Lethal monointoxication by overdosage of MDEA

Forensic Science International

Volumn 91, Issue 2, 1998, Pages 91-101

  Weinmann, Wolfgang ^a   Bohnert, Michael ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

3,4 methylenedioxy N ethylamphetamine; Ecstasy; Hair analysis; Overdose; Symptoms of intoxication; Tissue distribution

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DRUG METABOLITE; N ETHYL 3,4 METHYLENEDIOXYAMPHETAMINE;

ADULT; AGGRESSIVENESS; ARTICLE; AUTOPSY; BLEEDING; BRAIN; CASE REPORT; CAUSE OF DEATH; COLLAPSE; DRUG BLOOD LEVEL; DRUG INTOXICATION; DRUG OVERDOSE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FEMALE; FEMORAL VEIN; FIRST AID; GAS CHROMATOGRAPHY; HAIR ANALYSIS; HALLUCINATION; HEART; HUMAN; MASS SPECTROMETRY; MOTOR DYSFUNCTION; MUSCLE SPASM; PRIORITY JOURNAL; RESPIRATION DEPRESSION; RESUSCITATION; SWEATING; UNCONSCIOUSNESS;

EID: 0032579567     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(97)00185-0     Document Type: Article

References (42)

1. Bundeskriminalamt, Bundeskriminalblatt, Sonderausgabe "Ecstasy/XTC", No. 178, Wiesbaden, 1995, pp. 24-27.
2. Greer G., Tolbert A. Subjective reports of the effects of 3,4-methylenedioxyamphetamine in a clinical setting. J. Psychoact. Drugs. 38:1991;339-344.
3. Henry J.A., Jeffreys K.J., Dawling S. Toxicity and deaths from 3,4-methylenedioxymethamphetamine ("Ecstasy"). Lancet. 340:1992;384-387.
4. Oranje W.A., von Pol P., Wurff A.v.d., Zeijen R.N., Stockbrugger R.W., Arends J.W. XTC-induced hepatitis. Neth. J. Med. 44:1994;56-59.
5. Milroy C.M., Clark J.C., Forrest A.R.W. Pathology of deaths associated with "Ecstasy" and "Eve" misuse. J. Clin. Pathol. 49:1996;149-153.
6. Chadwick I.S., Curry P.D., Linsley A., Freemont A.J., Doran B. Ecstasy, 3,4-methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia. J. R. Soc. Med. 84:1991;371.
7. Screaton G.R., Singer M., Cairns H.S., Thrasher A., Sarner M., Cohen S.L. Hyperpyrexia and rhabdomyolysis after MDMA ("Ecstasy") abuse. Lancet. 339:1992;667-668.
8. Watson J.D., Ferguson C., Hinds C.J., Skinner R., Coakley J.H. Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place? Anaesthesia. 48:1993;1057-1060.
9. Fahal I.B., Sallomi D.F., Yaqoob M., Bell G.M. Acute renal failure after Ecstasy. Br. Med. J. 305:1992;29.
10. Maxwell D.L., Polkey M.I., Henry J.A. Hyponatraemia and catatonic stupor after taking "Ecstasy" Br. Med. J. 307:1993;1399.
11. Kessel B. Hyponatraemia after ingestion of "Ecstasy" Br. Med. J. 308:1994;414.
12. Lee J.W. Catatonic stupor after "Ecstasy" Br. Med. J. 308:1994;414.
13. Hughes J.C., McCabe M., Evans R.J. Intracranial haemorrhage associated with ingestion of "Ecstasy" Arch. Emerg. Med. 10:1993;372-374.
14. Harries D.P., Silva R.N. Ecstasy and intracerebral haemorrhage. Scott. Med. J. 37:1992;150-152.
15. Gledhill J.A., Moore D.F., Bell D., Henry J.A. Subarachnoid haemorrhage associated with MDMA abuse. J. Neurol. Neurosurg. Psychiatry. 56:1993;1036-1037.
16. Rothwell P.M., Grant R. Cerebral venous sinus thrombosis induced by Ecstasy. J. Neurol. Neurosurg. Psychiatry. 56:1993;1035.
17. Manchanda S., Connolly M.J. Cerebral infarction in association with Ecstasy abuse. Postgrad. Med. J. 69:1993;874-875.
18. McCann U.D., Ridenour A., Shaham Y., Ricaurte G.A. Serotonin neurotoxicity after (±) 3,4-methylenedioxymethamphetamine (MDMA; "Ecstasy"): a controlled study in humans. Neuropsychopharmacology. 10:1994;129-138.
19. Steele T.D., McCann U.D., Ricaurte G.A. 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"): pharmacology and toxicology in animals and humans. Addiction. 89:1994;539-551.
