The Eph receptor tyrosine kinases and the ephrins - Roles in nervous system development

European Journal of Neuroscience

Volumn 10, Issue 2, 1998, Pages 405-408

  Holder, Nigel ^a,b   Cooke, Julie ^a,b   Brennan, Caroline ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Eph receptors; Neural patterning

Indexed keywords

EPHRIN; LIGAND; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

FOREBRAIN; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; RHOMBENCEPHALON; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; LIGANDS; NERVOUS SYSTEM; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 0031812491     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1998.00032.x     Document Type: Short Survey

References (40)

1. Bartley, T.D., Hunt, R.W., Welcher, A.A., Boyle, W.J., Parker, V.P., Lindberg, R.A., Lu, H.S., Colombero, A.M., Elliot, R.A., Guthrie, B.A., Holst, P.L., Skrine, J.D., Toso, R.J., Zhang, M., Fernandez, E., Trail, G., Hunter, T. & Fox, G.M. (1994) B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature, 368, 558-560.
2. Becker, N., Seitanidou, T., Murphy, P., Mattei, M.-G., Topilko, P., Nieto, A., Wilkinson, D., Charnay, P. & Gilardi-Henstriet, P. (1994) Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech. Dev., 47, 3-17.
3. Bergemann, A., Hwai-Jong, C., Brambilla, R., Klein, R. & Flanagan, J. (1995) Elf-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol. Cell. Biol., 15, 4921-4929.
4. Brambilla, R. & Klein, R. (1995) Telling axons where to go: A role for Eph receptor tyrosine kinases in guidance. Mol. Cell. Neurosci., 6, 487-495.
5. Brambilla, R., Schnapp, A., Casagranda, F., Labrador, J., Bergeman, A., Flanagan, J., Pasquale, E. & Klein, R. (1995) Membrane bound LERK2 ligand can signal through three different Eph-related receptor tryrosine kinases. EMBO J., 14, 3116-3126.
6. Brennan, C., Monshau, B., Lindberg, R., Guthrie, B., Drescher, U., Bonhoeffer, F. & Holder, N. (1997) Two Eph receptor tyrosine kinase ligands control. axon growth and may be involved in the creation of the retinotectal map in zebrafish. Development, 124, 655-664.
7. Bruckner, K., Pasquale, E. & Klein, R. (1997) Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science, 275, 1640-1643.
8. Cheng, H.-J. & Flanagan, J. (1994) Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek 1 receptor tyrosine kinases. Cell, 79, 157-168.
9. Cheng, H.-J., Nakamoto, M., Bergemann, A. & Flanagan, J. (1995) Complimentary gradients in expression and binding of Elf-1 and Mek4 in development of the topographic retinotectal projection map. Cell, 82, 371-381.
10. Donoghue, M., Lewis, R., Merlie, J. & Sanes, J. (1996) The eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal muscles. Mol. Cell. Neurosci., 8, 185-198.
11. Drescher, U., Kremoser, C., Handwerker, C., Loschinger, J., Noda, M. & Bonhoeffer, F. (1995) In vitro guidance of retinal ganglion cell axons by RAGS, a 25kDa tectal protein related to the ligands for Eph receptor tyrosine kinases. Cell, 82, 359-370.
12. Flenniken, A., Gale, N., Yancopoulos, G. & Wilkinson, D. (1996) Distinct and overlapping expression patterns of ligands for Eph related receptor tyrosine kinases during mouse development. Dev. Biol., 179, 382-401.
13. Friedman, G. & O'Leary, D. (1996) Eph receptor tyrosine kinases and their ligands in neural development. Curr. Opin. Neurobiol., 6, 127-133.
14. Gale, N., Flenniken, A., Compton, D., Jenkins, N., Copeland, N., Gilbert, D., Davis, S., Wilkinson, D. & Yancopoulos, G. (1996a) Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments. Oncogene, 13, 1343-1352.
15. Gale, N., Holland, S., Valenzuela, D., Flenniken, A., Pan, L., Ryan, T., Henkemeyer, M., Strebhardt, K., Hirai, H., Wilkinson, D., Pawson, T., Davis, S. & Yancopoulos, G. (1996b) Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron, 17, 9-19.
16. Gao, P., Zhang, J., Yokoyama, M., Racey, B., Dreyfus, C., Black, I. & Zhou, R. (1996) Regulation of topographic projection in the brain: elf-1 in the hippocamposeptal system. Proc. Natl Acad. Sci. USA, 93, 11161-11166.
17. Henkemeyer, M., Marengere, L., McGlade, J., Olivier, J., Conlon, R., Holmyard, D., Letwin, K.C. & Pawson, T. (1994) Immunolocalisation of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. Oncogene, 9, 1001-1014.
