Role of cytokines in the pathogenesis of the euthyroid sick syndrome

European Journal of Endocrinology

Volumn 138, Issue 6, 1998, Pages 603-614

  Bartalena, Luigi ^a   Bogazzi, Fausto ^a   Brogioni, Sandra ^a   Grasso, Lucia ^a   Martino, Enio ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; CYTOKINE; CYTOKINE RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 6; THYROGLOBULIN; THYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CYTOKINE RELEASE; EUTHYROID SICK SYNDROME; GRAVES DISEASE; HASHIMOTO DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REVIEW; THYROID FUNCTION;

ANIMALS; CELLS, CULTURED; CYTOKINES; EUTHYROID SICK SYNDROMES; HUMANS; RECEPTORS, CYTOKINE; THYROID GLAND; TUMOR CELLS, CULTURED;

EID: 0031863759     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1380603     Document Type: Review

References (111)

1. Docter R, Krenning EP, de Jong M & Hennemann G. The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clinical Endocrinology 1993 39 499-518.
2. 3) in undiluted serum by equilibrium dialysis/radioimmunoassay. Thyroid 1996 6 255-259.
3. Engler D & Burger AG. The deiodination of the iodothyronines and their derivatives in man. Endocrine Reviews 1984 5 151-184.
4. Kaptein EM, Feinstein EI, Nicoloff JT & Massry SG. Serum reverse triiodothyronine and thyroxine kinetics in patients with chronic renal failure. Journal of Clinical Endocrinology and Metabolism 1983 57 181-189.
5. LoPresti JS, Fried JC, Spencer CA & Nicoloff JT. Unique alterations of thyroid hormone indices in the acquired immunodeliciency syndrome (AIDS). Annals of Internal Medicine 1989 110 970-975.
6. Woolf PD, Lee LA, Hamill RW & McDonald JF. Thyroid test abnormalities in traumatic brain injury: correlation with neurologic impairment and sympathetic nervous system activation. American Journal of Medicine 1988 84 201-208.
7. Wiersinga WM & Boelen A. Thyroid hormone metabolism in nonthyroidal illness. Current Opinion in Endocrinology and Diabetes 1996 3 422-427.
8. Bartalena L, Pacchiarotti A, Palla R, Antonangeli L, Mammoli C, Monzani F et al. Lack of nocturnal serum thyrotropin (TSH) surge in patients with chronic renal failure undergoing regular maintenance hemofiltration: a case of central hypothyroidism. Clinical Nephrology 1990 34 30-34.
9. Arem R & Deppe S. Fatal nonthyroidal illness may impair nocturnal thyrotropin levels. American Journal of Medicine 1990 88 258-262.
10. Romijn JA & Wiersinga WM. Decreased nocturnal surge of thyrotropin in nonthyroidal illness. Journal of Clinical Endocrinology and Metabolism 1990 70 35-42.
11. Bartalena L, Martino E, Brandi LS, Falcone M, Pacchiarotti A, Ricci C et al. Lack of nocturnal serum thyrotropin surge after surgery. Journal of Clinical Endocrinology and Metabolism 1990 70 293-296.
12. Bartalena L, Placidi GF, Martino E, Falcone M, Pellegrini L, Dell'Osso L et al. Nocturnal serum thyrotropin (TSH) surge and the TSH response to TSH-releasing hormone: dissociation in untreated depressives. Journal of Clinical Endocrinology and Metabolism 1990 71 650-655.
13. Lee H-Y, Suhl J, Pekary AE & Hershman JM. Secretion of thyrotropin with reduced concanavalin-A binding activity in patients with severe nonthyroid illness. Journal of Clinical Endocrinology and Metabolism 1987 65 942-945.
14. Faber J, Kirkegaard C, Rasmussen B, Westh B, Busch-Sorensen M & Jensen IW. Pituitary-thyroid axis in critical illness. Journal of Clinical Endocrinology and Metabolism 1987 65 315-320.
15. Chopra IJ. Euthyroid sick syndrome: is it a misnomer? Journal of Clinical Endocrinology and Metabolism 1997 82 329-334.
16. Lim CF, Bernard BF, de Jong M, Docter R, Krenning EP & Hennemann G. A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia. Journal of Clinical Endocrinology and Metabolism 1993 76 318-324.
17. Lim CF, Docter R, Visser TJ, Krenning EP, Bernard P, van Toor H et al. Inhibition of thyroxine transport into cultured rat hepatocyles by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids. Journal of Clinical Endocrinology and Metabolism 1993 76 1165-1172.
