Circulating factors as markers and mediators of endothelial cell dysfunction in preeclampsia

Seminars in Reproductive Endocrinology

Volumn 16, Issue 1, 1998, Pages 17-31

  Taylor, Robert N ^a,d   De Groot, Christianne J M ^a,b   Cho, Yong K ^a,c   Lim, Kee Hak ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Inje University   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelial cell dysfunction; Preeclampsia

Indexed keywords

CARDIOLIPIN ANTIBODY; CELL ADHESION MOLECULE; CYTOKINE; ENDOTHELIN 1; ENDOTHELIN DERIVATIVE; FATTY ACID; GROWTH FACTOR; LIPID; LIPID PEROXIDE; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY; PLASMINOGEN ACTIVATOR; PROCOAGULANT; PROSTACYCLIN; PROSTAGLANDIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VERY LOW DENSITY LIPOPROTEIN;

CYTOKINE RELEASE; ENDOTHELIUM INJURY; HUMAN; IMMUNE RESPONSE; LIPID PEROXIDATION; MITOGENESIS; OBESITY; PATHOGENESIS; PREECLAMPSIA; PRIORITY JOURNAL; REVIEW; SYNCYTIOTROPHOBLAST; THROMBOCYTE; VASCULAR DISEASE;

EID: 0031802535     PISSN: 07348630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1016249     Document Type: Review

References (155)

