Cross-talk between retinoic acid and interferons: Molecular mechanisms of interaction in acute promyelocytic leukemia cells

Leukemia and Lymphoma

Volumn 30, Issue 5-6, 1998, Pages 467-476

  Garattini, Enrico ^a   Mologni, Luca ^a   Ponzanelli, Isabella ^a   Terao, Mineko ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

All trans retinoic acid; APL; Interferons; Intracellular signaling; Jak STAT; Retinoids

Indexed keywords

ALPHA INTERFERON; INTERFERON; RETINOIC ACID; RETINOIC ACID RECEPTOR;

ACUTE MYELOBLASTIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; HUMAN; PRIORITY JOURNAL; REMISSION; REVIEW; SECOND MESSENGER;

EID: 0031852401     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199809057559     Document Type: Review

References (55)

1. Hong, W. K. and Itri, L. M. (1994). Retinoids and human cancer. In: The retinoids: Biology, Chemisty and Medicine. Sporn, M. B., Roberts, A.B. and Goodman, D.S. (eds.). 2nd edition. pp. 597-630, (Raven Press, New York, NY).
2. Warrell, R. P., Jr., Maslak, P., Eardley, A., Heller, G., Miller, W. H., Jr. and Frankel, S. R. (1994). Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience. Leukemia, 8. (Suppl 2), S33-S37.
3. Chomienne, C., Fenaux, P. and Degos, L, (1996). Retinoid differentiation therapy in promyelocytic leukemia. FASEB, J, 10, 1025-1030.
4. Dombret, H., Sutton, L., Duarte, M., Daniel, M. T., Leblond, V., Castaigne, S. and Degos, L. (1992). Combined therapy with all-trans retinoic acid and high-dose chemotherapy in patients with hyperleukocytic acute promyelocytic leukemia and severe visceral hemorrage. Leukemia, 6, 1237-1242.
5. Kantarjian, H. M., Keating, M. J., Walters, R. S., Estey, E. H., McCredie, K. B., Smith, T. L., Dalton, W. T., Jr., Cork, A., Trujillo, J. M. and Freireich, E. J. (1997). Acute promyelocytic leukemia. M.D. Anderson hospital experience. Am. J. Med., 80, 789-797.
6. Grignuni, F., Fugioli, M., Ferrucci, P. F., Alcalay, M. and Pelicci, P. G. (1993). The molecular genetics of acute promyelocytic leukemia. Blood Rev., 7, 87-93.
7. Giannǐ, M., Li Calzi, M., Terao, M., Guiso, G., Caccia, S., Barbui, T., Rambaldi, A. and Garattini, E. (1996). AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells. Blood, 87, 1520-1531.
8. Giannǐ, M., Terao, M., Zanotta, S., Barbui, T., Rambaldi, A. and Garattini, E. (1994). Retinoic acid and granulocyte colony-stimulating factor synergistically induce leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. Blood, 83, 1909-1921.
9. Giannǐ, M., Terao, M., Norio, P., Barbui, T., Rambaldi, A. and Garattini, E. (1995). All-trans retinoic acid and cyclic adenosine monophosphate cooperate in the expression of leukocyte alkaline phosphatase in acute promyelocytic leukemia cells. Bood, 85, 3619-3635.
10. Giannǐ, M., Li Calzi, M., Terao, M., Rambaldi, A. and Garattini. E. (1995). Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells. Bioehem. Biophys. Res Commun., 208, 846-854.
11. Lippman, S., Parkinson, D., Itri, L., et al. (1992). 13-cis-retinoic acid and interferon-alfa 2a: effective combination therapy for advanced squamous cell carcinoma of the skin. J. Natl. Cancer Inst., 84, 235-241.
12. Lippman, S., Kavanagh, J., Paredes-Espinoza, M., et al. (1992). 13-cis retinoic acid plus interferon-alfa-2a: highly active systemic therapy for squamous cell carcinoma of the cervix. J. Natl. Cancer Inst., 84, 241-245.
13. Marth, C., Daxenbichler, G. and Dapunt, O. (1986). Synergistic antiproliferative effect of human recombinant interferons and retinoic acid in cultured breast carcinoma cells. J. Natl. Cancer Inst., 77, 1197-1202.
14. Giguere, V., Ong, E. S., Sequi, P. and Evans, R. M. (1987). Identification of a receptor for the morphogen retinoic acid. Nature, 330, 624-629.
15. Brand, N. J., Petkovich, M., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P. and Dejean, A. (1988). Identification of a second human retinoic acid receptor. Nature, 330, 850-853.
16. Krust, A., Kastner, P., Petkovich, M., Zelent, A. and Chambon, P. (1989). A third human retinoic acid receptor, hRAR-γ. Proc. Natl. Acad. Sci. USA, 86, 5310-5314.
