Hyperleptinemia: An early sign of juvenile obesity. Relations to body fat depots and insulin concentrations

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 3 34-3, 1996, Pages

  Caprio, S ^a   Tamborlane, W V ^b   Silver, D ^b   Robinson, C ^b   Leibel, R ^b   McCarthy, S ^b   Grozman, A ^b   Belous, A ^b   Maggs, D ^b   Sherwin, R S ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

subcutaneous fat; visceral fat

Indexed keywords

ADOLESCENT; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; HUMAN; INSULIN RESISTANCE; MALE; OBESITY; PRIORITY JOURNAL; SCHOOL CHILD; SUBCUTANEOUS FAT;

EID: 2942609858     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.3.e626     Document Type: Article

References (15)

1. Caprio, S., L. D. Hyman, C. Limb, S. McCarthy, R. Lange, R. S. Sherwin, G. Shulman, and W. V. Tamborlane. Central adiposity and its metabolic correlates in obese adolescent girls. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E118-E126, 1995.
2. Considine, R. V., E. L. Considine, and C. J. Williams. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. Clin. Invest. 95: 2986-2988, 1995.
3. Considine, R. V., M. K. Sinha, M. L. Heiman, A. Kriauciumas, T. N. Stephens, M. R. Nyce, J. P. Ohanessian, C. C. Marco, L. J. McKee, T. L. Bauer, and J. F. Caro. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292-295, 1996.
4. Funahashi, T, I. Shimomuza, H. Hiraoka, T. Arai, M. Takahashi, T. Nakamuza, S. Nozaki, S. Yamashita, K. Takemure, K. Tokunega, and Y. Matsuzawa. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VHM)-lesioned rats. Biochem. Biophys. Res. Commun. 211: 469-475, 1995.
5. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by obese gene. Science Wash. DC 269: 543-546, 1995.
6. Hamilton, B. S., D. Paglia, A. Y. M. Kwan, and M. Deitel. Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med. 1: 953-956, 1995.
7. Hammer, L. D., H. C. Kroemer, D. M. Wilson, P. L. Litter, and S. M. Dornbush. Standardized percentile curve of body mass index for children and adolescents. Am. J. Dis. Child. 145: 259-263, 1991.
8. Lonnquist, F., P. Arner, L. Nordfors, and M. Schalling. Overexpression of the obese (ob) gene in adipose tissue of human subjects. Nature Med. 1: 950-953, 1995.
9. Maffei, M., H. Fei, G. H. Lee, C. Dani, P. Leroy, Y. Zhang, R. Proenca, R. Negrel, G. Ailhaud, and J. M. Friedman. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc. Natl. Acad. Sci. USA 92: 6957-6960, 1995.
10. Maffei, M., J. Halaas, E. Ravussin, R. E. Pratley, G. H. Lee, Y. Zhang, H. Frey, S. Kim, R. Lallone, S. Raamganathan, P. A. Kern, and J. M. Friedman. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1: 1155-1161, 1995.
11. Masuzaki, H., Y. Ogawa, N. Satoh, T. Okazaki, H. Shigemoto, K. Mori, N. Tamura, K. Hosoda, Y. Hoshimasa, H. Himgami, T. Kawada, and K. Nakao. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44: 853-855, 1995.
12. Ogawa, Y., H. Masuzaki, N. Isse, T. Okazaki, K. Mori, M. Shigemoto, N. Satoh, N. Tamura, K. Hosoba, Y. Hoshimasa, H. Jingami, T. Kawada, and K. Nakao. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J. Clin. Invest. 96: 1647-1652, 1995.
13. Saladin, R., P. DeVos, M. Guerre-Millo, A. Lepturque, J. Girard, B. Staels, and J. Auwery. Transient increase in obese gene expression after food intake or insulin administration. Nature Lond. 377: 527-529, 1995.
14. Staten, M. A., W. G. Totty, and W. M. Kohrt. Measurement of fat distribution by magnetic resonance imaging. Invest. Radiol. 24: 345-349, 1989.
15. Zhang, Y., R. Prenea, M. Maffei, M. Borone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature Lond. 372: 425-431, 1994.