Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: Evidence for H3 receptor heterogeneity?

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 353, Issue 5, 1996, Pages 482-488

  Schlicker, E ^a   Kathmann, M ^a   Bitschnau, H ^a   Marr, I ^a   Reidemeister, S ^b   Stark, H ^b   Schunack, W ^b  

^a UNIVERSITY OF BONN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

3H N Methylhistamine binding; Acetylcholine release; Guinea pig ileum strips; Histamine H3 receptors; Iodoproxyfan; Mouse brain cortex slices; Noradrenaline release

Indexed keywords

ALPHA METHYLHISTAMINE; CLOBENPROPIT; DESIPRAMINE; HISTAMINE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; IODOPROXYFAN; NORADRENALIN; PARTIAL AGONIST; RADIOLIGAND; RAUWOLSCINE; RECEPTOR SUBTYPE; TELE METHYLHISTAMINE; THIOPERAMIDE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ELECTROSTIMULATION; GUINEA PIG; ILEUM; MALE; MOUSE; NONHUMAN; NORADRENALIN RELEASE; RAT; RECEPTOR AFFINITY; SMOOTH MUSCLE CONTRACTILITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUINEA PIGS; HISTAMINE ANTAGONISTS; HISTAMINE H2 ANTAGONISTS; IMIDAZOLES; INTESTINE, SMALL; IODINE RADIOISOTOPES; MALE; METHYLHISTAMINES; MICE; PIPERIDINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029868849     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00169166     Document Type: Article

References (30)

1. 3) of histamine receptor. Nature 302:832-837
2. 3-receptors. Nature 327:117-123
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
4. 3 receptors inhibit cholinergic neurotransmission. J Pharmacol Exp Ther 258:325-331
5. De Lean A, Hancock AA, Lefkowitz RJ (1982) Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol 21:5-16
6. Furchgott RF (1972) The classification of adrenoceptors (adrenergic receptors). An evaluation from the standpoint of receptor theory. In: Blaschko H, Muscholl E (eds) Handbook of experimental pharmacology, vol 33. Springer, Berlin Heidelberg New York, pp 283-335
7. 3-selective ligands. Br J Pharmacol 101:621-624
8. 125I]-iodophenpropit, to rat brain. Br J Pharmacol 113:355-362
9. 3 receptor model. Naunyn-Schmiedeberg's Arch Pharmacol 348:498-503
10. 3 receptors. Psychopharmacology 116:464-468
11. α-methylhistamine. Biochem Biophys Res Commun 168:979-986
12. 3-receptor: A target for developing new drugs. Progr Drug Res 39:127-165
13. 3 receptors. Pharmacol Res [Suppl] 31:272
14. 3 receptors. J Pharmacol Exp Ther 271:452-459
15. 3-receptors. In: Schwartz JC, Haas HL (eds) The histamine receptor. Wiley-Liss, New York, pp 57-72
16. McPherson GA, Molenaar P, Raper C, Malta E (1983) Analysis of dose-response curves and calculation of agonist dissociation constants using a weighted nonlinear curve fitting program. J Pharmacol Methods 10:231-241
17. 3A receptor-mediated inhibition of noradrenaline release in the mouse brain cortex. Naunyn-Schmiedeberg's Arch Pharmacol 345:489-493
18. 3 receptor models. Br J Pharmacol 112:1043-1048 and 113:657 (erratum)
19. 3 heteroreceptors. Fundam Clin Pharmacol 8:128-137
20. 3 receptors. Inflamm Res 44:296-300
21. Schwartz JC, Arrang JM, Garbarg M, Pollard H, Ruat M (1991) Histaminergic transmission in the mammalian brain. Physiol Rev 71:1-51
22. Schwartz JC, Arrang JM, Garbarg M, Lecomte JM, Ganellin CR, Fkyerat A, Tertiuk W, Schunack W, Lipp R, Stark H, Purand K (1992) International Patent Application, January 10, 1992, WO 93/14070
23. 3 receptor heterogeneity. Naunyn-Schmiedeberg's Arch Pharmacol 350:375-379
24. 3-receptor antagonists. Eur J Med Chem 29:695-700
25. 3-receptor antagonists of the amide type. Eur J Pharm Sci 3:95-104
26. 3 receptors controlling non-adrenergic, non-cholinergic contractions of the guinea-pig isolated ileum. Br J Pharmacol 105:667-674
27. 3 subtype. J Pharmacol Exp Ther 243:874-880
28. 3-receptor. Eur J Med Chem 27:511-518
29. 3 ligands. Methods Find Exp Clin Pharmacol 14:747-752
30. 3-histamine receptor subtypes. Mol Pharmacol 38:610-613