17. Zelent, A., Krust, A., Petkovich, M., Kastner, P. and Chambon, P. (1989). Cloning of murine a and b retinoic acid receptors and a novel receptor g predominantly expressed in skin. Nature, 339, 714-717.
18. Zhang, X-K., Hoffmann, B., Tran, PB-V., Graupner, G. and Pfahl, M. (1992). Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature, 355, 441-146.
19. Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A. and Evans, R. M. (1992). Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev., 6, 329-344.
20. Levin, A. A., Sturzenbecker, L. J., Kazmer, S., Bosakowski, T., Huselton, C., Allenby, G., Speck, J., Kratzeisen, C., Rosenberg, M., Lovey, A. and Grippo, J. F. (1992). 9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRa. Nature, 355, 359-361.
21. Heyman, R. A., Mangelsdorf, D. J., Dyck, J. A., Stein, R. B., Eichele, G., Evans, R. M. and Thaller, C. (1992). 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell, 68, 397-406.
22. Lanotte, M., Martin Thouvenin, V., Najman, S., Balerini, P., Valensi, F. and Berger, R. (1991). NB4, a maturation inducible cell line with t(15;I7) marker isolated from a human acute promyelocytic leukemia (M3). Blood, 77, 1080-1086.
23. Agadir, A., Comic, M., Jerome, M., Menot, M. L., Cambier, N., Gaub, M. P., Gourmel, B., Lefebvre, P., Degos, L. and Chomienne, C. (1995). Characterization of nuclear retinoic acid binding activity in sensitive leukemic cell lines: cell specific uptake of ATRA and RARα protein modulation. Biochem. Biophys. Res. Commun., 213, 112-122.
24. Chomienne, C., Balitrand, N., Ballerini, P., Castaigne, S., de Thé, H. and Degos, L. (1991). All-trans retinoic acid modulates the retinoic acid receptor alpha in promyelocytic cells. J Clin. Invest., 88, 2150-2154.
25. Giannǐ, M., Terao, M., Gambacorti Passerini, C., Rambaldi, A. and Garattini, E. (1996). Effects of 1,25-dihydroxy vitamin D3 on all-trans retinoic acid sensitive and resistant acute promyelocytic leukemia cells. Biochem. Biophys. Res Commun., 224, 50-56.
26. Duprez, E., Lillehaug, J. R., Gaub, M. P. and Lanotte, M. (1996). Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells. Oncogene, 12, 2443-2450.
27. Borrow, J., Goddard, A. D., Sheer, D. and Solomon, E. (1990). Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science, 249, 1577-1580.
28. Ruthardt, M., Testa, U., Nervi, C., Ferrucci, P. F., Grignani, F., Puccetti, E., Grignani, F., Peschle, C. and Pelicci, P. G. (1997). Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor a (RARα) and PLZF-RARa fusion proteins on retinoic acid signalling. Mol. Cell. Biol., 17, 4859-4869.
29. Nason Burchenal, K., Gandini, D., Botto, M., Allopenna, J., Scale, J. R., Cross, N. C., Goldman, J. M., Dmitrovsky, E. and Pandolfi, P. P. (1996). Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line. Blood, 88, 3926-3936.
30. Chelbi-Alix, M. K., Pelicano, L., Quignon, F., Koken, M. H. M., Venturing, L., Stadler, M., Pavlovic, J., Degos, L. and de Thé, H. (1995). Induction of the PML protein by interferons in normal and APL cells. Leukemia, 9, 2027.
31. Giannǐ, M., Zanotta, S., Terao, M., Rambaldi, A. and Garattini, E. (1996). Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells: potentiation of the induction of retinoid-dependent differentiation markers. Int. J. Cancer, 68, 75-83.
32. Yoshida, H., Kitamura, K., Tanaka, K., Omura, S., Miyazaki, T., Hachiya, T., Ohno, R. and Naoe, T. (1996). Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway. Cancer Res., 56, 2945-2948.
33. Raelson, J. V., Nervi, C., Rosenauer, A., Benedetti, L., Monczak, Y., Pearson, M., Pelicci, P. G. and Miller, W. H. J. (1996). The PML/RAR alpha oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells. Blood, 88, 2826-2832.
34. Dermime, S., Grignani, F., Clerici, M., Nervi, C., Sozzi, G., Talamo, G. P., Marchesi, E., Formelli, F., Parmiani, G., Pelicci, P. G. and Passerini-Gambacorti, C. (1993). Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/rar alpha protein. Blood, 82, 1573-1577.
35. Garattini, E. and Gianni, M. (1996). Leukocyte alkaline phosphatase a specific marker for the post-mitotic neutrophilic granulocyte: regulation in acute promyelocytic leukemia. Leuk. Lymphoma, 23, 493-503.
