Plasma thrombopoietin levels in thrombocytopenic states: Implication for a regulatory role of bone marrow megakaryocytes

British Journal of Haematology

Volumn 101, Issue 3, 1998, Pages 420-424

  Hou, M ^a   Andersson, P O ^a   Stockelberg, D ^a   Mellqvist, U H ^a   Ridell, B ^a   Wadenvik, H ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood platelets; Myelodysplastic syndrome; Thrombocytopenia; Thrombopoietin

Indexed keywords

THROMBOPOIETIN;

ADOLESCENT; ADULT; APLASTIC ANEMIA; ARTICLE; BONE MARROW HYPOPLASIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; MEGAKARYOPOIESIS; MYELODYSPLASTIC SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; THROMBOCYTOPENIA;

ADOLESCENT; ADULT; AGED; BONE MARROW CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MEGAKARYOCYTES; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PLATELET COUNT; THROMBOCYTOPENIA; THROMBOPOIETIN;

EID: 0031833014     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00747.x     Document Type: Article

References (34)

1. Basser, R.L., Rasko, J.E.J., Clarke, K., Cebon, J., Green, M.D., Hussein, S., Alt, C., Menchaca, D., Tomita, D., Marty, J., Fox, R.M. & Begley, C.G. (1996) Thrombopoietic effects of pegylated recombinant human megakaryocyte and development factor (PEG-rHuMGDF) in patients with advanced cancer. Lancet, 348, 1279-1281.
2. Chang, M., Suen, Y., Meng, G., Buzby, J., Bussel, J., Shen, V., van de Ven, C. & Cairo, M. (1996) Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production. Blood, 88, 3554-3362.
3. Cerutti, A., Custodi, P., Duranti, M., Noris, P. & Balduini, C.L. (1997) Thrombopoietin levels in patients with primary and reactive thrombocytosis. British Journal of Haematology, 99. 281-284.
4. de Sauvage, F.J., Hass, P.E., Spencer, S.D., Mollony, B.E., Gurney, A.L., Spencer, S.A., Darbonne, W.C., Henzel, W.J., Wong, S.C., Kuang, W., Oles. K.J., Hutgren, B., Solberg, L.A., Jr, Goeddel, D. & Eaton, D.L. (1994) Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature, 369, 533-538.
5. Emmons, R.V.B., Reid, D.M., Cohen, R.L., Meng, G., Young, N.S., Dunbar, C.E. & Shulman, N.R. (1996) Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood, 87, 4068-4071.
6. Fanucchi, M., Glaspy, J., Crawford, J., Garst, J., Figlin, R., Sheridan, W., Menchaca, D., Tomita, D., Ozer, H. & Harker, L. (1997) Effects of polyethylene-glycol-conjugated recombinant human megakaryocyte growth and development factor on platelet counts after chemotherapy for lung cancer. New England Journal of Medicine, 336, 404-409.
7. Farese, A.M., Hunt, P., Boone, T. & MacVittie, J. (1995) Recombinant human megakaryocyte growth and development factor stimulates thrombopoiesis in normal nonhuman primates. Blood, 86, 54-59.
8. Folman, C.C., von dem Borne, A.E.G.K., Rensink, I.H.J.A.M., Gerritsen, W., van der Schott, C.E., de Haas, M. & Aarden, L. (1997) Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay. Thrombosis and Haemostasis, 78, 1262-1267.
9. Horikawa, Y., Matsumura, I., Hashimoto, K., Shiraga, M., Kosugi, S., Tadokoro, S., Kato, T., Miyazaki, H., Tomiyama, Y., Kurata, Y., Matsuzawa, Y. & Kanakura, Y. (1997) Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood, 90, 4031-4038.
10. Ichikawa, N., Ishida, F., Shimodaira, S., Tahara, T., Kato, T. & Kitano, K. (1996) Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Thrombosis and HaemoStasis, 76, 156-160.
11. Kaushansky, K. (1995) Thrombopoietin: the primary regulator of platelet production. Blood, 86, 419-451.
12. Kaushansky, K., Lok, S., Holley, R.D., Broudy, W.C., Lin, N., Bailey, M.C., Forstrom, J.W., Buddle, M.M., Ort, P.J., Hagen, F.S., Roth, G.J., Papayannopoulou, T. & Foster, D.C. (1994) Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature, 369, 568-571.
13. Kojima, S., Matsuyama, T., Kodera, Y., Tahara, T.& Kato, T. (1997) Measurement of endogenous plasma thrombopoietin in patients with acquired aplastic anaemia by a sensitive enzyme-linked immunosorbent assay. British Journal of Haematology, 97, 538-545.
14. Kosugi, S., Kurata, Y., Tomiyama, Y., Tahara, T., Kato, T., Tadokoro, S., Shiraga, M., Honda, S., Kanakura, Y. & Matsuzawa, Y. (1996) Circulating thrombopoietin level in chronic immune thrombocytopenic purpura. British Journal of Haematology, 93, 704-706.
