Blood levels of transforming growth factor-beta 1 (TGF-β1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon-beta 1b (IFN- β1b)

Clinical and Experimental Immunology

Volumn 113, Issue 1, 1998, Pages 96-99

  Nicoletti, F ^a,d   Di Marco, R ^b   Patti, F ^b   Reggio, E ^b   Nicoletti, A ^b   Zaccone, P ^b   Stivala, F ^b   Meroni, P L ^c   Reggio, A ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c IRCCS   (Italy)

^d NONE   (Italy)

Author keywords

Autoimmune diseases; Immunotherapy; Interferon beta; Multiple sclerosis; Transforming growth factor beta

Indexed keywords

INTERFERON BETA SERINE; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RECURRENT DISEASE; SEX DIFFERENCE; SUBCUTANEOUS DRUG ADMINISTRATION;

ADJUVANTS, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERFERON-BETA; MALE; MULTIPLE SCLEROSIS; RECOMBINANT PROTEINS; RECURRENCE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031849699     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00604.x     Document Type: Article

References (17)

1. Olsson T. Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1995; 144:245-68.
2. Wahl SM, McCarthy-Francis N, Mergenhagen SE. Inflammatory and immunomodulatory roles of TGF-β. Immunol Today 1989; 10:258-61.
3. Swanborg RH. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin Immunol Immunopathol 1995; 77:4-13.
4. Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β-1 secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 1996; 98:70-77.
5. Link J, Soderstrom M, Olsson T, Hojebereg B, Ljungdahl A, Link H. Increased transforming growth factor-β, interleukin-4 and interteron-γ in multiple sclerosis. Ann Neurol 1994; 36:379-86.
6. Arnason BGW. Interferon-beta in multiple sclerosis. Clin Immunol Immunopathol 1996; 81:1-11.
7. Poser CM, Paty DW, Scheinberg L et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983; 13:227-31.
8. Nicoletti F, Patti F, Di Marco R, Zaccone P, Nicoletti A, Meroni PL, Reggio A. Circulating levels of IL-1ra in patients with relapsing remitting multiple sclerosis are normal during remission phases but significantly increased either during exacerbations or in response to IFN-β treatment. Cytokine 1996; 8:395-400.
9. 1 or IL-6 plasma levels and clinical features of spondyloarthropathies. Br J Rheumatol 1997; 36:400-1.
10. Zauli G, Gugliotta L, Catani L, Vianelli N, Borgatti P, Mattioli Belmonte M, Tura S. Increased serum levels of transforming growth factor β-1 in patients affected by thrombotic thrombocytopenic purpura (TTP): its implications on bone marrow haematopoiesis. Br J Haematol 1993; 84:381-6.
11. Sindern E, Schweppe K, Ossege LM, Malin JP. Potential role of transforming growth factor-β1 in terminating the immune response in patients with Guillain-Barré syndrome. J Neurol 1996; 243:264-8.
12. Tsukada N, Matsuda M, Miyagi K, Yanagisawa N. Increased levels of intercellular adhesion molecule-1 (ICAM-1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis. Neurology 1993; 43:2679-82.
13. Bendtzen K. Cytokines and natural regulator of cytokines. Immunol Letters 1994; 43:111-23.
14. Link J, Fredrikson S, Soderstrom M, Olsson T, Hojeberg B, Ljungdahl A, Link H. Organ-specific autoantigens induce transforming growth factor-β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Ann Neurol 1994; 35:197-203.
15. Beck J, Rondot P, Jullien P, Wietzerbin J, Lawrence DA. TGF-β-like activity produced during regression of exacerbations in multiple sclerosis. Acta Neurol Scand 1991; 84:452-5.
16. 1 by T cell lines of patients with active multiple sclerosis. J Immunol 1993; 151:979-89.
17. Rudick AR, Ransohoff RM, Peppler R, VanderBrug Medendorp S, Lehmann P, Alam J. Interferon beta induces interleukin-10 expression: relevance to multiple sclerosis. Ann Neurol 1996; 40:618-27.