36. Tkatch, L. S., Rubin, K. A., Ziegler, S. F. and Tweardy, D. J. (1995). Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J. Leukocyte Biol., 57, 964-971.
37. Rambaldi, A., Terao, M., Bettoni, S., Tini, M. L., Bassan, R., Barbui, T. and Garattini, E. (1990). Expression of leukocyte alkaline phosphatase gene in normal and leukemic cells: regulation of the transcript by granulocyte colony-stimulating factor. Blood, 76, 2565-2571
38. Rambaldi, A., Terao, M., Bettoni, S., Battoni, R., Battista, R., Barbui, T. and Garattini, E. (1989). Differences in the expression of alkaline phosphatase mRNA in chronic myelogenous leukemia and paroxysmal nocturnal hemoglobinuria polymorphonuclear leukocytes. Blood, 73, 1113-1115.
39. Pedersen, B. (1982). Functional and biochemical phenotype in relation to cellular age of differentiated neutrophils in chronic myeloid leukemia. Br. J. Haematol., 51, 339-344.
40. Williams, B. R. G. and Haque, S. J. (1997). Interacting pathways of Interferon signaling. Sem. in Oncol., 24 (suppl. 9), S9.70-S9.77.
41. Matikainen, S., Ronni, T., Hurme, M., Pine, R. and Julkunen, I. (1996). Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood, 88, 114-123.
42. Matikainen, S., Ronni, T., Lehtonen, A., Sareneva, T., Melen, K., Nordling, S., Levy, D. E. and Julkunen, I. (1997). Retinoic acid induces signal transducer and activator of transcription (STAT)1. STAT2. and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons. Cell Growth Diff., 8, 687-698.
43. Gianni, M., Terao, M., Fortino, I., Li Calzi, M., Viggiano, V., Barbui, T., Rambaldi, A. and Garattini, E. (1997) Stat1 is induced and activated by all-truns retinoic acid in acute promyelocytic leukemia cells. Blood, 89, 1001-1012.
44. Kumar, R. and Korutla, L. (1995). Growth inhibition of human acute promyelocylic leukemia NB-4 cells by inteferons and all-trans retinoic acid: trans-modulation of inducible gene expression pathways. Anticancer Res., 15, 353-360.
45. Kolla, V., Lindner, D. J., Weihua, X., Borden, E. C. and Kalvakolanu, D. V. (1996). Modulation of interferon(IFN)-inducible gene expression by retinoic acid. J. Biol. Chem., 271, 10508-10514.
46. Weihua, X., Kolla, V. and Kalvakolanu, D. V. (1997). Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. J. Biol. Chem., 272, 9742-9748.
47. Nguyen, H., Lin, R. and Hiscott, J. (1997). Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins. Oncogene, 15, 1425-1435.
48. Harada, H., Fujita, T., Miyamoto, M., Kimura, Y., Maruyama, M., Furia, A., Miyata, T. and Taniguchi, T. (1989). Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell, 58, 729-739.
49. Lamphier, M. and Taniguchi, T. (1994). The transcription factors IRF-1 and IRF-2: linking the Interferon response and cell growth control. The Immunologist, 2, 167-171.
50. Benech, P., Mory, Y., Revel, M. and Chebath, J. (1985). Structure of two forms of interferon-induced (2′-5′) olygo A synthetase of human cells based on cDNAs and gene sequences. EMBO J., 4, 2249-2259.
51. White, J. A., Guo, Y-D., Baetz, K., Beckett-Jones, B., Bonasoro, J., Hsu, K. E., Dilworth, F. J., Jones, G. and Petkovich, M. (1996). Identification of the retinoic acid-inducible all-trans retinoic acid 4-hydroxylase. J. Biol. Chem., 271, 29922-29927.
52. Muindi, J., Frankel, S. R., Miller, W. H. Jr., Jakubowski, A., Scheinberg, D. A., Young, C. W., Dmitrovsky, E. and Warrell, R. P. J. (1992). Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia [published erratum appears in Blood 1992 Aug 1;80(3):855]. Blood, 79, 299-303.
53. Kuwahara, S. K. and Mannering, G. J. (1993). Effects of interferon. polyriboinosinic acid-polyribocytidilic acid and steroids on the cytochrome P450 system of cultured primary mouse hepatocytes, Pharmacol. Toxicol., 72, 199-204.
54. Koller, E., Krieger, O., Kasparu, H. and Lutz, D. (1991). Restoration of all-trans retinoic acid sensitivity by interferon in acute promyelocytic leukemia (letter). Lancet, 338, 1154-1155.
55. ITALIAN COOPERATIVE GROUP STUDY On CHRONIC MYELOID LEUKEMIA (1994). Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. N. Engl. J Med., 330, 820-825.