Effects of mibefradil on large and small coronary arteries in conscious dogs: Role of vascular endothelium

Journal of Cardiovascular Pharmacology

Volumn 28, Issue 2, 1996, Pages 271-277

  Karila Cohen, Daniel ^a   Dubois Randé, Jean Luc ^b   Giudicelli, Jean François ^a   Berdeaux, Alain ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b HENRI MONDOR HOSPITAL   (France)

Author keywords

Calcium antagonist; Conscious dogs; Coronary arteries; Endothelium; Ergonovine; Mibefradil

Indexed keywords

CALCIUM CHANNEL; ERGOMETRINE; GLYCERYL TRINITRATE; MIBEFRADIL; VASOCONSTRICTOR AGENT;

ANGIOPLASTY; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM ANTAGONISM; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; HEART HEMODYNAMICS; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

ANIMALS; BENZIMIDAZOLES; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CORONARY CIRCULATION; CORONARY VESSELS; DOGS; ENDOTHELIUM, VASCULAR; ERGONOVINE; HEART RATE; MIBEFRADIL; TETRAHYDRONAPHTHALENES; VASODILATION; VASODILATOR AGENTS;

EID: 0029780536     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199608000-00014     Document Type: Article

References (33)

1. Panza JA, Quyyumi AA, Brush JE, Epstein SE. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N Engl J Med 1990;323:22-7.
2. Nabel EG, Ganz P, Gordon JB, Alexander RW, Selwyn AP. Dilation of normal and constriction of atherosclerotic coronary arteries caused by cold pressor test. Circulation 1988;77:43-52.
3. Zeiher AM, Drexler H, Wollschläger H, Just H. Modulation of coronary vascular tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991;83:391-401.
4. Dubois-Randé JL, Dupouy P, Aptecar E, et al. Comparison of the effects of exercise and cold pressor test on the vasomotor response of normal and atherosclerotic coronary arteries and their relation to flow-mediated mechanism. Am J Cardiol 1995;76:467-73.
5. Clozel JP, Osterrieder W, Kleinbloesem CH, et al. Ro 40-5967: a new nondihydropyridine calcium antagonist. Cardiovasc Drug Rev 1991;9:4-17.
6. 2+ channels by Ro 40-5967. Circ Res 1994;75:144-8.
7. 2+ current is expressed in hypertrophied adult feline left ventricular myocytes. Circ Res 1993;73:777-82.
8. Vassort G, Alvarez J. Cardiac T-type calcium current: pharmacology and roles in cardiac tissues. J Cardiovasc Electrophysiol 1994;5:376-93.
9. 2+ channels are abnormal in genetically determined cardiomyopathic hamster hearts. Circ Res 1994;75:149-55.
10. Zhou Z, Lipsius SL. T-Type calcium current in latent pacemaker cells isolated from cat right atrium. J Mol Cell Cardiol 1994;26:1211-9.
11. 2+ antagonist Ro 40-5967 on the endothelium-dependent response of isolated arteries. J Cardiovasc Pharmacol 1994;23:869-73.
12. Onto K, Satoh K, Taira N. Cardiovascular profile of Ro 40-967, a new nondihydropyridine calcium antagonist, delineated in isolated, blood-perfused dog hearts. J Cardiovasc Pharmacol 1993;22:293-9.
13. 2+ channel blocker with potent vasodilator but weak inotropic action. J Cardiovasc Pharmacol 1989;13:754-9.
14. 2+ in dog coronary arterial vascular muscle cells by Ro 40-5967. J Cardiovasc Pharmacol 1994;24:1-7.
15. Su J, Renaud N, Carayon A, Crozatier B, Hittinger L. Effects of the calcium channel blockers, diltiazem and Ro 40-5967, on systemic haemodynamics and plasma noradrenaline levels in conscious dogs with pacing-induced heart failure. Br J Pharmacol 1994;113:395-402.