20. Stone D.M., Johnson M., Hanson G.R., Gibb J.W. A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives. Eur. J. Pharmacol. 134:1987;245-248.
21. Cox D.E., Williams K.R. "ADAM" or "EVE"? - a toxicological conundrum. Forensic Sci. Int. 77:1996;101-108.
22. Maurer H.H. On the metabolism and the toxicological analysis of Methylenedioxyphenylalkylamine designer drugs by gas chromatography-mass spectrometry. Ther. Drug Monit. 18:1996;465-470.
23. Maurer H.H., Ensslin H., Kovar K.-A. On the metabolism of designer drugs. Part I: studies on methylenedioxyethylamphetamine (MDE) in rats. Bull. Soc. Sci. Med. Grand-Duche Luxemb. 127:1990;467-471.
24. Lim H.K., Foltz R.L. Identification of metabolites of 3,4-(methylenedioxy)-methamphetamine in human urine. Chem. Res. Toxicol. 2:1989;142-143.
25. Lim H.K., Foltz R.L. In vivo and in vitro metabolism of 3,4-(methylenedioxy)methamphetamine in the rat: identification of metabolites using an ion trap detector. Chem. Res. Toxicol. 1:1988;370-378.
26. K. Pfleger, H.H. Maurer, A. Weber, in: Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites. VCH Verlagsgesellschaft mbH, Weinheim, 1992.
27. Maurer H.H. Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry. J. Chromatogr. 580:1992;3-41.
28. Terada M., Yamamoto T., Yoshida T., Kuroiwa Y., Yoshimura S. Rapid and highly sensitive method for determination of methamphetamine and amphetamine in urine by electron-capture gas chromatography. J. Chromatogr. 237:1982;285-292.
29. W. Weinmann, C. Bohn, Quantitation of drugs of abuse by SPE and GC/MS using microliter-amounts of serum. Proc. of the 44th Conf. of the American Soc. Mass Spectrometry, Portland, 1996, p. 977.
30. W. Weinmann, M. Svoboda, SPE combined with Flow-Injection Ionspray-MS/MS: fast, specific and simultaneous quantitation of drugs from serum, Proc. of the TIAFT conference, Interlaken 1996, in press.
31. Skopp G., Aderjan R., Köster J. Haaranalyse zur Diagnose toxischer Hepatitiden nach Mißbrauch von Ecstasy. Dtsch. Med. Wochenschr. 120:1995;1165-1168.
32. Ensslin H.K., Kovar K.-A., Maurer H.H. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, "Eve") and its metabolites in urine by gas chromatography-mass spectrometry (GC/MS) and fluorescence polarization immunoassay (FPIA). J. Chromatogr. B. 683/2:1996;189-197.
33. Tehan B., Hardern R., Bodenham A. Hyperthermia associated with 3,4-methylendioxyethamphetamine ("Eve"). Anaesthesia. 48:1993;507-510.
34. Woods J.D., Henry J.A. Hyperpyrexia induced by 3,4-methylendioxyamphetamine. Lancet. 340:1992;305.
35. Gouzoulis E., Borchardt D., Hermle L. A case of toxic psychosis induced by "eve" Arch. Gen. Psychiatry. 50:1993;75.
36. Kew M., Bersohn I., Seftel H., Kent G. Liver damage in heatstroke. Am. J. Med. 49:1970;192-202.
37. Rubel L.R., Ishak K.G. The liver in fatal exertional heatstroke. Liver. 3:1983;249-260.
38. R.G. Petersdorf, Hypothermia and hyperthermia, in: Harrison's Principles of Internal Medicine, 13th ed., McGraw-Hill, 1994, pp. 2473-2479.
39. S.B. Karch, The Pathology of Drug Abuse, CRC Press, Boca Raton, 1993, pp. 206-218.
40. Rohrig T.P., Prouty R.W. Tissue distribution of methylenedioxymethamphetamine. J. Anal. Toxicol. 16:1992;52-53.
41. Dowling G.P., McDonough III E.T., Bost R.O. "Eve" and "Ecstasy". A report of five deaths associated with the use of MDEA and MDMA. J. Am. Med. Assoc. 257:1987;1615-1617.
42. Forrest A.R., Galloway J.H., Marsh I.D., Strachan G.A., Clark J.C. A fatal overdose with 3,4-methylenedioxymethamphetamine derivates. Forensic Sci. Int. 64:1994;57-59.