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Volumn 39, Issue 6, 1998, Pages 599-606

Pathogenesis of immunogenic hyperthyroidism and endocrine orbitopathy;Pathogenese der immunogenen hyperthyreose und endokrinen orbitopathie

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL ADHESION MOLECULE; CYTOKINE; HLA DR ANTIGEN; THYROTROPIN RECEPTOR;

EID: 0031806481     PISSN: 00209554     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001080050219     Document Type: Review
Times cited : (10)

References (70)
  • 3
    • 0028088933 scopus 로고
    • A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy
    • Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994) A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 78:256-260
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 256-260
    • Bahn, R.S.1    Dutton, C.M.2    Heufelder, A.E.3    Sarkar, G.4
  • 4
    • 0024436440 scopus 로고
    • Presence of antibodies in the sera of patients with Graves' disease recognizing a 23 kDa fibroblast protein
    • Bahn RS, Gorman CA, Johnson CM, Smith TJ (1989) Presence of antibodies in the sera of patients with Graves' disease recognizing a 23 kDa fibroblast protein. J Clin Endocrinol Metab 69:622-628
    • (1989) J Clin Endocrinol Metab , vol.69 , pp. 622-628
    • Bahn, R.S.1    Gorman, C.A.2    Johnson, C.M.3    Smith, T.J.4
  • 5
    • 0027365837 scopus 로고
    • Mechanisms of disease: Pathogenesis of Graves'ophthalmopathy
    • Bahn RS, Heufelder AE (1993) Mechanisms of disease: Pathogenesis of Graves'ophthalmopathy. N Engl J Med 329:1468-1475
    • (1993) N Engl J Med , vol.329 , pp. 1468-1475
    • Bahn, R.S.1    Heufelder, A.E.2
  • 6
    • 0027749580 scopus 로고
    • Graves' ophthalmopathy: Current concepts regarding pathogenesis and management
    • Burch HB, Wartofsky L (1993) Graves' ophthalmopathy: current concepts regarding pathogenesis and management. Endocr Rev 14:747-793
    • (1993) Endocr Rev , vol.14 , pp. 747-793
    • Burch, H.B.1    Wartofsky, L.2
  • 7
    • 0022039971 scopus 로고
    • Immune mechanisms in Graves'disease
    • Burman KD, Baker JR (1985) Immune mechanisms in Graves'disease. Endocr Rev 6:183-232
    • (1985) Endocr Rev , vol.6 , pp. 183-232
    • Burman, K.D.1    Baker, J.R.2
  • 10
    • 7144228024 scopus 로고
    • A genomic TSH receptor point mutation is highly associated with autoimmune thyroid disease in females
    • Cuddihy RM, Dutton CM, Bahn RS (1994) A genomic TSH receptor point mutation is highly associated with autoimmune thyroid disease in females. Thyroid 4: S-26
    • (1994) Thyroid , vol.4
    • Cuddihy, R.M.1    Dutton, C.M.2    Bahn, R.S.3
  • 11
    • 7144253198 scopus 로고    scopus 로고
    • Human hyaluronan synthetase gene expression in retroorbital fibroblasts from patients with Graves'ophthalmopathy
    • Cuddihy RM, Dutton CM, Spicer AP, McDonald JA, Bahn RS (1997) Human hyaluronan synthetase gene expression in retroorbital fibroblasts from patients with Graves'ophthalmopathy. Thyroid 7 [Suppl 1]: S1-11
    • (1997) Thyroid , vol.7 , Issue.1 SUPPL.
    • Cuddihy, R.M.1    Dutton, C.M.2    Spicer, A.P.3    McDonald, J.A.4    Bahn, R.S.5
  • 12
    • 0025779157 scopus 로고
    • Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease
    • Davies TF, Martin A, Concepcion ES, Graves P, Cohen L, Ben-Nun A (1991) Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med 325:238-244
    • (1991) N Engl J Med , vol.325 , pp. 238-244
    • Davies, T.F.1    Martin, A.2    Concepcion, E.S.3    Graves, P.4    Cohen, L.5    Ben-Nun, A.6
  • 13
    • 0024332927 scopus 로고
    • The causes of autoimmune thyroid disease
    • DeGroot LJ, Quintans J (1989) The causes of autoimmune thyroid disease. Endocr Rev 10:537-562
    • (1989) Endocr Rev , vol.10 , pp. 537-562
    • Degroot, L.J.1    Quintans, J.2
  • 14
    • 7144229436 scopus 로고    scopus 로고
    • Thyrotropin receptor is expressed in Graves'orbital connective tissue specimens, but is lost in late-passage orbital fibroblasts
    • Dutton CM, Joba W, Spitzweg C, Heufelder AE, Bahn RS (1997) Thyrotropin receptor is expressed in Graves'orbital connective tissue specimens, but is lost in late-passage orbital fibroblasts. Thyroid 7 [Suppl 1]: S1-105
    • (1997) Thyroid , vol.7 , Issue.1 SUPPL.