16. Véniant M, Clozel JP, Hess P, Wolfgang R. Ro 40-5967, in contrast to diltiazem, does not reduce left ventricular contractility in rats with chronic myocardial infarction. J Cardiovasc Pharmacol 1991;17:277-84.
17. 2+ inward currents by Ro 40-5967 and verapamil: relation to negative inotropy. Eur J Pharmacol 1991;196:205-7.
18. Richard V, Tron C, Blanc T, Thuillez C. Infarct size-limiting properties of Ro 40-5967, a novel nondihydropyridine calcium channel antagonist, in anesthetized rats: comparison with verapamil. J Cardiovasc Pharmacol 1995;25:552-7.
19. Drieu La Rochelle C, Richard V, Dubois-Randé JL, et al. Potassium channel openers dilate large epicardial coronary arteries in conscious dogs by an indirect, endothelium-dependent mechanism. J Pharmacol Exp Ther 1992;263:1091-6.
20. Berdeaux A, Ghaleh B, Dubois-Randé JL, et al. Role of vascular endothelium in exercise-induced dilation of large epicardial coronary arteries in conscious dogs. Circulation 1994;89:2799-808.
21. Ghaleh B, Dubois-Randé JL, Hittinger L, Giudicelli JF, Berdeaux A. Comparisons of the effects of nicorandil, pinacidil, nicardipine and nitroglycerin on coronary vessels in the conscious dog: role of the endothelium. Br J Pharmacol 1995;114:496-502.
22. Ghaleh B, Béa ML, Dubois-Randé JL, Giudicelli JF, Hittinger L, Berdeaux A. Endothelial modulation of β-adrenergic dilation of large coronary arteries in conscious dogs. Circulation 1995;92:2627-35.
23. Waters DD, Theroux P, Szlachcic J, Dauwe F. Provocative testing with ergonovine to assess the efficacy of treatment with nifedipine, diltiazem and verapamil in variant angina. Am J Cardiol 1981;48:123-30.
24. Lablanche JM, Danchin N, Morice MC, Monassier JP, Blanchard D, Bonnet JI. Reflexions d'un comité d'experts de la Société Française de Cardiologie concernant l'usage du maléate de méthylergométrine (Methergin) dans la détection d'une vasomotricité coronaire anormale. Arch Mal Coeur 1995;88:247-53.
25. Chu A, Cobb FR. Vasoactive effects of serotonin on proximal coronary arteries in conscious dogs. Circ Res 1987;61 (suppl II):II-81-7.
26. Hayashi Y, Tomoike H, Nagasawa K, et al. Functional and anatomical recovery of endothelium after denudation of coronary artery. Am J Physiol 1988;254:H1081-90.
27. Caputo L, Tedgui A, Levy B. Control of carotid vasomotor tone by local renin-angiotensin system in normotensive and spontaneously hypertensive rats. Role of endothelium and flow. Circ Res 1995;77:303-9.
28. Giudicelli JF, Drieu La Rochelle C, Berdeaux A. Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs. J Pharmacol Exp Ther 1990;255:836-42.
29. Clozel JP, Banken L, Osterrieder W. Effects of Ro 40-5967, a novel calcium antagonist, on myocardial function during ischemia induced by lowering coronary perfusion pressure in dogs: comparison with verapamil. J Cardiovasc Pharmacol 1989;14:713-21.
30. Hintze TH, Vatner SF. Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs. Circ Res 1983;52(suppl I):139-46.
31. Portegies MCM, Schmitt R, Kraaij CJ. Lack of negative inotropic effects of the new calcium antagonist Ro 40-5967 in patients with stable angina pectoris. J Cardiovasc Pharmacol 1991;18:746-51.
32. Vatner SF, Braunwald E. Cardiovascular control mechanisms in the conscious state. TV Engl J Med 1975;293;970-5.
33. Duncker DJ, Saxena PR, Verdouw PD. Systemic haemodynamics of dihydropyridine derivatives in conscious pigs with or without propranolol. Eur J Pharmacol 1988;157:401-9.