Serum leptin and insulin in paediatric end-stage liver disease and following successful orthotopic liver transplantation

Clinical Endocrinology

Volumn 48, Issue 4, 1998, Pages 401-406

  Roberts, Graham A ^a   Holt, Richard I G ^c   Ghatei, Mohammed A ^a,b   Baker, Alastair J ^a   Bloom, Stephen R ^a   Miell, John P ^c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN;

ANTHROPOMETRY; ARTICLE; BODY FAT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATOR GENE; SKINFOLD THICKNESS;

ANTHROPOMETRY; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INSULIN; LEPTIN; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; POSTOPERATIVE PERIOD; PROTEINS; RADIOIMMUNOASSAY; REGRESSION ANALYSIS; STATISTICS, NONPARAMETRIC;

EID: 0031836378     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00448.x     Document Type: Article

References (31)

1. Busuttil, R.W., Seu, P., Millis, J.M., Olthoff, K.M., Hiatt, J.R., Milewicz, A., Nuesse, B., el-Khoury, G., Raybould, D. & Nyerges, A. (1991) Liver transplantation in children. Annals of Surgery, 213, 48-57.
2. Caprio, S., Tamborlane, W.V., Silver, D., Robinson, C., Leibel, R., McCarthy, S., Grozman, A., Belous, A., Maggs, D. & Sherwin, R.S. (1996) Hyperleptinemia: an early sign of juvenile obesity. Relations to body fat depots and insulin concentrations. American Journal of Physiology, 271, E626-E630.
3. Caro, J.F., Kolaczynski, J.W., Nyce, M.R., Ohannesian, J.P., Opentanova, I., Goldman, W.H., Lynn, R.B., Zhang, P.L., Sinha, M.K. & Considine, R.V. (1996) Decreased cerebrospinal fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348, 159-161.
4. Chin, S.E., Shepherd, R.W., Thomas, B.J., Cleghorn, G.J., Patrick, M.K., Wilcox, J.A., Ong, T.H., Lynch, S.V. & Strong, R. (1992) The nature of malnutrition in children with end stage liver disease awaiting orthotopic liver transplantation. American Journal of Clinical Nutrition, 56, 164-168.
5. Cumin, F., Baum, H.P. & Levens, N. (1996) Leptin is cleared from the circulation primarily by the kidney. International Journal of Obesity and Related Metabolic Disorders, 20, 1120-1126.
6. Cusin, I., Rohner-Jeanrenaud, F., Stricker-Krongrad, A. & Jeanrenaud, B. (1996) The weight reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes, 45, 1446-1450.
7. Dua, A., Hennes, M.I., Hoffmann, R.G., Maas, D.L., Krakower, G.R., Sonnenberg, G.E. & Kissebah, A.H. (1996) Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African American women. Diabetes, 45, 1635-1637.
8. Fredrich, R.C., Lollmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B.B., Lowell, B.B. & Flier, J.S. (1995) Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Journal of Clinical Investigation, 96, 1658-1663.
9. Frisancho, A.R. (1981) New norms of upper limb fat and muscle areas for assessment of nutritional status. American Journal of Clinical Nutrition, 34, 2540-2545.
10. Goulet, O.J., de Ville de Goyet, J., Otte, J.B. & Ricour, C. (1987) Preoperative nutritional evaluation and support for liver transplantation in children. Transplantation Proceedings, 19, 3249-3255.
11. Grinspoon, S., Gulick, T., Askari, H., Landt, M., Lee, K., Anderson, E., Ma, Z., Vignati, L., Bowsher, R., Herzog, D. & Klibanski, A. (1996) Serum leptin levels in women with anorexia nervosa. Journal of Clinical Endocrinology and Metabolism, 81, 3861-3863.
12. Grunfeld, C., Pang, M., Shigenaga, J.K., Jensen, P., Lallone, R., Friedman, J. & Feingold, K.R. (1996) Serum leptin levels in the acquired immunodeficiency syndrome. Journal of Clinical Endocrinology and Metabolism, 81, 4342-4346.
