Upregulation of intracellular glutathione by fibroblast-derived factor(s): Enhanced survival of activated T cells in the presence of low Bcl- 2

Blood

Volumn 89, Issue 7, 1997, Pages 2453-2460

  Hyde, Helena ^b   Borthwick, Nicola J ^b   Janossy, George ^b   Salmon, Michael ^b   Akbar, Arne N ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACIVICIN; BUTHIONINE SULFOXIMINE; CYSTEINE; CYSTINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; INTERLEUKIN 2; PROTEIN BCL 2;

ARTICLE; CELL CULTURE; CELL FRACTIONATION; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; DNA SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

EID: 0030982912     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.7.2453     Document Type: Article

References (60)

1. Surh CD, Sprent J: T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372:100, 1994
2. Murphy KM, Heimberger AB, Loh DY: Induction by antigen of intrathymic apoptosis of CD4+ CD8+ TCR1o thymocytes in vivo. Science 250:1720, 1990
3. Sprent J: T and B memory cells. Cell 76:315, 1994
4. Akbar AN, Salmon M, Savill J, Janossy G: A possible role for bcl-2 in regulating T-cell memory - a 'balancing act' between cell death and survival. Immunol Today 14:526, 1993
5. Freitas AA, Rocha BB: Lymphocyte lifespans: Homeostasis, selection and competition. Immunol Today 14:25, 1993
6. Razvi ES, Welsh RM: Apoptosis in viral infections. Adv Virus Res 45:1, 1995
7. Selin LK, Welsh RM: Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes. Curr Opin Immunol 6:553, 1994
8. Ellis RE, Yuan JY, Horvitz HR: Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663, 1991
9. Wyllie AH, Kerr JF, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 68:251, 1980
10. Dhein J, Walczak H, Baumler C, Debatin KM, Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438, 1995
11. Smith CA, Farrah T, Goodwin RG: The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death. Cell 76:959, 1994
12. Akbar AN, Borthwick N, Salmon M, Gombert W, Bofill M, Shamsadeen N, Pett S, Pilling D, Grundy JE, Janossy G: The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory. J Exp Med 178:427, 1993
13. Akbar AN, Borthwick NJ, Wickremasinghe RG, Panayiotidis P, Pilling D, Bofill M, Krajewski S, Reed RC, Salmon M: Interleukin-2 receptor common gamma chain signalling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal. Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not proapoptotic (bax, bcl-xS) gene expression. Eur J Immunol 26:294, 1996
14. Scott S, Pandolfi F, Kurnick JT: Fibroblasts mediate T cell survival: A proposed mechanism for retention of primed T cells. J Exp Med 172:1873, 1990
15. Gombert W, Borthwick NJ, Wallace DL, Hyde H, Bofill M, Pilling D, Beverley PCL, Janossy G, Salmon M, Akbar AN: Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: A selective effect on Bel-XL expression. Immunology 89:397, 1996
16. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE: Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262:1274, 1993
17. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241, 1993
18. Sandstrom PA, Pardi D, Tebbey PW, Dudek RW, Terrian DM, Folks TM: Lipid hydroperoxide-induced apoptosis: Lack of inhibition by Bcl-2 over-expression. FEBS Lett 365:66, 1995
19. Giardino I, Edelstein D, Brownlee M: Bcl-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells. J Clin Invest 97:1422, 1996
20. Droge W, Pottmeyer-Gerber C, Schmidt H, Nick S: Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172:151, 1986
21. Fidelus RK, Tsan MF: Enhancement of intracellular glutathione promotes lymphocyte activation by mitogen. Cell Immunol 97:155, 1986
22. Suthanthiran M, Anderson ME, Sharma VK, Meister A: Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci USA 87:3343, 1990
23. Gmunder H, Roth S, Eck HP, Gallas H, Mihm S, Droge W: Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells. Cell Immunol 130:520, 1990
24. Messina JP, Lawrence DA: Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase. J Immunol 143:1974, 1989
25. Noelle RJ, Lawrence DA: Modulation of T-cell function. II. Chemical basis for the involvement of cell surface thiol-reactive sites in control of T-cell proliferation. Cell Immunol 60:453, 1981
26. Hamilos DL, Wedner HJ: The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation. J Immunol 135:2740, 1985
27. Frei B: Reactive oxygen species and antioxidant vitamins: Mechanisms of action. Am J Med 97:5S, 1994
28. Bast A, Haenen GR, Doelman CJ: Oxidants and antioxidants: State of the art. Am J Med 91:2S, 1991
