Short-term hemodynamic effects of mibefradil in dogs with chronic heart failure: Comparison with diltiazem

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 746-752

  Shimoyama, Hisashi ^a   Sabbah, Hani N ^a,b   Tanimura, Mitsuhiro ^a   Borzak, Steven ^a   Goldstein, Sidney ^a  

^a HENRY FORD HEART AND VASCULAR INSTITUTE   (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ANTAGONIST; DILTIAZEM; MIBEFRADIL;

ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BOLUS INJECTION; CALCIUM ANTAGONISM; CONTROLLED STUDY; DOG; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART STROKE VOLUME; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; VASODILATATION;

EID: 0031835630     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bers DM (1991) Ca influx via sarcolemmal Ca channels, In Excitation-Contraction Coupling and Cardiac Contractile Force, pp 49-69, Kluwer Academic Publishers, Boston.
2. 2+ channel antagonist Ro 40-5967 in vascular muscle cells cultured from dog coronary and saphenous arteries. Naunyn-Schmeideberg Arch Pharmacol 348: 191-196.
3. Boden WE, Bough EW, Reichman MJ, Rich VB, Young PM, Korr KS and Schulman RS (1985) Beneficial effects of high-dose diltiazem in patients with persistent effort angina on β-blockers and nitrates: A randomized, double blind, placebo-controlled cross-over study. Circulation 71:1197-1205.
4. Braunwald E (1982) Mechanism of action of calcium channel blocking agents. N Engl J Med 307:1618-1627.
5. Clozel JP, Banken L and Osterriender W (1989) Effects of Ro 40-5967, a novel calcium antagonist, on myocardial function during ischemia induced by lowering coronary perfusion pressure in digs: Comparison with verapamil. J Cardiovasc Pharmacol 14:713-721.
6. 3H]desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts. Cardiovasc Drug Ther 4:731-736.
7. Elkayam U, Weber L, McKay C and Rahimtoola S (1985) Spectrum of acute hemodynamic effects of nifedipine in severe congestive heart failure. Am J Cardiol 56:560-566.
8. Freedman DD and Waters DD (1987) "Second generation" dihydropyridine calcium antagonists: greater vascular selectivity and some unique applications. Drugs 34:578-598.
9. 2+ channel currents in myocytes from guinea-pig coronary artery. J Physiol 443:703-725.
10. Gengo PG, Sabbah HN, Steffen RP, Sharpe JK, Kono T, Stein PD and Goldstein S (1992) Myocardial beta-adrenoceptor and voltage sensitive calcium channel changes in a canine model of chronic heart failure. J Mol Cell Cardiol 24:1361-1369.
11. Giles TD (1997) Pharmacologic and clinical perspectives on mibefradil: A new T-channel selective calcium antagonist. Introduction. Am J Cardiol 80:1C-3C.
12. Goldstein RE, Boccuzzi SJ, Cruess D and Nattel S (1991) The Adverse Experience Committee and Multicenter Diltiazem Postinfarction Group. Diltiazem increases late-onset congestive heart failure in postinfarction patients with early reduction in ejection fraction. Circulation 83:52-60.
13. Hagiwara N, Irisawa H and Kameyama M (1988) Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol 395:233-253.
14. Karila-Cohen D, Dubois-Rande J-L, Giudicelli J-F and Berdeaux A (1996) Effects of mibefradil on large and small coronary arteries in conscious dogs: Role of vascular endothelium. J Cardiovasc Pharmacol 28:271-277.
15. Krikler DM (1987) Calcium antagonists for chronic stable angina pectoris. Am J Cardiol 599:95B-100B.
16. Leier CV and Boudoulas H (1997) Renal disorders and heart disease, in Heart Disease, 5th ed. (Braunwald E ed) pp 1914-1948, WB Saunders Company, Philadelphia.
17. ++ channels. J Pharmacol Exp Ther 271:1483-1488.
18. 2+ channels by Ro 40-5967. Circ Res 75:144-148.
19. 2+ channel in development of tension in heart muscle. J Mol Cell Cardiol 19:527-553.