    • Dutton, C.M.1    Joba, W.2    Spitzweg, C.3    Heufelder, A.E.4    Bahn, R.S.5
  • 16
    • 0026984740 scopus 로고
    • Heterogenous responses of recombinant human thyrotropin receptor to immunoglobulins from patients with Graves' disease
    • Endo T, Ohmori M, Ikeda M, Anzai E, Onaya T (1992) Heterogenous responses of recombinant human thyrotropin receptor to immunoglobulins from patients with Graves' disease. Biochem Biophys Res Commun 186:1391-1396
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 1391-1396
    • Endo, T.1    Ohmori, M.2    Ikeda, M.3    Anzai, E.4    Onaya, T.5
  • 19
    • 0025876149 scopus 로고
    • A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism
    • Heldin N-E, Gustavsson B, Westermark K, Westermark B (1991) A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. J Clin Endocrinol Metab 73:1374-1376
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1374-1376
    • Heldin, N.-E.1    Gustavsson, B.2    Westermark, K.3    Westermark, B.4
  • 20
    • 0029923832 scopus 로고    scopus 로고
    • Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis, and nonautoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR)
    • Heuer M, Aust G, Ode-Hakim S, Scherbaum WA (1997) Different cytokine mRNA profiles in Graves' disease, Hashimoto's thyroiditis, and nonautoimmune thyroid disorders determined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR). Thyroid 6:97-106
    • (1997) Thyroid , vol.6 , pp. 97-106
    • Heuer, M.1    Aust, G.2    Ode-Hakim, S.3    Scherbaum, W.A.4
  • 21
    • 0029156401 scopus 로고
    • Involvement of the orbital fibroblast and TSH receptor in the pathogenesis of Graves' ophthalmopathy
    • Heufelder AE (1995) Involvement of the orbital fibroblast and TSH receptor in the pathogenesis of Graves' ophthalmopathy. Thyroid 5:331-340
    • (1995) Thyroid , vol.5 , pp. 331-340
    • Heufelder, A.E.1
  • 23
    • 0026469859 scopus 로고
    • Evidence for the presence of a functional TSH-receptor in retroocular fibroblasts from patients with Graves'ophthalmopathy
    • Heufelder AE, Bahn RS (1992) Evidence for the presence of a functional TSH-receptor in retroocular fibroblasts from patients with Graves'ophthalmopathy. Exp Clin Endocrino 100:62-67
    • (1992) Exp Clin Endocrino , vol.100 , pp. 62-67
    • Heufelder, A.E.1    Bahn, R.S.2
  • 24
    • 0026663136 scopus 로고
    • Modulation of intercellular adhesion molecule-1 (ICAM-1) by cytokines and Graves' IgGs in cultured Graves' retroocular fibroblasts
    • Heufelder AE, Bahn RS (1992) Modulation of intercellular adhesion molecule-1 (ICAM-1) by cytokines and Graves' IgGs in cultured Graves' retroocular fibroblasts. Eur J Clin Invest 22:529-537
    • (1992) Eur J Clin Invest , vol.22 , pp. 529-537
    • Heufelder, A.E.1    Bahn, R.S.2
  • 25
    • 0027459740 scopus 로고
    • Detection and localization of cytokine immunoreactivity in retroocular connective tissue in Graves' ophthalmopathy
    • Heufelder AE, Bahn RS (1993) Detection and localization of cytokine immunoreactivity in retroocular connective tissue in Graves' ophthalmopathy. Eur J Clin Invest 23:10-17
    • (1993) Eur J Clin Invest , vol.23 , pp. 10-17
    • Heufelder, A.E.1    Bahn, R.S.2
  • 26
    • 0027458622 scopus 로고
    • Elevated expression in situ of selectin and immunoglobulin superfamily adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy
    • Heufelder AE, Bahn RS (1993) Elevated expression in situ of selectin and immunoglobulin superfamily adhesion molecules in retroocular connective tissues from patients with Graves' ophthalmopathy. Clin Exp Immunol 91:381-389