18. Everts ME, Lim CF, Moerings EPCM, Docter R, Visser TJ, de Jong M et al. Effects of a furan fatty acid and indoxyl sulfate on thyroid hormone uptake in cultured anterior pituitary cells. American Journal of Physiology 1995 268 E974-E979.
19. Whitcher JT & Evans SW. Cytokines in disease. Clinical Chemistry 1990 36 1269-1281.
20. Svenson M, Kayser L, Hansen MB, Krogh Rasmussen A & Bendtzen K. Interleukin-1 receptors on human thyroid cells and on the rat thyroid cell line FRTL-5. Cytokine 1991 3 125-130.
21. Pang H-P, Hershman JM, Chung M & Pekary AE. Characterization of tumor necrosis factor-α receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin. Endocrinology 1989 125 1783-1788.
22. Grubeck-Loebenstein B, Bichan G, Chantry D, Kassal H, Londei M, Pirich K et al. Analysis of intrathyroidal cytokine production in thyroid autoimmune disease: thyroid follicular cells produce interleukin-1α and interleukin-6. Clinical and Experimental Immunology 1989 77 324-330.
23. Kawabe Y, Eguchi K, Shimomura C, Mine M, Otsubo T, Ueki Y et al. Interleukin-1 production and action in thyroid tissue. Journal of Clinical Endocrinology and Metabolism 1989 68 1174-1183.
24. Weetman AP, Bright-Thomas R & Freeman M. Regulation of interleukin-6 release by human thyrocytes. Journal of Endocrinology 1990 127 357-361.
25. Del Prete GF, Mavilia C, Giudizi MG, De Carli M, Mastromauro C, Toccafondi R et al. IFN-γ and TNF-α upregulate IL-6 production by human thyrocytes. In: Cytokines: Basic Principles and Clinical Applications, pp 71-76. Eds S Romagnani & AK Abbas. New York: Raven Press, 1990.
26. Iwamoto M, Sakihama T, Kimura N, Tasaka K & Onaya T. Augmented interleukin 6 production by rat thyrocytes (FRTL-5): effect of interleukin 1β and thyroid-stimulating hormone. Cytokine 1991 3 345-349.
27. Diamant M, Kayser L, Rasmussen AK, Bech K & Feldt-Rasmussen U. Interleukin-6 production by thyroid epithelial cells. Enhancement of interleukin-1. Autoimmunity 1991 11 21-26.
28. Kennedy RL, Jones TH, Davies R, Justice SK & Lemoine NR. Release of interleukin-6 by thyroid epithelial cells immortalized by simian virus 40 DNA transfection. Journal of Endocrinology 1992 133 477-482.
29. Weetman AP, Bennett GL & Wong WLT. Thyroid follicular cells produce interleukin-8. Journal of Clinical Endocrinology and Metabolism 1992 75 328-330.
30. Zheng RQH, Abeny E, Chu CQ, Field M, Grubeck-Loebenstein B, Maini RN et al. Detection of interleukin-6 and interleukin-1 production in human thyroid epithelial cells by non-radioactive in situ hybridization and immunohistochemical methods. Clinical and Experimental Immunology 1991 83 314-319.
31. Rutenfrantz I, Kruse A, Rink L, Wenzel B, Arbholdt H & Kirchner H. In situ hybridization of the mRNA for interferon-γ, interferon-α, interferon-β, interleukin-1β and interleukin-6 and characterization of infiltrating cells in thyroid tissues. Journal of Immunological Methods 1992 148 233-242.
32. Ajjan RA, Watson PF & Weetman AP. Detection of IL-12, IL-13, and IL-15 messenger ribonucleic acid in the thyroid of patients with autoimmune thyroid disease. Journal of Clinical Endocrinology and Metabolism 1997 82 666-669.
33. Weetman AP. Recent progress in thyroid autoimmunity: an overview for the clinician. Thyroid Today 1996 29 1-9.
34. Bartalena L, Brogioni S, Grasso L, Rago T, Vitti P, Pinchera A & Martino E. Interleukin-6: a marker of thyroid-destructive processes? Journal of Clinical Endocrinology and Metabolism 1994 79 1424-1427.
35. Heufelder AE. Pathogenesis of Graves' ophthalmopathy: recent controversies and progress. European Journal of Endocrinology 1995 135 532-541.
