Functional magnetic resonance imaging of cerebellar activation during the learning of a visuomotor dissociation task

Human Brain Mapping

Volumn 4, Issue 3, 1996, Pages 210-226

  Flament, Didier ^a   Ellermann, Jutta M ^a,b   Kim, Seong Gi ^a,b   Uǧurbil, Kamil ^a,b   Ebner, Timothy J ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

cerebellum; error correction; functional magnetic resonance imaging; humans; motor learning; step tracking

Indexed keywords

ADULT; ARTICLE; BRAIN MAPPING; CEREBELLUM CORTEX; DISSOCIATION; FUNCTIONAL ANATOMY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LEARNING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TASK PERFORMANCE; VISUOMOTOR COORDINATION;

EID: 0030448825     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/hbm.460040302     Document Type: Article

References (76)

1. Albus JS (1971): A theory of cerebellar function. Math Biosci 10:25-61.
2. Anderson BJ, Li X, Alcantara AA, Isaacs KR, Black JE, Greenough WT (1994): Glial hypertrophy associated with synaptogenesis following motor-skill learning, but not with angiogenesis following exercise. Glia 11:73-80.
3. Andersson G, Armstrong DM (1987): Complex spikes in Purkinje cells in the lateral vermis (b-zone) of the anterior cerebellum during locomotion. J Physiol 385:107-134.
4. Atkeson CB (1989): Learning arm kinematics and dynamics. Annu Rev Neurosci 12:157-183.
5. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS (1993): Processing strategies for time-course data sets in functional MRI of the human brain. Magn Reson Med 30:161-173.
6. Barmarck NH, Simpson JR (1980): Effects of microlesions of dorsal cap of inferior olive of rabbits on optokinetic and vestibuloocular reflexes. J Neurophysiol 43:182-206.
7. Bloedel JR (1993): "Involvement in" versus "Storage of" TINS 16:451-452.
8. Bloedel JR, Bracha V, Kelly TM, Wu J-Z (1991): Substrates for motor learning. Does the cerebellum do it all? Ann NY Acad Sci 627:305-318.
9. Bloedel JR, Bracha V, Milak MS (1993a): Progressive changes in the modulation of cerebellar nuclear neurons during the learning of a complex forelimb movement. Soc Neurosci Abstr 19:1278.
10. Bloedel JR, Bracha V, Milak MS (1993b): Role of the cerebellar nuclei in the learning and performance of forelimb movements in the cat. In Mano N, Hamada I, DeLong R (eds): Role of the Cerebellum and Basal Ganglia in Voluntary Movement. Amsterdam: Elsevier, pp 21-31.
11. Brodal P, Bjaalie JG (1992): Organization of the pontine nuclei. Neurosci Res 13:83-118.
12. Decety J, Kawashima R, Gulyas B, Roland PE (1992): Preparation for reaching: a PET study of the participating structures in the human brain. NeuroReport 3(9):761-764.
13. Dufosse M, Ito M, Jastreboff PJ, Miyashita Y (1978): A neuronal correlate in rabbit's cerebellum to adaptive modification of the vestibulo-ocular reflex. Brain Res 150:611-616.
14. Dugas C, Smith AM (1992): Responses of cerebellar Purkinje cells to slip of a hand-held object. J Neurophysiol 67:483-495.
15. Ekerot C-F, Kano M (1985): Long-term depression of parallel fibre synapses following stimulation of climbing fibers. Brain Res 342:357-360.
16. Ellermann JM, Flament D, Kim S-G, Fu Q-G, Merkle H, Ebner TJ, Ugurbil K (1994): Spatial patterns of functional activation of the cerebellum investigated using high field (4T) MRI. NMR Biomed 7:63-68.
17. Fiez JA, Petersen SE, Cheney MK, Raichle ME (1992): Impaired non-motor learning and error detection associated with cerebellar damage. Brain 115:155-178.
18. Flament D, Ellermann J, Ugurbil K, Ebner TJ (1994): Functional magnetic resonance imaging (fMRI) of cerebellar activation while learning to correct for visuo-motor errors. Soc Neurosci Abstr 20:20.
19. Friston KJ, Frith CD, Passingham RE, Liddle PF, Frackowiak RSJ (1992): Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. Proc R Soc Lond Biol 248:223-228.
20. Friston KJ, Jezzard P, Turner R (1994): Analysis of functional MRI time-series. Hum Brain Map 1:153-171.
21. Gauthier GM, Hofferer J, Hoyt WF, Stark L (1979): Visual-motor adaptation. Quantitative demonstration in patients with posterior fossa involvement. Arch Neurol 36:155-160.