    • (1993) Clin Exp Immunol , vol.91 , pp. 381-389
    • Heufelder, A.E.1    Bahn, R.S.2
  • 27
    • 0027193635 scopus 로고
    • Soluble intercellular adhesion molecule-1 (sICAM-1) in sera of patients with Graves' ophthalmopathy and thyroid diseases
    • Heufelder AE, Bahn RS (1993) Soluble intercellular adhesion molecule-1 (sICAM-1) in sera of patients with Graves' ophthalmopathy and thyroid diseases. Clin Exp Immunol 92:296-302
    • (1993) Clin Exp Immunol , vol.92 , pp. 296-302
    • Heufelder, A.E.1    Bahn, R.S.2
  • 28
    • 0029100637 scopus 로고
    • Analysis of T-cell antigen receptor variable region gene usage in patients with thyroid-related pretibial dermopathy
    • Heufelder AE, Bahn RS, Scriba PC (1995) Analysis of T-cell antigen receptor variable region gene usage in patients with thyroid-related pretibial dermopathy. J Invest Dermatol 105:372-378
    • (1995) J Invest Dermatol , vol.105 , pp. 372-378
    • Heufelder, A.E.1    Bahn, R.S.2    Scriba, P.C.3
  • 29
    • 0027722302 scopus 로고
    • Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy
    • Heufelder AE, Dutton CM, Sarkar G, Donovan KA, Bahn RS (1993) Detection of TSH receptor RNA in cultured fibroblasts from patients with Graves' ophthalmopathy and pretibial dermopathy. Thyroid 3:297-300
    • (1993) Thyroid , vol.3 , pp. 297-300
    • Heufelder, A.E.1    Dutton, C.M.2    Sarkar, G.3    Donovan, K.A.4    Bahn, R.S.5
  • 30
    • 0028913719 scopus 로고
    • Analysis of retroorbital T cell antigen receptor variable region gene usage in patients with Graves' ophthalmopathy
    • Heufelder AE, Herterich S, Ernst G, Bahn RS, Scriba PC (1995) Analysis of retroorbital T cell antigen receptor variable region gene usage in patients with Graves' ophthalmopathy. Eur J Endocrinol 132:266-277
    • (1995) Eur J Endocrinol , vol.132 , pp. 266-277
    • Heufelder, A.E.1    Herterich, S.2    Ernst, G.3    Bahn, R.S.4    Scriba, P.C.5
  • 31
    • 0030025044 scopus 로고    scopus 로고
    • Characterization of adhesion receptors on cultured microvascular endothelial cells derived from the retroorbital connective tissue of patients with Graves' ophthalmopathy
    • Heufelder AE, Scriba PC (1996) Characterization of adhesion receptors on cultured microvascular endothelial cells derived from the retroorbital connective tissue of patients with Graves' ophthalmopathy. Eur J Endocrinol 134:51-60
    • (1996) Eur J Endocrinol , vol.134 , pp. 51-60
    • Heufelder, A.E.1    Scriba, P.C.2
  • 32
    • 0029798821 scopus 로고    scopus 로고
    • Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease
    • Heufelder AE, Wenzel BE, Scriba PC (1996) Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease. J Clin Endocrinol Metab 81:3733-3739
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3733-3739
    • Heufelder, A.E.1    Wenzel, B.E.2    Scriba, P.C.3
  • 33
    • 0030877209 scopus 로고    scopus 로고
    • Regulation of intercellular adhesion molecule-1 expression in human thyroid cells in vitro and human thyroid tissue transplanted to the nude mouse in vivo: Role of Graves'immunoglobulins and human TSH receptor
    • Hörmann R, Spitzweg C, Poertl S, Mann K, Heufelder AE, Schumm-Draeger PM (1997) Regulation of intercellular adhesion molecule-1 expression in human thyroid cells in vitro and human thyroid tissue transplanted to the nude mouse in vivo: Role of Graves'immunoglobulins and human TSH receptor. J Clin Endocrinol Metab 82:2048-2055
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2048-2055
    • Hörmann, R.1    Spitzweg, C.2    Poertl, S.3    Mann, K.4    Heufelder, A.E.5    Schumm-Draeger, P.M.6
