Thrombopoietin enhances the α(IIb)β3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase

Blood

Volumn 89, Issue 3, 1997, Pages 883-895

  Zauli, Giorgio ^a   Bassini, Alessandra ^b   Vitale, Marco ^b   Gibellini, Davide ^b   Celeghini, Claudio ^b   Caramelli, Elisabetta ^b   Pierpaoli, Sabina ^b   Guidotti, Lia ^b   Capitani, Silvano ^b  

^a Dept of Morphology and Embryology   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FIBRINOGEN; FIBRONECTIN; ISOTHIOCYANIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; THROMBOPOIETIN; WORTMANNIN;

ARTICLE; ENZYME MECHANISM; FIBRINOGEN METABOLISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE ADHERENCE; IMMUNOREACTIVITY; MEGAKARYOPOIESIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ANALYSIS;

EID: 0030952228     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.3.883     Document Type: Article

References (60)

1. Zauli G, Catani L: Human megakaryocyte biology and pathophysiology. Crit Rev Oncol Hematol 21:135, 1995
2. Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendling F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
3. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Solberg LA Jr, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
4. Lok S, Kaushansky K, Holly R, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Mathewes SL, Balley MC, Forstrom JW, Buddle MM, Osborn SG, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
5. Kaushansky K, Lok S, Holly R, Broudy VC, Lin N, Balley MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayoannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
6. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorious J, Cosman D, Vainchenker W: c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
7. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samai B, Nichol JL, Swift S, Johnson MJ, Hsu RY, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Del Castillo J, Biron J, Cole S, Hu CT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
8. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
9. Hunt P, Li Y-S, Nichol JL, Hokom MM, Bogenberger JM, Swift SE, Skrine JD, Hornkohl AC, Lu H, Clogston C, Merewether LA, Johnson MJ, Parker V, Knudten A, Farese A, Hsu RY, Garcia A, Stead R, Bosselman RA, Bartley TD: Purification and biologic characterization of plasma-derived megakaryocyte growth and developmental factor. Blood 86:540, 1995
10. Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C: Thrombopoietin, the Mpl ligand, is essential for full megakaryocyte development. Proc Natl Acad Sci USA 92:3234, 1995
11. Debili N, Wendling F, Cosman D, Titeux M, Florindo C, Dusanter-Fourt I, Schooley K, Methia N, Charon M, Nador R, Bettaieb A, Vainchenker W: The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets. Blood 85:391, 1995
12. Banu N, Wang JF, Deng B, Groopman JE, Avraham H: Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 86:1331, 1995
13. Guerriero R, Testa U, Gabbianelli M, Mattia E, Montesoro E, Macioce G, Pace A, Ziegler B, Hassan HJ, Peschle C: Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid culture. Blood 86:3823, 1995
14. Gurney AL, Caver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl deficient mice. Science 265:1445, 1994
15. Chen J, Herceg-Hariacek L, Groopman JE, Grabarek J: Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 86:4054, 1995
16. Philips DR, Charo IF, Parise LV, Fitzgerald LA: The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831, 1988
17. + cells are enriched for multipotent hematopoietic progenitors, but not for pluripotent stem cells. Exp Hematol 24:236, 1996
18. + bone marrow cells) are enriched with megakaryocytes expressing CD4. Blood 87:1353, 1996
19. Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIbIIIa complex during platelet activation. J Biol Chem 260:11107, 1985
20. Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH: Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 270:11358, 1995
21. Handagama P, Scarborough RM, Shuman MA, Bainton DF: Endocytosis of fibrinogen into megakaryocytes and alpha-granules is mediated by alpha IIb (glycoprotein IIb-IIIa). Blood 82:135, 1993
22. Martin P, Papayannopoulou T. HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression. Science 216:1233, 1982
23. Long MW, Heffner CH, Williams JL, Peters C, Prochownik EV: Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest 85:1072, 1990
24. Namciu S, Lieberman MA, Stavnezer E: Induction of the cski proto-oncogene by phorbol ester correlates with induction of megakaryocyte differentiation. Oncogene 9:1407, 1994
25. Zauli G, Bassini A, Catani L, Gibellini D, Celeghini C, Borgatti P, Caramelli E, Guidotti L, Capitani S: PMA-induced megakaryocytic differentiation of HEL cells is accompanied by striking modifications of protein kinase C catalytic activity and isoform composition at the nuclear level. Br J Haematol 92:530, 1996
26. Salgado F, Fischer E, Kikly K, Pelus LM, Erickson-Miller C: Megakaryocytic differentiation of M-07e and HEL cell lines but not of K562 or UT7-Epo cell lines induced by thrombopoietin. Blood 86:366a, 1995 (abstr, suppl. 1)
