miranda ^b   Schuitemaker, Hanneke ^b   Coutinho, Roel ^b  

^a MUNICIPAL HEALTH SERVICE   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; DISEASE COURSE; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SEROCONVERSION; SYNCYTIUM; VIRUS LOAD;

EID: 0031875687     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515627     Document Type: Article

References (19)

1. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
2. Wei X, Ghosh SK, Taylor ME, et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-22.
3. + cell depletion and progression to AIDS. Ann Intern Med 1993;118:681-8.
4. + T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals. J Virol 1993;67:1772-7.
5. Spijkerman IJB, Koot M, Prins M, et al. Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users compared with homosexual men. AIDS 1995;9:1085-92.
6. + lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126:946-54.
7. 4+ T-cell count, and function: markers with reciprocal predictive value over time after seroconversion. AIDS 1997;11:1799-806.
8. + T cell decline in vivo. Virology 1996;219:87-95.
9. Jurriaans S, Van Gemen B, Weverling GJ, et al. The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course? Virology 1994;204:223-33.
10. Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakobsen PH, Gerstoft J. Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996;10:167-73.
11. Koot M, van't Wout AB, Kootstra NA, de Goede REY, Tersmette M, Schuitemaker H. Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection. J Infect Dis 1996;173:349-54.
12. van Griensven GJP, Tielman RAP, Goudsmit J, et al. Risk factors and prevalence of HIV antibodies in homosexual men in the Netherlands. Am J Epidemiol 1987;125:1048-57.
13. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep 1992;41(RR-17):1-19.
14. Simmons G, Wilkinson D, Reeves JD, et al. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either CXCR4 or CCR5 as coreceptors for virus entry. J Virol 1996;70:8355-60.
15. Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-70.
16. de Jong MD, Veenstra J, Stilianakis NI, et al. Host-parasite dynamics and outgrowth of virus containing a single K70R amino acid change in reverse transcriptase are responsible for the loss of human immunodeficiency virus type 1 RNA load suppression by zidovudine. Proc Natl Acad Sci USA 1996;93:5501-6.
17. Fouchier RAM, Schuitemaker H. Molecular determinants of human immunodeficiency virus type 1 phenotype variability. Eur J Clin Invest 1996;26:175-85.
18. Groenink M, Fouchier RAM, Broersen S, et al. Relation of phenotype evolution of HIV-1 to envelope V2 configuration. Science 1993;260:1513-6.
19. + lymphocyte count improves assessment of antiretroviral therapeutic response. Ann Intern Med 1997;126:929-38.