36. Zakarija M & McKenzie JM. Influence of cytokines on growth and differentiated function of FRTL-5 cells. Endocrinology 1989 125 1260-1265.
37. Pang H-P, Hershman JM, Smith V, Pekary AE & Sugawara M. The mechanism of action of tumour necrosis factor-α and interleukin-1 on FRTL-5 rat thyroid cells. Acta Endocrinologica 1990 123 203-210.
38. Westermark K, Nilsson M & Karlsson FA. Effects of interleukin 1 alpha on porcine thyroid follicles in suspension culture. Acta Endocrinologica 1990 122 505-512.
39. Nolte A, Bechtner G, Rafferzeder M & Gartner R. Interleukin-1β (IL-1β) binds to intact porcine thyroid follicles, decreases iodide uptake, but has no effect on cAMP formation or proliferation. Hormone and Metabolic Research 1994 26 413-418.
40. Weetman AP. Recombinant gamma-interferon stimulates iodide uptake and cyclic AMP production by FRTL-5 thyroid cell line. FEBS Letters 1987 221 91-94.
41. Kraiem Z, Sobel E, Sadeh O, Kinarty A & Lahat N. Effects of γ-interferon on DR antigen expression, growth, 3,5,3′-triiodothyronine secretion, iodide uptake, and cyclic adenosine 3′,5′-monophosphate accumulation in cultured human thyroid cells. Journal of Clinical Endocrinology and Metabolism 1990 71 817-824.
42. 125I organification and thyroid hormone release by interleukin-1, tumor necrosis factor-α, and interferon-γ in human thyrocytes in suspension culture. Journal of Clinical Endocrinology and Metabolism 1990 70 1735-1743.
43. Yamashita S, Kimura H, Ashizawa K, Nagayama Y, Hirayu H, Izumi M et al. Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression. Journal of Endocrinology 1989 122 177-183.
44. Krogh Rasmussen A, Feldt-Rasmussen U & Bendtzen K. The effect of interleukin-1 on the thyroid gland. Autoimmunity 1993 16 141-148.
45. Krogh Rasmussen A, Kayser L, Feldt-Rasmussen U & Bendtzen K. Influence of tumor necrosis factor-α, tumor necrosis factor-β and interferon-gamma, separately and added together with interleukin-1δ, on the function of cultured human thyroid cells. Journal of Endocrinology 1994 143 359-365.
46. Poth M, Tseng YC & Wartofsky L. Inhibition of TSH activation of human cultured thyroid cells by tumor necrosis factor: an explanation for decreased thyroid function in systemic illness. Thyroid 1991 1 235-240.
47. Krogh Rasmussen A, Kayser L, Feldt-Rasmussen U, Bech K, Bendtzen K, Diamant M et al. Interleukin-6 is not a second mediator of interleukin-1 induced suppression of thyroid function in cultured human thyrocytes. Experimental and Clinical Endocrinology 1991 97 179-181.
48. Kung AWC & Lau KS. Interferon-γ inhibits thyrotropin-induced thyroglobulin gene transcription in cultured human thyrocytes. Journal of Clinical Endocrinology and Metabolism 1990 70 1512-1517.
49. Misaki T, Tramontano D & Ingbar SH. Effects of rat gamma- and non-gamma-interferons on the expression of Ia antigen, growth, and differentiated functions of FRTL-5 cells. Endocrinology 1988 123 2849-2857.
50. Nagayama Y, Izumi M, Ashizawa K, Kiriyama T, Yokoyama N, Morita S et al. Inhibitory effect of interferon-gamma on the response of human thyrocytes to thyrotropin (TSH) stimulation: relationship between the response to TSH and the expression of DR antigen. Journal of Clinical Endocrinology and Metabolism 1987 64 949-953.
51. Ashizawa K, Yamashita S, Tobinaga T, Magayama Y, Kimura H, Hirayu H et al. Inhibition of human thyroid peroxidase gene expression by interleukin 1. Acta Endocrinologica 1989 121 465-469.
52. Tominaga T, Yamashita S, Nagayama Y, Morita S, Yokoyama N, Izumi M et al. Interleukin 6 inhibits human thyroid peroxidase gene expression. Acta Endocrinologica 1991 124 290-294.
53. Ashizawa K, Yamashita S, Nagayama Y, Kimura H, Hirayu H, Izumi M et al. Interferon-γ inhibits thyrotropin-induced thyroidal peroxidase gene expression in cultured human thyrocytes. Journal of Clinical Endocrinology and Metabolism 1989 69 475-477.
