Characterization of an atypical muscarinic cholinoceptor mediating contraction of the guinea-pig isolated uterus

British Journal of Pharmacology

Volumn 124, Issue 8, 1998, Pages 1615-1622

  Boxall, Donna K ^a   Ford, Anthony P D W ^b   Choppin, Agnes ^b   Nahorski, Stefan R ^a   Challiss, R A John ^a   Eglen, Richard M ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Guinea pig (uterus); L 660,863; Muscarinic acetylcholine receptors; Selective alkylation; Smooth muscle contraction; Tripitramine; Zamifenacin

Indexed keywords

3 (3 AMINO 1,2,4 OXADIAZOL 5 YL)QUINUCLIDINE; ATROPINE; CARBACHOL; CYCLIC AMP; DIETHYLSTILBESTROL; FORSKOLIN; METHOCTRAMINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROTOXIN; PERTUSSIS TOXIN; TRIPITRAMINE; UNCLASSIFIED DRUG; ZAMIFENACIN;

ALKYLATION; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; GUINEA PIG; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR AFFINITY; UTERUS CONTRACTION;

ADENYLATE CYCLASE; ANIMALS; DIETHYLSTILBESTROL; ESTROGENS, NON-STEROIDAL; FEMALE; GUINEA PIGS; INOSITOL PHOSPHATES; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; PARASYMPATHOLYTICS; PERTUSSIS TOXIN; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; UTERINE CONTRACTION; UTERUS; VIRULENCE FACTORS, BORDETELLA;

EID: 0031843494     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702002     Document Type: Article

References (44)

1. ARKINSTALL, S.J. & JONES, C.T. (1990). Influence of pregnancy on G-protein coupling to adenylyl cyclase activation in guinea-pig myometrium. J. Endocrinol., 127, 15-24.
2. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitive uses of drug antagonists. Br. J. Pharmacol., 14, 48-58.
3. 4 subtypes mediates contraction of the rabbit iris sphincter. Naunyn-Schmiedeberg's Arch. Pharmacol., 345, 611-618.
4. BOXALL, D.K., FORD, A.P.D.W., CHALLISS, R.A.J., NAHORSKI, S.R. & EGLEN, R.M. (1997). Atypical muscarinic cholinoceptor mediating carbachol-induced contraction in guinea pig isolated uterus. Br. J. Pharmacol., 120, 62P.
5. CAULFIELD, M.P. (1993). Muscarinic receptors: characterization, coupling and function. Pharmacol. Ther., 58, 319-379.
6. CHALLISS, R.A.J. & BLANK, J.L. (1997). Muscarinic acetylcholine receptor signalling pathways in smooth muscle. In Muscarinic receptor subtypes in smooth muscle, ed. Eglen, R.M. pp. 39-86; CRC Press.
7. CHALLISS, R.A.J., PATEL, N. & ARCH, J.R.S. (1992). Comparative effects of BRL 38277, nitrendipine and isoprenaline on carbachol- and histamine-stimulated phosphoinositide metabolism in airway smooth muscle. Br. J. Pharmacol., 105, 997-1003.
8. 50) of an enzymatic reaction. Biochem. Pharmacol., 22, 3099-3108.
9. 2 receptors. Br. J. Pharmacol., 114, 1507-1517.
10. DAHLQUIST, F. (1978). The meaning of Scatchard and Hill plots. Methods Enzymol., 48, 270-276.
11. DANIELS, D. & ALVAREZ, R. (1992). A separation method for the assay of adenylyl cyclase, intracellular cAMP and cyclic AMP phosphodiesterase using tritium-labelled substrates. Anal. Biochem., 203, 76-82.
12. DOODS, H.N., WILLIM, K.D., BODDEKE, H.W.G.M. & ENTZEROTH, M. (1993). Characterization of muscarinic receptors in guinea-pig uterus. Eur. J. Pharmacol., 250, 223-230.
13. DÖRJE, F., FRIEBE, T., TACKE, R., MUTSCHLER, E. & LAMBRECHT, G. (1990). Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 284-289.
14. DÖRJE, F., LEVEY, A.I. & BRANN, M.R. (1991). Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol. Pharmacol., 40, 459-462.
15. EGLEN, R.M., FORD, A.P.D.W., LEVINE, W.B., HARRIS, G.C., MICHEL, A.D. & WHITING, R.L. (1992). Multidisciplinary analysis of muscarinic receptors in guinea-pig isolated ileum, atria and uterus in vitro. In Trends in receptor research, ed. Angeli, P., Gulini, U. & Quaglia, W. pp. 273-293; Elsevier Science Publishers B.V.
16. 3 receptors in guinea-pig ileum and atria in vitro. Br. J. Pharmacol., 109, 946-953.
17. EGLEN, R.M., HEGDE, S.S. & WATSON, N. (1997). Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev., 48, 531-565.
18. EGLEN, R.M., MICHEL, A.D. & WHITING, R.L. (1989). Characterization of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus. Br. J. Pharmacol., 96, 497-499.
19. EGLEN, R.M., REDDY, H., WATSON, N. & CHALLISS, R.A.J. (1994). Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol. Sci., 15, 114-119.
20. FORD, A.P.D.W., LEVINE, W.B., BAXTER, G.S., HARRIS, G.C., EGLEN, R.M. & WHITING, R.L. (1991). Pharmacological, biochemical and molecular characterization of muscarinic receptors in the guinea-pig ileum: a multidisciplinary study. Mol. Neuropharmacol., 1, 117-127.
21. 4-selective muscarinic antagonist. Life Sci., 60, 12.
22. 4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle. Naunyn Schmiedeberg's Arch. Pharmacol., 356, 505-516.
23. HARRIS, G.C., FORD, A.P.D.W., WONG, E.H.F., KUNYSZ, E.A., PFISTER, J.R., EGLEN, R.M. & WHITING, R.L. (1991). Characterization of the action of L-660,863 (3-(3-amino-1,2,4-ozadiazol-5-yl)quinuclidine) at muscarinic receptors in vitro. Br. J. Pharmacol., 102, 197P.
24. 4-receptors. FEBS Lett., 352, 91-94.
25. KEEN, M. (1991). Testing models of agonism for G protein-coupled receptors. Trends Pharmacol. Sci., 12, 371-374.
26. LEFF, P. (1995). The two state model of receptor activation. Trends Pharmacol. Sci., 16, 89-97.
27. LEIBER, D., MARC, S. & HARBON, S. (1990). Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea-pig myometrium. J. Pharmacol. Exp. Ther., 252, 800-809.
28. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. & RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275.
29. MAHESH, V.K., NUNAN, L.M., HALONEN, M., YAMAMURA, H.I., PALMER, J.D. & BLOOM, J.W. (1992). A minority of muscarinic receptors mediate rabbit tracheal smooth muscle contraction. Am. J. Respir. Cell Mol. Biol., 6, 279-286.
30. MARC, S., LEIBER, D. & HARBON, S. (1988). Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Biochem. J., 255, 705-713.
31. MATUCCI, R., BIANCHI, B., MANTELLI, L., GHELARDINI, C., VANNELLI, G.B. & MAGGI, M. (1996). Influence of estrogens on muscarinic receptor density and contractile response in the guinea-pig uterus. J. Reprod. Fertil., 107, 153-160.
32. MUNNS, M. & PENNEFATHER, J.N. (1998). Pharmacological characterization of muscarinic receptors in the uterus of oestrogen-primed and pregnant rats. Br. J. Pharmacol., 123, 1639-1644.
33. 2+ in vascular smooth muscle. J. Hypertension, 12, S133-S143.
34. RIEMER, R.K., GOLDFIEN, A. & ROBERTS, J.M. (1987). Estrogen increases adrenergic-but not cholinergic-mediated production of inositol phosphates in rabbit uterus. Mol. Pharmacol., 32, 663-668.
35. 3 receptors mediate contraction of human central and peripheral airway smooth muscle. Pulmon. Pharmacol., 3, 47-51.
36. SATO, Y., HOTTA, H., NAKAYAMA, H. & SUZUKI, H. (1996). Sympathetic and parasympathetic regulation of the uterine blood flow and contraction in the rat. J. Auton. Nervous System, 59, 151-158.
37. 4-subtype selective muscarinic antagonist. Life Sci., 60, 10.
38. TETSURO, T., SHIN-ICHI, B., TAKASAKI, K., OKUMURA, M., SATO, H., TERAOKA, H., KITAZAWA, T. & OHGA, A. (1994). Muscle layer and regional differences in autonomic innervation and responsiveness to transmitter agents in swine myometrium. J. Auton. Pharmacol., 14, 213-227.
39. 2 muscarinic receptor in smooth muscle of guinea-pig ileum. Mol. Pharmacol., 44, 102-110.
40. TRAURIG, H.H. & PAPKA, R.E. (1993). Autonomie efferent and visceral sensory innervation of the female reproductive system: special reference to the functional roles of nerves in reproductive organs. In Nervous control of the urogenital system. ed. Maggi, C.A. pp. 103-141; Harwood Academic Publishers.
41. VAROL, F.G., HADJI-CONSTANTINOU, M., ZUSPAN, F.P. & NEFF, N.H. (1989). Gestational alterations in phospholipase-C coupled muscarinic response. Life Sci., 45, 1739-1743.
42. WIENER, H.L. & THALODY, G.P. (1993). Differential attenuation of the responses to adenosine and methoxamine in isolated rabbit aorta. J. Pharmacol. Exp. Ther., 267, 828-837.
43. WRAY, S. (1993). Uterine contraction and physiological mechanisms of modulation. Am. J. Physiol., 264, C1-C18.
44. YANG, C.M., CHOU, S.P. & SUNG, T.C. (1991). Muscarinic subtypes coupled to generation of different second messengers in isolated tracheal smooth muscle cells. Br. J. Pharmacol., 104, 613-618.