Thymic hyperplasia in patients with Graves' disease: Identification of thyrotropin receptors in human thymus

Journal of Clinical Investigation

Volumn 98, Issue 10, 1996, Pages 2228-2234

  Murakami, Masami ^a   Hosoi, Yasuhiro ^a   Negishi, Tetsuo ^a   Kamiya, Yuji ^a   Miyashita, Kazuya ^a   Yamada, Masanobu ^a   Iriuchijima, Tokuji ^a   Yokoo, Hideaki ^a   Yoshida, Ichiro ^a   Tsushima, Yoshito ^b   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

computed tomography; immunohistochemistry; Northern blot analysis; polymerase chain reaction; Western blot analysis

Indexed keywords

COMPLEMENTARY DNA; THYROTROPIN RECEPTOR; THYROTROPIN RECEPTOR ANTIBODY;

ADULT; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; GRAVES DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; THYMUS HYPERPLASIA; TISSUE DISTRIBUTION;

EID: 10544243368     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119032     Document Type: Article

References (33)

1. Smith, B.R., S.M. McLachlan, and J. Furmaniak. 1988. Autoantibodies to the thyrotropin receptor. Endocr. Rev. 9:106-120.
2. Kohn, L.D . H. Shimura, Y. Shimura, A. Hidaka, C. Giuliani, G. Napolitano, M. Ohmori, G. Laglia, and M. Saji. 1995. The thyrotropin receptor. Vitam. Horm. 50:287-384.
3. Levinson, A.I., B. Zweiman, and R.P. Lisak. 1987. Immunopathogenesis and treatment of myasthenia gravis. J. Clin. Immunol. 7:187-197.
4. Engel, W.K., J.L. Trotter, D.E. McFarlin, and C.L. McIntosh, 1977. Thymic epithelial cell contains acetylcholine receptor. Lancer i: 1310-1311.
5. Kao, I., and D.B. Drachman. 1977. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis. Science (Wash. DC). 195: 74-75.
6. Fuchs, S., I. Schmidt-Hopfeld, G. Tridente, and R. Terrab-Hazdai. 1980. Thymic lymphocytes bear a surface antigen which cross-reacts with acetylcholine receptor. Nature (Lond.). 287:162-164.
7. Hara, Y., S. Ueno, T. Uemichi, N. Takahashi, S. Yorifuji, Y. Fujii, and S. Tarui. 1991. Neoplastic epithelial cells express a-subunit of muscle nicotinic acetylcholine receptor in thymomas from patients with myasthenia gravis. FEBS Lett. 279:137-140.
8. Wheatley, L.M., D. Urso, K. Tumas, J. Maltzman, E. Loh, and A.I. Levinson. 1992. Molecular evidence for the expression of nicotinic acetylcholine receptor α-chain in mouse thymus. J. Immunol. 148:3105-3109.
9. Mihovilovic, M., and A.D. Roses. 1993. Expression of α-3, α-5, and β-4 neuronal acetylcholine receptor subunit transcripts in normal and myasthenia gravis thymus: identification of thymocytes expressing the α-3 transcripts. J. Immunol. 151:6517-6524.
10. Hara, H., K. Hayashi, K. Ohta, N. Itoh, and M. Ohta. 1993. Nicotinic acetylcholine receptor mRNAs in myasthenic thymuses: association with intrathymic pathogenesis of myasthenia gravis. Biochem. Biophys. Res. Commun. 194:1269-1275.
11. Halsted, W.S. 1914. Significance of the thymus gland in Graves' disease. Bull. Johns Hopkins Hosp. 25:223-234.
12. Michie, W., J.S. Beck, R.G. Mahaffy, E.F. Honein, and G.B. Fowler. 1967. Quantitative radiological and histological studies of the thymus in thyroid disease. Lancet. i:691-695.
13. Franken, E.A. 1968. Radiologie evidence of thymic enlargement in Graves' disease. Radiology. 91:20-22.
14. Van Herle, A.J., and I.J. Chopra. 1971. Thymic hyperplasia in Graves' disease. J. Clin. Endocrinol. 32:140-146.
15. Bergman, T.A., C.N. Mariash, and J.H. Oppenheimer. 1982. Anterior mediastinal mass in a patient with Graves' disease. J. Clin. Endocrinol. Metab. 55:587-588.