15. Kunishima, S., Tahara, T., Kato, T., Kobayashi, S., Saito, H. & Naoe, T. (1996) Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders. European Journal of Haematolagy, 57, 68-71.
16. Kuter, D.J., Beeler, D.L. & Rosenberg, R.D. (1994) The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proceedings of the National Academy of Sciences of the United States of America, 91, 11104-11108.
17. Kuter, D.J. & Rosenberg, R.D. (1994) Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood, 84, 1464-1472.
18. Kuter, D.J. & Rosenberg, R.D. (1995) The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood, 85, 2720-2750.
19. Li, J., Xin, Y. & Kuter, D.J. (1996) Analysis of the thrombopoietin receptor (Mpl) on platelets from normal and essential thrombocythemic (ET) patients. Blood, 88, (Suppl. 1). 545a.
20. Lok, S., Kaushansky, K., Holly, R.D., Kuijper, J.L., Loften-Day, C.E., Oort, P.J., Grant, F.J., Heipel, M.D., Burkhead, S.K., Kramer, J.M., Bell, L.A., Sprecher, C.A., Blumberg, H., Honson, R., Prunkard, D., Chiang, A.F.T., Mathews, S.L., Bailey, M.C., Forstrom, J.W., Buddle, M.M., Osborn, S.G., Evans, S.J., Sheppard, P.O., Presnell, S.R., O'Hara, P.J., Hagen, F.S., Roth, G. & Fostor, D.C. (1994) Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature, 369, 565-568.
21. Marsh, J.C.W., Gibson, F.M., Prue, R.L., Bowen, A., Dunn, V.T., Hornkohl, A.C. & Nichol, J.L. (1996) Serum thronibopoietin levels in patients with aplastic anaemia. British Journal of Haematology, 95, 605-610.
22. Martin, T.G., Somberg, K.A., Meng, G., Cohen, R.L., Heid, C.A., de Sauvage, F.J. & Shuman, M.A. (1997) Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Annals of Internal Medicine, 127, 285-288.
23. Meng, Y.G., Martin, T.G., Peterson, M.L., Shuman, M.A., Cohen, R.L. & Wong, W.L. (1996) Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation. British Journal of Haematology, 95, 535-541.
24. Nagata, Y., Shozaki, Y., Nagahisa, H., Nagasawa, T., Abe, T. & Todokoro, K. (1997) Serum thrombopoietin is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis. Thrombosis and Haemostasis, 77, 808-814.
25. Naish, S.J. (1989) Handbook of Immunochemical Staining Methods. Dako, Capinteria, California.
26. Shimodaira, S., Ishida, F., Ichikawa, N., Tahara, T., Kato, T., Kodaira, H., Ito, T., Tanaka, E., Sodeyama, T., Kiyosawa, K. & Kitano, K. (1996) Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis. Thrombosis and Haemostasis, 76, 545-548.
27. Shivdasani, R.A., Fiedler, P., Keller, G.A., Orkin, S.H. & de Sauvage. F.J. (1997) Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood, 90, 1821-1827.
28. Stoffel, R., Wiestner, A. & Skoda, R.C. (1996) Thrombopoietin in thrombocytopenic mice: evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood, 87, 567-575.
29. Tahara, T., Usuki, K., Sato, H., Ohashi, H., Morita, H., Tsumura, H., Matsumoto, A., Miyazaki, H., Urabe, A. & Kato, T. (1996) A senstitive sandwich ELISA for measuring thrombopoietin in human serum: serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. British Journal of Haematology, 93, 783-788.
30. Ulich, T.R., del Castillo, J., Yin, S., Swift, S., Padilla, D., Senaldi, G., Bennet, L., Shutter, J., Bogenberger, J., Sun, D., Samal, B., Shimamoto, G., Lee, R., Steinbrink, R., Boone, T., Sheridan, W.T. & Hunt, P. (1995) Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood, 86, 971-976.
31. Usuki, K., Tahara, T., Iki, S., Endo, M., Osawa, M., Kitazume, K., Kato, K., Miyazaki, H. & Urabe, A. (1996) Serum thrombopoietin level in various hematological diseases. Stem Cells, 14, 558-565.
32. Vigon, I., Dreyfus, F., Melle, J., Viguie, F., Ribrag, V., Cocault, L., Souyri, M. & Gisselbrecht, S. (1993) Expression of the c-mpl protooncogene in human hematologie malignancies. Blood, 82, 877-883.
33. Wadenvik, H., Kutti, J., Ridell, B., Revesz, P., Jacobsson, S., Magnusson, B., Westin, J. & Vilén, L. (1991) The effect of alfa-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia. Blood, 77, 2103-2108.
34. Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D. & Vainchenker, W. (1994) c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature, 369, 571-574.