18. Henkemeyer, M., Orioli, D., Henderson, J., Saxton, T., Roder, J., Pawson, T. & Klein, R. (1996) Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell, 86, 35-46.
19. Hirai, H., Maru, Y., Hagiwara, K., Nishida, J. & Takaku, F. (1987) A novel putative tyrosine kinase receptor encoded by the eph gene. Science, 238, 1717-1720.
20. Holland, S., Gale, N., Mbamalu, G., Yancopoulos, G., Henkemeyer, M. & Pawson, T. (1996) Bidirectional signalling through the Eph-family receptor Nuk and its transmembrane ligands. Nature, 383, 722-725.
21. Kenny, D., Bronner-Fraser, M. & Marcelle, C. (1995) The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum. Dev. Biol., 172, 708-716.
22. Kilpatrick, T., Brown, A., Lai, C., Gassman, M., Goulding, M. & Lemke, G. (1996) Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol. Cell. Neurosci., 7, 62-74.
23. Krull, C., Lansford, R., Gale, N., Collazo, A., Marcelle, C., Yancopoulos, G., Fraser, S. & Bronner-Fraser, M. (1997) Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr. Biol., 7, 571-580.
24. Marcus, R., Gale, N., Morrison, M., Mason, C. & Yancopoulos, G. (1996) Eph family receptors and their ligands distribute in opposing gradients in the developing mouse retina. Dev. Biol., 180, 786-789.
25. Monschau, B., Kremoser, C., Ohta, K., Tanaka, H., Kaneko, T., Yamada, T., Handwerker, C., Hornberger, M., Loschinger, J., Pasquale, E., Siever, D., Verderame, M., Muller, B., Bonhoeffer, F. & Drescher, U. (1997) Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons. EMBO J., 16, 1258-1267.
26. Nakamoto, M., Cheng, H.-J., Friedman, G., McLaughlin, T., Hansen, M., Yoon, C., O'Leary, D. & Flanagan, J. (1996) Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell, 86, 755-766.
27. Nieto, M.A., Gilardi-Hebenstreit, P., Charnay, P. & Wilkinson, D.G. (1992) A receptor tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development, 116, 1137-1150.
28. Ohta, K., Nakamura, M., Hirokawa, K., Tanaka, S., Iwana, A., Suda, T., Ando, M. & Tanaka, H. (1996) The receptor tyrosine kinase, Cek 8, is transiently expressed on subtypes of motor neurons in the spinal cord during development. Mech. Dev., 54, 59-69.
29. Orioli, D., Henkemeyer, M., Lemke, G., Klein, R. & Pawson, T. (1996) Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J., 15, 6035-6049.
30. Pandey, A., Lindberg, R. & Dixit, V. (1995) Receptor orphans find a family. Curr. Biol., 5, 986-989.
31. Pasquale, E.B., Deerinck, T.J., Singer, S.J. & Ellisman, M.H. (1992) Cek5, a membrane receptor-type tyrosine kinase, is in neurons of the embryonic and postnatal avian brain. J. Neurosci., 12, 3956-3967.
32. Pasquale, E., Connor, R., Rocholl, D., Schnurch, H. & Risau, W. (1994) Cek5, a tyrosine kinase of the Eph subclass, is activated during neural retina differentiation. Dev. Biol., 163, 491-502.
33. Smith, A., Robinson, V., Patel, K. & Wilkinson, D. (1997) The EphA4 and EphBl receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr. Biol., 7, 561-570.
34. Tuzi, N. & Gullick, W. (1994) Eph, the largest known family of putative growth factor receptors. Br. J. Cancer, 69, 417-421.
35. Van der Geer, P., Hunter, T. & Lindberg, R. (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol., 10, 251-337.
36. Wang, H. & Anderson, D. (1997) Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron, 18, 383-396.
37. Winslow, J., Moran, P., Valverde, J., Shih, A., Yuan, J., Wong, S., Tsai, S., Goddard, A., Henzel, W., Hefti, F., Beck, K. & Caras, I. (1995) Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron, 14, 973-981.
38. Xu, Q., Alldus, G., Holder, N. & Wilkinson, D.G. (1995) Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development, 121, 4005-4016.
39. Xu, Q., Alldus, G., Macdonald, R., Wilkinson, D. & Holder, N. (1996) Function of the Eph-related receptor tyrosine kinase gene rtk1 is required for regional specification in the zebrafish forebrain. Nature, 381, 319-322.
40. Zhang, J.-H., Cerretti, D., Yu, T., Flanagan, J. & Zhou, R. (1996) Detection of ligands in regions anatomically connected to neurons expressing the Eph receptor Bsk: potential roles in neuron-target interaction. J. Neurosci., 16, 7182-7192.