22. Gilbert PFC, Thach WT (1977): Purkinje cell activity during motor learning. Brain Res 128:309-328.
23. Glickstein M (1992): The cerebellum and motor learning. Curr Opin Neurobiol 2:802-806.
24. Grafton ST, Mazziotta JC, Presty S, Friston KJ, Frackowiak RS, Phelps ME (1992): Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. J Neurosci 12:2542-2548.
25. Grafton ST, Woods RP, Tyszka M (1994): Functional imaging of procedural motor learning: relating cerebral blood flow with individual subject performance. Hum Brain Map 1:221-234
26. Haase A, Frahm J, Matthaei D, Hanicke W, Merboldt KD (1986): FLASH imaging. Rapid NMR imaging using low flip angle pulses. J Magn Reson Imag 67:258-266.
27. Haier RJ, Siegel BV, MacLachlan A, Soderling E, Lottenberg S, Buchsbaum MS (1992): Regional glucose metabolic changes after learning a complex visuospatial/motor task: a positron emission tomographic study. Brain Res 570:134-143.
28. Holmes G (1939): The cerebellum of man. Brain 62(1):1-30.
29. Hu X, Kim S-G (1994): Reduction of signal fluctuation in functional MRI using navigator echoes. Magn Reson Med 31:495-503.
30. Isaacs KR, Anderson BJ, Alcantara AA, Black JE, Greenough WT (1992): Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. J Cereb Blood Flow Metab 12:110-119.
31. Ito M (1982): Cerebellar control of the vestibulo-ocular reflex-around the flocculus hypothesis. Annu Rev Neurosci 5:275-296.
32. Ito M (1989): Long-term depression. Annu Rev Neurosci 12:85-102.
33. Ito M, Kano M (1982): Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neurosci Lett 33:253-258.
34. Ito M, Sakurai M, Tongroach P (1982): Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol (Lond) 324:113-134.
35. Jenkins IH, Brooks DJ, Nixon PD, Frackowiak RSJ, Passingham RE (1994). Motor sequence learning: a study with positron emission tomography. J Neurosci 14(6):3775-3790.
36. Kawato M, Gomi H (1993): Feedback-error-learning model of cerebellar motor control. In Mano N, Hamada I, DeLong MR (eds): Role of the Cerebellum and Basal Ganglia in Voluntary Movement. Amsterdam: Elsevier, pp 51-61.
37. Kelly TM, Zou CC, Bloedel JR (1990): Classical conditioning of the eyeblink reflex in the decerebrate-decerebellate rabbit. Behav Brain Res 38:7-18.
38. Kim JH, Wang J-J, Ebner TJ (1987): Climbing fiber afferent modulation during treadmill locomotion in the cat J Neurophysiol 57:787-802.
39. Kim S-G, Ashe J, Georgopoulos AP, Merkle H, Ellermann JM, Menon RS, Ogawa S, Ugurbil K (1993a): Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 69:297-302.
40. Kim S-G, Ashe J, Hendrich K, Ellermann JM, Merkle H, Ugurbil K, Georgopoulos AP (1993b): Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness. Science 261:615-617.
41. Kim S-G, Ugurbil K, Strick PL (1994): Activation of a cerebellar output nucleus during cognitive processing. Science 265:949-951.
42. Krupa DJ, Thompson JK, Thompson RF (1993): Localization of a memory trace in the mammalian brain. Science 260:989-991.
43. Llinas R, Welsh JP (1993): On the cerebellum and motor learning. Curr Opin Neurobiol 3:958-965.
44. Lou J-S, Bloedel JR (1992): Responses of sagittally aligned Purkinje cells during perturbed locomotion: synchronous activation of climbing fiber inputs. J Neurophysiol 68:570-580.
45. Marr D (1969): A theory of cerebellar cortex. J Physiol (Lond) 202:437-470.
46. Miles FA, Lisberger SG (1981): Plasticity in the vestibulo-ocular reflex: a new hypothesis. Annu Rev Neurosci 4:273-299.
47. Miles FA, Braitman DJ, Dow BM (1980). Long-term adaptive changes in primate vestibuloocular reflex. IV. Electrophysiological observations in flocculus of adapted monkeys. J Neurophysiol 43:1477-1493.
48. Ojakangas CL, Ebner TJ (1991): Scaling of the metrics of visually-guided arm movements during motor learning in primates. Exp Brain Res 85:314-323.
49. Ojakangas CL, Ebner TJ (1992): Purkinje cell complex and simple spike changes during a voluntary arm movement learning task in the monkey. J Neurophysiol 68:2222-2236.
50. Ojakangas CL, Ebner TJ (1994): Purkinje cell complex spike activity during voluntary motor learning: relationship to kinematics. J Neurophysiol 72:2617-2630.
