Gene identification in asthma and allergy

International Archives of Allergy and Immunology

Volumn 116, Issue 4, 1998, Pages 247-252

  Moffatt, Miriam F ^a   Cookson, William O C M ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Asthma; Atopy; Genes; Linkage association

Indexed keywords

ALLERGEN; IMMUNOGLOBULIN E;

ALLERGY; ASTHMA; ATOPY; CHROMOSOMAL LOCALIZATION; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; HUMAN; PRIORITY JOURNAL; REVIEW;

ASTHMA; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN; GENES, IMMUNOGLOBULIN; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; POLYMORPHISM, GENETIC;

EID: 0031874286     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000023952     Document Type: Review

References (67)

1. Moffatt MF, Sharp PA, Faux JA, Young RP, Cookson WOCM, Hopkin JM: Factors confounding genetic linkage between atopy and chromosome 11q. Clin Exp Allergy 1992;22: 1046-1051.
2. Cookson WOCM, Sharp PA, Faux JA, Hopkin JM: Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q. Lancet 1989;i:1292-1295.
3. Marsh DG, Meyers DA: A major gene for allergy - Fact or fancy? Nat Genet 1992;2:252-254.
4. Young RP, Lynch J, Sharp PA, Faux JA, Cookson WOCM, Hopkin JM: Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J Med Genet 1992; 29:236-238.
5. Shirakawa T, Morimoto K, Hashimoto T, Furuyama J, Yamamoto M, Takai S: Linkage between severe atopy and chromosome 11q in Japanese families. Clin Genet 1994;46:125-129.
6. Collée JM, ten Kate LP, de Vries HG, Kliphuis JW, Bouman K, Scheffer H, Gerritsen J: Allele sharing on chromosome 11q13 in sibs with asthma and atopy. Lancet 1993;42:936.
7. Herwerden L, Harrap SB, Wong ZYH, Abramson MJ, Kutin JJ, Forbes AB, Raven J, Lanigan A, Walters EH: Linkage of high affinity receptor gene with bronchial hyperreactivity. even in absence of atopy. Lancet 1995:346:1262-1265.
8. Fölster-Holst R, Moises HW, Yang L, Fritsch W, Weissenbach J, Christophers E: Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families. Hum Genet 1998:102:236-239.
9. Cookson WOCM, Young RP, Sandford AJ, et al: Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet 1992; 340:381-384.
10. Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA, Young RP, Nakamura Y, Lathrop GM, Cookson WOCM, Hopkin JM: Localisation of atopy and the ß subunit of the high affinity IgE receptor (FcεRI) on chromosome 11q. Lancet 1993;341:332-334.
11. Sandford AJ, Moffatt MF, Daniels SE, Nakamura Y, Lathrop GM, Hopkin JM, Cookson WOCM: A genetic map of chromosome 11q. including the atopy locus. Eur J Hum Genet 1995:3:188-194.
12. Shirakawa TS, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA, Ra C, Cookson WOCM, Hopkin JM: Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nat Genet 1994;7: 125-129.
13. Hill MR, James AL, Faux JA, Ryan G, Hopkin JM, le Souef P, Musk AW, Cookson WOCM: FcεRI-β polymorphism and risk of atopy in a general population sample. Br Med J 1995; 311:776-779.
14. Adra CN, Lelias J-M, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B: Cloning of the cDNA for a haemopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: Evidence for a family of proteins with four membrane spanning regions. Proc Natl Acad Sci 1994;91:10178-10182.
15. Hill MR, Cookson WOCM: A new variant of the β subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β E237G ): Associations with measures of atopy and bronchial hyperresponsiveness. Hum Mol Genet 1996;5:959-962.
16. Shirakawa TS, Mao XQ, Sasaki S, Nomoto TE, Kawai M, Morimoto K, Hopkin JM: Association between atopic asthma and a coding variant of FcεRI-β in a Japanese population. Hum Mol Genet 1996;5:2068.
17. Cox HE, Moffatt MF, Faux JA, Walley AJ, Coleman R, Trembath RC, Cookson WOCM, Harper JI: Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br J Dermatol 1998; 138:182-187.
18. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Erlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH: Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum IgE concentrations. Science 1994:264:1152-1155.
19. Meyers DA, Postma DS. Panhuysen CIM, Xu J, Amelung PJ, Levitt RC, Bleeker ER: Evidence for a locus regulation total serum IgE levels mapping to chromosome 5. Genomics 1994;23:464-470.