13. Hickey, M.S., Considine, R.V., Israel, R.G., Mahar, T.L., McCammon, M.R., Tyndall, G.L., Houmard, J.A. & Caro, J.F. (1996) Leptin is related to body fat content in male distance runners. American Journal of Physiology, 271, E938-E940.
14. Holt, R.I.G., Broide, E., Buchanon, C.R., Miell, J.P., Baker, A.J., Mowat, A.P. & Mieli-Vergani, G. (1997) Orthotopic liver transplantation reverses the adverse nutritional changes of end-stage liver disease in children. American Journal of Clinical Nutrition, 65, 534-542.
15. Holt, R.I.G., Jones, J.S., Stone, N.M., Baker, A.J. & Miell. J.P. (1996) Sequential changes in insulin like growth factor I (IGF I) and IGF binding proteins in children with end stage liver disease before and after successful orthotopic liver transplantation. Journal of Clinical Endocrinology and Metabolism, 81, 160-168.
16. Larsson, H. & Ahren, B. (1996) Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women. Journal of Clinical Endocrinology and Metabolism, 81, 4428-4432.
17. Lee, G.H., Proenca, R., Montez, J.M., Carroll, K.M., Darvishzadeh, J.G., Lee, J.I. & Friedman, J.M. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, 632-635.
18. Lynn, R.B., Cao, G.Y., Considine, R.V., Hyde, T.M. & Caro, J.F. (1996) Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice, Biochemical and Biophysical Research Communications, 219, 884-889.
19. Ma, Z., Gingerich, R.L., Santiago, J.V., Klein, S., Smith, C.H. & Landt, M. (1996) Radioimmunoassay of leptin in human plasma. Clinical Chemistry, 42, 942-946.
20. Masuzaki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosoda, K. & Yoshimasa, Y. (1995) Human obese gene expression. Adipocyte specific expression and regional differences in the adipose tissue. Diabetes, 44, 855-858.
21. Merabet, E., Dagogo-Jack, S., Coyne, D.W., Klein, S., Santiago, J.V., Hmiel, S.P. & Landt, M. (1997) Increased plasma leptin concentration in end-stage renal disease. Journal of Clinical Endocrinology and Metabolism, 82, 847-850.
22. Mercer, J.G., Hoggard, N., Williams, L.M., Lawrence, C.B., Hannah, L.T. & Trayhurn, P. (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Letters, 387, 113-116.
23. Miell, J.P., Englaro, P. & Blum, W.F. (1996) Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Hormone and Metabolic Research, 28, 704-707.
24. Muller, M.J., Lautz, H.U., Plogmann, B., Burger, M., Korber, J. & Schmidt, F.W. (1992) Energy expenditure and substrate oxidation in patients with cirrhosis: the impact of cause, clinical staging and nutritional state. Hepatology, 15, 782-794.
25. Rentsch, J., Levens, N. & Chiesi, M. (1995) Recombinant ob gene product reduces food intake in fasted mice. Biochemical and Biophysical Research Communications, 214, 131-136.
26. Schwartz, M.W., Peskind, E., Raskind, M., Boyko, E.J. & Porte, D. (1996) Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nature Medicine, 2, 589-593.
27. Shmueli, E., Miell, J.P., Alberti, K.G. & Record, C.O. (1996) High insulin-like growth factor binding protein I levels in cirrhosis: link with insulin resistance. Hepatology, 24, 127-133.
28. Stehling, O., Doring, H., Ertl, J., Preibisch, G. & Schmidt, I. (1996) Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. American Journal of Physiology, 271, R1770-R1774.
29. Stewart, S.M., Uauy, R., Waller, D.A., Kennard, B.D., Benser, M. & Andrews, W.S. (1989) Mental and motor development, social competence, and growth one year after successful pediatric liver transplantation. Journal of Pediatrics, 114, 574-581.
30. Tanner, J.M. & Whitehouse, R.H. (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Archives of Disease in Childhood, 51, 170-179.
31. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J.M. (1994) Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425-432.