Cytokine receptors: Structures and signal transduction

International Reviews of Immunology

Volumn 16, Issue 5-6, 1998, Pages 617-634

  Onishi, Mayumi ^a   Nosaka, Tetsuya ^a   Kitamura, Toshio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cytokine receptor; Jak; Signal transduction; STAT

Indexed keywords

EID: 0031831907     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189809043011     Document Type: Article

References (51)

1. Bazan, J.F. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87 (1990) 6934-6938.
2. Miyajima, A., Hara, T. and Kitamura, T. Common subunits of cytokine receptors: a basis for the functional redundancy of multiple cytokines. Trends Biochem. Sciences 17 (1992) 378-382.
3. Lopez, A.F., Eglinton, J.M., Lyons, A.B., Tapley, P.M., To, L.B., Park, L.S., Clarke, S.C. and Vadas, M.A. Human interleukin-3 inhibits the binding of granulocyte-macrophage colony-stimulating factor and interleukin-5 to basophils and strongly enhances their functional activity. J. Cell. Physiol. 145 (1990) 69-77.
4. Kitamura, T., Sato, N., Arai, K. and Miyajima, A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell 66 (1991) 1165-1174.
5. Watowich, S.S., Hilton, D.J. and Lodish, H.F. Activation and inhibition of erythropoietin receptor function: role of receptor dimerization. Mol. Cell Biol. 14 (1994) 3535-3549.
6. Alexander, W.S., Metcalf, D. and Dunn, A.R. Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorigenicity. EMBO J. 14 (1995) 5569-5578.
7. Takaki, S., Murata, Y., Kitamura, T., Miyajima, A., Tominaga, A. and Takatsu, K. Reconstitution of the functional receptors for murine and human interleukin-5. J. Exp. Med. 177 (1993) 1523-1529.
8. Sakamaki, K., Miyajima, I., Kitamura, T. and Miyajima, A. Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 11 (1992) 3541-3549.
9. Muto, A., Watanabe, S., Itoh, T., Miyajima, A., Yokota, T. and Arai, K. Roles of the cytoplasmic domains of the alpha and beta subunits of human granulocyte-macrophage colony-stimulating factor receptor. J. Allergy Clin. Immunol. 96 (1995) 1100-1114.
10. Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T. and Kishimoto, T. Cloning and expression of the human interleukin-6 (BSF-2/IFNβ2) receptor. Science 241 (1988) 825-828.
11. Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T. and Kashimoto, T. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58 (1989) 573-581.
12. Nakamura, Y., Russell, S.M., Mess, S.A., Friedmann, M., Erdos, M., Francois, C., Jacques, Y., Adelstein, S. and Leonard, W.J. Heterodimerization of the IL-2 receptor b- and g-chain cytoplasmic domains is required for signalling. Nature 369 (1994) 330-333.
13. Caput, D., Laurent, P., Kaghad, M., Lelias, J.M., Lefort, S., Vita, N. and Ferrara, P. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J. Biol. Chem. 271 (1996) 16921-16926.
14. Hilton, D.J., Zhang, J.G., Metcalf, D., Alexander, W.S., Nicola, N.A. and Willson, T. A. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93 (1996) 497-501.
15. Mui, A.L.-F., Wakao, H., O'Farrell, A., Harada, N. and Miyajima, A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 14 (1995) 1166-1175.
16. Taniguchi, T. Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268 (1995) 251-255.
17. Ihle, J.N. STATs: signal transducers and activators of transcription. Cell 84 (1996) 331-334.
18. Schindler, C. and Darnell, J., Jr. Transcriptional respones to polypeptide ligands; the JAK-STAT pathway. Annu. Rev. Biochem. 64 (1995) 621-651.
19. Zhang, X., Blenis, J., Li, H.C., Schindler, C. and Chen-Kiang, S. Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science 267 (1995) 1990-1994.
20. Wen, Z., Zhong, Z. and Darnell, J.E., Jr. Maximal activation of transcription by STAT1 and STAT3 requires both tyrosin and serine phoshorylation. Cell 82 (1995) 241-250.
21. Beadling, C., Babbage, J.W. and Cantrell, D.A. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2/MAPkinase pathway. EMBO J. 15 (1996) 1902-1913.
22. Bhat, G.J., Thekkumkara, T.J., Thomas, W.G., Conrad, K.M. and Baker, K.M. Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Crosstalk between angiotensin II and interleukin-6 nuclear signaling. J. Biol. Chem. 270 (1995) 19059-19065.
23. Marrero, M.B., Schieffer, B., Paxton, W.G., Heerdt, L., Berk, B.C., Delafontaine, P. and Bernstein, K.E. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375 (1995) 247-250.
24. Nosaka, T., van Deursen, J.M., Tripp, R.A., Thierfelder, W.E., Witthuhn, B.A., McMickle, A.P., Doherty, P.C., Grosveld, G.C. and Ihle, J.M. Defective lymphoid development in mice lacking Jak3. Science 270 (1995) 800-802.
25. Park, S.Y., Saijo, K., Takahashi, T., Osawa, M., Arase, H., Hirayama, N., Miyake, K., Nakauchi, H., Shirasawa, T. and Saito, T. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 3 (1995) 771-782.
26. Thomis, D.C., Gurniak, C.B., Tivol, E., Sharpe, A.I. and Berg, L.J. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270 (1995) 794-797.
