T cell receptor (TCR) Vβ gene usage in bronchoalveolar lavage and peripheral blood T cells from asthmatic and normal subjects

Clinical and Experimental Immunology

Volumn 112, Issue 3, 1998, Pages 363-374

  Hodges, E ^a   Dasmahapatra, J ^a   Smith, J L ^a   Quin, C T ^a   Lanham, S ^a   Krishna, M T ^a   Holgate, S T ^a   Frew, A J ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Asthma; Bronchoalveolar lavage; Genetics; T cell receptor; T lymphocyte

Indexed keywords

ALLERGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; MONOCLONAL ANTIBODY; RNA; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE; GENOTYPE; HUMAN; HUMAN CELL; LUNG LAVAGE; MALE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVOCATION TEST; T LYMPHOCYTE;

ADULT; AMINO ACID SEQUENCE; ASTHMA; DNA, COMPLEMENTARY; FEMALE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOPHENOTYPING; MALE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0031833613     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00611.x     Document Type: Article

References (43)

1. Frew AJ, Kay AB. Eosinophils and T-lymphocytes in late phase allergic reactions. J Allergy Clin Immunol 1990; 85:533-9.
2. Corrigan CJ, Kay AB. T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992; 13:501-7.
3. Punnonen J, Aversa G, Cocks BG, De Vries JE. Role of IL-4 and IL-13 in synthesis of IgE and expression of CD23 by human B-cells. Allergy 1994; 49:576-86.
4. Saito H, Hatake K, Dvorak AM, Leiferman KM, Donnenberg AD, Arai N, Ishizaka K, Ishizaka T. Selective differentiation/proliferation of hematopoietic cells by recombinant human interleukins. Proc Natl Acad Sci USA 1988; 85:2288-92.
5. Azzawi M, Bradley B, Jeffery PK et al. Identification of activated T lymphocytes and eosinophils in stable atopic asthma. Am Rev Respir Dis 1990; 142:1407-13.
6. Wilson JW, Djukanovic R, Howarth PH, Holgate ST. Lymphocyte activation in bronchoalveolar lavage and peripheral blood in atopic asthma. Am Rev Respir Dis 1992; 145:958-60.
7. Robinson DS, Hamid Q, Ying S et al. Predominant 'TH2-like' bronchoalveolar lavage T-lymphocyte population in atopic asthma. N Engi J Med 1992; 326:298-304.
8. Pabst R, Binns RM. Lymphocytes migrate from the bronchoalveolar space to regional bronchial lymph nodes. Am J Respir Crit Care Med 1995; 151:495-9.
9. Lecossier D, Valeyre D, Loiseau A, Cadranel J, Tazi A, Battesti JP, Hance AJ. Antigen-induced proliferative response of lavage and blood T-lymphocytes. Am Rev Respir Dis 1991; 144:861-8.
10. Marguerie C, Lunardi C, So A. PCR-based analysis of the TCR repertoire in human autoimmune diseases. Immunol Today 1992; 13:336-8.
11. Kappler J, Kotzin B, Herron L et al. V13-specific stimulation of human T-cells by staphylococcal toxins. Science 1989; 244:811-3.
12. Pluschke G, Rickens G, Taube H, Kroninger S, Melchers I, Peter HH, Eishmann K, Krawinkel U. Biased T-cell receptor Vα region repertoire in the synovial fluid of rheumatoid arthritis patients. Eur J Immunol 1991; 21:2749-54.
13. Maruyama T, Saito IS, Miyake S, Hashimoto H, Sato K, Yagita H, Okamura K, Miyasaka N. A possible role of two hydrophobic amino acids in antigen recognition by synovial T-cells in rheumatoid arthritis. Eur J Immunol 1993; 23:2059-65.
14. Zagon G, Tumang JR, Li Y, Friedman SM, Crow MK. Increased frequency of VH17-positive T-cells in patients with rheumatoid arthritis. Arthritis Rheum 1994; 37:1431-40.
15. Oksenberg JR, Stuart S, Bejovich AB, Bell RB, Erlich HA, Steinman L, Bernard CA. Limited heterogeneity of rearranged T-cell receptor V-α transcripts in brains of multiple sclerosis patients. Nature 1990; 345:344-6.
16. Vandevyver C, Mertens N, van den Elsen P et al. Clonal expansion of myelin basic protein-reactive T-cells in patients with multiple sclerosis: restricted T-cell receptor V gene rearrangements and CDR3 sequences. Eur J Immunol 1995; 25:958-68.
17. Lunardi C, Marguerie C, So AK. An altered repertoire of T-cell receptor V gene expression by rheumatoid synovial fluid T-lymphocytes. Clin Exp Immunol 1992; 90:440-6.
18. Bellocq A, Lecossier D, Pierre-Audiger C, Tazi A, Valeyre D, Hance AJ. T cell receptor repertoire of T-lymphocytes recovered from the lung and blood of patients with sarcoidosis. Am J Respir Crit Care Med 1994; 149:646-54.
19. Forrester JM, Wang Y, Ricalton N, Fitzgerald JE, Loveless J, Newman LS, King TE, Kotzin BL. TCR expression of activated T cell clones in the lungs of patients with pulmonary sarcoidosis. J Immunol 1994; 153:4291-302.
