Evidence for muscarinic M4 receptors mediating nonadrenergic noncholinergic relaxations in rabbit anococcygeus muscle

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 4, 1997, Pages 505-516

  Gross, Jan ^a   Mutschler, Ernst ^a   Lambrecht, Günter ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

M4 receptors; Muscarinic receptor subtypes; NANC relaxation; Nicotinic receptors; Nitric oxide (NO); Nitric oxide synthase inhibitors; Rabbit anococcygeus muscle

Indexed keywords

11 [[4 [4 (DIETHYLAMINO)BUTYL] 1 PIPERIDYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; [4 [(3 CHLOROPHENYL)CARBAMOYLOXY] 2 BUTYNYL]TRIMETHYLAMMONIUM; ACETYLCHOLINE; ATROPINE; CARBACHOL; CLOZAPINE; GUANETHIDINE; HEXAMETHONIUM; HIMBACINE; MEPYRAMINE; METHOCTRAMINE; MUSCARINIC AGENT; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL N (1 METHYL 4 PYRROLIDINO 2 BUTYNYL)ACETAMIDE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; NORADRENALIN; OXOTREMORINE; OXOTREMORINE M; PIRENZEPINE; PROPRANOLOL; RANITIDINE; TETRODOTOXIN; TRIPITRAMINE; ATROPINE DERIVATIVE; METHYLATROPINE; MUSCARINE; MUSCARINIC RECEPTOR; N(G) NITROARGININE; NICOTINE; NITRIC OXIDE;

ANIMAL TISSUE; ANOCOCCYGEUS MUSCLE; ARTICLE; CONTROLLED STUDY; MALE; MUSCLE RELAXATION; NONADRENERGIC NONCHOLINERGIC NERVE; NONHUMAN; RABBIT; ANIMAL; DRUG EFFECT; ELECTROSTIMULATION; IN VITRO STUDY; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; ATROPINE DERIVATIVES; ELECTRIC STIMULATION; HEXAMETHONIUM; MALE; MUSCARINE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE RELAXATION; MUSCLE, SKELETAL; NICOTINE; NITRIC OXIDE; NITROARGININE; RABBITS; RECEPTOR, MUSCARINIC M4; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; TETRODOTOXIN;

EID: 0030608953     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005084     Document Type: Article

References (54)

1. Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Br J Pharmacol 14:48-58
2. Baumgold J, Drobnick A (1989) An agonist that is selective for adenylate cyclase-coupled muscarinic receptors. Mol Pharmacol 36:465-470
3. Boksa P, Quik M, Mitchell JB, Collier B, O'Neil W, Quirion R (1989) Pharmacological activity of N-methyl-carbamylcholine, a novel acetylcholine receptor agonist with selectivity for nicotinic receptors. Eur J Pharmacol 173:93-108
4. Bolden C, Cusack B, Richolson E (1991) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells. J Pharmacol Exp Ther 260:576-580
5. Buckley NJ, Bonner TI, Buckley CM, Brann MR (1989) Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol 35:469-476
6. Caulfield MP, Brown DA (1991) Pharmacology of the putative muscarinic receptor mediating Ca-current inhibition in neuroblastoma x glioma hybrid (NG 108-15) cells. Br J Pharmacol 104:39-44
7. Caulfield MP (1993) Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 58:319-379
8. Cellek S, Kasakov L, Moncada S (1996) Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase. Br J Pharmacol 118:137-140
9. Creed KE, Gillespie JS, McCaffery H (1977) The rabbit anococcygeus muscle and its response to field stimulation and to some drugs. J Physiol (Lond) 273:121-135
10. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann MR (1991) Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 256:727-733
11. Doods HN, Willim KD, Boddeke HWGM, Entzeroth M (1993a) Characterization of muscarinic receptors in guinea-pia uterus. Eur J Pharmacol 250:223-230
12. 2 antagonists: Novel structures and pharmacology. Life Sci 52:497-503
13. Ehlert F, Delen F, Yun S, Friedman D, Self D (1989) Coupling of subtypes of the muscarinic receptor to adenylate cyclase in the corpus striatum and heart. J Pharmacol Exp Ther 251:660-671
14. 4(m4) muscarinic receptor subtype. Mol Pharmacol 46:1028-1035
15. Furness JB, Bornstein JC, Murphy R, Pompolo S (1992) Roles of peptides in transmission in the enteric nervous system. Trends Neurosci 15:66-71
16. Gilbert R, Rattan S, Goyal RK (1984) Pharmacologic identification, activation and antagonism of two muscarine receptor subtypes in the lower esophageal sphincter. J Pharmacol Exp Ther 230:284-291
17. Gillespie JS, McGrath JC (1974) The response of the cat anococcygeus muscle to nerve or drug stimulation and a comparison with the rat anococcygeus. Br J Pharmacol 50:109-118
18. Gitler MS, Reba RC, Cohen VI, Rzeszotarski WJ, Baumgold J (1992) A novel m2-selective muscarinic antagonist: binding characteristics and autoradioaraphic distribution in rat brain. Brain Res 582:253-260
19. Graham AM, Sneddon P (1993) Evidence for nitric oxide as an inhibitory neurotransmitter in rabbit isolated anococcygeus. Eur J Pharmacol 237:93-99
20. Gross J, Waelbroeck M, Mutschler E, Lambrecht G (1995a) Functional characterization of neuronal muscarinic receptors in rabbit anococcygeus muscle. Life Sci 56:1038
21. 4 muscarinic receptors in rabbit anococcygeus muscle. Naunyn-Schmiedeberg's Arch Pharmacol 351[Suppl]:R134
22. Gustafsson BI, Delbro DS (1988) Effects of indomethacin on non-adrenergic, non-cholinergic motility of stomach and small intestine. Eur J Pharmacol 147:67-72
23. Jolkkonen M, van Giersbergen PLM, Hellmanm U, Wernstedt C, Karlsson E (1994) A toxin from the green mamba Dendroaspis angusticeps: amino acid sequence and selectivity for muscarinic m4 receptors. FEBS Lett 352:91-94
24. Kasakov L, Cellek S, Moncada S (1995) Characterization of nitrergic neurotransmission during short- and long-term electrical stimulation of the rabbit anococcygeus muscle. Br J Pharmacol 115:1149-1154
25. Kenakin T (1993) Pharmacologic analysis of drug-receptor interaction. Raven Press, New York
26. Kilbinger H, Schneider R, Siefken H, Wolf D, D'Augostino G (1991) Characterization of prejunctional muscarinic autoreceptors in guinea-pig trachea. Br J Pharmacol 103:1757-1763
27. 2 receptor? Life Sci 52:577
28. 2-purinoceptor antagonists. J Auton Pharmacol 16:341-344
29. Lambrecht G, Moser U, Grimm U, Pfaff O, Hermanni U, Hildebrandt C, Waelbroeck M, Christophe J, Mutschler E (1993) New functionally selective muscarinic agonists. Life Sci 52:481-488
30. Lambrecht G, Gross J, Hacksell U, Hermanni U, Hildebrandt C, Hou X, Moser U, Nilsson BM, Pfaff O, Waelbroeck M, Wehrle J, Mutschler E (1995) The design and pharmacology of novel selective muscarinic agonists and antagonists. Life Sci 56:815-822
31. 4 binding sites in rabbit lung, chicken heart and NG 108-15 cells. Mol Pharmacol 38:805-815
32. 35S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br J Pharmacol 109:1120-1127
33. Maggio R, Barbier P, Bolognesi ML, Minarini A, Tedeschi D, Melchiorre C (1994) Binding profile of the selective muscarinic receptor antagonist tripitramine. Eur J Pharmacol 268:459-462
34. 2 receptor. J Pharmacol Exp Ther 250:565-572
35. 1 receptors stimulate a nonadrenergic noncholinergic inhibitory pathway in the isolated rat duodenum. J Pharmacol Exp Ther 244:680-684
36. Miller JH, Aagaard PJ, Gibson VA, McKinney M (1992) Binding and functional selectivity of himbacine for cloned and neuronal muscarinic receptors. J Pharmacol Exp Ther 263:663-667
37. Minarini A, Bolognesi ML, Budriesi, R. Canossa M, Chiarini A, Spampinato S, Melchiorre C (1994) Design, synthesis and biological activity of some methoctramine-related tetramines bearing an 11-Acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one moiety: Structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines. J Med Chem 37:3363-3372
38. Monferrini E, Cereda E, Ladinsky H, Donetti A, Giraldo E (1990) Guanylpirenzepine distinghuishes between neuronal m1 and m4 muscarinic receptors. J Recept Res 10:81-96
39. Pfaff O, Gross J, Waelbroeck M, Mutschler E, Lambrecht G (1995) Functional characterization of muscarinic receptors in rat duodenum. Life Sci 56:1038
40. Rand MJ (1992) Nitrergic transmission: Nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol 19:147-169
41. Reynolds GP (1992) Developments in the drug treatment of schizophrenia. Trends Pharmacol Sci 13:116-121
42. Richards MH, van Giersbergen (1995) Human muscarinic receptors expressed in AL9 and CHO cells: activation by full and partial agonists. Br J Pharmacol 114:1241-1249
43. 4 muscarinic receptors. J Pharmacol Exp Ther 266:142-146
44. Smits GJM, Lefebvre RA (1996) ATP and nitric oxide: inhibitory NANC neurotransmitters in the longitudinal muscle-myenteric plexus preparation of the rat ileum. Br J Pharmacol 118:695-703
45. 3. Eur J Pharmacol 80:93-98
46. Tallarida RJ, Murray RB (1986) Manual of pharmacologic calculations with computer programs. Springer, Berlin Heidelberg New York Tokyo
47. Vockert EK, Lambrecht G, Mutschler E (1993) Characterization of prejunctional muscarinic receptors on noradrenergic nerves in rabbit peripheral lung. Naunyn-Schmiedeberg's Arch Pharmacol 347[Suppl]:R455
48. 4) in rat forebrain. Mol Pharmacol 38:267-273
49. Waelbroeck M, Camus J, Tastenoy M, Mutschler E, Strohmann C, Tacke R, Lambrecht G, Christophe J (1991) Binding affinities of hexahydro-difenidol and hexahydro-sila-difenidol analogues at four muscarinic receptor subtypes: Constitutional and stereochemical aspects. Eur J Pharmacol 206:95-103
50. 1 receptors. Eur J Pharmacol 305:187-192
51. Wai SS, Coupar IM (1976) The inhibitory response of the rabbit anococcygeus muscle. Clin Exp Pharmacol Physiol 3:141-145
52. Windscheif U, Pfaff O, Ziganshin AU, Hoyle CHV, Bäumen HG, Mutschler E, Burnstock G, Lambrecht G (1995) Inhibitory action of PPADS on relaxant responses to adenine nucleotides or electrical field stimulation in guinea-pig taenia coli and rat duodenum. Br J Pharmacol 115:1509-1517
53. Xian H, Coggan JS, Knopper SR, Kreulen DL (1994) The muscarinic agonist oxotremorine methiodide evokes a nicotinic response in mammalian sympathetic neurons. Eur J Pharmacol 259:21-25
54. 4 receptor agonist. Eur J Pharmacol 269:R1-R2