Stroma-conditioned medium and sufficient prestimulation improve fibronectin fragment-mediated retroviral gene transfer into human primitive mobilized peripheral blood stem cells through effects on their recovery and transduction efficiency

Leukemia

Volumn 12, Issue 6, 1998, Pages 951-959

  Breems, D A ^a   Van Driel, E M ^a   Hawley, R G ^b   Siebel, K E ^a   Ploemacher, R E ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Carboxy terminal fibronectin fragment; Mobilized peripheral blood stem cells; Retroviral gene transfer; Stroma conditioned medium

Indexed keywords

CD34 ANTIGEN; FIBRONECTIN;

ARTICLE; CLINICAL ARTICLE; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; LYMPHOMA; MYELOMA; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RETROVIRUS; TARGET CELL;

EID: 0031805286     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401028     Document Type: Article

References (16)

1. To LB, Haylock DN, Simmons PJ, Juttner CA. The biology and clinical uses of blood stem cells. Blood 1997; 89: 2233-2258.
2. Dunbar CE, Cottler-Fox M, O'Shaughnessy JA, Doren S, Carter C, Berenson R, Brown S, Moen RC, Greenblatt J, Stewart FM, Leitman SF, Wilson WH, Cowan K, Young NS, Nienhuis AW. Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation. Blood 1995; 85: 3048-3057.
3. Fruehauf S, Breems DA, Knaän-Shanzer S, Brouwer KB, Haas R, Löwenberg B, Nooter K, Ploemacher RE, Valerio D, Boesen JJB. Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobble-stone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123. Hum Gene Ther 1996; 7: 1219-1231.
4. + peripheral blood progenitor cells after introduction of a mutated dihydrofolate reductase cDNA via retroviral gene transfer. Blood 1995; 85: 566-574.
5. 6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. Proc Natl Acad Sci USA 1996; 93: 14088-14093.
6. Brenner MK, Rill DR, Holladay MS, Heslop HE, Moen RC, Buschle M, Krance RA, Santana VM, Anderson WF, Ihle JN. Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet 1993; 342: 1134-1137.
7. + cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood 1994; 83: 3068-3076.
8. Kohn DB, Weinberg KI, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, Hanley ME, Annett G, Brooks JS, EI-Khoureiy A, Lawrence K, Wells S, Moen RC, Bastian J, Williams-Herman DE, Elder M, Wara D, Bowen T, Hershfield MS, Mullen CA, Blaese RM, Parkman R. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nature Med 1995; 1: 1017-1023.
9. Cornetta K, Srour EF, Moore A, Davidson A, Broun ER, Hromas R, Moen RC, Morgan RA, Rubin L, Anderson WF, Hoffman R, Tricot G. Retroviral gene transfer in autologous bone marrow transplantation for adult acute leukemia. Hum Gene Ther 1996; 7: 1323-1329.
10. Roberts AW, Metcalf D. Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines. Blood 1995; 86: 1600-1605.
11. Knaän-Shanzer S, Valerio D, Van Beusechem VW. Cell cycle state, response to hemopoietic growth factors and retroviral vector-mediated transduction of human hemopoietic stem cells. Gene Therapy 1996; 3: 323-333.
12. + cells. Exp Hematol 1996; 24: 738-747.
13. Jordan CT, Yamasaki G, Minamoto D. High-resolution cell cycle analysis of defined phenotypic subsets within primitive human hematopoietic cell populations. Exp Hematol 1996; 24: 1347-1352.
14. Miller DC, Adam MA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of transfection. Mol Cell Biol 1990; 10: 4239-4242.
15. Roe T, Reynolds TC, Yu G, Brown PO. Integration of murine leukemia virus DNA depends on mitosis. EMBO J 1993; 12: 2099-2108.
16. Williams DA, Rios M, Stephens C, Patel VP. Fibronectin and VLA-4 in haematopoietic stem cell-microenvironment interactions. Nature 1991; 352: 438-441.