Thyroid hormone metabolism in nonthyroidal illness

Current Opinion in Endocrinology and Diabetes

Volumn 3, Issue 5, 1996, Pages 422-427

  Wiersinga, Wilmar M ^a   Boelen, Anita ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003875040     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-199610000-00011     Document Type: Article

References (37)

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2. 3 is indicated in these patients.
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9. 3 increased cardiac output and lowered systemic vascular resistance but did not change outcome or alter the need for standard postoperative therapy.
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23. 3 was negatively related to serum sTNFαRp55, sTNFαR275, sIL-2R, IL-IRA, and IL-6. Serum sTNAαRp75 and IL-6 were independent determinants of serum T3 in nonthyroidal illness, accounting for 35% and 14% respectively of the variability in T3. The results suggest that the sick euthyroid syndrome is part of the acute phase response during illness generated by activation of the cytokine network.
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26. 3.
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33. 3-receptor occupancy.
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36. Poll T van der, Zee KJ van, Endert E, Coyle SM, Stiles DM, Pribble JP, Catalano MA, Moldawer LL, Lowey SF: Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. J Clin Endocrinol Metab 1995, 80:1341-1346. Administration of lipopolysaccharide to healthy volunteers induced changes in thyroid hormone metabolism resembling the sick euthyroid syndrome. These changes were not influenced by coinfusion of the naturally occurring IL-1 receptor antagonist, implying that endogenous IL-1 does not play an important role in the development of the sick euthyroid syndrome.
37. Boelen A, Platvoet-ter Schiphorst MC, Rooijen N van, Wiersinga WM: Selective macrophage depletion in the liver does not prevent the development of the sick euthyroid syndrome in the mouse. Europ J Endocrinol 1996, 134:513-520.