Molecular modelling and footprinting studies of DNA minor groove binders: Bisquaternary ammonium heterocyclic compounds

Anti-Cancer Drug Design

Volumn 13, Issue 5, 1998, Pages 463-488

  Slickers, P ^a   Hillebrand, M ^a,b   Kittler, L ^a   Lober G ^a   Suhnel J ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Bisquaternary ammonium heterocycles; DNA binding; Quantitative footprinting; Radius of curvature; Semiempirical quantum chemical calculations; Sequence specificity; Torsional energy

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; HETEROCYCLIC COMPOUND; SN 18071; SN 4094; SN 5754; SN 6053; SN 6113; SN 6131; SN 6132; SN 6324; SN 6570; SN 6999; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; DNA CONFORMATION; DNA FOOTPRINTING; DNA SEQUENCE; DRUG CONFORMATION; DRUG DNA BINDING; MOLECULAR MODEL; PRIORITY JOURNAL;

DEOXYRIBONUCLEASE I; DNA; DNA FOOTPRINTING; HETEROCYCLIC COMPOUNDS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEIC ACID CONFORMATION; PLASMIDS; QUATERNARY AMMONIUM COMPOUNDS;

EID: 0031854480     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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