Analysis of particle size and lipid composition as determinants of the metabolic clearance of human high density lipoproteins in a rabbit model

Journal of Lipid Research

Volumn 39, Issue 6, 1998, Pages 1162-1172

  Lamarche, Benoît ^a   Uffelman, Kristine D ^a   Steiner, George ^a   Barrett, P Hugh R ^b   Lewis, Gary F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b University of Washington   (United States)

Author keywords

Hepatic lipase; Hypertriglyceridemia; Kinetics; Metabolism; Rabbits; Radioisotopes

Indexed keywords

HIGH DENSITY LIPOPROTEIN; LIVER TRIACYLGLYCEROL LIPASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; HYPERTRIGLYCERIDEMIA; LIPID COMPOSITION; LIPID METABOLISM; LIPOLYSIS; LIPOPROTEIN BLOOD LEVEL; PARTICLE SIZE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEIN A-II; BLOOD PROTEINS; CHOLESTEROL; CHOLESTEROL ESTERS; CHROMATOGRAPHY, GEL; FASTING; FATTY ACIDS, NONESTERIFIED; HUMANS; KINETICS; LIPASE; LIPOPROTEINS, HDL; LIVER; METABOLIC CLEARANCE RATE; MIDDLE AGED; PHOSPHOLIPIDS; RABBITS; TRIGLYCERIDES;