1. Chesley LC. Hypertensive disorders in pregnancy. New York: Appleton-Century-Crofts, 1978:777-822
2. Cook HW, Briggs JB. Clinical observations on blood pressure. Johns Hopkins Hosp Rep 1903;11:452-534
3. Young J. Recurrent pregnancy toxaemia and its relation to placental damage. Trans Edinburgh Obstet Soc 1927;47: 61-76
4. Bell ET. Renal lesions in the toxemias of pregnancy. Am J Pathol 1932;8:1-42
5. Spargo BH, Lichtig C, Luger AM, et al. The renal lesion in preeclampsia: Examination by light-, electron- and immunofluorescence-microscopy. In: Lindheimer MD, Katz AI, Zuspan FP (eds). Hypertension in Pregnancy. New York: Wiley; 1976:129-137
6. Schneider CL. The active priciple of placental toxin: Thromboplastin; and its inactivator in blood: Antithromboplastin. Am J Physiol 1947;149:123-129
7. Dieckmann WJ. The toxemias of pregnancy. In: Factors influencing eclampsia in pregnant women. St Louis: CV Mosby, 1941:250-251
8. Roberts JM, Taylor RN, Musci TJ, et al. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161: 1200-1204
9. Sheehan HL, Lynch JB. Pathology of toxaemia of pregnancy. London: Churchill, 1973
10. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much ado about nothing? Am J Obstet Gynecol 1990;162:311-316
11. Belizan JM, Villar J, Repke J. The relationship between calcium intake and pregnancy-induced hypertension: Up-to-date evidence. Am J Obstet Gynecol 1988;158:898-902
12. Khong TY, Sawyer IH, Heryet AR. An immunohistologic study of endothelialization of uteroplacental vessels in human pregnancy: Evidence that endothelium is focally disrupted by trophoblast in preeclampsia. Am J Obstet Gynecol 1992;167:751-756
13. Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? [see comments]. J Clin Invest 1997;99:2152-2164
14. de Groot CJM, Murai JT, Vigne J-L, et al. Eicosanoid secretion by human endothelial cells exposed to normal pregnancy and preeclampsia plasma in vitro. Prostagland Leuk Essen Fatty Acids (in press)
15. Zeek PM, Assali NS. Vascular changes in the decidua associated with eclamptogenic toxemia. Am J Clin Pathol 1950;20:1099-1109
16. Nadji P, Sommers SC. Lesions of toxemia in first trimester pregnancies. Am J Clin Pathol 1973;59:344-348
17. De Wolf F, Robertson WB, Brosens I. The ultrastructure of acute atherosis in hypertensive pregnancy. Am J Obstet Gynecol 1975;123:164-174
18. Raines EW, Ross R. Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis. Br Heart J 1993;69:S30-37
19. Shanklin DR, Sibai BM. Ultrastructural aspects of preeclampsia. II. Mitochondrial changes. Am J Obstet Gynecol 1990;163:943-953
20. Kitzmiller JL, Benirschke K. Immunofluorescent study of placental bed vessels in pre-eclampsia of pregnancy. Am J Obstet Gynecol 1973;115:248-251
21. Taylor RN. Review: Immunobiology of preeclampsia. Am J Reprod Immunol 1997;37:79-86
22. Gant NF, Daley GL, Chand S, et al. A study of angiotensin II pressor response throughout primigravid pregnancy. J Clin Invest 1973;52:2682-2689
23. Bower S, Schuchter K, Campbell S. Doppler ultrasound screening as part of routine antenatal scanning: Prediction of pre-eclampsia and intrauterine growth retardation. Br J Obstet Gynaecol 1993;100:989-994
24. Belfort M. Doppler assessment of retinal blood flow velocity during parenteral magnesium treatment in patients with preeclampsia. Magnesium Res 1993;6:239-246
25. Watson KV, Moldow CF, Ogburn PL, et al. Magnesium sulfate: Rationale for its use in preeclampsia. Proc Natl Acad Sci USA 1986;83:1075-1078
26. Branch DW, Dudley DJ, LaMarche S, et al. Sera from preeclamptic patients contain factor(s) that stimulate prostacyclin production by human endothelial cells. Prostagland Leuko Essen Fatty Acids 1992;45:191-195
27. Pascoal I, Umans J. Effect of pregnancy on mechanisms of relaxation in human omental microvessels. Hypertension 1996;28:183-187
28. McCarthy AL, Woolfson RG, Raju SK, et al. Abnormal endothelial cell function of resistance arteries from women with preeclampsia. Am J Obstet Gynecol 1993;168:1323-1330
29. Poston L. Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia. Am J Obstet Gynecol 1996;175:1668-1674
30. Pober JS, Cotran RS. Cytokines and endothelial cell biology. Physiol Rev 1990;70:427-451
31. Gryglewski RJ, Botting RM, Vane JR. Mediators produced by the endothelial cell. Hypertension 1988;12:530-548