16. Gunn, A., W. Michie, and W.J. Irvine. 1964. The thymus in thyroid disease. Lancet. ii:776-778.
17. Baron, R.L., J.K.T. Lee, S.S. Sagel, and R.R. Peterson. 1982. Computed tomography of the normal thymus. Radiology. 142:121-125.
18. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
19. Liberi, F., A. Lefort, C. Gerard, M. Parmentier, J. Perret, M. Ludgate, J.E. Dumont, and G. Vassart. 1989. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 165:1250-1255.
20. Nagayama, Y., K.D. Kaufman, P. Seto, and B. Rapoport. 1989. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 165:1184-1190.
21. Murakami, M., K. Miyashita, M. Yamada, T. Iriuchijima, and M. Mori. 1992. Characterization of human thyrotropin receptor-related peptide-like immunoreactivity in peripheral blood of Graves' disease. Biochem. Biophys. Res. Commun. 186:1074-1080.
22. Murakami, M., K. Miyashita, H. Mizuma, M. Yamada, T. Iriuchijima, T. Takeuchi, and M. Mori. 1996. Discrete characteristics of antibodies raised against thyrotropin receptor-related peptides whose sequences are not conserved in the luteinizing hormone/chorionic gonadotropin receptor. J. Clin. Endocrinol. Metab. 81:1747-1752.
23. Yokoo, H., and Y. Nakazato. 1996. A monoclonal antibody that recognizes a carbohydrate epitope of human protoplasmic astrocytes. Acta Neuropathol. 91:23-30.
24. Mizukami, Y., T. Hashimoto, A. Monomura, T. Michigishi, S. Nakamura, M. Noguchi, and S. Matsukawa. 1994. Immunohistchemical demonstration of thyrotropin (TSH)-receptor in normal and human diseased human thyroid tissues using monoclonal antibody against recombinant human TSH-receptor protein. J. Clin. Endocrinol. Metab. 79: 616-619.
25. Gross, B., M. Misrahi, S. Sar,and E. Milgrom. 1991. Composite structure of the human thyrotropin receptor gene. Biochem. Biophys. Res. Commun. 177:679-687.
26. Graves, P.N., Y. Tomer, and T.F. Davies. 1992. Cloning and sequencing of a 1.3 kh variant of human thyrotropin receptor mRNA lacking the transmembrane domain. Biochem. Biophys. Res. Commun. 187:1135-1143.
27. Russo, D., G.D. Chazenbalk, Y. Nagayama, H.L. Wadswort, and B. Rapoport. 1991. A new structural model for the thyrotropin (TSH) receptor, as determined by covalent cross-linking of TSH to the recombinant receptor in intact cells: evidence for a single polypeptide chain. Mol. Endocrinol. 5:1607-1612.
28. Ban, T., S. Kosugi, and L.D. Kohn. 1992. Specific antibody to the thyrotropin receptor identifies multiple receptor forms in membranes of cells transfected with wild-type receptor complementary deoxyribonucleic acid: characterization of their relevance to receptor synthesis, processing, structure, and function. Endocrinology. 131:815-829.
29. Höhn, E.O. 1959. Action of certain hormones on the thymus of the domestic hen. J. Endocrinol. 19:282-287.
30. Ernstrom, V., and B. Larsson. 1966. Thymic and thoracic duct contribution to blood lymphocytes in normal and thyroxine treated guinea-pig. Acta Physiol. Scand. 66:189-195.
31. Fabris, N. 1973. Immunodepression in thyroid-deprived animals. Clin. Exp. Immunol. 15:601-611.
32. Weetman, A.P., A.M. McGregor, and R. Hall. 1984. Evidence for an effect of antithyroid drugs on the natural history of Graves' disease. Clin. Endocrinol. 21:163-172.
33. Wortsman, J., P. McConnachie, J.R. Baker, and K.D. Burman. 1988. Immunoglobulins that cause a thymocyte proliferation from a patient with Graves' disease and an enlarged thymus. Am. J. Med. 85:117-121.