54. Asakawa H, Hanafusa T, Kobayashi T, Takai S-I, Kono N & Tarui S. Interferon-γ reduces the thyroid peroxidase content of cultured human thyrocytes and inhibits its increase induced by thyrotropin. Journal of Clinical Endocrinology and Metabolism 1992 74 1331-1335.
55. Yamazaki K, Yamada E, Kanaji Y, Shizume K, Wang D-S, Maruo N et al. Interleukin-6 (IL-6) inhibits thyroid function in the presence of soluble IL-6 receptor in cultured human thyroid follicles. Endocrinology 1996 137 4857-4863.
56. Zeki K, Azuma H, Suzuki H, Morimoto I & Eto S. Effects of interleukin-1 on growth and adenosine 3′,5′-monophosphate generation of the rat thyroid cell line. FRTL-cells. Acta Endocrinologica 1991 124 60-66.
57. Mine M, Tramontano D, Chin WW & Ingbar SH. Interleukin-1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture. Endocrinology 1987 120 1212-1214.
58. Chen G, Pekary AE & Hershman JM. Aging of FRTL-5 rat thyroid cells causes sensitivity to cytotoxicity induced by tumor necrosis factor-α. Endocrinology 1992 131 863-870.
59. Zakarija M, Horniceck FJ, Levis S & McKenzie JM. Effects of gamma-interferon and tumor necrosis factor α on thyroid cells: induction of class II antigen and inhibition of growth stimulation. Molecular and Cellular Endocrinology 1988 58 129-136.
60. Wassen FWJS, Moerings EPCM, van Toor H, De Vrey EA, Hennemann G & Everts ME. Effects of interleukin-1β on thyrotropin secretion and thyroid hormone uptake in cultured rat anterior pituitary cells. Endocrinology 1996 137 1591-1598.
61. Kennedy JA, Wellby ML & Zotti R. Effect of interleukin-1β, tumour necrosis factor-α and interleukin-6 on the control of thvrotropin secretion. Life Sciences 1995 57 487-501.
62. Bernton EW, Beach JE, Holaday JW, Smallridge RC & Fein HG. Release of multiple hormones by direct action of interleukin-1 on pituitary cells. Science 1987 238 519-521.
63. Bartalena L, Farsetti A, Flink IL & Robbins J. Effects of interleukin-6 on the expression of thyroid hormone-binding protein genes in cultured human hepatoblastoma-derived (Hep G2) cells. Molecular Endocrinology 1992 2 313-323.
64. Bartalena L, Hammond GL, Farsetti A, Flink IL & Robbins J. Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells. Endocrinology 1993 133 291-295.
65. Perlmutter DH, Dinarello CA, Punsal PI & Colten HR. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. Journal of Clinical Investigation 1986 78 1349-1354.
66. Ramadori G, van Damm J, Rider H & Meyer K. Interleukin-6, the third mediator of acute phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1β and tumour necrosis factor α. European Journal of Immunology 1988 12 1259-1264.
67. Doherty GM, Lange JR, Langstein HN, Alexander HR, Buresh CM & Norton JA. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-α. Journal of Immunology 1992 149 1666-1670.
68. Boelen A, Platvoet-ter Schiphorst MC, Bakker O & Wiersinga WM. The role of cytokines in the lipopolysaccharide-induced sick euthyroid syndrome in mice. Journal of Endocrinology 1995 146 475-483.
69. Boelen A, Maas MAW, Lowik CWGM, Platvoet-ter Schiphorst MC & Wiersinga WM. Induced illness in interleukin-6 (IL-6) knockout mice: a causal role of IL-6 in the development of the low 3,5,3′-triiodothyronine syndrome. Endocrinology 1996 137 5250-5254.
70. Boelen A, Platvoet-ter Schiphorst MC & Wiersinga WM. Immunoneutralization of IL-1, tumor necrosis factor, interleukin-6 or interferon-γ does not prevent the LPS-induced sick euthyroid syndrome in mice. Journal of Endocrinology 1997 153 115-122.
71. Onoda N, Tsushima T, Isozaki O, Emoto N, Demura H, Arai M et al. Effect of interleukin-6 on hypothalamic-pituitary-thyroid axis in rat. In: Eighty Years of Hashimoto Disease, pp 355-359. Eds S Nagataki, T Mori & K Torizuka. Amsterdam: Elsevier Science, 1993.
72. Bartalena L, Grasso L, Brogioni S & Martino E. Interleukin 6 effects on the pituitary-thyroid axis in the rat. European Journal of Endocrinology 1995 131 302-306.
