Effects of cerebellar nuclear inactivation on the learning of a complex forelimb movement in cats

Journal of Neurophysiology

Volumn 79, Issue 5, 1998, Pages 2447-2459

  Wang, Jian Jun ^a   Shimansky, Yury ^a   Bracha, Vlastislav ^a   Bloedel, James R ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCIMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAT; CEREBELLUM NUCLEUS; DENTATE NUCLEUS; LEARNING; LIMB MOVEMENT; MENTAL PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; TASK PERFORMANCE;

EID: 0031812328     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1998.79.5.2447     Document Type: Article

References (38)

1. ANDERSEN, R. A., SNYDER, L. H., Li, C.-S., AND STRICANNE, B. Coordinate transformations in the representation of spatial information. Curr. Opin. Neurobiol. 3: 171-176, 1993.
2. BAEV, K. V., ESIPENKO, V. B., AND SHIMANSKY, Y. P. Afferent control of central pattern generators: experimental analysis of scratching in the decerebrate cat. Neuroscience 42: 237-247, 1991.
3. BAEV, K. V. AND SHIMANSKY, Y. P. Principles of organization of neural systems controlling automatic movements in animals. Prog. Neurobiol. 39: 45-112, 1992.
4. BLOEDEL, J. R. AND BRACHA, V. On the cerebellum, cutaneomuscular reflexes, movement control, and the elusive engrams of memory. Behav. Brain Res. 68: 1-44, 1995.
5. BLOEDEL, J. R., BRACHA, V., AND MILAK, M. S. Role of the cerebellar nuclei in the learning and performance of forelimb movements in the cat. In: Role of the Cerebellum and Basal Ganglia in Voluntary Movement, edited by N. Mano, I. Hamada, and M. R. DeLong. Amsterdam: Elsevier, 1993a, p. 21-31.
6. BLOEDEL, J. R., BRACHA, V., MILAK, M., AND SHIMANSKY, Y. Cerebellar contributions to the acquisition and execution of learned reflex and volitional movements. The cerebellum: from structure to control. In: Progress in Brain Research, edited by C. I. DeZeeuw. Amsterdam: Elsevier, 1997, vol. 114, p. 499-509.
7. BLOEDEL, J. R., BRACHA, V., SHIMANSKY, Y., AND MILAK, M. S. The role of the cerebellum in the acquisition of complex volitional forelimb movements. In: The Acquisition of Motor Behavior in Vertebrates, edited by J. R. Bloedel. T. J. Ebner, and S. P. Wise. Cambridge: MIT Press, 1996, p. 319-342.
8. BLOEDEL, J. R., MILAK, M. S., AND BRACHA, V. Cerebellar nuclear role in the acquisition of skilled movements: does it relate to strategy specifications? (Abstract) Eur. J. Neurosci. 6 Suppl. : 126, 1993b.
9. FLAMENT, D., ELLERMANN, J. M., KIM, S.-G., UGURBIL, K., AND EBNER, T. J. Functional magnetic resonance imaging of cerebellar activation during the learning of a visuomotor dissociation task. Hum. Brain Mapping 4: 210-226, 1996.
10. FLANAGAN, J. R. AND WING, A. M. The role of internal models in motion planning and control: evidence from grip force adjustments during movements of hand-held loads. J. Neurosci. 17: 1519-1528, 1997.
11. FRISTON, K. J., FRITH, C. D., PASSINGHAM, R. E., LIDDLE, P. F., AND FRACKOWIAK, R.S.J. Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. Proc. R. Soc. Lond. B Biol. Sci. 248: 223-228, 1992.
12. GAUTHIER, G. M., HOFFERER, J.-M., HOYT, W. F., AND STARK, L. Visual-motor adaptation. Quantitative demonstration in patients with posterior fossa involvement. Arch. Neurol. 36: 155-160, 1979.
13. GERDES, V. G. AND HAPPEE, R. The use of internal representation in fast goal-directed movements: a modeling approach. Biol. Cybern. 70: 513-524, 1994.
14. GIBSON, A. R., HORN, K. M., AND VAN KAN, P.L.E. Grasping cerebellar function. In: Insights into the Reach to Grasp Movement, edited by K. M. B. Bennett and U. Castiello. New York: Elsevier, 1994, p. 85-108.
15. GILBERT, P.F.C. AND THACH, W. T. Purkinje cell activity during motor learning. Brain Res. 128: 309-328, 1977.
16. GILMAN, S., CARR, D., AND HOLLENBERG, J. Kinematic effects of deafferentation and cerebellar ablation. Brain 99: 311-330, 1976.