EID: 0031864748     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Bainton, D., N.E. Miller, C. H. Bolton, J. W. Yarnell, P. M. Sweetnam, I. A. Baker, B. Lewis, and P. C. Elwood. 1992. Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Br. Heart J. 68: 60-66.
2. Assmann, G., and H. Schulte. 1992. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Am. J. Cardiol 70: 733-737.
3. Miller, G. J., and N. E. Miller. 1977. Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet. 1: 16-18.
4. Gordon, D. J., and B. M. Rifkind. 1989. High density lipoprotein: the clinical implications of recent studies. N. Engl. J. Med. 321: 1311-1316.
5. Manninen, V., L. Tenkanen, P. Koshinen, J. K. Huttunen, M. Mänttäri, O. P. Heinonen, and M. H. Frick. 1992. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Hebinki Heart Study: implications for treatment. Circulation. 85: 37-45.
6. Eisenberg, S. 1984. High density lipoprotein metabolism. J. Lipid Res. 25: 1017-1058.
7. Funke, H. 1997. Genetic determinants of high density lipoprotein levels. Curr. Opin. Lipidol. 8: 189-196.
8. Brinton, E. A., S. Eisenberg, and J. L. Breslow. 1994. Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler. Thromb. 14: 707-720.
9. Brinton, E. A., S. Eisenberg, and J. L. Breslow. 1989. Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women. J. Clin. Invest. 84: 262-269.
10. Nestel, P. J. 1987. High-density lipoproteius turnover. Am. Heart J. 113: 518-521.
11. Brinton, E. A., S. Eisenberg, and J. L. Breslow. 1991. Increased apoA-I and apoA-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia. J. Clin. Invest. 87: 536-544.
12. Saku, K., R. Liu, T. Ohta, S. Jimi, I. Matsuda, and K. Arakawa. 1994. Plasma HDL levels are regulated by the catabolic rate of large particles of lipoprotein containing apoA-I. Biochem. Biophys. Res. Commun. 200:557-561.
13. Horowitz, B. S., I. J. Goldberg, J. Merab, T. M. Vanni, R. Ramakrishnan, and H. N. Ginsberg. Increased plasma and renal clearance of an exchangeable pool of apolipoprotem A-I in subjects with low levels of high density lipoprotein cholesterol. J. Clin. Invest. 91: 1743-1752.
14. Lamarche, B., J. P. Després, M. C. Pouliot, D. Prud'Homme, S. Moorjani, P. J. Lupien, A. Nadeau, A. Tremblay, and C. Bouchard. 1993. Metabolic heterogeneity associated with high plasma triglyceride or low HDL cholesterol levels in men. Arterioscler. Thromb. 13: 33-40.
15. Austin, M. A. 1989. Plasma triglycerides as a risk factor tor coronary heart disease. The epidemiologic evidence and beyond. Am. J. Epidemiol. 129: 249-259.
16. Reichl, D., and N. E. Miller. 1989. Pathophysiology of reverse cholesterol transport. Insight from inherited disorders of lipoprotein metabolism. Arterioscler. Thromb. Vasc. Biol. 9: 785-797.
17. Lewis, G. F. B. Lamarche, K. D. Uffelman, A. C. Heatherington, M. A. Honing, L. W. Szeto, and P. H. R. Barrett. 1997. Clearance of post-prandial and lipolytically modified human HDL in rabbits and rats. J. Lipid Res. 38: 1771-1781.
18. Fan, J., J. Wang, A. Bensadoun, S. J. Lauer, Q. Dang, R. W. Mahley, and J. M. Taylor. 1994. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc. Natl. Acad. Sci. USA. 91: 8724-8728.
19. McFarlane, A. S. 1958. Efficient trace labeling of proteins with iodine. Nature. 182: 53-57.
20. Lewis, G. F., V. G. Cabana, B. Lamarche, K. D. Uffelman, and G. S. Getz. 1997. Production of small HDL particles after intravenous heparin in hypertriglyceridemic diabetic and non-diabetic individuals. Studies before and after gemfibrozil therapy. Metabolism. In press.
21. Li, Z., J. R. McNamara, J. M. Ordovas, and E. J. Schaefer. 1994. Analysis of high density lipoproteins by a modified gradient gel electrophoresis method. J. Lipid Res. 35: 1698-1711.
22. Yamaguchi, Y., Y. Marui, and C. Hayashi. 1981. Determination of ester cholesterol in serum. Clin. Chem. 27: 1305-1306.
23. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275.
24. SAS Institute Inc. 1989. The ANOVA procedure. In SAS/STAT User's Guide, version 6. SAS Institute Inc., Cary, NC. 943.
25. Fan, J., S. P. McCormick, R. M. Krauss, S. Taylor, R. Quan, J. M. Taylor, and S. G. Young. 1995. Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL. Arterioscler. Thromb. Vasc. Biol. 15: 1889-1899.
26. Quig, D. W., and D. B. Zilversmit. 1988. Plasma lipid transfer activity in rabbits: effects of dietary hyperlipidemias. Atherosclerosis. 70: 263-271.
27. Quig, D. W., and D. B. Zilversmit. 1989. High density lipoprotein metabolism in a rabbit model of hyperalphalipoproteinemia. Atherosclerosis. 76: 9-19.