  • 34
    • 0030811018 scopus 로고    scopus 로고
    • Soluble interleukin-1 receptor antagonist serum levels in smokers and nonsmokers with Graves' ophthalmopathy undergoing orbital radiotherapy
    • Hofbauer LC, Mühlberg T, König A, Heufelder G, Schworm H-D, Heufelder AE (1997) Soluble interleukin-1 receptor antagonist serum levels in smokers and nonsmokers with Graves' ophthalmopathy undergoing orbital radiotherapy. J Clin Endocrinol Metab 82:2244-2247
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2244-2247
    • Hofbauer, L.C.1    Mühlberg, T.2    König, A.3    Heufelder, G.4    Schworm, H.-D.5    Heufelder, A.E.6
  • 35
    • 0028847909 scopus 로고
    • Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain
    • Hunt N, Willey KP, Abend N, Balvers M, Jähner D, Northemann W, Ivell R (1995) Novel splicing variants of the human thyrotropin receptor encode truncated polypeptides without a membrane-spanning domain. Endocrine 3:233-240
    • (1995) Endocrine , vol.3 , pp. 233-240
    • Hunt, N.1    Kp, W.2    Abend, N.3    Balvers, M.4    Jähner, D.5    Northemann, W.6    Ivell, R.7
  • 37
    • 4244211910 scopus 로고    scopus 로고
    • Expression and regulation of hyaluronan synthase (HS) mRNAs in primary human fibroblasts: Potential insights into diseases of the thyroid
    • Kaback LA, Smith TJ (1997) Expression and regulation of hyaluronan synthase (HS) mRNAs in primary human fibroblasts: potential insights into diseases of the thyroid. Thyroid 7 [Suppl 1]:S1-10
    • (1997) Thyroid , vol.7 , Issue.1 SUPPL.
    • Kaback, L.A.1    Smith, T.J.2
  • 38
    • 0022489986 scopus 로고
    • The lack of specifity of ophthalmic immunglobulins in Graves' disease
    • Kadlubowski M, Irvine MJ, Rowland AC (1986) The lack of specifity of ophthalmic immunglobulins in Graves' disease. J Clin Endocrinol Metab 63:990-995
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 990-995
    • Kadlubowski, M.1    Irvine, M.J.2    Rowland, A.C.3
  • 39
    • 1842404766 scopus 로고    scopus 로고
    • Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves'disease
    • Kallmann BA, Hüther M, Tubes M, Feldkamp J, Bertrams J, Gries FA, Lampeter EF, Kolb H (1997) Systemic bias of cytokine production toward cell-mediated immune regulation in IDDM and toward humoral immunity in Graves'disease. Diabetes 46:237-243
    • (1997) Diabetes , vol.46 , pp. 237-243
    • Kallmann, B.A.1    Hüther, M.2    Tubes, M.3    Feldkamp, J.4    Bertrams, J.5    Gries, F.A.6    Lampeter, E.F.7    Kolb, H.8
  • 40
    • 0025824725 scopus 로고
    • A 64 kDa membrane antigen is a recurrent epitope for natural antibodies in patients with Graves'thyroid and ophthalmic abnormalities
    • Kendler DL, Rootman J, Huber GK, Davies TF (1991) A 64 kDa membrane antigen is a recurrent epitope for natural antibodies in patients with Graves'thyroid and ophthalmic abnormalities. Clin Endocrinol 35:539-547
    • (1991) Clin Endocrinol , vol.35 , pp. 539-547
    • Kendler, D.L.1    Rootman, J.2    Huber, G.K.3    Davies, T.F.4
  • 41
    • 0026522437 scopus 로고
    • Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: These determinants have no homologous sequence on gonadotropin receptors
    • Kosugi S, Ban T, Akamizu T, Kohn LD (1992) Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid-stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxedema: these determinants have no homologous sequence on gonadotropin receptors. Mol Endocrinol 6:168-180
    • (1992) Mol Endocrinol , vol.6 , pp. 168-180
    • Kosugi, S.1    Ban, T.2    Akamizu, T.3    Kohn, L.D.4
  • 42
    • 0027532027 scopus 로고
    • Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor
    • Kosugi S, Ban T, Kohn L (1993) Identification of thyroid-stimulating antibody-specific interaction sites in the N-terminal region of the thyrotropin receptor. Mol Endocrinol 7:114-130
    • (1993) Mol Endocrinol , vol.7 , pp. 114-130
    • Kosugi, S.1    Ban, T.2    Kohn, L.3
  • 43
    • 0030816688 scopus 로고    scopus 로고
    • A CTLA-4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism
    • Kotsa K, Watson PF, Weetman AP (1997) A CTLA-4 gene polymorphism is associated with both Graves' disease and autoimmune hypothyroidism. Clin Endorinol 46:551-554
    • (1997) Clin Endorinol , vol.46 , pp. 551-554
    • Kotsa, K.1    Watson, P.F.2    Weetman, A.P.3
  • 44
    • 0029186816 scopus 로고    scopus 로고
    • Circulating intercellular adhesion molecule-1 (ICAM-1) in sera of patients with Graves' disease and Hashimoto disease
    • Lee JH, An MA, Jeon JS, Song CU, Shong M, Kim YK, Ro HK (1997) Circulating intercellular adhesion molecule-1 (ICAM-1) in sera of patients with Graves' disease and Hashimoto disease. J Intern Med 10:10-15
    • (1997) J Intern Med , vol.10 , pp. 10-15
    • Lee, J.H.1    An, M.A.2    Jeon, J.S.3    Song, C.U.4    Shong, M.5    Kim, Y.K.6    Ro, H.K.7
  • 45
    • 0029097929 scopus 로고
    • Enhanced cAMP accumulation by the human thyrotropin receptor variant with the Pro52Thr substitution in the extracellular domain
    • Loos U, Hagner S, Bohr URM, Bogatkewitsch GS, Jakobs KH, van Koppen CJ (1995) Enhanced cAMP accumulation by the human thyrotropin receptor variant with the Pro52Thr substitution in the extracellular domain. Eur J Biochem 232:62-65
    • (1995) Eur J Biochem , vol.232 , pp. 62-65
    • Loos, U.1    Hagner, S.2    Bohr, U.R.M.3    Bogatkewitsch, G.S.4    Jakobs, K.H.5    Van Koppen, C.J.6
  • 47
    • 0030959502 scopus 로고    scopus 로고
    • High circulating IL-6 level in Graves' ophthalmopathy
    • Molnar I, Balazs C (1997) High circulating IL-6 level in Graves' ophthalmopathy. Autoimmunity 25:91-96
    • (1997) Autoimmunity , vol.25 , pp. 91-96
    • Molnar, I.1    Balazs, C.2
  • 48
    • 10544243368 scopus 로고    scopus 로고
    • Thymic hyperplasia in patients with Graves' disease
    • Murakami M, Hosoi Y, Negishi T et al. (1996) Thymic hyperplasia in patients with Graves' disease. J Clin Invest 98:2228-2234
    • (1996) J Clin Invest , vol.98 , pp. 2228-2234
    • Murakami, M.1    Hosoi, Y.2    Negishi, T.3
  • 49
    • 0028337046 scopus 로고
    • High affinity binding of thyrotropin (TSH) and thyroid-stimulating autoantibody for the TSH receptor extracellular domain
    • Nagayama Y, Takeshita A, Luo W, Ashizawa K, Yokoyama N, Nagataki S (1994) High affinity binding of thyrotropin (TSH) and thyroid-stimulating autoantibody for the TSH receptor extracellular domain. Thyroid 4:155-159
    • (1994) Thyroid , vol.4 , pp. 155-159
    • Nagayama, Y.1    Takeshita, A.2    Luo, W.3    Ashizawa, K.4    Yokoyama, N.5    Nagataki, S.6
  • 50
    • 0030851597 scopus 로고    scopus 로고
    • Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy
    • Pappa A, Calder V, Ajjan R, Fells P, Ludgate M, Weetman, Lightman S (1997) Analysis of extraocular muscle-infiltrating T cells in thyroid-associated ophthalmopathy. Clin Exp Immunol 109:362-369
    • (1997) Clin Exp Immunol , vol.109 , pp. 362-369
    • Pappa, A.1    Calder, V.2    Ajjan, R.3    Fells, P.4    Ludgate, M.5    Weetman6    Lightman, S.7
  • 51
    • 0031009232 scopus 로고    scopus 로고
    • Adhesion molecule expression in vivo on extraocular muscle (EOM) in thyroid-associated ophthalmopathy (TAO)
