Widespread expression of Fos protein induced by acute haloperidol administration in the rat brain

Psychiatry and Clinical Neurosciences

Volumn 52, Issue 3, 1998, Pages 353-359

  Suzuki, Michio ^a   Sun, Yue Ji ^a   Murata, Masahiko ^a   Kurachi, Masayoshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Acute treatment; Antipsychotic action; Fos; Haloperidol; Rat brain

Indexed keywords

HALOPERIDOL; PROTEIN C FOS;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS NUCLEUS; IMMUNOHISTOCHEMISTRY; MALE; NUCLEUS ACCUMBENS; ONCOGENE C FOS; PROTEIN INDUCTION; PUTAMEN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SUBSTANTIA NIGRA;

EID: 0031836689     PISSN: 13231316     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1819.1998.00391.x     Document Type: Article

References (35)

1. Kurachi M, Yasui S, Shibata R et al. Changes in local cerebral glucose utilization and dopamine metabolism in the rat brain following acute administration of haloperidol. Jpn. J. Psychiatr. Neurol. 1993; 47: 921-928.
2. McCulloch J, Savaki HE, Sokoloff L. Distribution of effects of haloperidol on energy metabolism in the rat brain. Brain Res. 1982; 243: 81-90.
3. Pizzolato G, Soncrant TT, Larson DM, Rapoport SI. Reduced metabolic response of the rat brain to haloperidol after chronic treatment. Brain Res. 1985; 337: 1-9.
4. Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am. J. Psychiatry 1996; 153: 466-476.
5. 3) as a target for neuroleptics. Nature 1990; 347; 146-151.
6. Van Tol HHM, Bunzow JR, Guan H-C et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991; 350: 610-614.
7. Morgan JI, Curran T. Stimulus-transcription coupling in neurons: Role of cellular immediate-early genes. Trends Neurosci. 1989; 12: 459-462.
8. Morgan JI, Curran T. Stimulus-transcription coupling in nervous system: Involvement of the inducible proto-oncogenes. Ann. Rev. Neurosci. 1991; 14: 421-451.
9. Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 1990; 4: 477-485.
10. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Science 1988; 240: 1328-1331.
11. Cohen BM, Wan W. The thalamus as a site of action of antipsychotic drugs. Am. J. Psychiatry 1996; 153: 104-106.
12. Deutch AY, Duman RS. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization. Neuroscience 1996; 70: 377-389.
13. Deutch AY, Lee MC, Iadorola MJ. Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action. Mol. Cell Neurosci. 1992; 3: 332-341.
14. Deutch AY, Öngür D, Duman RS. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: A novel locus of antipsychotic drug action. Neuroscience 1995; 66: 337-346.
15. 2 dopamine receptor antagonists induce Fos and related proteins in rat striatal neurons. Neuroscience 1990; 37: 287-294.
16. Merchant KM, Dorsa DM. Differential induction of neurotensin and c-fos gene expression by typical and atypical antipsychotics. Proc. Natl Acad. Sci. USA 1993; 90: 3447-3451.
17. Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE. Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc. Natl Acad. Sci. USA 1992; 89: 4270-4274.
18. Robertson GS, Fibiger HC. Neuroleptics increase c-fos expression in the forebrain: Contrasting effects of haloperidol and clozapine. Neuroscience 1992; 46: 315-328.
19. Wan W, Ennulat DJ, Cohen BB. Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain. Brain Res. 1995; 688: 95-104.
20. MacGibbon GA, Lawlor PA, Bravo R, Dragunow M. Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja. Mol. Brain Res. 1994; 23: 21-32.
21. Kamisada M, Oguchi E, Yagi G. Basic evaluation of enzyme immunoassay for haloperidol level and its clinical application. J. Clin. Ther. Med. 1988; 4: 639-645 (in Japanese).
22. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic Press, Sydney, 1986.
23. 3 receptor antagonist GR103691 with typical and atypical neuroleptics. Eur. J. Pharmacol. 1996; 318: 283-293.
24. Sebens JD, Koch T, Horst GJT, Korf J. Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment. Eur. J. Pharmacol. 1995; 273: 175-182.
25. Nishio T, Narita M, Satoh K. Imuunocytochemical study on the effect of neuroleptics on proto-oncogene c-fos expression in the rat forebrain. Jpn J. Neuropsychopharmacol. 1993; 15: 391-399 (in Japanese).
26. Björklund A, Lindvall O. Dopamine-containing systems in the CNS. In: Björklund A, Hökflet T (ed.). Handbook of Chemical Neuroanatomy: Classical transmitters in the CNS Vol. 2. Elsevier, Amsterdam, 1984: 55-122.
27. 2 receptor mRNA. Brain Res. 1991; 564: 203-219.
28. Guo N, Klitenick MA, Tham C-S, Fibiger HC. Receptor mechanisms mediating clozapine-induced c-fos expression in the forebrain. Neuroscience 1995; 65: 747-756.
29. Dahmen N, Fischer V, Hödl P et al. Induction of c-fos gene expression by the selective sigma receptor ligand EMD 57445 in rat brain. Eur. Neuropsychopharmacol. 1996; 6: 237-243.
30. Boergman RJ, Vincent SR. Involvement of adenosine and glutamate receptors in the induction of c-fos in the striatum by haloperidol. Synapse 1996; 22: 70-77.
31. Ziolkowska B, Höllt V. The NMDA receptor antagonist MK-801 markedly reduces the induction of c-fos gene by haloperidol in the mouse striatum. Neurosci. Lett. 1993; 156: 39-42.
32. Merchant KM, Dobie DJ, Filloux FM, Toazke M, Aravagrir M, Dorsa DM. Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions. J. Pharmacol. Exp. Ther. 1994; 271: 460-471.
33. 3 receptors. Cereb. cortex 1996; 6: 561-570.
34. Kurachi M, Yasui S, Shibata R et al. Comparative study of dopamine metabolism with local cerebral glucose utilization in rat brain following the administration of haloperidol dacanoate. Biol. Psychiatry 1994; 36: 110-117.
35. Sun Y-Z, Suzuki M, Kurachi T et al. Expression of Fos protein in the limbic regions of the rat following haloperidol decanoate. Brain Res. 1998; (in press).