Immunology of inflammatory bowel disease

Current Opinion in Gastroenterology

Volumn 14, Issue 4, 1998, Pages 289-294

  MacDermott, Richard P ^a  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CELL ADHESION MOLECULE; CELL NUCLEUS ANTIGEN; GAMMA INTERFERON; HISTONE; INTERLEUKIN 12; INTERLEUKIN 1BETA; NEUTROPHIL CYTOPLASMIC ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR;

CELL FUNCTION; ENDOTHELIUM CELL; ENTERITIS; HEALING; HELPER CELL; IMMUNOLOGY; IMMUNOPATHOGENESIS; INFLAMMATION; REVIEW; T LYMPHOCYTE;

EID: 0031856660     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-199807000-00003     Document Type: Review

References (27)

1. Hornquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer •• L, Harriman GR: Gαi2 deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 1997, 158:1068-1077. An outstanding series of experiments in which analyses of the mucosal immune system of a mouse model of UC revealed marked increases in IL-12, helper (CD4+) T cell, Th, cytokine (IFN-γ and IL-1β), and lgG levels.
2. +, TCRβ-bearing T cells in the development of colitis in TCRα-deficient mice may be related to the polyclonal activation of B cells, which produce serum and mucosal antibodies against both food antigens and self antigens.
3. high T cells, which are shown to travel to the intestine of recipient SCID mice, which then develop colitis due to T-cell reactivity stimulated by luminal bacteria or bacterial products.
4. 1 cytokine production and can be inhibited by cyclosporine.
5. Ehrhardt RO, Ludviksson BR, Gray B, Neurath M, Strober W: Induction •• and prevention of colonic inflammation in IL-2-deficient mice. J Immunol 1997, 158:566-573. An excellent study that demonstrates that colitis in IL-2 knockout mice is centrally regulated by IL-12, which leads to large amounts of IFNγ produced by CD4+ T cells and can be inhibited by the administration of anti-IL-12.
6. Simpson SJ, Hollander GA, Mizoguchi E, Allen D, Bhan AK, Wang B, •• Terhorst C: Expression of proinflammatory cytokines by TCRαβ+ and TCRγδ+ T cells in an experimental model of colitis, Eur J Immunol 1997, 27:17-25. A provocative study using the transfer of specific T-cell subpopulations into T-cell-deficient mice to demonstrate that both TCRαβ T cells and TCRγδ T cells are capable of producing IFN and TNF and thus participate in the mediation of colitis.
7. McVay LD, Li B, Biancaniello R, Creighton MA, Bachwich D, Lichtenstein •• G, Rombeau JL, Carding SR: Changes in human mucosal γδ T cell repertoire and function associated with the disease process in inflammatory bowel disease, Mol Med 1997, 3:182-203. This outstanding analysis of human IBD mucosa demonstrates the important contribution of γδ T cells, which express a Vδ1-(Dδ3)-Jδ1-encoded TCR and participate in chronic inflammation through the production of cytokines such as IFNγ.
8. 1 cell-mediated processes by increasing the production of IFNγ.
9. Monteleone G, Biancone L, Marasco R, Morrone G, Marasco O, Luzza F, • Pallone F: Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997, 112:1169-1178. This important study demonstrates the synthesis and secretion of IL-12 by CD but not UC lamina propria mononuclear cells.
10. Mizoguchi E, Mizoguchi A, Chiba C, Niles JL, Bhan AK: Antineutrophil •• cytoplasmic antibodies in T-cell receptor α-deficient mice with chronic colitis. Gastroenterology 1997, 113:1828-1835. This excellent study demonstrates that perinuclear ANCAs are present in the sera and are produced by B cells from mesenteric lymph nodes and the colon of TCRα-deficient mice that develop colitis.
11. Eggena MP, Targan SR, Vidrich A, Clemons DF, Iwanczyk L, Braun J: Histone H1: the UC-specific pANCA target antigen [abstract]. FASEB J 1996, 10:A1079.
12. Cohavy O, Eggena MP, Parseghian M, Hamkalo B, Targan SR, Gordon LK, Braun J: Histone H1, a candidate pANCA antigen in ulcerative colitis [abstract]. Gastroenterology 1997, 112:A951.