    • Pappa A, Calder V, Fells P, Lightman S (1997) Adhesion molecule expression in vivo on extraocular muscle (EOM) in thyroid-associated ophthalmopathy (TAO). Clin Exp Immunol 108:309-313
    • (1997) Clin Exp Immunol , vol.108 , pp. 309-313
    • Pappa, A.1    Calder, V.2    Fells, P.3    Lightman, S.4
  • 52
    • 0027987376 scopus 로고
    • Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues
    • Paschke R, Metcalfe A, Alcalde L, Vassart G, Weetman A, Ludgte M (1994) Presence of nonfunctional thyrotropin receptor variant transcripts in retroocular and other tissues. J Clin Endocrinol Metab 79:1234-1238
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1234-1238
    • Paschke, R.1    Metcalfe, A.2    Alcalde, L.3    Vassart, G.4    Weetman, A.5    Ludgte, M.6
  • 53
    • 7144263791 scopus 로고    scopus 로고
    • Graves' disease: Heterogeneity within a multifactorial polygenic disease? What is the phenotype?
    • Philippou G, de Roux N, Ratanachatyavong S, Campbell RD, McGregor AM (1997) Graves' disease: heterogeneity within a multifactorial polygenic disease? What is the phenotype? Thyroid 7:680
    • (1997) Thyroid , vol.7 , pp. 680
    • Philippou, G.1    De Roux, N.2    Ratanachatyavong, S.3    Campbell, R.D.4    McGregor, A.M.5
  • 54
    • 0027534279 scopus 로고
    • Smoking and risk of Graves'disease
    • Prummel MF, Wiersinga WM (1993) Smoking and risk of Graves'disease. J Am Med Assoc 269:479-482
    • (1993) J Am Med Assoc , vol.269 , pp. 479-482
    • Prummel, M.F.1    Wiersinga, W.M.2
  • 55
    • 0027182791 scopus 로고
    • Tissue specificity and serologic reactivity of an autoantigen associated with autoimmune thyroid disease
    • Ross PV, Koenig RJ, Arscott P et al. (1993) Tissue specificity and serologic reactivity of an autoantigen associated with autoimmune thyroid disease. J Clin Endocrinol Metab 77:433-438
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 433-438
    • Ross, P.V.1    Koenig, R.J.2    Arscott, P.3
  • 56
    • 0030929220 scopus 로고    scopus 로고
    • Increased expression of the Na+/I-symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue
    • Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, Onaya T (1997) Increased expression of the Na+/I-symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab 82:3331-3336
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3331-3336
    • Saito, T.1    Endo, T.2    Kawaguchi, A.3    Ikeda, M.4    Nakazato, M.5    Kogai, T.6    Onaya, T.7
  • 57
    • 0023930006 scopus 로고
    • Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy
    • Salvi M, Miller A, Wall JR (1988) Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy. FEBS Lett 232:135-139
    • (1988) FEBS Lett , vol.232 , pp. 135-139
    • Salvi, M.1    Miller, A.2    Wall, J.R.3
  • 58
    • 0025093629 scopus 로고
    • Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities
    • Salvi M, Zhang Z-G, Haegert D et al. (1990) Patients with endocrine ophthalmopathy not associated with overt thyroid disease have multiple thyroid immunological abnormalities. J Clin Endocrinol Metab 70:89-94
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 89-94
    • Salvi, M.1    Zhang, Z.-G.2    Haegert, D.3
  • 60
    • 0010244303 scopus 로고    scopus 로고
    • Analysis of human sodium iodide symporter gene expression in patients with thyroid diseases
    • (Minneapolis/USA) OR 30-1
    • Spitzweg C, Joba W, Heufelder AE (1997) Analysis of human sodium iodide symporter gene expression in patients with thyroid diseases. 79th Annual Meeting of The Endocrine Society (Minneapolis/USA) 108:OR 30-1
