Extracellular K+ induces locomotor-like patterns in the rat spinal cord in vitro: Comparison with NMDA or 5-HT induced activity

Journal of Neurophysiology

Volumn 79, Issue 5, 1998, Pages 2643-2652

  Bracci, E ^a,b   Beato, M ^a   Nistri, A ^a  

^a SISSA   (Italy)

^b MRC Centre for Immune Regulation   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM ION; RITANSERIN; SEROTONIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LOCOMOTION; MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SYNAPTIC TRANSMISSION;

EID: 0031841243     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.79.5.2643     Document Type: Article

References (27)

1. ANWYL, R. Neurophysiological actions of 5-hydroxytryptamine in the vertebrate nervous system. Prog. Neurobiol. 35: 451-468, 1990.
2. BALLERINI, L., BRACCI, E., AND NISTRI, A. Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord. Eur. J. Neurosci. 7: 1229-1234, 1995.
3. BARANAUSKAS, G. AND NISTRI, A. Sensitization of pain pathways in the spinal cord: cellular mechanisms. Prog. Neurobiol. 54: 349-365, 1998.
4. BEATO, M., BRACCI, E., AND NISTRI, A. Contribution of NMDA and non-NMDA glutamate receptors to locomotor pattern generation in the neonatal rat spinal cord. Proc. R. Soc. Lond. B Biol. Sci. 264: 877-884, 1997.
5. BRACCI, E., BALLERINI, L., AND NISTRI, A. Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord. J. Neurophysiol. 75: 640-647, 1996a.
6. BRACCI, E., BALLERINI, L., AND NISTRI, A. Localization of rhythmogenic networks responsible for spontaneous bursts induced by strychnine and bicuculline in the rat isolated spinal cord. J. Neurosci. 16: 7063-7076, 1996b.
7. CAZALETS, J. R., BORDE, M., AND CLARAC, F. The synaptic drive from spinal locomotor network to motoneurons in the newborn rat. J. Neurosci. 16: 298-306, 1996.
8. CAZALETS, J. R., SQALLI-HOUSSAINI, Y., AND CLARAC, F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino-acids in neonatal rat. J. Physiol. (Lond.) 455: 187-204, 1992.
9. COWLEY, K. C. AND SCHMIDT, B. J. A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord. Neurosci. Lett. 171: 147-150, 1994.
10. COWLEY, K. C. AND SCHMIDT, B. J. Regional distribution of the locomotor pattern-generating network in the neonatal rat spinal cord. J. Neurophysiol. 77: 247-259, 1997.
11. ELLIOTT, P. AND WALLIS, D. I. Serotonin and L-norepinephrine as mediators of altered excitability in neonatal rat motoneurons studied in vitro. Neuroscience 47: 533-544, 1992.
12. FULTON, B. AND WALTON, K. Electrophysiological properties of neonatal rat motoneurons studied in vitro. J. Physiol. (Lond.) 370: 651-678, 1986.
13. Ho, S. AND O'DONOVAN, M. J. Regionalization and intersegmental coordination of rhythm-generating networks in the spinal cord of the chick embryo. J. Neurosci. 13: 1354-1371, 1993.
14. HOCHMAN, S., JORDAN, L. M., AND MACDONALD, J. F. N-methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord. J. Neurophysiol. 72: 565-577, 1994a.
15. HOCHMAN, S., JORDAN, L. M., AND SCHMIDT, B. J. TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons. J. Neurophysiol. 72: 2559-2562, 1994b.
16. HULTBORN, H. AND KIEHN, O. Neuromodulation of vertebrate motor neuron membrane properties. Curr. Opin. Neurobiol. 2: 770-775, 1992.
17. KIEHN, O., JOHNSON, B. R. AND RAASTAD, M. Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity. Neuroscience 75: 263-273, 1996.
18. KIEHN, O. AND KJAERULFF, O. Spatio-temporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J. Neurophysiol. 75: 1472-1482, 1996.
19. KJAERULFF, O. AND KIEHN, O. Distribution of network generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. J. Neurosci. 16: 5777-5794, 1996.
20. KREMER, E. AND LEV -TOV, A. Localization of the spinal network associated with generation of hindlimb locomotion in the neonatal rat and organization of its transverse coupling system. J. Neurophysiol. 77: 1155-1170, 1997.
21. KUDO, N. AND YAMADA, T. N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro. Neurosci. Lett. 75: 43-48, 1987.
22. KUDO, N., OZAKI, S., AND YAMADA, T. Ontogeny of rhythmic activity in the spinal cord of the rat. In: Neurobiological Basis of Human Locomotion, edited by M. Shimamura, S. Grillner, and V. Edgerton. Tokyo: Japan Scientific Societies Press, 1991, p. 127-136.
23. MANUEL, N. A., WALLIS, D. I., AND CRICK, H. Ketanserin-sensitive depressant action of 5-HT receptor agonists in the neonatal rat spinal cord. Br. J. Pharmacol. 116: 2647-2654, 1995.
24. MAYER, M. L. AND WESTBROOK, G. L. The physiology of excitatory amino acids in vertebrate central nervous system. Prog. Neurobiol. 28: 197-276 1987.
25. ROSSIGNOL, S. Neural control of Stereotypic limb movements. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc. Press, 1996, sect. 12, p. 173-216.
26. SQALLI-HOUSSAINI, Y., CAZALETS, J. R., AND CLARAC, F. Oscillatory properties of the central pattern generator for locomotion in neonatal rats. J. Neurophysiol. 70: 803-813, 1993.
27. TAKAHASHI, T. AND BERGER, A. J. Direct excitation of spinal motoneurones by serotonin. J. Physiol. (Lond.) 423: 63-76,1990.