17. ITO, M. Cerebellar control of the vestibulo-ocular reflex-around the flocculus hypothesis. Annu. Rev. Neurosci. 5: 275-296, 1982.
18. JUEPTNER, M., STEPHAN, K. M., FRITH, C. D., BROOKS, D. J., FRACKOWIAK, R.S.J., AND PASSINGHAM, R. E. Anatomy of motor learning. I. Frontal cortex and attention to action. J. Neurophysiol. 77: 1313-1324, 1997.
19. KOLB, F. P., IRWIN, K. B., BLOEDEL, J. R., AND BRACHA, V. Conditioned and unconditioned forelimb reflex systems in the cat: involvement of the intermediate cerebellum. Exp. Brain Res. 144: 255-270, 1997.
20. LI, J., SMITH, S. S., AND MCELLIGOTT, J. G. Cerebellar nitric oxide is necessary for vestibulo-ocular reflex adaptation, a sensorimotor model of learning. J. Neurophysiol. 74: 489-493, 1995.
21. LISBERGER, S. G., MILES, F. A., AND ZEE, D. S. Signals used to compute errors in monkey vestibuloocular reflex: possible role of flocculus. J. Neurophysiol. 52: 1140-1153, 1984.
22. MARR, D. A theory of cerebellar cortex. J. Physiol. (Lond.) 202: 437-470, 1969.
23. MARTIN, J. H. Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat. Neurosci. Lett. 127: 160-164, 1991.
24. MARTIN, T. A., KEATING, J. G., GOODKIN, H. P., BASTIAN, A. J., AND THACH, W. T. Throwing while looking through prisms. I. Focal olivocerebellar lesions impair adaptation. Brain 119: 1183-1198, 1996.
25. MILAK, M. S., BRACHA, V., AND BLOEDEL, J. R. Relationship of simultane-ously recorded cerebellar nuclear neuron discharge to the acquisition of a complex, operantly conditioned forelimb movement in cats. Exp. Brain Res. 105: 325-330, 1995.
26. MILAK, M., SHIMANSKY, Y., BRACHA, V., AND BLOEDEL, J. R. Effects of inactivating individual cerebellar nuclei on the performance and retention of a complex, operantly conditioned forelimb movement. J. Neurophysiol. 78: 939-958, 1997.
27. OJAKANGAS, C. L. AND EBNER, T. J. Purkinje cell complex and simple spike changes during a voluntary arm movement learning task in the monkey. J. Neurophysiol. 68: 2222-2236, 1992.
28. ROBINSON, D. A. Adaptive gain control of vestibuloocular reflex by the cerebellum. J Neurophysiol. 39: 954-969, 1976.
29. SEITZ, R. J., CANAVAN, A.G.M., YAGUEZ, L., HERZOG, H., TELLMANN, L., KNORR, U., HUANG, Y., AND HOMBERG, V. Successive role of the cerebellum and premotor cortices in trajectorial learning. Neuroreport 5: 2541 -2544, 1994.
30. SHIMANSKY, Y. P. Sensory information processing in a neural system for movement control. In: Neurocomputers and Attention, edited by A. V. Holden and V. I. Kryukov. Manchester: Manchester University Press, 1991, p. 647-656.
31. SHIMANSKY, Y., WANG, J.-J., BLOEDEL, J. R., AND BRACHA, V. Effects of inactivating the deep cerebellar nuclei on the learning of a complex forelimb movement. Soc. Neurosci. Abstr. 20: 21, 1994.
32. SHIMANSKY, Y., WANG, J.-J., BRACHA, V., AND BLOEDEL, J. R. Cerebellar inactivation abolishes the capability of cats to compensate for unexpected but not expected perturbations of a reach movement. Soc. Neurosci. Abstr. 21: 914, 1995.
33. SOECHTING, J. F. AND FLANDERS, M. Moving in three-dimensional space: frames of reference, vectors, and coordinate systems. Annu. Rev. Neurosci. 15: 167-191, 1992.
34. THACH, W. T. On the specific role of the cerebellum in motor learning and cognition: clues from PET activation and lesion studies in man. Behav. Brain Sci. 19: 411-431, 1996.
35. THACH, W. T., GOODKIN, H. P., AND KEATING, J. G. The cerebellum and the adaptive coordination of movement. Annu. Rev. Neurosci. 15: 403-442, 1992.
36. THOMPSON, R. F. The neurobiology of learning and memory. Science 223: 941-947, 1986.
37. WEINER, M. J., HALLETT, M., AND FUNKENSTEIN, H. H. Adaptation to lateral displacement of vision in patients with lesions of the central nervous system. Neurology 33: 766-772, 1983.
38. WOLPERT, D. M., GHAHRAMANI, Z., AND JORDAN, M. I. An internal model for sensorimotor integration. Science 269: 1880-1882, 1995.