The synaptic drive from the spinal locomotor network to motoneurons in the newborn rat

Journal of Neuroscience

Volumn 16, Issue 1, 1996, Pages 298-306

  Cazalets, Jean René ^a   Borde, Michel ^b   Clarac, François ^a  

^a CNRS   (France)

^b Facultad de Ciencias   (Uruguay)

Author keywords

electrophysiology; excitatory amino acids; glycine; locomotion; motoneuron drive; spinal cord

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ACETIC ACID; BICUCULLINE; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM CHLORIDE; SEROTONIN; STRYCHNINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRODE; EXCITATORY POSTSYNAPTIC POTENTIAL; LOCOMOTION; LUMBAR SPINAL CORD; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD MOTONEURON; SYNAPTIC TRANSMISSION;

EID: 0030044517     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-01-00298.1996     Document Type: Article

References (34)

1. Birch PJ, Grossman CJ, Hayes AG (1988) 6,7-Dinitro-quinoxaline-2,3-dione and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor. Eur J Pharmacol 156:177-180.
2. Cazalets JR, Borde M, Clarac F (1995) Localization and organization of the central pattern generator for hindlimb locomotion in newborn rat. J Neurosci 15:4943-4951.
3. Cazalets JR, Sqalli-Houssaini Y, Clarac F (1992) Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol (Lond) 474:173-181.
4. Cazalets JR, Sqalli-Houssaini Y, Clarac F (1994) GABAergic inactivation of the central pattern generators for locomotion in isolated neonatal rat spinal cord. J Physiol (Lond) 455:187-204.
5. Cohen AH, Wallén P (1980) The neuronal correlate of locomotion in fish. "Fictive swimming" induced in an in vitro preparation of the lamprey spinal cord. Exp Brain Res 41:11-18.
6. Dale N, Roberts A (1984) Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming. J Physiol (Lond) 348:527-543.
7. Douglas JR, Noga BR, Dai X, Jordan LM (1993) The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in the adult cat. J Neurosci 13:990-1000.
8. Fenaux F, Corio M, Palisses R, Viala D (1991) Effects of an NMDA-receptor antagonist, MK-801, on central locomotor programming in the rabbit. Exp Brain Res 86:393-401.
9. Grillner S (1981) Control of locomotion in bipeds, tetrapods and fish. In: Handbook of physiology. The nervous system II (Brookhart JM, Mountcastle VB, eds), pp 1179-1236. Bethesda, MD: American Physiological Society.
10. Grillner S, Matsushima T (1991) The neural network underlying locomotion in lamprey, synaptic and cellular mechanisms. Neuron 7:1-15.
11. Grillner S, McClellan A, Sigvardt K, Wallén P, Wilén M (1981) Activation of NMDA-receptors elicits "'fictive locomotion" in lamprey spinal cord in vitro. Acta Physiol Scand 113:549-551.
12. Jahr CE, Yoshioka K (1986) Ia afferent excitation of motoneurones in the in vitro new-born rat spinal cord is selectively antagonized by kynurenate. J Physiol (Lond) 370:515-530.
13. Jordan LM (1983) Factors determining motoneuron rhythmicity during fictive locomotion. Symp Soc Exp Biol 37:423-444.
14. Jordan LM (1991) Brainstem and spinal cord mechanisms for the initiation of locomotion. In: Neurobiology basis of human locomotion (Shimamura M, Grillner S, Edgerton VR, eds), pp 3-20. Tokyo: Japanese Science Society.
15. Kiehn O, Kjaerulff O (1995) Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J Neurophysiol, in press.
16. Kudo N, Ozaki S, Yamada T (1991) Ontogeny of rhythmic activity in the spinal cord of the rat. In: Neurobiological basis of human locomotion (Shimamura M, Grillner S, Edgerton VR, eds), pp 126-137. Tokyo: Japanese Science Society.
17. Liu G, Feldman JL, Smith JC (1990) Excitatory amino acid-mediated transmission of inspiratory drive to phrenic motoneurons. J Neurophysiol 64:423-436.
18. Miller S, Scott PD (1977) The spinal locomotor generator. Exp Brain Res 30:387-403.
19. Orsal D, Perret C, Cabelguen JM (1986) Evidence of rhythmic inhibitory synaptic influences in hindlimb motoneurons during fictive locomotion in the thalamic cat. Exp Brain Res 64:217-224.
20. Perret C (196) Synaptic influences contributing to the pattern of limb motoneuron activity during fictive locomotion in the cat. In: Neurobiology of vertebrate locomotion (Grillner S, Stein PSG, Stuart DG, Forssberg H, Herman RM, eds), pp 173-185. New York: MacMillan.
21. Pinco M, Lev-Tov A (1993) Synaptic excitation of α-motoneurons by dorsal root afferents in the neonatal rat spinal cord. J Neurophysiol 70:406-417.
22. Pratt CA, Jordan LM (1987) Ia inhibitory interneurons and Renshaw cells as contributors to the spinal mechanisms of fictive locomotion. J Neurophysiol 57:56-71.
23. Roberts A, Soffe SR, Clarke JDW, Dale N (1983) Initiation and control of swimming in amphibian embryos. Symp Soc Exp Biol 37:261-284.
24. Roberts A, Soffe SR, Dale N (1986) Spinal interneurones and swimming in frog embryos. In: Neurobiology of vertebrate locomotion (Grillner S, Stein PSG, Stuart DG, Forssberg H, Herman RM, eds), pp 279-306. New York: MacMillan.
25. Russell DF, Wallén P (1983) On the control of myotomal motoneurons during "fictive swimming" in the lamprey spinal cord in vitro. Acta Physiol Scand 117:161-170.
26. Shefchyk SJ, Jordan LM (1985) Excitatory and inhibitory postsynaptic potentials in α-motoneurons produced during fictive locomotion by stimulation of the mesencephalic locomotor region. J Neurophysiol 53:1345-1355.
27. Soffe SR (1987) Ionic and pharmacological properties of reciprocal inhibition in Xenopus embryo motoneurons. J Physiol (Lond) 382:463-473.
28. Soffe SR (1989) Role of glycinergic inhibition and N-methyl-D-aspartate receptor mediated excitation in the locomotor rhythmicity of one half of the Xenopus embryo central nervous system. Eur J Neurosci 1:561-571.
29. Smith JC, Feldman JL Schmidt BJ (1988) Neural mechanisms generating locomotion studied in mammalian brain stem-spinal cord in vitro. FASEB J 2:2283-2288.
30. Sqalli-Houssaini Y, Cazalets JR, Clarac F (1991) A cooling/heating system for use with in vitro preparations: study of temperature effects on newborn rat rhythmic activities. J Neurosci Methods 39:131-139.
31. Sqalli-Houssaini Y, Cazalets JR, Clarac F (1993a) Oscillatory properties of the central pattern generator for locomotion in neonatal rats. J Neurophysiol 70:803-813.
32. Sqalli-Houssaini Y, Cazalets JR, Martini F, Clarac F (1993b) Induction of fictive locomotion by sulphur-containing amino acids in an in vitro newborn rat preparation. Eur J Neurosci 5:1226-1232.
33. Wheatley M, Edamura M, Stein RB (1992) A comparison of intact and in vitro locomotion in an adult amphibian. Exp Brain Res 88:609-614.
34. Wheatley M, Jovanovic K, Stein RB, Lawson V (1994) The activity of interneurons during locomotion in the in vitro necturus spinal cord. J Neurophysiol 71:2025-2032.