27. Powis G, Bonjouklian R, Bergren MM, Gallegos A, Abraham R, Ashendel C, Zalkow L, Matter WF, Dodge J, Grindey G, Vlahos CJ: Wortmannin, a potent and selective inhibitor of phosphatidylinositol 3-kinase. Cancer Res 54:2419, 1994
28. Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen S-C, Zon G, Gewirtz AM, Perussia B, Calabretta B: Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. Blood 86:726, 1995
29. + hematopoietic progenitor cells by HIV-1 or gp120 is mediated by endogenous TGF-β1. J Exp Med 183:99, 1996
30. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC: PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167, 1989
31. Ginsberg MH, Forsyth J, Lightsey A, Chediak J, Plow EF: Reduced surface expression and binding of fibronectin by thrombinstimulated thrombasthenic platelets. J Clin Invest 71:619, 1983
32. Zhang Z, Vuori K, Reed JC, Ruoslahti E: The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 92:6161, 1995
33. Guinebault C, Payrastre B, Racaud-Sultan C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H: Integrin-dependent translocation of phosphoinosidite 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J Cell Biol 129:831, 1995
34. Rodriguez-Linares B, Watson SP: Thrombopoietin potentiates activation of human platelets in association with JAK2 and TYK2 phosphorylation. Biochem J 316:93, 1996
35. Clark EA, Brugge JS: Integrins and signal transduction pathways: The road taken. Science 268:233, 1995
36. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH: Integrin cytoplasmic domains mediated inside-out signal transduction. J Cell Biol 124:1047, 1994
37. Verfaillie CM, McCarthy JB, McGlave PB: Differentiation of promitive human multipotent hematopoietic progenitors into single lineage clonogenic progenitors is accompanied by alterations in their interaction with fibronectin. J Exp Med 174:693, 1991
38. + cells to fibronectin in an activation-dependent way. Blood 81:344, 1993
39. Yamada KM, Miyamoto S: Integrin transmembrane signaling and cytoskeletal control. Curr Biol 7:681, 1995
40. Panayotou G, Waterfield MD: Phosphatidyl-inositol 3-kinase: A key enzyme in diverse signalling processes. Tr Cell Biol 2:358, 1992
41. Nakanishi H, Brewer KA, Exton JH: Activation of the ζ isoenzyme of protein kinase C by phosphatidylinositol 3, 4, 5-tris-phosphate. J Biol Chem 268:13, 1993
42. Weng Q-P, Andrabi K, Klippel A, Kozlowski MT, Williams LT: Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation. Proc Natl Acad Sci USA 92:5744, 1995
43. Hong Y, Martin JF, Vainchenker W, Erusalimsky JD: Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells. Blood 87:123, 1996
44. 3-dependent adhesion of human erythroleukemic cells to activation-dependent monoclonal antibodies. Blood 87:968, 1996
45. 3 in a lymphocyte expression system. J Biol Chem 270:18631, 1995
46. Woscholski R, Dhand R, Fry MJ, Waterfield MD, Parker PJ: Biochemical characterization of the free catalytic p110a and the complexed heterodimeric p110-p85 forms of the mammalian phosphatidylinositol 3-kinase. J Biol Chem 269:25067, 1994
47. Kim H-H, Sierke SL, Koland JG: Epidermal growth factor-dependent association of phosphatidylinositol 3-kinase with the erbB3 gene product. J Biol Chem 269:24747, 1994
48. Sung CK, Sanchez-Margalet V, Goldfine ID: Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule kinking the insulin receptor, p62, and GTPase-activating protein. J Biol Chem 269:12503, 1994
49. Coughlin SR, Escobedo JA, Williams LT: Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243:1191, 1989
50. Kapeller R, Prasad KVS, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC: Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. J Biol Chem 269:1927, 1994
51. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902, 1994
52. Roche S, Koegl M, Courtneidge SA: The phosphatidylinositol 3-kinase a is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci USA 91:9185, 1994
53. Rottapel R, Reedijk M, Williams DE, Lyman SD, Anderson DM, Pawson T, Bernstein A: The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signalling proteins is induced by the Steel factor. Mol Cell Biol 11:3043, 1991
54. Damen JE, Mui AL-F, Puil L, Pawson T, Krystal G: Phosphatidylinositol 3-kinase associates, via its Src homology 2 domains with the activated erythropoietin receptor. Blood 81:3204, 1993
55. Redijk M, Liu X, Pawson T: Interactions of phosphortidylinositol kinase, GTPase-activity protein (GAP), and GAP-associated proteins with the colony-stimulating factor receptor. Mol Cell Biol 10:5601, 1990
56. Corey S, Equinoa A, Puyana-Theall K, Bolen JB, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR: Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and Src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 12:2681, 1993
57. Shimizu Y, Mobley JL, Finkelstein LD, Chan ASH: A role for phosphatidylinositol 3-kinase in the regulation of β1 integrin activity by the CD2 antigen. J Cell Biol 131:1867, 1995
58. Drachman JG, Griffin JD, Kaushansky K: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979, 1995
59. Dexter TM: Haemopoiesis in long-term bone-marrow cultures. A review. Acta Haematol 62:299, 1979
60. Zuckerman KS, Wicha MS: Extracellular matrix production by the adherent cells of long term murine bone marrow cultures. Blood 61:540, 1983