20. Muller JE, Turi ZG, Pearle DL, Schneider JF, Sarfas DH, Morrison J, Stone PH, Rude RE, Rosner B, Sobel BE, Tate C, Scheiner E, Roberts R, Henekens CH and Braunwald E (1984) Nifedipine and conventional therapy for unstable angina pectoris: A randomized double-blind comparison. Circulation 69:728-739.
21. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res 73:777-782.
22. Osterrieder W and Holck M (1989) In vitro pharmacological profile of Ro 40-5967 a novel calcium channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 13:754-759.
23. Packer M (1989) Pathophysiological mechanisms underlying the adverse effects of calcium channel-blocking drugs in patients with chronic heart failure. Circulation 80:IV59-IV67.
24. Packer M (1989a) Second generation calcium channel blockers in the treatment of chronic heart failure: Are they any better than their predecessors. J Am Coll Cardiol 14:1339-1342.
25. Portegies MCM, Schmitt R, Kraaij CJ, Brat SHJG, Gassner A, Hagemeijer F, Pozenel H, Prager G, Viersma JW, van der Wall EE, Kleinbloesem CH and Lie KI (1991) Lack of negative inotropic effects of the new calcium antagonist Ro 40-5967 in patients with stable angina pectoris. J Cardiovasc Pharmacol 18:746-751.
26. Porter CB, Walsh RA, Badke RA and O'Rourke RA (1983) Differential effects of diltiazem and nitroprusside on left ventricular function on experimental chronic volume overload. Circulation 68:685-692.
27. Psaty BM, Heckbert SR, Koepsell TD, Siscovick DS, Raghunathan TE, Weiss NS, Rosendaal FR, Lemaitre RN, Smith NL, Wahl PW, Wagner EH and Furberg CD (1995) The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA 274:620-625.
28. Rousseau MF, Vincent MF, van Hoof F, van der Berghe G, Charlier AA and Pouleur H (1984) Effects of nicardipine and nisoldipine on myocardial metabolism, coronary blood flow and oxygen supply in angina pectoris. Am J Cardiol 54:1189-1194.
29. Sabbah HN, Stein PD, Kono T, Gheorghiade M, Levine TB, Jafri S, Hawkins ET and Goldstein S (1991) A canine model of chronic heart failure produced by multiple sequential intracoronary microembolizations. Am J Physiol 260:H1379-H1384.
30. Sabbah HN, Shimoyama H, Kono T, Gupta RC, Sharov VG, Scicli G, Levine TB and Goldstein S (1994) Effects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction. Circulation 89:2852-2859.
31. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 75:149-155.
32. Shimoyama H, Sabbah HN, Borzak S, Tanimura M, Shevlyagin S, Scicli G and Goldstein S (1996) Short-term hemodynamic effects of endothelin receptor blockade in dogs with chronic heart failure. Circulation 94:779-784.
33. Singh BN and Nademanee K (1987) Use of calcium antagonists for cardiac arrhythmias. Am J Cardiol 59:153B-162B.
34. Su J, Renaud N, Carayon A, Crozatier B and Hittinger L (1994) Effects of the calcium channel blockers, diltiazem and Ro40-5967, on hemodynamics and plasma noradrenaline levels in conscious dogs with pacing-induced heart failure. Br J Pharmacol 113:395-402.
35. Tan LB, Murray RG and Littler WA (1987) Felodipine in patients with chronic heart failure: discrepant hemodynamic and clinical effects. Br Heart J 58:122-128.
36. The Multicenter Diltiazem Postinfarction Trial Research Group (1988) The effect of diltiazem on mortality and reinfarction after myocardial infarction. N Engl J Med 319:385-392.
37. Véniant M, Clozel JP, Hess P and Wolfgang R (1991a) Ro 40-5967, in contrast to diltiazem, does not reduce left ventricular contractility in rats with chronic myocardial infarction. J Cardiovasc Pharmacol 17:277-284.
38. Veniant M, Clozel JP, Hess P and Wolfgang R (1991b) Hemodynamic profile of Ro 40-5967 in conscious rats: Comparison with diltiazem, verapamil and amlodipine. J Cardiovasc Pharmacol 18(suppl 10):S55-S58.