28. Son, Y. S. C., and D. B. Zilversmit. 1986. Increased lipid transfer activities in hyperlipidemic rabbit plasma. Arterioscler. Thromb. Vasc. Biol. 6:345-351.
29. Saku, K. R. Liu, S. Jimi, K. Matsuo, K. Yamamoto, T. Yanagita, and K. Arakawa. 1995. Combined effects of pravastatin and probucol on high-density lipoprotein apolipoprotein A-I kinetics in cholesterol-fed rabbits. Jpn. Circ. J. 59: 292-298.
30. Saku, K., K. Yamamoto, T. Sakai, T. Yanagida, K. Hidaka, J. Sasaki, and K. Arakawa. 1989. Kinetics of HDL-apoA-I in the WHHL rabbit, an animal model of familial hypercholesterolemia. Atherosclerosis. 79: 225-230.
31. Sugano, M., N. Makino, and T. Yanaga. 1997. Effect of dietary omega-3 eicosapentaenoic acid supplements on cholesteryl ester transfer from HDL in cholesterol-fed rabbits. Biochim. et Biophys. Acta. 1346: 17-24.
32. Fragoso, Y. D., and E. R. Skinner. 1996. Cholesterol-loading of peripheral tissues alters the interconversion of high density lipoprotein subfractions in rabbits. Int. J. Biochem. Cell Biol. 28: 151-163.
33. Acton, S., Rigotti. A, K. T. Landschulz, S. Z. Xu, H. H. Hobbs, and M. Krieger. 1996. Identification of scavenger receptors SR-BI as a high density lipoprotein receptor. Science. 271: 518-520.
34. Rigotti, A., B. Trigatti, J. Babitt, M. Penman, S. Xu, and M. Krieger. 1997. Scavenger receptor B1 - a cell surface receptor for high density lipoprotein. Curr. Opin. Lipidol. 8: 181-188.
35. Wang, N., W. Weng, J. L. Breslow, and A. R. Tall. 1996. Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control. J. Biol. Chem. 271: 21001-21004.
36. Newnham, H. H., G. J. Hopkins, S. Devlin, and P. J. Barter. 1990. Lipoprotein lipase prevents the hepatic lipase-induced reduction in particle size of high density lipoproteins during incubation of human plasma. Atherosclerosis. 82: 167-176.
37. Clay, M. A., H. H. Newnham, and P. J. Barter. 1991. Hepatic lipase promotes a loss of apolipoprotein A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro. Arterioscler. Thromb. 11:415-422.
38. Clay, M. A., H. H. Newnham, T. M. Forte, and P. J. Barter. 1992. Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apoA-I from HDL and subsequent formation of discoidal HDL. Biochim. Biophys. Acta. 1124: 52-58.
39. Marques-Vidal, P., C. Azema, X. Collet, H. Chap, and B. P. Perret. 1991. Hepatic lipase-mediated hydrolysis versus liver uptake of HDL phospholipids and triacylglycerols by the perfused rat liver. Biochim. Biophys. Acta. 1082: 185-194.
40. Tall, A. R. 1993. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34: 1255-1274.
41. Newnham, H. H., and P. J. Barter. 1990. Synergistic effects of lipid transfers and hepatic lipase in the formation of very small high-density lipoproteins during incubation of human plasma. Biochim. Biophys. Acta. 1044: 57-64.
42. Liang, H. Q., K. A. Rye, and P. J. Barter. 1996. Remodelling of reconstituted high density lipoproteins by lecithin:cholesterol acyltransferase. J. Lipid Res. 37: 1962-1970.
43. Vaisman, B. L., H. G. Klein, M. Rouis, A. M. Berard, M. R. Kindt, G. D. Talley, S. M. Meyn, R. F. Hoyt, Jr., S. M. Marcovina, and J. J. Albers. 1995. Overexpression of human lecithin:cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J. Biol. Chem. 270: 12269-12275.
44. Zuckerman, S. H., and G. F. Evans. 1995. Cholesteryl ester transfer protein inhibition in hypercholesterolemic hamsters: kinetics of apoprotein changes. Lipids. 30: 307-311.
45. Hayek, T., N. Azrolan, R. B. Verdery, A. Walsh, T. Chajek-Shaul, L. B. Agellon, A. R. Tall, and J. L. Breslow. 1993. Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particles sizes, and metabolism. J. Clin. Invest. 92: 1143-1152.
46. Rader, D. J., G. Castro, L. A. Zech, J. C. Fruchart, and H. B. Brewer, Jr. 1991. In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpAT, A-II. J. Lipid Res. 32: 1849-1859.
47. von Eckardstein, A., Y. Huang, and G. Assmann. 1994. Physiological role and clinical relevance of high-density lipoprotein subclasses. Curr. Opin. Lipidol. 5: 404-416.
48. Okamoto, Y., H. Tsujii, Y. Haga, S. Tanaka, and H. Nakano. 1994. Determination of apolipoprotein E in high density lipoprotein fraction by immunofixation method and turbidimetric immunoasay after precipitation. J. Atheroscler. Thromb. 1: 23-29.
49. Krimbou, L., M. Tremblay, J. Davignon, and J. S. Cohn. 1997. Characterization of human plasma apolipoprotein E-containing lipoproteins in the high density lipoprotein size range: focus on pre-betal-LpE, pre-beta2-LpE, and alpha-LpE. J. Lipid Res. 38: 35-48.