Effect of PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on growth and differentiation of the HEL cell line

Haematologica

Volumn 83, Issue 5, 1998, Pages 385-391

  Catani, Lucia ^a,b   Gugliotta, Luigi ^a   Motta, Mariarosa ^a   Tazzari, Pierluigi ^b   Baravelli, Stefano ^a   Tura, Sante ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

HEL cell line; Maturation; PEG rHuMGDF; Proliferation; Thrombopoietin

Indexed keywords

MACROGOL; RECOMBINANT MEGAKARYOCYTE GROWTH AND DEVELOPMENT FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ERYTHROLEUKEMIA CELL; FLOW CYTOMETRY; GROWTH REGULATION; HUMAN; HUMAN CELL; MEGAKARYOPOIESIS; PLOIDY;

CELL DIFFERENTIATION; CELL DIVISION; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; THROMBOPOIETIN; TUMOR CELLS, CULTURED;

EID: 0031808773     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Gewirtz AM. Human megakaryocytopoiesis. Semin Hematol 1986; 23:27-32.
2. Mazur EM. Human megakaryocytopoiesis and platelet production: a review. Exp Hematol 1987; 15:340-50.
3. Hoffman R. Regulation of megakaryocytopoiesis. Blood 1989; 74:1196-212.
4. Zauli G, Catani L. Human megakaryocyte biology and pathophysiology. Crit Rev Oncol Hematol 1995; 21: 135-57.
5. Debili N, Hegyi E, Navarro S, et al. In vitro effects of hematopoietic growth factors on the proliferation, endoreduplication and maturation of human megakaryocytes. Blood 1991; 77:2326-32.
6. Gordon MS, Hoffman R. Growth factors affecting human thrombopoiesis: potential agents for the treatment of thrombocytopenia. Blood 1992; 80:302-7.
7. Kaushansky K. Thrombopoietin: the primary regulator of platelet production. Blood 1995; 86:419-31.
8. Kaushansky K. Thrombopoietin: in vitro predictions, in vivo realities. Am J Hematol 1996; 53:188-91.
9. De Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis by the c-mpl ligand. Nature 1994; 369:533-8.
10. Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 1994; 369:565-8.
11. Kaushansky K, Lok S, Holly RD, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 1994; 369:568-71.
12. Wendling F, Maraskowsky E, Debili N, et al. c-mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369:571-4.
13. Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 1994; 77:1117-24.
14. Soury M, Vigon I, Penciolelli JF, Heard J-M, Tambourin P, Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990; 63:1137-47.
15. Keleman E. Specific thrombopoietin cloned and sequenced - with personal retrospect and clinical prospects. Leukemia 1995; 9:1-2.
16. Suzukawa K, Satoh H, Taniwaki M, Yokota J, Morishita K. The human thrombopoietin gene is located on chromosome 3q26.33-q27, but is not transcriptionally activated in leukemia cells with 3q21 and 3q26 abnormalities (3q2126 syndrome). Leukemia 1995; 9:1328-31.
17. Debili N, Wendling F, Cosman D, et al. The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 1995; 85:391-401.
18. Drexler HG, Quentemeier H. Thrombopoietin: expression of its receptor Mpl and proliferative effects on leukemic cells. Leukemia 1996; 10:1405-21.
19. Choi ES, Nichol JL, Hokom MM, Xornkohl AC, Hunt P. Platelets generated in vitro from pro-platelet displaying human megakaryocytes are functional. Blood 1995; 85:402-13.
20. Farese AM, Hunt P, Boone T, Mac Vittie TJ. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal human primates. Blood 1995; 86:54-63.
21. Basser RL, Rasko JEJ, Clarke K, et al. Thrombopoietic effects of pegylated recombinant human MGDF (PEG-rHuMGDF) in patients with advanced cancer. Lancet 1996; 348:1279-81.
22. Martin P, Papayannopoulou T. HEL cells: a new erythroleukemia cell line with spontaneous and induced globin expression. Science 1982; 216:1233-5.
23. Ogura M, Morishima Y, Ohno R, et al. Establishment of a novel human megakaryoblastic leukemia cell line, Meg-01, with positive Philadelphia chromosome. Blood 1985; 66:1384-92.
24. Sato T, Fuse A, Eguchi M. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia. Br J Haematol 1989; 72:184-90.
25. Greenberg SM, Rosenthal DS, Greeley TA, Tantravahi R, Handin RI. Characterization of a new megakaryocyte cell line: the Dami cell. Blood 1988; 72:1968-77.
26. Avanzi G, Lista P, Giovinazzo B, et al. Selective growth response to IL-3 of a human cell line with megakaryoblastic features. Br J Haematol 1988; 69:359-66.
27. Fugman DA, Witte DP, Jones CLA, Aronow BJ, Lieberman MA. In vitro establishment and characterization of a human megakaryoblastic cell line. Blood 1990; 75:1252-8.
28. Mouthon M, Freund M, Titeux M, et al. Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis. Blood 1994; 84:1085-91.
29. Aster RH. Platelet specific alloantigen systems: hystory, clinical significance and molecular biology. In: Alloimmunity and beyond. Ed. Nance ST. 89, 1993. p. 203-9.
30. Komatsu N, Kunitama M, Yamada M, et al. Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. Blood 1996; 87:4552-60.
31. Tabilio A, Rosa JP, Testa U, et al. Expression of platelet membrane glycoproteins and α-granule proteins by a human erythroleukemia cell line (HEL). EMBO J 1984; 3:453-9.
32. Quentemeier H, Zaborski M, Graf G, Ludwig WD, Drexler HG. Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells. Leukemia 1996; 10:297-310.
33. Drexler HG, Zaborski M, Quentemeier H. Thrombopoietin supports the continuous growth of cytokine-dependent human leukemia cell lines. Leukemia 1997; 11:541-51.
34. Zauli G, Bassini A, Viatale M, et al. Thrombopoietin enhances the allb3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI3 kinase. Blood 1997; 89:883-95.
35. Bonsi L, Grossi A, Strippoli P, et al. An erythroid and megakaryocytic common precursor cell line (B1647) expressing both c-mpl and erythropoietin receptor (Epo-R) proliferates and modifies globin chain synthesis in response to megakaryocyte growth and development factor (MGDF) but not to erythropoietin (Epo). Br J Haematol 1997; 98:549-59.
36. Nagahisa H, Nagata Y, Ohnuki T, et al. Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 1996; 87:1309-16.
37. Ito T, Ishida Y, Kashiwagi R, Kuriya S. Recombinant human C-Mpl ligand is not a direct stimulator of proplatelet formation in mature human megakaryocytes. Br J Haematol 1996; 94:387-90.
38. Carlo-Stella C, Tabilio A. Stem cells and stem cell transplantation. Haematologica 1996; 81:573-87.