Diazoxide- and leptin-activated K(ATP) currents exhibit differential sensitivity to englitazone and ciclazindol in the rat CRI-G1 insulin-secreting cell line

British Journal of Pharmacology

Volumn 124, Issue 7, 1998, Pages 1557-1565

  Harvey, J ^a   Ashford, M L J ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Ciclazindol; Diazoxide; Englitazone; K(ATP) channels; Leptin

Indexed keywords

ANTIDIABETIC AGENT; CICLAZINDOL; DIAZOXIDE; ENGLITAZONE; LEPTIN; POTASSIUM CHANNEL; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; CELL LINE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOPYRANS; CELL LINE; DIAZOXIDE; HYPOGLYCEMIC AGENTS; INDOLES; INSULIN; LEPTIN; MEMBRANE POTENTIALS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEINS; RATS; THIAZOLES; THIAZOLIDINEDIONES;

EID: 0031827584     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702000     Document Type: Article

References (30)

1. ASHCROFT, F.M. & RORSMAN, P. (1991). Electrophysiology of the pancreatic β cell. Prog. Biophys. Mol. Biol., 54, 87-143.
2. ASHFORD, M.L.J. (1990). Potassium channels and modulation of insulin secretion. In Potassium Channels: Structure, Classification, Function and Therapeutic Potential. ed Cook, N.S. 300-325. Chichester: Ellis Horwood Limited.
3. CARO, J.F., SINHA, M.K., KOLACZYNSKI, J.W., ZHANG, P.L. & CONSIDINE, R.V. (1996). Leptin: the tale of an obesity gene. Diabetes, 45, 1455-1462.
4. CARRINGTON, C.A., RUBERY, E.D., PEARSON, E.C. & HALES, C.N. (1986). Five new insulin-producing cell lines with differing secretory properties. J. Endocrinol., 109, 193-200.
5. DUNNE, M.J. (1989). Protein phosphorylation is required for diazoxide to open ATP-sensitive potassium channels in insulin (RINm5F) secreting cells. FEBS Lett., 250, 262-266.
6. FUJITA, T., YOSHIOKA, S., YOSHIOKA, T., USHIYAMA, I. & HOROKOSHI, H. (1988). Characterisation of new antidiabetic agent CS-045: studies in KK and ob/ob mice and Zucker rats. Diabetes, 37, 1549-1558.
7. GHOSE, K., RAMA RAO, V.A., BAILEY, J. & COPPEN, A. (1978). Antidepressant activity and pharmacological interactions of ciclazindol. Psychopharmacol., 57, 109-114.
8. HARVEY, J., MCKENNA, F., HERSON, P.S., SPANSWICK, D. & ASHFORD, M.L.J. (1997a). Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J. Physiol., 504.3, 527-535.
9. ATP. currents, activated by diazoxide or leptin,4 in the insulin secreting cell line CRI-G1. Br. J. Pharmacol., 122, 289P.
10. HARVEY, J. & ASHFORD, M.L.J. (1998). Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K channels in the rat insulinoma cell line CRI-G1. J. Physiol. 510.1, 47-61.
11. + channels. Neuron, 16, 1011-1017.
12. + channels in pancreatic beta cells. Diabetes, 46, 1087-1093.
13. + currents recorded from an insulin-secreting cell line. Br. J. Pharmacol., 97, 1039-1050.
14. LEE, K. & BODEN, P. (1997). Troglitazone inhibits type 2 KATP channel activity and depolarises tolbutamide-sensitive neurones in the rat ventromedial hypothalamus. Brain Res., 751, 165-168.
15. ATP channel activity by troglitazone in CRI-G1 insulin secreting cells. Eur. J. Pharmacol., 313, 163-167.
16. + channels and stimulates insulin secretion in CRI-G1 insulin-secreting cells. Mol. Pharmacol., 49, 715-720.
17. ATP channels by sulphonylureas in CRI-G1 insulin secreting cells. Br. J. Pharmacol., 111, 632 -640.
18. LEE, K., OZANNE, S.E., ROWE, I.C.M., HALES, C.N. & ASHFORD, M.L.J. (1994b). The effects of trypsin on ATP-sensitive potassium channel properties and sulphonylurea receptors in the CRI-G1 insulin secreting cell line. Mol. Pharmacol., 45, 176-185.
19. + channel present in rat cortical neurons. J. Physiol., 488, 319-337.
20. MASUDA, K., OKAMOTO, Y., KATO, S., MIURA, T., TSUDA, K., HORIKOSHI, H., ISHIDA, H. & SEINO, Y. (1995). Effects of troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia, 38, 24-30.
21. NOACK, T.H., EDWARDS, G., DEITMER, P., GREENGRASS, P., MORITA, T., ANDERSSON, P.-O., CRIDDLE, D., WYLIE, M.G. & WESTON, A.H. (1992). The involvement of potassium channels in the action of ciclazindol in rat portal vein. Br. J. Pharmacol., 106, 17-24.
22. ATP and calcium-activated non-selective cation channels in CRI-G1 insulin-secreting cells. Br. J. Pharmacol., 121, 531-539.
23. SOHDA, T., MIZUNO, K., MOMOSE, Y., IKEDA, H., FUJITA, T. & MEGURO, K. (1992). Studies on antidiabetic agents II. Novel thiazolidinedione derivatives as potent hypoglycaemic and hypolipidemic agents. J. Med. Chem., 35, 2617-2626.
24. STEVENSON, R.W., HUTSON, N.J., KRUP, M.N., VOIKMANN, R.A., HOLLAND, G.F., EGGLER, J.F., CLARK, D.A., MCPHERSON, R.K., HALL, K.L., DANBURY, B.H., GIBBS, E.M & KRUETTER, D.K. (1990). Actions of novel antidiabetic agent englitazone in hyperglycaemic and hyperinsulinemic ob/ob mice. Diabetes, 39, 1218-1227.
25. STURGESS, N.C., KOZLOWSKI, R.Z., CARRINGTON, C.A., HALES, C.N. & ASHFORD, M.L.J. (1988). Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br. J. Pharmacol., 95, 83-94.
26. TARTAGLIA, L.A., DEMSKI, M., WENG, X., DENG, N., CULPEPPER, J., DEVOS, R., RICHARDS, G.J., CAMPFIELD, L.A., CLARK, F.T., DEEDS, J., MUIR, C., SANKER, S., MORIARTY, A., MOORE, K.J., SMUTKO, J.S., MAYS, G.G., WOOLF, E.A., MONROE, C.A. & TEPPER, R.I. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271.
27. + channel in mouse pancreatic beta cells. Pflugers Arch., 407, 493-499.
28. + channels in the absence of the sulphonylurea receptor. Nature, 387, 179-183.
29. ZHANG, Y., PROENCA, R., MAFFEI, M., BARONE, M., LEOPOLD, L. & FREIDMAN, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.
30. + currents in pancreatic B cells. Naunyn-Schmeideberg's Arch Pharmacol., 337, 225-230.