Chemotherapy primes malignant glioma cells for CD95 ligand-induced apoptosis up-stream of caspase 3 activation

European Journal of Pharmacology

Volumn 352, Issue 1, 1998, Pages 111-115

  Hueber, Arno ^a   Winter, Stephan ^a   Weller, Michael ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

Apoptosis; Caspase; CD95; Chemotherapy; Glioma

Indexed keywords

CASPASE 3; CISPLATIN; CYTARABINE; CYTOTOXIC AGENT; FAS ANTIGEN; TENIPOSIDE; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE TRANSFER; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SENSITIZATION;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CASPASE 3; CASPASES; ENZYME ACTIVATION; GLIOMA; HUMANS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0031852453     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00335-5     Document Type: Article

References (16)

1. Chin, K.V., Pastan, I., Gottesman, M.M., 1993. Function and regulation of the human multidrug resistance gene. Adv. Cancer Res. 60, 157-180.
2. Friesen, C., Herr, I., Krammer, P.H., Debatin, K.M., 1996. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Med. 2, 574-577.
3. Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.L., Schröter, M., Burns, K., Mattmann, C., Rimoldi, D., French, L.E., Tschopp, J., 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388, 190-195.
4. Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G., Farahani, R., McLean, M., Ikeda, J.E., MacKenzie, A., Korneluk, R.G., 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379, 349-353.
5. Medema, J.P., Scaffidi, C., Kischkel, F.C., Shechenko, A., Mann, M., Krammer, P.H., Peter, M.E., 1997. FLICE is activated by association with the CD95 death-inducing signalling complex (DISC). EMBO J. 16, 2794-2804.
6. Müller, M., Strand, S., Hug, H., Heinemann, E.M., Walczak, H., Hoffmann, W.J., Stremmel, W., Krammer, P.H., Galle, P.R., 1997. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Invest. 99, 403-413.
7. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., Nagata, S., 1993. Lethal effect of the anti-Fas antibody in mice. Nature 364, 806-809.
8. Roth, W., Fontana, A., Trepel, M., Reed, J.C., Dichgans, J., Weller, M., 1997. Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics. Cancer Immunol. Immunother. 44, 55-63.
9. Schulz, J.B., Bremen, D., Reed, J.C., Lommatzsch, J., Takayama, S., Wüllner, U., Löschmann, P.A., Klockgether, T., Weller, M., 1997. Cooperative interception of neuronal apoptosis by BCL-2 and BAG-1 expression: prevention of caspase activation and reduced production of reactive oxygen species. J. Neurochem. 69, 2075-2086.
10. Takamiya, Y., Abe, Y., Tanaka, Y., Tsugu, A., Kazuno, M., Oshika, Y., Maruo, K., Ohnishi, Y., Sato, O., Yamazaki, H., Kijima, H., Ueyama, Y., Tamaoki, N., Nakamura, M., 1997. Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts. Br. J. Cancer 76, 445-450.
11. Toth, K., Vaughan, M.M., Peress, N.S., Slocum, H.K., Rustum, Y.M., 1996. MDR P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors. Am. J. Pathol. 149, 853-858.
12. Van Meir, E.G., Kikuchi, T., Tada, M., Li, H., Diserens, A.C., Wojcik, B.E., Huang, H.J.S., Friedmann, T., de Tribolet, N., Cavenee, W.K., 1994. Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res. 54, 649-653.
13. Weller, M., Frei, K., Groscurth, P., Krammer, P.H., Yonekawa, Y., Fontana, A., 1994. Anti-Fas/APO-1 antibody-mediated apoptosis of cultured human malignant glioma cells. Induction and modulation of sensitivity by cytokines. J. Clin. Invest. 94, 954-964.
14. Weller, M., Malipiero, U.V., Aguzzi, A., Reed, J.C., Fontana, A., 1995a. Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J. Clin. Invest. 95, 2633-2643.
15. Weller, M., Malipiero, U., Rensing-Ehl, A., Barr, P., Fontana, A., 1995b. Fas/APO-1 gene transfer for human malignant glioma. Cancer Res. 55, 2936-2944.
16. Winter, S., Roth, W., Dichgans, J., Weller, M., 1998. Synergistic activity of CD95 ligand and teniposide (VM26) does not involve enhanced formation of cleavable DNA complexes or changes in CD95/CD95 ligand expression. Eur. J. Pharmacol. 341, 323-328.