51. Oldfield RC (1971): The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 9:97-113.
52. Oscarsson P (1980): Functional organization of olivary projection to the cerebellar anterior lobe. In Courville J (ed): The Inferior Olivary Nucleus: Anatomy and Physiology. New York: Raven Press, pp 279-290.
53. Pastor AM, de la Cruz RR, Baker R (1994): Cerebellar role in adaptation of the goldfish vestibuloocular reflex. J Neurophysiol 72:1383-94.
54. Robinson DA (1976): Adaptive gain control of vestibuloocular reflex by the cerebellum. J Neurophysiol 39:954-969.
55. Sanes JN, Dimitrov B, Hallett M (1990): Motor learning in patients with cerebellar dysfunction. Brain 113:103-120.
56. Sanes JN, Donoghue JP, Thangarj V, Edelman RR, Warach S (1995): Shared neuronal substrates controlling hand movements in human cortex. Science 268:1775-1777.
57. Seitz RJ, Canavan AGM, Yaguez L, Herzog H, Tellmann L, Knorr U, Huang Y, Homberg V (1994): Successive roles of the cerebellum and premotor cortices in trajectorial learning. NeuroReport 4:2541-2544.
58. Seitz RJ, Roland PE (1992): Learning of sequential finger movements in man: a combined kinematic and positron emission tomography (PET) study. Eur J Neurosci 4:154-165.
59. Seitz RJ, Roland PE, Bohm C, Greitz T, Stone-Elander S (1990): Motor learning in man: a positron emission tomographic study. NeuroReport 1:17-20.
60. Sereno MI, Dale AM, Reppas JB, Kwong KK, Belliveau JW, Brady TJ, Rosen BR, Tootell RBH (1995): Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 268:889-893.
61. Shadmehr R, Mussa-Ivaldi FA (1994): Adaptive representation of dynamics during learning of a motor task. J Neurosci 14:3208-3224.
62. Shanbhag SJ, Ebner TJ (1994): Analysis of kinematic and dynamic parameters of human motor learning. Soc Neurosci Abstr 20: 1411.
63. Snedecor GW, Cochran WG (1978): Statistical Methods. Ames, Iowa: Iowa State University Press.
64. Steinmetz JE, Sears LL, Gabriel M, Kubota Y, Poremba A, Kang E (1991): Cerebellar interpositus nucleus lesions disrupt classical nictitating membrane conditioning but not discriminative avoidance learning in rabbits. Behav Brain Res 45:71-80.
65. Steinmetz JE, Lavond DG, Ivkovich D, Logan CG, Thompson RF (1992): Disruption of classical eyelid conditioning after cerebellar lesions: damage to a memory trace system or a simple performance deficit? J Neurosci 12:4403-4426.
66. Stone LS, Lisberger SG (1990): Visual responses of Purkinje cells in the cerebellar flocculus during smooth-pursuit eye movements in monkeys. II. Complex spikes. J Neurophysiol 63:1262-1275.
67. Thach WT, Goodkin HP, Keating JG (1992): The cerebellum and the adaptive coordination of movement. Annu Rev Neurosci 15:403-442.
68. Thompson RF (1986): The neurobiology of learning and memory. Science 233:941-947.
69. Thompson RF (1991): Are memory traces localized or distributed? Neuropsychologia 29:571-582.
70. Tootell RBH, Reppas JB, Kwong KK, Malach R, Born RT, Brady TJ, Rosen BR, Belliveau JW (1995): Functional analysis of human MT and related visual cortical areas using magnetic resonance imaging. J Neurosci 15:3215.
71. Topka H, Valls-Sole J, Massaquoi SG, Hallett M (1993): Deficit in classical conditioning in patients with cerebellar degeneration. Brain 116:961-969.
72. Wang J-J, Kim JH, Ebner TJ (1987): Climbing fiber afferent modulation during a visually guided, multi-joint arm movement in the monkey. Brain Res 410:323-329.
73. Weiner MJ, Hallett M, Funkenstein HH (1983): Adaptation to lateral displacement of vision in patients with lesions of the central nervous system. Neurology 33:766-772.
74. Welsh JP, Harvey JA (1989): Cerebellar lesions and the nictitating membrane reflex: performance deficits of the conditioned and unconditioned response. J Neurosci 9:299-311.
75. Yeo CH, Hardiman MJ, Glickstein M (1985): Classical conditioning of the nictitating membrane response of the rabbit: I. Lesions of the cerebellar nuclei. Exp Brain Res 60:87-98.
76. Yeo CH, Hardiman MJ, Glickstein M (1986): Classical conditioning of the nictitating membrane response of the rabbit. IV. Lesions of the inferior olive. Exp Brain Res 63:81-92.