Evidence that cannabinoid-induced: Inhibition of electrically evoked contractions of the myenteric plexus - longitudinal muscle preparation of guinea-small intestine can be modulated by Ca2+ and cAMP1

Canadian Journal of Physiology and Pharmacology

Volumn 76, Issue 3, 1998, Pages 340-346

  Coutts, Angela A ^a   Pertwee, Roger G ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Calcium; cAMP; Cannabinoid; Myenteric; Normorphine

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; NORMORPHINE;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; EXTRACELLULAR CALCIUM; GUINEA PIG; MUSCLE ISOMETRIC CONTRACTION; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE;

1-METHYL-3-ISOBUTYLXANTHINE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADENYLATE CYCLASE TOXIN; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CANNABINOIDS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FORSKOLIN; GUINEA PIGS; INTESTINE, SMALL; MALE; MORPHINE DERIVATIVES; MORPHOLINES; MUSCLE CONTRACTION; MYENTERIC PLEXUS; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RECEPTORS, OPIOID, MU; VIRULENCE FACTORS, BORDETELLA;

EID: 0031844258     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-76-3-340     Document Type: Article

References (24)

1. Colquhoun, D. 1971. Lectures on biostatistics. Oxford University Press, Oxford.
2. Coutts, A.A., and Pertwee, R.G. 1997. Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus. Br. J. Pharmacol. 121: 1557-1566.
3. Deadwyler, S.A., Hampson, R.E., Mu, J., Whyte, A., and Childers, S. 1995. Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process. J. Pharmacol. Exp. Ther. 273: 734-743.
4. Devane, W.A., Hanus, L., Breuer, A., Pertwee, R.G., Stevenson, L.A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., and Mechoulam, R. 1992. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (Washington. D.C.), 258: 1946-1949.
5. 2 receptors. Mol. Pharmacol. 48: 443-450.
6. Gifford, A.N., and Ashby, C.R. 1996. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A. J. Pharmacol. Exp. Ther. 277: 1431-1436.
7. Greenberg, R., Kosterlitz, H.W., and Waterfield, A.A. 1970. The effects of hexamethonium, morphine and adrenaline on the output of acetylcholine from the myenteric plexus - longitudinal muscle preparation of the ileum. Br. J. Pharmacol. Suppl. 40: 553P.
8. Hong, S.J., Roan, Y.F., and Chang, C.C. 1996. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by ω-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br. J. Pharmacol. 118: 797-803.
9. Kojima, Y., Takahashi, T., Fujina, M., and Owyang, C. 1994. Inhibition of cholinergic transmission by opiates in ileal myenteric plexus is mediated by kappa receptor. Involvement of regulatory G protein and calcium N-channels. J. Pharmacol. Exp.Ther. 268: 965-970.
10. Kosterlitz, H.W., and Waterfield, A.A. 1972. Effects of calcium and manganese on acetylcholine release from the myenteric plexus of the guinea-pig and rabbit ileum. Br. J. Pharmacol. 45: 157P-158P.
11. Lavidis, N.A. 1995. Effect of morphine on the nerve terminal impulse and transmitter release from sympathetic varicosities innervating the mouse vas deferens. Br. J. Pharmacol. 116: 2852-2859.
12. Lord, J.A.H., Waterfield, A.A., Hughes, J., and Kosterlitz, H.W. 1977. Endogenous opioid peptides: multiple agonists and receptors. Nature (London), 267: 495-499.
13. Martin, M.I., Goicoechea, C., Ormazabal, M.J., and Alfaro, M.J. 1996. Influence of pertussis toxin on the calcitonin-opioid interaction in isolated tissues. Br. J. Pharmacol. 119: 804-806.
14. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., and Bonner, T.I. 1990. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (London), 346: 561-564.
15. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N.E., Schatz, A.R., Gopher, A., Almog, S., Martin, B.R., Compton, D.R., Pertwee, R.G., Griffin, G., Bayewitch, M., Barg, J., and Vogel, Z. 1995. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50: 83-90.
16. Munro, S., Thomas, K.L., and Abu-Shaar, M. 1993. Molecular characterization of a peripheral receptor for cannabinoids. Nature (London), 365: 61-65.
17. Nixon, G.F., Pyne, N.J., Wadsworth, R.M., Hamilton, C.A., and Reid, J.L. 1995. Pertussis toxin sensitive endothelin-1 coupling to inositol phosphate formation via a GTP-binding protein: comparison to SHR and WKY cultured aortic smooth muscle cells. Clin. Exp. Hypertens. 17: 507-522.
18. Paton, W.D.M., and Zar, M.A. 1968. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips. J. Physiol. (London), 194: 13-33.
19. 2 receptors. Pharmacol. Ther. 74: 1-52.
20. 1 receptors in mouse urinary bladder. Br. J. Pharmacol. 118: 2053-2058.
21. Pertwee, R.G., Stevenson, L.A., Elrick, D.B., Mechoulam, R., and Corbett, A.D. 1992. Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of the guinea-pig small intestine. Br. J. Pharmacol. 105: 980-984.
22. Pertwee, R.G., Fernando, S.R., Nash, J.E., and Coutts A.A. 1996a. Further evidence for the presence of cannabinoid CB, receptors in guinea-pig small intestine. Br. J. Pharmacol. 118: 2199-2205.
23. 8-tetrahydrocannabinol in two isolated tissue preparations. Eur. J. Pharmacol. 315: 195-201.
24. Schlicker, E., Timm, J., and Göethert, M. 1996. Cannabinoid receptor-mediated inhibition of dopamine release in the retina. Naunyn-Schmiedeberg s Arch. Pharmacol. 354: 791-795.