Genetic interaction between YPT6 and YPT1 in Saccharomyces cerevisiae

Yeast

Volumn 14, Issue 10, 1998, Pages 915-922

  Li, Baojie ^a   Warner, Jonathan R ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

SLY1; Small GTP binding proteins; SSD1; YPT1; YPT6

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN;

ALLELE; ARTICLE; CONTROLLED STUDY; FUNGAL GENETICS; GENE OVEREXPRESSION; GENETIC ANALYSIS; GROWTH; LETHALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVE MUTANT;

BIOLOGICAL TRANSPORT; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; GOLGI APPARATUS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; MONOMERIC GTP-BINDING PROTEINS; MUTATION; RAB GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPPRESSION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0031815504     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(199807)14:10<915::AID-YEA291>3.0.CO;2-Y     Document Type: Article

References (27)

1. Becker, J., Tan, T. J., Trepte, H. H. and Gallwitz, D. (1991). Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity. EMBO J. 10, 785-792.
2. Beranger, F., Paterson, H., Powers, S., deGunzburg, J. and Hancock, J. (1994). The effector domain of Rab6, plus a highly Hydrophobic C terminus, is required for Golgi apparatus localization. Mol. Cell. Biol. 14, 744-758.
3. Dascher, C., Ossig, R., Gallwitz, D. and Schmitt, H. D. (1991). Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily. Mol. Cell. Biol. 11, 872-885.
4. Goud, B., Yang, C., Roa, M., Martinez, O. and Mayau, V. (1994). Study of rab6, a ras-like GTP-binding protein associated with the Golgi complex. Ann. NY Acad. Sci. 710, 192-196.
5. Graham, T. R. and Emr, S. D. (1991). Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec 18 (NSF) mutant. J. Cell Biol. 114, 207-218.
6. Jedd, G., Richardson, C. and Litt, R. (1995). The Ypt1 GTPase is essential for the first two steps of the yeast secretory pathway. J. Cell Biol. 131, 583-590.
7. Jones, S., Crosby, J., Salamero, J. and Howell, K. (1993). A cytosolic complex of p62 and rab6 associates with TGN38/41 and is involved in budding of exocytic vesicles from the trans-Golgi network. J. Cell Biol. 122, 775-788.
8. Ju, Q. D. and Warner, J. R. (1991). Competent Saccharomyces cerevisiae cells can be frozen and used for transformation with high frequency. Trends in Genetics 7, 242.
9. Li, B. (1997). Crosstalk between the secretory pathway and ribosome synthesis in Saccharomyces cerevisiae. Ph.D. Thesis submitted to the Albert Einstein College of Medicine of Yeshiva University.
10. Li, B. and Warner, J. R. (1996). Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J. Biol. Chem. 271, 16813-16819.
11. Lian, J. P., Stone, S., Jiang, Y., Lyons, P. and Ferro-Novick, S. (1994). Ypt1p implicated in v-SNARE activation. Nature 372, 698-701.
12. Lupashin, V. V. and Waters, M. G. (1997). t-SNARE activation through transient interaction with a Rab-like guanosine triphosphatase. Science 276, 1255-1258.
13. Martinez, O., Schmidt, A., Salamero, J., Hoflack, B., Roa, M. and Goud, B. (1994). The small GTP-binding protein rab6 functions in intra-Golgi transport. J Cell Biol. 127, 1575-1588.
14. Mayer, T., Touchot, N. and Elazar, Z. (1996). Transport between cis and medial Golgi cisternae requires the function of the Ras-related protein Rab6. J. Biol. Chem. 271, 16097-16103.
15. Mizuta, K. and Warner, J. R. (1994). Continued functioning of the secretory pathway is essential for ribosome synthesis. Mol. Cell. Biol. 14, 2493-2502.
16. Mulholland, J., Wesp, A., Riezman, H. and Botstein, D. (1997). Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretory vesicle. Mol. Biol. Cell 8, 1481-1499.
17. Novick, P. and Brennwald, P. (1993). Friends and family: the role of the Rab GTPases in vesicular traffic. Cell 75, 597-601.
18. Ossig, R., Dascher, C., Trepte, H. H., Schmitt, H. D. and Gallwitz, D. (1991). The yeast SLY gene products, suppressors of defects in the essential GTP-binding Ypt1 protein, may act in endoplasmic reticulum-to-Golgi transport. Mol. Cell. Biol. 11, 2980-2993.
19. Pryer, N. K., Wuestehube, L. J. and Schekman, R. (1992). Vesicle-mediated protein sorting. Ann. Rev. Biochem. 61, 471-516.
20. Rothman, J. E. and Wieland, F. T. (1996). Protein sorting by transport vesicles. Science 272, 227-234.
21. Rothman, J. H. and Stevens, T. H. (1986). Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell 47, 1041-1051.
22. Sapperstein, S. K., Lupashin, V. V., Schmitt, H. D. and Waters, M. G. (1996). Assembly of the ER to Golgi SNARE complex requires Uso1p. J. Cell Biol. 132, 755-767.
23. Schmitt, H. D., Wagner, P., Pfaff, E. and Gallwitz, D. (1986). The ras-related YPT1 gene product in yeast: a GTP-binding protein that might be involved in microtubule organization. Cell 47, 401-412.
24. Schmitt, H. D., Puzicha, M. and Gallwitz, D. (1988). Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium. Cell 53, 635-647.
25. Segev, N., Mulhollan, J. and Botstein, D. (1988). The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell 52, 915-924.
26. Søgaard, M., Tani, K., Ye, R. R., et al. (1994). A Rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78, 937-948.
27. Tsukada, M. and Gallwitz, D. (1996). Isolation and characterization of SYSgenes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. J. Cell Sci. 109, 2471-2481.