73. van Haasteren GAC, van der Meer MJM, Hermus ARMM, Linkels E, Klootwijk W, Kaptein E et al. Different effects of the continuous infusion of interleukin-1 and interleukin-6 on the hypothalamic-hypophysial-thyroid axis. Endocrinology 1994 135 1336-1345.
74. Lyson K & McCann SM. The effect of interleukin-6 on pituitary hormone release in vivo and in vitro. Neuroendocrinology 1991 54 262-266.
75. Dubuis JM, Dayer JM, Siegrist-Kaiser CA & Burger AG. Human recombinant interleukin-1β decreases plasma thyroid hormone and thyroid stimulating hormone levels in rats. Endocrinology 1988 123 2175-2181.
76. Hermus ARMM, Sweep CGJ, van der Meer MJM, Ross HA, Smals AGH, Benraad TJ et al. Continuous infusion of interleukin-1β induces a nonthyroidal illness syndrome in the rat. Endocrinology 1992 131 2139-2146.
77. Fujii T, Sato K, Ozawa M, Asono K, Imamura H, Kanaji Y et al. Effect of interleukin-1 (IL-1) on thyroid hormone metabolism in mice: stimulation by IL-1 of iodothyronine 5′-deiodinating activity (type I) in the liver. Endocrinology 1989 124 167-174.
78. Enomoto T, Sugawa H, Kosugi S, Inoue D, Mori T & Imura H. Prolonged effects of recombinant interleukin-1α on mouse thyroid function. Endocrinology 1990 127 2322-2327.
79. Ozawa M, Sato K, Han DC, Kawakami M, Tsushima T & Shizume K. Effects of tumor necrosis factor-α/cachectin on thyroid hormone metabolism in mice. Endocrinology 1988 123 1461-1467.
80. 4 binding without affecting pituitary-thyroid activity in rats. American Journal of Physiology 1992 263 E1099-E1105.
81. Panciera DL, Helfand SC & Soergel SA. Acute effects of continuous infusion of human recombinant interleukin-2 on serum thyroid hormone concentrations in dogs. Research in Veterinary Science 1995 58 96-97.
82. Mooradian AG, Reed RL, Osterweil D, Schiffman R & Scuderi P. Decreased serum triiodothyronine is associated with increased concentrations of tumor necrosis factor. Journal of Clinical Endocrinology and Metabolism 1990 71 1239-1242.
83. Reincke M, Allolio B, Petzke F, Heppner C, Mbulamberi D, Vollmer D et al. Thyroid dysfunction in African trypanosomiasis: a possible role for inflammatory cytokines. Clinical Endocrinology 1993 39 455-461.
84. Chopra IJ, Sakane S & Chua Teco GN. A study of the serum concentration of tumor necrosis factor-α in thyroidal and nonthyroidal illnesses. Journal of Clinical Endocrinology and Metabolism 1991 72 1113-1116.
85. Boelen A, Schiphorst Platvoet-ter MC & Wiersinga WM. Association between serum interleukin-6 and 3,5,3′-triiodothyronine in nonthyroidal illness. Journal of Clinical Endocrinology and Metabolism 1993 77 1695-1699.
86. Bartalena L, Brogioni S, Grasso L, Velluzzi F & Martino E. Relationship of the increased serum interleukin-6 concentration to changes of thyroid function in nonthyroidal illness. Journal of Endocrinological Investigation 1994 17 269-274.
87. Bartalena L, Brogioni S, Grasso L & Martino E. Interleukin-6 and the thyroid. European Journal of Endocrinology 1995 132 386-393.
88. Hashimoto H, Igarashi N, Yachie A, Miyawaki T & Sato T. The relationship between serum levels of interleukin-6 and thyroid hormone in children with acute respiratory infection. Journal of Clinical Endocrinology and Metabolism 1994 78 288-291.
89. Amado JA, Lopez-Espadas F, Vàzquez-Barquero A, Salas E, Riancho JA, Lòpez-Cordovilla JJ et al. Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acute-phase reactants. Metabolism 1995 44 812-816.
90. Yokoe T, Iino Y, Takei H, Horiguchi J, Koibuchi Y, Maemura M et al. Changes of cytokines and thyroid function in patients with recurrent breast cancer. Anticancer Research 1997 17 695-697.
91. Murai H, Murakami S, Ishida K & Sugawara M. Elevated serum interleukin-6 and decreased thyroid hormone levels in post-operative patients and effects of IL-6 on thyroid cell function in vitro. Thyroid 1996 6 601-606.