13. Abad E, Tural C, Mirapeix E, Cuxart A: Relationship between ANCA and clinical activity in inflammatory bowel disease: variation in prevalence of ANCA and evidence of heterogeneity. J Autoimmun 1997, 10:175-180.
14. Folwaczny C, Noehl N, Endres SP, Heldwein W, Loeschke K, Fricke H: Antinuclear autoantibodies in patients with inflammatory bowel disease: high prevalence in first-degree relatives. Dig Dis Sci 1997, 42:1593-1597.
15. Sobajima J, Ozaki S, Osakada F, Uesugi H, Shirakawa H, Yoshida M, • Nakao K: Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2. Clin Exp Immunol 1997. 107:135-140. A novel series of experiments demonstrating that the HMG nonhistone chromosomal proteins HMG1 and HMG2, which are distributed in the nuclei and cytoplasm and act as transcription factors, are target antigens of pANCAs from patients with UC.
16. Folwaczny C, Noehl N, Tschop K, Endres SP, Heldwein W, Loeschke K, • Fricke H: Goblet cell autoantibodies in patients with inflammatory bowel disease and their first-degree relatives. Gastroenterology 1997, 113:101-106. A solid observation describing a high prevalence of GABs in both IBD patients and their first-degree relatives.
17. Troncone R, Caputo N, Campanozzi A, Cucciardi M, Esposito V, Russo R, DeVizia B, Greco L, Cucchiara S: Gut lavage IgG and interleukin 1 receptor antagonist: interleukin 1β ratio as markers of intestinal inflammation in children with inflammatory bowel disease. Gut 1997, 41:60-65.
18. Paige DG, Leonard JN, Wojnarowska F, Fry L: Linear IgA disease and ulcerative colitis. Br J Dermatol 1997, 136:779-782.
19. Salmi M, Rajala P, Jalkanen S: Homing of mucosal leukocytes to joints: distinct endothelial ligands in synovium mediate leukocyte-subtype adhesion. J Clin Invest 1997, 99:2165-2172. This outstanding series of observations delineates the distinct endothelial ligands involved in the trafficking of activated mucosal leukocytes in patients with UC to synovial endothelial venules with resultant activation and cytokine production producing chronic reactive arthritis in IBD.
20. Binion DG, West GA, Ina K, Ziats NP, Emancipator SN, Fiocchi C: •• Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997, 112:1895-1907. A creative group of studies describing the culture of microvascular ECs following isolation from IBD intestine and demonstration of their enhanced ability to bind leukocytes as a result of increased adhesion molecule expression.
21. Boehme MWJ, Autschbach F, Zuna I, Scherbaum WA, Stange E, Raeth U, • Sieg A, Stremmel W: Elevated serum levels and reduced immunohistochemical expression of thrombomodulin in active ulcerative colitis. Gastroenterology 1997, 113:107-117. An intnguing observation of elevated, soluble thrombomodulin as a marker of EC damage in patients with UC, which may indicate the future value of serum thrombomodulin levels as a marker of disease activity in patients with UC.
22. 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. Gut 1997, 40:241-246.
23. Goke M, Hoffman JC, Evers J, Kruger H, Manns MP; Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease. J Gastroenterol 1997, 32:480-486.
24. McCafferty DM, Mudgett JS, Swain MG, Kubes P: Inducible nitric oxide •• synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997, 112:1022-1027. A superb series of experiments using iNOS-deficient mice to demonstrate that the induction of iNOS plays a critical protective role in promoting healing in response to intestinal inflammation and injury.
25. Kimura H, Miura S, Shigematsu T, Ohkubo N, Tsuzuki Y. Durose I, Higuchi H, Akiba Y, Hokari R, Hirokawa M. et al.: Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn's disease. Dig Dis Sci 1997, 42:1047-1054.
26. Dagli U, Balk M, Yucel D, Ulker A, Over H, Saydam G, Sahin B; The role of reactive oxygen metabolites in ulcerative colitis. Inflamm Bowel Dis 1997, 3:260-264.
27. Blackburn AC, Doe WF, Buffinton GD: Colonic antioxidant status in dextran sulfate-induced colitis in mice, Inflamm Bowel Dis 1997, 3:198-203.