20. Postma SD, Bleeker ER, Amelung PJ. Holyroyd, Xiu J, Panhuysen CIM, Meyers DA, Levitt RC: Genetic susceptibility to asthma-bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 1995; 333:894-900.
21. Amelung PG, Bleeker ER, Postma DS, Panhuysen CIM, Holroyd KJ, Meyers DA, Levitt RC: A locus regulating bronchial responsiveness maps to 5q. Am Respir Crit Care Med 1995;151:A341.
22. Panhuysen CIM, Xu J, Amelung PA, Holroyd KJ, Postma DS, Levitt RC, Meyers DA, Bleeker ER: Evidence for two loci regulating total IgE levels. Am J Resp Crit Care Med 1995; 151:A341.
23. Doull IJM, Lawrence S, Watson M, Begishvili T, Beasley RW, Lampe F, Holgate ST, Morion NE: Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial responsiveness. Am J Respir Crit Care Med 1996:153:1280-1284.
24. Walley AJ, Bhattacharyya S, Leaves N, Daniels SE, Cookson WOCM: Linkage and allelic association of chromosome 5 microsatellite markers with atopic asthma phenotypes in a general population sample. Am J Respir Crit Care Med 1997;155:A257.
25. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, Borish L: Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25(suppl 2):74-78.
26. Walley AJ, Cookson WOCM: Investigation of an interleukin 4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996;33:689-692.
27. Barnes KC, Neely JD, Duffy DL, Freidhoff LR, Breazeale DR, Schou C, Naidu RP, Levett PN, Renault B, Kucherlapti R, Iozzino S, Ehrlich E, Beaty TH, Marsh DG: Linkage of asthma and total serum IgE concentration to markers on chromosome 12q: Evidence from Afro-Caribbean and Caucasian populations. Genomics 1996;37:41-50.
28. Nickel R, Wahn U, Hizawa N, Maestri N, Duffy DL, Barnes KC, Beyer K, Forster J, Bergmann R, Zepp F, Wahn V, Marsh DG: Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German multicenter allergy study. Genomics 1997;46:159-162.
29. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA: The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-1725.
30. Deichmann KA, Heinzmann A, Forster J, Dischinger S, Mehl C, Brueggenolte E, Hildebrandt F, Moseler M, Kuehr J: Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin Exp Allergy 1998; 2:151-155.
31. Sears MR, Herbison GP, Holdaway MD, et al: The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma. Clin Allergy 1989; 18:419-424.
32. Levine BB, Stember RH, Fontino M: Ragweed hayfever: Genetic control and linkage to HL-A haplotypes. Science 1972;178:1201-1203.
33. Marsh DG, Meyers DA, Bias WB: The epidemiology and genetics and atopic allergy. N Engl J Med 1981;305:1551-1559.
34. Blumenthal MN, Awdeh Z, Alper C, Yunis E: Ra5 immune responses, HLA antigens and complotypes (abstract). J Allergy Clin Immunol 1985;75:155.
35. Freidhoff LR, Ehrlich-Kautzky E, Meyers DA, Ansari AA, Bias WB, Marsh DG: Association of HLA-DR3 with human immune response to Lol p I and Lol p II allergens in allergic subjects. Tissue Antigens 1988;31:211-219.
36. Ansari AA, Freidhoff LR, Meyers DA, Bias WB, Marsh DG: Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5. Hum Immunol 1989;25:59-71.
37. Sriramarao P, Selvakumar B, Damodaran C, Rao BS, Prakash O, Rao PV: Immediate hypersensitivity to Parthenium hysterophorus. I. Association of HLA antigens and Parthenium rhinitis. Clin Exp Allergy 1990;20:555-560.
38. Fischer GF, Pickl WF, Fae I, Ebner C, Ferreira F, Breiteneder H, Vikoukal E, Scheiner O, Kraft D: Association between IgE response against Bet v I, the major allergen of birch pollen, and HLA-DRB alleles. Hum Immunol 1992;33:259-265.
39. Marsh DG, Freidhoff LR, Ehrlich-Kautzky E, Bias WB, Roebber M: Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans, Immunogenetics 1987;26 (4-5):230-236.
40. Reid MJ, Nish WA, Whitman BA, Goetz DW, Hylander RD, Parker WA Jr, Freeman TM: HLA-DR4-associated nonresponsiveness to mountain cadar allergen. J Allergy Clin Immunol 1992;89:593-598.
41. Lympany P, Kemeny DM, Welsh KI, Lee TH: An HLA-associated nonresponsiveness to mellitin: A component of bee venom. J Allergy Clin Immunol 1990;86:160-170.
42. Sasazuki T, Nishimura Y, Muto M, Ohta N: HLA-linked genes controlling immune response and disease susceptibility. Immunol Rev 1983;70:51-75.
43. Young RP, Dekker JW, Wordsworth BP, Schou C, Pile KD, Matthiesen F, Rosenberg WMC, Bell JI, Hopkin JM, Cookson WOCM: HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy 1994;24:431-439.