92. Saatvedt K & Lindberg H. Depressed thyroid function following paediatric cardiopulmonary bypass: association with interleukin-6 release? Scandinavian Journal of Thoracic and Cardiovascular Surgery 1996 30 61-64.
93. Davies PH, Black EG, Sheppard MC & Franklyn JA. Relationship between serum interleukin-6 and thyroid hormone concentrations in 270 hospital in-patients with non-thyroidal illness. Clinical Endocrinology 1996 44 199-205.
94. Boelen A, Schiphorst Platvoet-ter MC & Wiersinga WM. Relationship between 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon-γ in patients with nonthyroidal illness. Journal of Endocrinological Investigation 1996 19 480-483.
95. Boelen A, Schiphorst Platvoet-ter MC & Wiersinga WM. Soluble cytokine receptors and the low 3,5,3′-triiodothyronine syndrome in patients with nonthyroidal disease. Journal of Clinical Endocrinology and Metabolism 1995 80 971-976.
96. van der Poll T, Romijn JA, Wiersinga WM & Sauerwein HP. Tumor necrosis factor: a putative mediator of the sick euthyroid syndrome in man. Journal of Clinical Endocrinology and Metabolism 1990 71 1567-1572.
97. Schultz M, Muller R, Von zur Muhlen A & Brabant G. Induction of hyperthyroidism by interferon-alpha. Lancet 1989 i 1452.
98. Fentiman IS, Thomas BS, Balkwill FR, Rubens RD & Hay ward JL. Primary hypothyroidism associated with interferon therapy of breast cancer. Lancet 1985 i 1166.
99. Baudin E, Marcellini P, Pouteau M, Colas-Linhart N, Le Floch JP, Lemonnier C et al. Reversibility of thyroid dysfunction induced by recombinant alpha interferon in chronic hepatitis C. Clinical Endocrinology 1993 39 657-661.
100. Corssmit EPM, Heylingenberg R, Endert E, Sauerwein HP & Romijn JA. Acute effects of interferon-α administration on thyroid hormone metabolism in healthy men. Journal of Clinical Endocrinology and Metabolism 1995 80 3140-3144.
101. Stouthard JML, van der Poll T, Endert E, Bakker PJM, Veenhof CHN, Sauerwein HP et al. Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. Journal of Clinical Endocrinology and Metabolism 1994 79 1342-1346.
102. van der Poll T, van Zee KJ, Endert E, Coyle SM, Stiles DM, Pribble JP et al. Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. Journal of Clinical Endocrinology and Metabolism 1995 80 1341-1346.
103. Cannon JG, Tompkins RG & Gelfand JA. Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. Journal of Infectious Diseases 1990 161 79-84.
104. Fong Y, Marano MA & Moldawer LL. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. Journal of Clinical Investigation 1990 85 1896-1904.
105. Mattijssen WJM, De Mulder PHM, Van Liessun PA, Corstens FHM, Franks CR & Wagener DJT. Hypothyroidism and goitre in a patient during treatment with interleukin-2. Cancer 1990 65 2686-2688.
106. Schwartentruber DJ, White DE, Zweig MH, Weintraub BD & Rosenberg SA. Thyroid dysfunction associated with immunotherapy for patients with cancer. Cancer 1991 68 2384-2390.
107. Vialettes B, Guillerand MA, Viens P, Stoppa A-M, Baume D, Sauvan R et al. Incidence rate and risk factors for thyroid dysfunction during recombinant interleukin-2 therapy in advanced malignancies. Acta Endocrinologica 1993 129 31-38.
108. Kung AWC, Lau CL, Wong KL & Tam CF. Thyroid function in patients treated with interleukin-2 and lymphokine-activated killer cells. Quarterly Journal of Medicine 1991 297 33-42.
109. Bartalena L, Marcocci C & Pinchera A. Cytokine antagonists: new ideas for the management of Graves' ophthalmopathy. Journal of Clinical Endocrinology and Metabolism 1996 81 446-448.
110. DeGroot LJ, Larsen PR & Hennemann G. The Thyroid and its Diseases, edn 6, p 171. New York: Churchill Livingstone, 1996.
111. Klemperer JD, Klein I, Gomez M, Helm RE, Ojamaa K, Thomas SJ et al. Thyroid hormone treatment after coronary-artery bypass surgery. New England Journal of Medicine 1995 333 1522-1527.