Hypoxia upregulates inducible (type II) nitric oxide synthase in an HIF-1 dependent manner in rat pulmonary microvascular but not aortic smooth muscle cells

Chest

Volumn 114, Issue 1 SUPPL., 1998, Pages

  Palmer, Lisa A ^a   Johns, Roger A ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; AORTA MEDIA; CELL PROLIFERATION; CONFERENCE PAPER; ENZYME REGULATION; GENE EXPRESSION REGULATION; HYPOXIA; LUNG ARTERY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER;

EID: 0031875355     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Melillo G, Musso T, Sica A, et al. A hypoxia responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 1995; 182:1683-93
2. Wang GL, Semenza GL. General involvement of hypoxia inducible factor-1 in the transcriptional response to hypoxia. Proc Natl Acad Sci USA 1993; 90:4304-08
3. Gleadle JM, Ebert BL, Firth JD, et al. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol 1995; 268:C1362-68
4. Le Cras TD, Xue C, Rengasamy A, et al. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol 1996; 270:L164-70
5. Xue C, Johns R. Upregulation of nitric oxide synthase correlates temporally with onset of pulmonary vascular remodeling in the hypoxic rat. Hypertension 1996; 28:743-53
6. Johnson BA, Lowenstein CJ, Schwarz MA, et al. Culture of pulmonary microvascular smooth muscle cells from intraacinar arteries of the rat: characterization and inducible production of nitric oxide. Am J Respir Cell Mol Biol 1994; 10:604-12
7. Owens GK, Loeb A, Gordon D, et al. Expression of smooth muscle-specific alpha-isoactin in cultured vascular smooth muscle cells: relationship between growth and cytodifferentiation. J Cell Biol 1986; 102:343-52