    • (1997) 79th Annual Meeting of the Endocrine Society , vol.108
    • Spitzweg, C.1    Joba, W.2    Heufelder, A.E.3
  • 61
    • 0030833751 scopus 로고    scopus 로고
    • Analysis of human thyrotropin receptor gene expression and immunoreactivity in human orbital tissue
    • Spitzweg C, Joba W, Hunt N, Heufelder AE (1997) Analysis of human thyrotropin receptor gene expression and immunoreactivity in human orbital tissue. Eur J Endocrinol 136:599-607
    • (1997) Eur J Endocrinol , vol.136 , pp. 599-607
    • Spitzweg, C.1    Joba, W.2    Hunt, N.3    Heufelder, A.E.4
  • 62
    • 0030981965 scopus 로고    scopus 로고
    • TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema
    • Stadlmayr W, Spitzweg C, Bichlmair A-M, Heufelder AE (1997) TSH receptor transcripts and TSH receptor-like immunoreactivity in orbital and pretibial fibroblasts of patients with Graves' ophthalmopathy and pretibial myxedema. Thyroid 7:3-12
    • (1997) Thyroid , vol.7 , pp. 3-12
    • Stadlmayr, W.1    Spitzweg, C.2    Bichlmair, A.-M.3    Heufelder, A.E.4
  • 63
    • 0026452944 scopus 로고
    • Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript
    • Takeshita A, Nagayama Y, Fujiyama K et al. (1992) Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. Biochem Biophys Res Commun 188:1214-1219
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 1214-1219
    • Takeshita, A.1    Nagayama, Y.2    Fujiyama, K.3
  • 64
    • 0027535804 scopus 로고
    • Suppression of autoimmune thyroid disease by FK 506; influence on thyroid-infiltrating cells, adhesion molecule expression and antithyroglobulin antibody production
    • Tamura K, Woo J, Murase N, Carrieri G, Nalesnik MA, Thomson AW (1993) Suppression of autoimmune thyroid disease by FK 506; influence on thyroid-infiltrating cells, adhesion molecule expression and antithyroglobulin antibody production. Clin Exp Immunol 91:368-375
    • (1993) Clin Exp Immunol , vol.91 , pp. 368-375
    • Tamura, K.1    Woo, J.2    Murase, N.3    Carrieri, G.4    Nalesnik, M.A.5    Thomson, A.W.6
  • 65
    • 0027510452 scopus 로고
    • Infection, thyroid disease, and autoimmunity
    • Tomer Y, Davies TF (1993) Infection, thyroid disease, and autoimmunity. Endocr Rev 14:107-120
    • (1993) Endocr Rev , vol.14 , pp. 107-120
    • Tomer, Y.1    Davies, T.F.2
  • 67
    • 0024559311 scopus 로고
    • Immunohistochemical analysis of the retrobulbar tissues in Graves' opthalmopathy
    • Weetman AP, Cohen S, Gatter KC, Fells D, Shine B (1989) Immunohistochemical analysis of the retrobulbar tissues in Graves' opthalmopathy. Clin Exp Immunol 75:222-227
    • (1989) Clin Exp Immunol , vol.75 , pp. 222-227
    • Weetman, A.P.1    Cohen, S.2    Gatter, K.C.3    Fells, D.4    Shine, B.5
  • 68
    • 0024334774 scopus 로고
    • T and B cell reactivity to extraocular and skeletal muscle in Graves'ophthalmopathy
    • Weetman AP, Fells P, Shine B (1989) T and B cell reactivity to extraocular and skeletal muscle in Graves'ophthalmopathy. Br J Ophthalmol 73:323-327
    • (1989) Br J Ophthalmol , vol.73 , pp. 323-327
    • Weetman, A.R.1    Fells, P.2    Shine, B.3
  • 69
    • 0023848109 scopus 로고
    • Antibodies to plasmid-encoded proteins of enteropathogenic Yersinia in patients with autoimmune thyroid disease
    • Wenzel BE, Heesemann J, Wenzel KW, Scriba PC (1988) Antibodies to plasmid-encoded proteins of enteropathogenic Yersinia in patients with autoimmune thyroid disease. Lancet 1:56
    • (1988) Lancet , vol.1 , pp. 56
    • Wenzel, B.E.1    Heesemann, J.2    Wenzel, K.W.3    Scriba, P.C.4


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