32. Branch DW, Dudley DJ, Mitchell MD. Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia. Lancet 1991;337:943-945
33. Resnick N, Gimbrone MAJ. Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J 1995;9:874-882
34. Kourembanas S, McQuillan LP, Leung GK, et al. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 1993;92:99-104
35. Taylor RN, Heilbron DC, Roberts JM. Growth factor activity in the blood of women in whom preeclampsia develops is elevated from early pregnancy. Am J Obstet Gynecol 1990;163:1839-1844
36. Taylor RN, Musci TJ, Kuhn RW, et al. Partial characterization of a novel growth factor from the blood of women with preeclampsia. J Clin Endocrinol Metab 1990;70:1285-1291
37. Varma M, de Groot CJM, Lanyi S, et al. Evaluation of plasma insulin-like growth factor-binding protein-3 as a potential predictor of preeclampsia. Am J Obstet Gynecol 1993;169:995-999
38. Lewitt MS, Scott FP, Clarke NM, et al. Developmental regulation of circulating insulin-like growth factor-binding proteins in normal pregnancies and in pre-eclampsia. Prog Growth Factor Res 1995;6:475-480
39. Yanagisawa M, Kurihara H, Kimura S, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-115
40. Watanabe Y, Naruse M, Monzen C, et al. Is big endothelin converted to endothelin-1 in circulating blood? J Cardiovasc Pharmacol 1991;17:S503-505
41. Suzuki N, Matsumoto H, Kitada C, et al. A sensitive sandwich-enzyme immunoassay for human endothelin. J Immunol Methods 1989;118:245-250
42. Schini VB, Vanhoutte PM. Endothelin-1: A potent vasoactive peptide. Pharmacol Toxicol 1991;69:303-309
43. Lerman A, Kubo SH, Tschumperlin LK, et al. Plasma endothelin concentrations in humans with end-stage heart failure and after heart transplantation. J Am Coll Cardiol 1992;20:849-853
44. Bodelsson G, Sjoberg NO, Stjernquist M. Contractile effect of endothelin in the human uterine artery and autoradiographic localization of its binding sites. Am J Obstet Gynecol 1992;167:745-750
45. Remuzzi G, Benigni A. Endothelins in the control of cardiovascular and renal function. Lancet 1993;342:589-593
46. Taylor RN, Varma M, Teng NNH, et al. Women with preeclampsia have higher plasma endothelin levels than women with normal pregnancies. J Clin Endocrinol Metab 1990;71:1675-1677
47. Nova A, Sibai BM, Barton JR, et al. Maternal plasma level of endothelin is increased in preeclampsia. Am J Obstet Gynecol 1991;165:724-727
48. Mastrogiannis DS, O'Brien WF, Krammer J, et al. Potential role of endothelin-1 in normal and hypertensive pregnancies. Am J Obstet Gynecol 1991;165:1711-1716
49. Benigni A, Orisio S, Gaspari F, et al. Evidence against a pathogenetic role for endothelin in pre-eclampsia. Br J Obstet Gynaecol 1992;99:798-802
50. McMahon LP, Redman CW, Firth JD. Expression of the three endothelin genes and plasma levels of endothelin in pre-eclamptic and normal gestations. Clin Sci (Colch) 1993;85:417-424
51. de Groot CJM, Taylor RN. New insights into the etiology of pre-eclampsia. Ann Med 1993;25:243-249
52. Genbacev O, Joslin R, Damsky CH, et al. Hypoxia alters early gestation human cytotrophoblast differentiation/invasion in vitro and models the placental defects that occur in preeclampsia. J Clin Invest 1996;97:540-550
53. Wiebke JL, Montrose-Rafizadeh C, Zeitlin PL, et al. Effect of hypoxia on endothelin-1 production by pulmonary vascular endothelial cells. Biochim Biophys Acta 1992;1134:105-111
54. Greenberg SG, Baker RS, Yang DS, et al. Effects of continuous infusion of endothelin-1 in pregnant sheep. Hypertension 1998;30:1585-1590
55. Dvorak HF, Brown LF, Detmar M, et al. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995;146:1029-1039
56. Baker PM, Davidge ST, Roberts JM. Plasma from women with preeclampsia increases endothelial cell nitric oxide production. Hypertension 1995;26:244-248
57. Sharkey AM, Cooper JC, Balmforth JR, et al. Maternal plasma levels of vascular endothelial growth factor in nor motensive pregnancies and in pregnancies complicated by pre-eclampsia. Eur J Clin Invest 1996;26:1182-1185
58. Cooper JC, Sharkey AM, Charnock-Jones DS, et al. VEGF mRNA levels in placentae from pregnancies complicated by pre-eclampsia. Br J Obstet Gynaecol 1996;103:1191-1196
59. Spector AA. Lipid and lipoprotein effects on endothelial eicosanoid formation. Semin Thromb Hemostas 1988;14: 196-201
60. Moncada S, Gryglewski R, Bunting S, et al. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976;263:663-665