44. Dekker JW, Nizankowska E, Schmitz-Schumann M, Pile K, Bochenek G, Dyczek A, Cookson WOCM, Szczeklik A: Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. Clin Exp Allergy 1997;27:574-577.
45. Loveridge JA, Rosenberg WMC, Kirkwood TBL, Bell JI: The genetic contribution to human T-cell receptor repertoire. Immunology 1991;74:246-250.
46. Moss PAH, Rosenberg WMC, Zintzaras E, Bell JI: Characterization of the human T cell receptor α-chain repertoire and demonstration of a genetic influence on Vα usage. Eur J Immunol 1993;23:1153-1159.
47. Gulwani-Akolar B, Posnett DN, Janson CH, Grunewald J, Wigzell H, Akolkar P, Gregersen PK, Silver J: T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J Exp Med 1991;174:1139-1146.
48. Robinson MA: Usage of human T-cell receptor V beta, J beta, C beta and V alpha gene segments is not proportional to gene number. Hum Immunol 1992;35:60-67.
49. Moffatt MF, Hill MR, Cornélis F, Schou C, Faux JA, Young RP, James AL, Ryan G. le Souef P, Musk AW, Hopkin JM, Cookson WOCM: Genetic linkage of the TCR-α/δ region to specific immunoglobulin E responses. Lancet 1994;343:1597-1600.
50. Robinson MA, Kindt TJ: Genetic recombination within the human T-cell receptor alpha-chain complex. Proc Natl Acad Sci USA 1987; 84:9089-9093.
51. Cornélls F, Hashimoto L, Loveridge J, MacCarthy A, Buckle V, Julier C, Bell J: Identification of a CA repeat at the TCRA locus using yeast artificial chromosomes: A general method for generating highly polymorphic markers at chosen loci. Genomics 1992;13:820-825.
52. Boysen C, Carlson C, Hood E, Hood L, Nickerson DA: Identifying DNA polymorphisms in human TCR A/D variable genes by direct sequencing of PCR products. Immunogenetics 1996;44:121-127.
53. Heinzel FP, Sadick MD, Mutha SS, Locksley RM: Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 1991;88:7011-7015.
54. Mohapatra SS, Monapatra S, Yang M, Ansari AA, Parronchi P, Maggi E, Romagnuni S: Molecular basis of cross-reactivity among allergen-specific human T cells. T-cell receptor Vu gene usage and epitope structure. Immunology 1994;81:15-20.
55. Moffatt MF, Schou C, Faux JA, Cookson WOCM: Germline TCR-A restriction of immunoglobulin E responses to allergen. Immunogenetics 1997;46:226-230.
56. Holt PG, McMenamin C: IgE and mucosal immunity: Studies on the role of intraepithelial Ia+ dendritic cells and δ/γ T-lymphocytes in regulation of T-cell activation in the lung. Clin Exp Allergy 1991;21(suppl): 148-152.
57. Reihsaus E, Innis M, MacIntyre N, Liggett SB: Mutations in the gene encoding the β2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 1993;8:334-339.
58. Turki J, Pak J, Green SA, Martin RJ, Liggett SB: Genetic polymorphisms of the β2-adrenergic receptor in nocturnal and nonnocturnal asthma. J Clin Invest 1995;95:1635-1641.
59. Holgate ST: Asthma genetics: Waiting to Inhale. Nat Genet 1997;15:227-229.
60. Green SA, Turki J, Innis M, Liggett SB: Amino-terminal polymorphisms of the human β2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 1994;33:9414-9419.
61. Hall IP, Wheatley A, Wilding P, Liggett SB: Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213-1214.
62. Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO: Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor α: Relevance to genetic predisposition to systemic lupus erythematosis. Proc Natl Acad Sci USA 1990;87:1233-1237.
63. Messer G, Spengler U, Jung MC, Honold G, Blömer K, Pape GR, Riethmüller G, Weiss EH: Polymorphic structure of the tumor necrosis factor (TNF) locus: An Ncol polymorphism in the first intron of the human TNF-β gene correlates with a variant amino acid in position 26 and a reduced level of TNF-β production. J Exp Med 1991;173:209-219.
64. Wilson AG, Symons JA, McDowell TL, di Giovine FS, Duff GW: Effects of a tumour necrosis factor (TNF-α) promotor base transition on transcriptional activity (abstract). Br J Rheumatol 1994;33:89.
65. Moffatt MF, Cookson WOCM: Tumour necrosis factor haplotypes and asthma. Hum Mol Genet 1997;6:551-554.
66. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, le Söuef PN, Lathrop GM, Musk AW, Cookson WOCM: A genome-wide search for quantitative trait loci underlying asthma. Nature 1996;383:247-250.
67. The Collaborative Study on the Genetics of Asthma (CSGA): A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 1997;15:389-392.