20. Forman JD, Klein JT, Silver RF, Liu MC, Greenlee JT, Moller DR. Selective activation and accumulation of oligoclonal VB-specific T-cells in active pulmonary sarcoidosis. J Clin Invest 1994; 94:1533-42.
21. Grunewald J, Shigematsu M, Nagai S, Mikuniya T, Wigzell H, Izumi T, Eklund AG. T-cell receptor V gene expression in HLA-typed Japanese patients with sarcoidosis. Am J Respir Crit Care Med 1995; 151:151-6.
22. Dohi M, Yamamoto K, Masuko K et al. Accumulation of multiple T-cell clonotypes in lungs of healthy individuals and patients with pulmonary sarcoidosis. J Immunol 1994; 152:1983-8.
23. Silver RF, Crystal RG, Moller DR. Limited heterogeneity of biased T-cell receptor VB gene usage in lung but not blood T-cells in active pulmonary sarcoidosis. Immunology 1996; 88:516-23.
24. Jones CM, Lake RA, Wijeyekoon JB, Mitchell DM, du Bois RM, O'Hehir RE. Oligoclonal V gene usage by T-lymphocytes in bronchoalveolar lavage fluid from sarcoidosis patients. Am J Respir Cell Mol Biol 1996; 14:470-7.
25. NHLBI workshop summary and guidelines. Investigative use of bronchoscopy, lavage and bronchial biopsies in asthma and other airway diseases. J Allergy Clin Immunol 1991; 88:808-14.
26. Kneba M, Bolz I, Linke B, Hiddeman W. Analysis of rearranged T-cell receptor beta-chain genes by polymerase chain reaction (PCR) DNA sequencing and automated high resolution PCR fragmentation analysis. Blood 1995; 86:3930-7.
27. Guersen A, Skinner MA, Townsend LA et al. Population study of T cell receptor VB gene usage in peripheral blood lymphocytes: differences in ethnic groups. Clin Exp Immunol 1993; 94:201-7.
28. Hu HZ, de Weger RA, Bosboom-Kelsbeek K, Tilanus MGJ, Rozing J, Schuurman HJ. T cell receptor VB variable gene family expression in human peripheral blood lymphocytes at the mRNA and membrane protein level. Clin Exp Immunol 1992; 88:335-40.
29. Malhotra V, Spielman R, Concannon P. Variability in T cell receptor VB gene usage in peripheral blood lymphocytes. J Immunol 1992; 149:1802-8.
30. Yurovsky VV, Bleecker ER, White B. Restricted T-cell antigen receptor repertoire in bronchoalveolar T-cells from normal humans. Hum Immunol 1996; 50:22-37.
31. Molfino NA, Doherty PJ, Suurman IL, Yang SX, Kesten S, Chapman KR, Slutsky AS. Analysis of the T-cell receptor V gamma region gene repertoire in bronchoalveolar lavage and peripheral blood of atopic asthmatics and healthy subjects. Clin Exp Immunol 1996; 104:144-53.
32. Grunewald J, Janson CH, Wigzell H. Biased expression of TcR V gene segments in CD4+ and CD8+ human peripheral blood T lymphocytes. Eur J Immunol 1991; 21:819-22.
33. Daves MP, Meyer MM, Munkirs DD. T cell receptor variable β genes show differential expression in CD4+ and CD8+ T-cells. Hum Immunol 1991; 32:194-202.
34. McCoy JP, Overton WR, Schroeder K, Blumstein L, Donaldson MH. Immunophenotypic analysis of the T cell receptor VB repertoire in CD4+ and CD8+ lymphocytes from normal peripheral blood. Comm Clin Cytometry 1996; 26:148-53.
35. Paliard X, West SG, Lafferty JA, Clements JR, Kappler JW, Marrack P, Kotzin BL. Evidence for the effects of a superantigen in rheumatoid arthritis. Science 1991; 253:325-9.
36. Usui Y, Kohsaka H, Eishi Y, Saito I, Marumo F, Miyasaka N. Shared amino acid motifs in T cell receptor β junctional regions of bronchoalveolar T-cells in patients with pulmonary sarcoidosis. Am J Respir Crit Care Med 1996; 54:5.
37. Gulwani-Akolkar B, Posnett DN, Janson CH, Grunewald J, Wigzell H, Akolkar PJ, Silver J. T cell receptor V segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J Exp Med 1991; 74:1139-46.
38. Moss PAH, Rosenberg WM, Zintaras E, Bell JI. Characterisation of the human T cell receptor α chain repertoire and demonstration of a genetic influence on Vα usage. Eur J Immunol 1993; 23:1153-9.
39. Davis MM, Bjorkman PJ. T-cell antigen receptor genes and T-cell recognition. Nature 1988; 334:395-402.
40. Akolkar PN, Gulwani-Akolkar B, Pergolizzi R, Bigler RD, Silver J. Influence of HLA genes on T cell receptor V segment frequencies and expression levels in peripheral blood lymphocytes. J Immunol 1993; 50:2761-73.
41. Hingorani R, Choi IH, Akolkar P, Gulwani-Akolkar B, Pergolizzi R, Silver J, Gregersen PK. Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J Immunol 1993; 51:5762-9.
42. Burastero SE, Borgonovo B, Gaffi D, Frittoli E, Wack A, Rossi GA, Crimi E. The repertoire of T-lymphocytes recovered by BAL from healthy non-smokers. Eur Respir J 1996; 9:319-27.
43. Burastero SE, Crimi E, Balbo A et al. Oligoclonality of lung T-lymphocytes following exposure to allergen in asthma. J Immunol 1995; 55:5836-46.