Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis

Thrombosis and Haemostasis

Volumn 76, Issue 4, 1996, Pages 545-548

  Shimodaira, Shigetaka ^a   Ishida, Fumihiro ^a   Ichikawa, Naoaki ^a   Tahara, Tomoyuki ^b   Kato, Takashi ^b   Kodaira, Hiroshi ^a   Ito, Toshiro ^a   Tanaka, Eiji ^a   Sodeyama, Takeshi ^a   Kiyosawa, Kendo ^a   Kitano, Kiyoshi ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KIRIN BREWERY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; THROMBOPOIETIN;

ARTICLE; BILIRUBIN BLOOD LEVEL; CHRONIC HEPATITIS; CONTROLLED STUDY; HUMAN; LIVER CIRRHOSIS; LIVER FUNCTION; MAJOR CLINICAL STUDY; NORMAL HUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 10344229413     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0038-1650620     Document Type: Article

References (30)

1. Aster RH. Pooling of platelets in the spleen: Role in the pathogenesis of "hypersplenic" thrombocytopenia. J Clin Invest 1966; 45: 645-57.
2. Harker LA, Finch CA. Thrombokinetics in man. J Clin Invest 1969; 48: 963-74.
3. 75Se]selenomethionine in man; Studies in diseases with normal coagulation and in hepatocellular disease with abnormal coagulation. Br J Haematol 1970; 18: 341-55.
4. Toghill PJ, Green S, Ferguson R. Platelet dynamics in chronic liver disease with special reference to the role of the spleen. J Clin Pathol 1977; 30: 367-71.
5. Stein SF, Harker LA. Kinetic and functional studies of platelets, fibrinogen, and plasminogen in patients with hepatic cirrhosis. J Lab Clin Med 1982; 99: 217-30.
6. 111Indium oxine label. Gut 1983; 24: 49-52.
7. Schmidt KG, Rasmussen JW, Bekker C, Madsen PER. Kinetics and in vivo distribution of 111-In-labelled autologous platelets in chronic hepatic disease: mechanisms of thrombocytopenia. Scand J Haematol 1985: 34: 39-46.
8. Marongiu F, Mamusa AM, Mameli G, Mulas G, Cambuli AB, Piga M, Tronci MB, Balestrieri A. Thrombocytopenia and liver cirrhosis evidence for relationship between platelet count, spleen size and hepatic synthetic activity. Thromb Res 1987; 45: 275-8.
9. Lozner EL. Differential diagnosis, pathogenesis and treatment of the thrombocytopenic purpuras. Am J Med 1953; 14: 459-68.
10. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang W-J, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994; 369: 533-8.
11. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Bailey MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994; 369: 565-8.
12. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannoupoulou T, Foster DC. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994; 369: 568-71.
13. Bartley TD, Bogenberger J, Hunt P, Li Y-S, Lu HS, Martin F, Chang M-S, Samal B, Nichol JL, Swift S, Johnson MJ, Hsu R-Y, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Castillo JDel, Biron J, Cole S, Hu MC-T, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117-24.
14. Sohma Y, Akahori H, Seki N, Hori T, Ogami K, Kato T, Shimada Y, Kawamura K, Miyazaki H. Molecular cloning and chromosomal localization of the human thrombopoietin gene. FEBS Letters 1994; 353: 57-61.
15. Ogami K, Shimada Y, Sohma Y, Akahori H, Kato T, Kawamura K, Miyazaki H. The sequence of a rat cDNA encoding thrombopoietin. Gene 1995; 158: 309-10.
16. Foster DC, Sprecher CA, Grant FJ, Kramer JM, Kuuper JL, Holly RD, Whitmore TE, Heipel MD Bell LA, Ching AFT, McGrane V, Hart C, O'hara PJ, Lok S. Human thrombopoietin: Gene structure, cDNA sequence, expression, and chromosomal localization. Proc Natl Acad Sci 1994; 91: 13023-7.
17. Gurney AL, Kuang W-J, Xie M-H, Malloy BE, Eaton DL, de Sauvage FJ. Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin. Blood 1995; 85: 981-8.
18. Shimada Y, Kato T, Ogami K, Horie K, Kokubo A, Kudo Y, Maeda E, Sohma Y, Akahori H, Kawamura K, Miyazaki H. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Exp Hematol 1995; 23: 1388-96.
19. Tahara T, Usuki K, Sato H, Ohashi H, Monta H, Tsumura H, Matsumoto A, Miyazaki H, Urabe A, Kato T. A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with hematopoietic disorders. Br J Haematol 1996; 93: 783-8.
20. Wendling F, Maraskovasky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369: 571-4.
21. Nichol JL, Hokom MM, Hornkohl A, Sheridan WP, Ohashi H, Kato T, Li YS, Bartley TD, Choi E, Bogenberger J, Skrine JD, Knudten A, Chen J, Trail G, Sleeman L, Cole S, Grampp G, Hunt P. Megakaryocyte growth and development factor: Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia. J Clin Invest 1995; 95: 2973-8.
22. Kuter DJ, Rosenberg RD. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 1995; 85: 2720-30.
23. Ulich TR, del Castillo J, Yin S, Swift S, Padilla D, Senaldi G, Bennett L, Shutter J, Bogenberger J, Sun D, Samal B, Shimamoto G, Lee R, Steinbrink R, Boone T, Sheridan WT, Hunt P. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86: 971-6.
24. Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci 1994; 91: 11104-8.
25. Ichikawa N, Ishida F, Shimodaira S, Tahara T, Kato T, Kitano K. Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura. Thromb Haemost 1996; 76: 156-60.
26. McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count. Blood 1995; 86: 3668-75.
27. Kishimoto T. The biology of interleukin-6. Blood 1989; 74 1-10.
28. Martinez J, Barsigian C. Coagulopathy of liver failure and vitamin K deficiency, Loscalzo J, Schafer AI (ed.). Thrombosis and Hemorrhage, pp 945-963, Blackwell Scientific Publications, Boston, 1993.
29. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H. Purification and characterization of thrombopoietin. J Biochem 1995; 118: 229-36.
30. Chen J, Herceg-Harjacek L, Groopman JE, Grabarek J. Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995; 86: 4054-62.