29. Halliwell B: Reactive oxygen species in living systems: Source, biochemistry, and role in human disease. Am J Med 91:14S, 1991
30. Meister A, Anderson ME: Glutathione. Annu Rev Biochem 52:711, 1983
31. Frei B, Stocker R, Ames BN: Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 85:9748, 1988
32. Liang CM, Lee N, Cattell D, Liang SM: Glutathione regulates interleukin-2 activity on cytotoxic T-cells. J Biol Chem 264:13519, 1989
33. Sandstrom PA, Mannie MD, Buttke TM: Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: Oxidative stress as a mediator of apoptosis. J Leukoc Biol 55:221, 1994
34. Jensen GL, Meister A: Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase. Proc Natl Acad Sci USA 80:4714, 1983
35. Bofill M, Gombert W, Borthwick NJ, Akbar AN, McLaughlin JE, Lee CA, Pinching AJ, Janossy G: Presence of CD3+ CD8+ Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients. Am J Pathol 146:1542, 1995
36. Salmon M, Scheel-Toellner D, Huissoon AP, Pilling D, Shamsadeen N, Hyde H, D'Angeac AD, Bacon PA, Emery P, Akbar AN: Inhibition of T cell apoptosis in the rheumatoid synovium. J Clin Invest 1997 (in press)
37. Allen L, Meek R, Yunis A: The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). Res Commun Chem Pathol Pharmacol 27:175, 1980
38. Ku RH, Billings RE: The role of mitochondrial glutathione and cellular protein sulfhydryls in formaldehyde toxicity in glutathi-one-depleted rat hepatocytes. Arch Biochem Biophys 247:183, 1986
39. Griffith OW, Meister A: Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 254:7558, 1979
40. Schick MR, Nguyen VQ, Levy S: Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels. J Immunol 151:1918, 1993
41. Gmunder H, Eck HP, Benninghoff B, Roth S, Droge W: Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine. Cell Immunol 129:32, 1990
42. Lee SH, Fujita N, Imai K, Tsuruo T: Cysteine produced from lymph node stromal cells suppresses apoptosis of mouse malignant T-lymphoma cells. Biochem Biophys Res Commun 213:837, 1995
43. Kavanagh TJ, Raghu G, White CC, Martin GM, Rabinovitch PS, Eaton DL: Enhancement of glutathione content in glutathione synthetase-deficient fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with normal fibroblasts. Exp Cell Res 212:69, 1994
44. Bannai S, Tsukeda H: The export of glutathione from human diploid cells in culture. J Biol Chem 254:3444, 1979
45. Jacobson MD, Raff MC: Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374:814, 1995
46. Muschel RJ, Bernhard EJ, Garza L, McKenna WG, Koch CJ: Induction of apoptosis at different oxygen tensions: Evidence that oxygen radicals do not mediate apoptotic signaling. Cancer Res 55:995, 1995
47. Zamzami N, Susin SA, Marchetti P, Hirsch T, Gomezmonterrey I, Castedo M, Kroemer G: Mitochondrial control of nuclear apoptosis. J Exp Med 183:1533, 1996
48. Miyawaki T, Kasahara Y, Kanegane H, Ohta K, Yokoi T, Yachie A: Expression of CD45R0 (UCHL1) by CD4+ and CD8+ T cells as a sign of in vivo activation in infectious mononucleosis. Clin Exp Immunol 83:447, 1991
49. Cheeseman SH: Infectious mononucleosis. Semin Hematol 25:261, 1988
50. Crawford DH, Brickell P, Tidman N, McConnell I, Hoffbrand AV, Janossy G: Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis. Clin Exp Immunol 43:291, 1981
51. Rickinson AB, Moss DJ, Wallace LE, Rowe M, Misko IS, Epstein MA: Long-term T-cell-mediated immunity to Epstein-Barr virus. Cancer Res 41:4216, 1981
52. Gray D, Matzinger P: T cell memory is short-lived in the absence of antigen. J Exp Med 174:969, 1991
53. Oehen S, Waldner H, Kundig TM, Hengartner H, Zinkernagel RM: Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen. J Exp Med 176:1273, 1992
54. Hou S, Hyland L, Ryan KW, Portner A, Doherty PC: Virus-specific CD8+ T-cell memory determined by clonal burst size. Nature 369:652, 1994
55. Lau LL, Jamieson BD, Somasundaram T, Ahmed R: Cytotoxic T-cell memory without antigen. Nature 369:648, 1994
56. Unutmaz D, Pileri P, Abrignani S: Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180:1159, 1994
57. Chiba T, Takahashi S, Sato N, Ishii S, Kikuchi K: Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur J Immunol 26:1164, 1996
58. Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH: Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497, 1995
59. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA: Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181:2029, 1995
60. Roederer M, Staal FJ, Ela SW, Herzenberg LA: N-acetylcysteine: Potential for AIDS therapy. Pharmacology 46:121, 1993