Limited loss of tolerance to islet autoantigens in ICA+ first degree relatives of patients with type I diabetes expressing the HLA DQB1*0602 allele

Journal of Autoimmunity

Volumn 9, Issue 3, 1996, Pages 423-425

  Gianani, R ^a   Verge, C F ^b   Moromisato Gianani, R I ^b   Yu, L ^b   Zhang, Y J ^b   Pugliese, A ^c   Eisenbarth, G S ^b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO DENVER   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

DQB1*0602 allele; GAD; IA 2; ICA; Insulin autoantibodies

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GLUTAMATE DECARBOXYLASE; HLA ANTIGEN; PANCREAS ISLET CELL ANTIBODY;

ADOLESCENT; ADULT; ALLELE; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HLA TYPING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RELATIVE; UNITED STATES;

EID: 0030175324     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0058     Document Type: Conference Paper

References (14)

1. 1. Sheehy M.J., Scharf S.J., Rowe J.R., Neme de Gimenez M.H., Meske L., Erlich H.A., Nepom B.S. 1989. A diabetes susceptible HLA haplotype is best defined by a combination of HLA-DR and DQ alleles. J. Clin. Invest. 83: 830-835
2. 2. Baisch J.M., Weeks T., Giles R., Hoover M., Stastny P., Capra J.D. 1990. Analysis of HLA-DQ genotypes and susceptibility in insulin dependent diabetes mellitus. N. Engl. J. Med. 322: 1836-1841
3. 3. Pugliese A., Gianani R., Moromisato R., Awdeh Z.L., Alper C.A., Erlich H.A., Jackson R.A., Eisenbarth G.S. 1995. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 44: 608-613
4. 4. Gianani, R., Pugliese A., Bonner-Weir S., Shiffrin A., Soeldner J., Erlich H.A., Awdeh Z.L., Alper C.A., Jackson R.A., Eisenbarth G.S. 1992. Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with Type I diabetes. Diabetes 41: 347-353
5. 5. Genovese S., Bonifacio E., McNally J.M., Dean B.M., Wagner R., Bosi E., Gale E.A., Bottazzo G.F. 1992. Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 35: 385-388
6. 6. Pugliese A., Gianani R., Alper C.A., Awdeh Z.L., Jackson R.A., Gordon M., Kaufman M., Pfeiffer F., Eisenbarth G.S. 1992. Class II determinants of restricted islet cell antibodies (Stiff-Man Syndrome like anti-GAD ICA) and protection from Type I diabetes (Abstract). Clin. Res. 40: 299A
7. 7. Payton M.A., Hawkes C.J., Christie M.R. 1995. Relationship of the 37,000 and 40,000 tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J. Clin. Invest. 96: 1506-1511
8. 8. Gianani R., Rabin D.U., Verge C.E, Yu L., Babu S.R., Pietrapaolo M., Eisenbarth G.S. 1995. ICA512 autoantibody radioassay. Diabetes 44: 1340-1344
9. 9. Rabin D.U., Pleasic S.M., Shapiro J.A., Yoo-Warren H., Oles J., Hicks J.M., Goldstein D., Rae P.M. 1994. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J. Immunol. 152: 3183-3186
10. 10. Vardi P., Dib S., Tuttleman M., Connelly J.E., Grinbergs M., Rabizadeh A., Riley W.J., Maclaren N.K., Eisenbarth G., Soeldner J. 1987. Competitive insulin autoantibody assay: prospective evaluation of subjects at high risk for developing of type I diabetes mellitus. Diabetes 36: 1286-1291
11. 11. Chase H.B., Voss M.A., Butler-Simon N., Hoops S., O'Brien D., Dobersen M.J. 1987. Diagnosis of pre-type I diabetes. J. Pediatr. 111: 807-812
12. 12. Srikanta S., Rabizadeh A., Omar M.A., Eisenbarth G.S. 1985. Assay for islet cell antibodies: protein A-monoclonal antibody method. Diabetes 34: 300-305
13. 13. Grubin C.E., Daniels T., Toivola B., Landin-Olsson M., Hagopian W.A., Li L., Karlsen A., Boel E., Michelsen B., Lernmark A. 1994. A novel radiobinding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37: 344-350
14. 14. Huang W., She J.X., Muir A., Laskowska D., Zorowich B., Schatz D., Maclaren N.K. 1994. High risk HLA-DR/DQ genotypes for IDDM confer susceptibility to autoantibodies but DQB1*0602 does not prevent them. J. Autoimmunity 7: 889-897