27. Murata, T., Noguchi, P.D. and Puri, R.K. Receptors for Interleukin (IL)-4 do not associate with the common g chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. J. Biol. Chem. 270 (1996) 30829-30836.
28. [281 Heim, M.H., Kerr, I.M., Stark, G.R. and Darnell, J.E.J. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science 267 (1995) 1347-1349.
29. Hemmann, U., Gerhartz, C., Heesel, B., Sasse, J., Kurapkat, G., Grotzinger, J., Wollmer, A., Zhong, Z. and Darnell, J.E. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130. II. Src homology SH2 domains define the specificity of Stat factor activation. J. Biol. Chem. 271 (1996) 12999-13007.
30. Leung, S., Qureshi, S.A., Kerr, I.M., Darnell, J.E.J. and Stark, G.R. Role of STAT2 in the alpha interferon signaling pathway. Mol. Cell. Biol. 15 (1995) 1312-13175.
31. Bacon, C.M., McVicar, D.W., Ortaldo, J.R., Rees, R.C., O'Shea, J.J. and Johnston, J.A. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181 (1995) 399-404.
32. Jacobson, N.G., Szabo, S.J., Weber-Nordt, R.M., Zhong, Z., Schreiber, R.D., Darnell, J.E.J. and Murphy, K.M. Interleukin 12 signaling in T helper type 1 (Th 1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription Stat3 and Stat4. J. Exp. Med. 181 (1995) 1755-1762.
33. Shimoda, K., van Deursen, J., Sangster, M.Y., Sarawar, S.R., Carson, R.T., Tripp, R.A., Chu, C., Quelle, F.W., Nosaka, T., Vignali, D.A., Doherty, P.C., Grosveld, G., Paul, W.E. and Ihle, J.N. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380 (1996) 630-633.
34. Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T. and Akira, S. Essential role of Stat6 in IL-4 signalling. Nature 380 (1996) 627-630.
35. Thiefelder, W.E., van Deursen, J.M., Yamamoto, T., Tripp, R.A., Sarawar, S.R., Carson, R.T., Samgster, M.Y., Vignali, D.A., Doherty, P.C., Grosveld, G.C. and Ihle, J.N. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382 (1996) 171-174.
36. Kaplan, M.H., Sun, Y.L., Hoey, T. and Gruby, M.J. Impaired IL-12 responses and enhanced development of Th 2 cells in Stat4 deficient mice. Nature 382 (1996) 174-177.
37. de Koning, J.P., Dong, F., Smith, L., Schelen, A.M., Barge, R.M., van der Plas, D.C., Hoefsloot, L.H., Lowenberg, B. and Touw, I.P. The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation. Blood 87 (1996) 1335-1342.
38. Minami, M., Inoue, M., Wei, S., Takeda, K., Matsumoto, M., Kishimoto, T. and Akira, S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloidcell line. Proc. Natl. Acad. Sci. USA 93 (1996) 3963-3966.
39. Mui, A.L.F., Wakao, H., Kinoshita, T., Kitamura, T. and Miyajima, A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 15 (1996) 2425-2433.
40. Friedmann, M.C., Migone, T., Russell, S.M. and Leonard, W.J. Different interleukin 2 receptor b-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. USA 93 (1996) 2077-2082.
41. Damen, J.E., Wakao, H., Miyajima, A., Krosl, J., Humphries, R.K., Cutler, R.L. and Krystal, G. Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. Embo J. 14 (1995) 5557-68,
42. Fujii, H., Nakagawa, Y., Schindler, U., Kawahara, A., Mori, H., Gouilleux, F., Groner, B., Ihle, J.N., Minami, Y., Miyazaki, T. and Taniguchui, T. Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission. Proc. Natl. Acad. Sci. USA 92 (1995) 5482-5486.
43. Quelle, F.W., Wang, D., Nosaka, T., Thierfelder, W.E., Stravopodis, D., Weinstein, Y. and Ihle, J.N. Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol. 16 (1996) 1622-1631.
44. Meraz, M.A., White, J.M., Sheehan, K.C., Back, E.A., Rodig, S.J., Dighe, A.S., Kaplan, D.H., Riley, J.K., Green lund, A.C., Campbell, D., Carver-Moore, K., DuBois, R.N., Clark, R., Aguet, M. and Schreiber, R.D. Targeted disruption of the Stat1 gene in mice reveals unexprected physiologic specificity in the JAK-STAT signaling pathway. Cell 84 (1996) 431-442.
45. Watanabe, S., Itoh, T., Arai, K. JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells. J. Biol. Chem. 271 (1996) 12681-12686.
46. Bignon, J.S. and Siminovitch, K.A. Identification of PTPlC mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoeitic cell differentiation and function. Clin. Immuno. Immunopath. 73 (1994) 168-179.
47. Klingmuller, U., Lorenz, U., Cantley, L.C., Neel, B.G. and Lodish, H.F. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of Jak2 and termination of proliferative signals. Cell 80 (1995) 726-738.
48. Chu, Y., Solski, P.A., Khosravi-Far, R., Der, C.J. and Kelly, K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. J. Biol. Chem. 271 (1996) 6497-6591.
49. Kim, T.K. and Maniatis, T. Regulation of interferon-gamma-activated STAT1 by the ubiquitin-proteasome pathway. Science 273 (1996) 1717-1719.
50. Bourette, R.P., Mouchiroud, G. and Ouazana, R. Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine plulipotent hematopoietic NSF60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potiential. Blood 81 (1993) 2511-2520.
51. Yoshikawa, A., Murakami, H. and Nagata, S. Distinct signal transduction through the tyrosine-containing domains of the granulocyte-colony simulating factor receptor. EMBO J. 14 (1995) 5288-5296.