61. Remuzzi G, Marchesi D, Zoja C, et al. Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia. Prostaglandins 1980;20:105-110
62. Friedman SA. Preeclampsia: A review of the role of prostaglandins. Obstet Gynecol 1988;71:122-137
63. Fitzgerald DJ, Entman SS, Mulloy K, et al. Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension. Circulation 1987;75:956-963
64. Sibai BM, Gordon T, Thom E, et al. Risk factors for preeclampsia in healthy nulliparous women: A prospective multicenter study. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. Am J Obstet Gynecol 1995;172:642-648
65. Lorentzen B, Drevon CA, Endresen MJ, et al. Fatty acid pattern of esterified and free fatty acids in sera of women with normal and pre-eclamptic pregnancy. Br J Obstet Gynaecol 1995;102:530-537
66. Endresen MJ, Lorentzen B, Henriksen T. Increased lipolytic activity of sera from pre-eclamptic women due to the presence of a lysophospholipase. Scand J Clin Lab Invest 1993;53:733-739
67. Endresen MJ, Morris J, Knight M, et al. Presence of lysophospholipase activity in placental syncytiotrophoblast microvillous membranes. Abstracts of the International Society for the Study of Hypertension in Pregnancy 1997:021
68. Sattar N, Bendomir A, Berry C, et al. Lipoprotein subtraction concentrations in preeclampsia: Pathogenic parallels to atherosclerosis. Obstet Gynecol 1997;89:403-408
69. Williams C, Coltart TM. Adipose tissue metabolism in pregnancy: The lipolytic effect of human placental lactogen. Br J Obstet Gynaecol 1978;85:43-46
70. Marcus C, Bolme P, Micha-Johansson G, et al. Growth hormone increases the lipolytic sensitivity for catecholamines in adipocytes from healthy adults. Life Sci 1994;54:1335-1341 .
71. Murai JT, Muzykanskiy E, Taylor RN. Maternal and fetal modulators of lipid metabolism correlate with the development of preeclampsia. Metabolism 1997;46:963-967
72. Obiekwe B, Sturdee D, Cockrill BL, et al. Human placental lactogen in pre-eclampsia. Br J Obstet Gynaecol 1984;91: 1077-1080
73. Schobel HP, Fischer T, Heuszer K, et al. Preeclampsia: A state of sympathetic overactivity. N Engl J Med 1996;335: 1480-1485
74. Barden, A., Beilin LJ, Ritchie J, et al. Plasma and urinary 8-iso-prostane as an indicator of lipid peroxidation in preeclampsia and normal pregnancy. Clin Sci 1996;91:711-718
75. Lim KH, Rice GE, de Groot CJM, et al. Plasma type II phospholipase A2 levels are elevated in severe preeclampsia. Am J Obstet Gynecol 1995;172:998-1002
76. Dizon-Townson DS, Nelson LM, Easton K, et al. The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996;175:902-905
77. Lindoff C, Ingemarsson I, Martinsson G, et al. Preeclampsia is associated with a reduced response to activated protein C. Am J Obstet Gynecol 1997;176:457-460
78. Dekker GA, de Vries JI, Doelitzsch PM, et al. Underlying disorders associated with severe early-onset preeclampsia. Am J Obstet Gynecol 1995;173:1042-1048
79. Taylor RN, Crombleholme WR, Friedman SA, et al. High plasma cellular fibronectin levels correlate with biochemical and clinical features of preeclampsia but cannot be at tributed to hypertension alone. Am J Obstet Gynecol 1991;165:895-901
80. Hsu CD, Copel JA, Hong SF, et al. Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension. Obstet Gynecol 1995;86:897-899
81. Paidas MJ, Taylor RN, Schwartzman H, et al. Third trimester type 1 and type 2 plasminogen activator inhibitor (PAI 1, PAI 2) levels are associated with preeclampsia. [Abstract]. Soc Gynecol Invest 1994:#O148
82. Estelles A, Gilabert J, Espana F, et al. Fibrinolytic parameters in normotensive pregnancy with intrauterine fetal growth retardation and in severe preeclampsia. Am J Obstet Gynecol 1991;165:138-142
83. Friedman SA, Schiff E, Emeis JJ, et al. Biochemical corroboration of endothelial involvement in severe preeclampsia. Am J Obstet Gynecol 1995;172:202-203
84. Kanfer A, Bruch JF, Nguyen G, et al. Increased placental antifibrinolytic potential and fibrin deposits in pregnancy-induced hypertension and preeclampsia. Lab Invest 1996;74:253-258
85. Shaarawy M, Didy HE. Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as biomarkers of endothelial damage in preeclampsia and eclampsia. Int J Gynaecol Obstet 1996;55:135-139
86. Hynes RO. Cell biology of the extracellular matrix. New York: Plenum Press, 1981:295-334
87. Aznar-Salatti J, Bastida E, