Pharmacological characterization of muscarinic receptors in the uterus of oestrogen-primed and pregnant rats

British Journal of Pharmacology

Volumn 123, Issue 8, 1998, Pages 1639-1644

  Munns, Melinda ^a,b   Pennefather, Jocelyn N ^a  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL WOMEN'S HOSPITAL   (Australia)

Author keywords

3H QNB; Carbachol; M2 muscarinic receptors; M3 muscarinic receptors; Muscarinic receptors; Myometrium; Oestrogen; Pregnancy; Uterine contractions

Indexed keywords

ATROPINE; BENZODIAZEPINE DERIVATIVE; CARBACHOL; ESTROGEN; HEXAHYDROSILADIFENIDOL; HIMBACINE; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; OTENZEPAD; PIRENZEPINE; QUINUCLIDINYL BENZILATE; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; LIGAND BINDING; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; RAT; UTERUS CONTRACTILITY; UTERUS CONTRACTION;

ANIMALS; BINDING, COMPETITIVE; ESTROGENS; FEMALE; KINETICS; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; PREGNANCY; PREGNANCY, ANIMAL; QUINUCLIDINYL BENZILATE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; UTERUS;

EID: 0031939148     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701794     Document Type: Article

References (33)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-58.
2. BELL, C. (1972). Autonomic nervous control of reproduction: circulatory and other factors. Pharmacol. Rev., 21, 657-710.
3. BOXALL, D.K., FORD, A.P.D.W., CHALLIS, R.A.J., NAHORSKI, S.R. & EGLEN, R.M. (1997). Atypical muscarinic cholinoceptor (mAChR) mediating carbachol-induced contraction of the guinea-pig uterus. Br. J. Pharmacol., 120, 62P.
4. BUCKLEY, N.J., BONNER, T.L., BUCKLEY, C.M. & BRANN, M.R. (1989). Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol. Pharmacol., 35, 469-476.
5. BOSELLI, C. & GRANA, E. (1995). Model of action of methoctramine, AF-DX-116 and hexahydrosiladifenidol in guinea-pig left atrium and ileum: comparison of Schild and resultant analysis. J. Autom. Pharmacol., 15, 115-127.
6. CAULFIELD, M.P. (1993). Muscarinic receptors characterization, coupling and function. Pharmacol. Ther., 58, 319-379.
7. CRANKSHAW, D.J. (1984). Muscarinic cholinoceptors in the rabbit's myometrium: A study of the relationship between binding and response. Eur. J. Pharmacol., 101, 1-10.
8. 3 muscarinic receptors in the circular muscle of the guinea-pig ileum. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 237-243.
9. DOODS, H.N., WILLIM, K.D., BODDEKE, H.W.G.M. & ENTZEROTH, M. (1993). Characterization of muscarinic receptors in guinea-pig uterus. Eur. J. Pharmacol., 250, 223-262.
10. DÖRJE, F., ERIEBE, T., TACKE, R., MUTSCLER, E. & LAMBRECHT, G. (1990a). Novel pharmacological profile of muscarinic receptors mediating contraction of the guinea-pig uterus. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 284-289.
11. DÖRJE, F., FRIEBE, T.,TACKE, R., MUTSCHLER, E. & LAMBRECHT, G. (1990b). Pharmacological characterisation of muscarinic receptors mediating contractions of guinea-pig uterus. Naunyn-Schmiedeberg's Arch. Pharmacol., 341 (Suppl.), R79.
12. DÖRJE, F., LEVEY, A.I. & BRANN, M.R. (1991a). Immunological detection of muscarinic receptor subtype proteins (m1-m5) in rabbit peripheral tissues. Mol. Pharmacol., 40, 459-462.
13. DÖRJE, F., WESS, J., LAMBRECHT, G., TACKE, R., MUTSCHLER, E. & BRANN, M.R. (1991b). Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J. Pharmacol. Exp. Ther., 256, 727-733.
14. EGLEN, R.M., HEDGE, S.S. & WATSON, N. (1996). Muscarinic receptor subtypes and smooth muscle function. Pharmacol. Rev., 48, 531-565.
15. EGLEN, R.M., MICHEL, A.D., LEVINE, W.B. & WHITING, R.L. (1991). Analysis of muscarinic receptors in guinea-pig oestrogen-dominated uterus, in vitro. Br. J. Pharmacol., 104, 44p.
16. EGLEN, R.M., MICHEL, A.D. & WHITING, R.L. (1989). Characterisation of the muscarinic receptor subtype mediating contractions of the guinea-pig uterus. Br. J. Pharmacol., 96, 497-499.
17. EGLEN, R.M., REDDY, H., WATSON, N. & CHALLISS, R. A.J. (1994). Muscarinic acetylcholine receptor subtypes in smooth muscle. Trends Pharmacol. Sci., 151, 114-119.
18. EGLEN, R.M. & WATSON, N. (1996). Selective muscarinic receptor agonists and antagonists. Pharmacol. Toxicol., 78, 59-68.
19. GARFIELD, R.E. (1986). Structural studies of innervation on non-pregnant rat uterus. Am. J. Physiol., 251, C42-C54.
20. GEIGY SCIENTIFIC TABLES. (1982). Introduction to Statistics, Statistical Tables, Mathematical Formulae, Vol 2, 8th edn. ed Lertner, C. p. 214. Basle, Switzerland: Ciba-Geigy Ltd.
21. LAMBRECHT, G., FEIFEL, R., MOSER, U., WAGNER-RÖDER, M., CHOO, L.K., CAMUS, J., TASTENOY, M., WAELBROECK, M., STROHMANN, C., TACKE, R., RODRIGUES DE MIRANDA, J.F., CHRISTOPHE, J. & MUTSCHLER, E. (1989). Pharmacology of hexahydro-difenidol, hexahydro-sila-difenidol and related selective muscarinic antagonists. Trends Pharmacol. Sci., 10(Supp.), 60-64.
22. 4 binding sites in rabbit lung, chicken heart, and NG 108-15 cells. Mol. Pharmacol., 38, 805-815.
23. LEIBER, D., MARC, S. & HARBON, S. (1990). Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea-pig myometrium. J. Pharmacol. Exp. Ther., 252, 800-809.
24. MCPHERSON, G.A. (1985). Analysis of radioligand binding experiments. A collection of computer programs for the IBM PC. J Pharmacol. Methods, 14, 213-228
25. MCPHERSON, G.A. (1994). RADLIG: A collection of programs for the analysis of radioligand binding experiments. Biosoft, U.K.
26. NAKANISHI, H. & WOOD, C. (1971). Cholinergic mechanism in the human uterus. J. Obstet. Gynecol. Br. Commonwealth, 78, 716-723.
27. PENNEFATHER, J.N., GILLMAN, T.A. & MITCHELSON, F. (1994). Muscarinic receptor binding sites in rat uterus are of the M2 subtype. Eur. J Pharmacol., 262, 297-300.
28. PENNEFATHER, J.N. & MUNNS, M. (1995). Characterization of muscarinic receptor subtype mediating contractions of the uterus of oestrogen-treated and pregnant rats. Br. J. Pharmacol., 115, 14P.
29. SATO, S., HAYASHI, R.H. & GARFIELD, R.E. (1989). Mechanical responses of the rat uterus, cervix and bladder to stimulation of hypogastric and pelvic nerves in vivo. Biol Reprod., 40, 209-219.
30. SCHACTERLE, G.R. & POLLACK, R.L. (1973). A simplified model for the quantitative assay of small amounts of protein in biological material. Anal. Biochem., 51, 654.
31. VAROL, F.G., HADJICONSTANTINOU, M., ZUSPAN, F.P. & HEFF, N.H. (1989). Pharmacological characterisation of the muscarinic receptors mediating phosphoinositide hydrolysis in rat myometrium. J. Pharmacol. Exp. Ther., 249, 11-15.
32. WATSON, N., MAGNUSSEN, H. & RABE, K.F. (1995). Pharmacological characterization of the muscarinic receptor subtypes mediating contraction of human peripheral airways. J. Pharmacol. Exp. Ther., 274, 1293-1297.
33. WIKLAND, M., DAHLSTROM, A. & HAGLID, K.G. (1984). Structural and functional evidence for the denervation of human myometrium during pregnancy. Obstet. Gynecol., 64, 503-509.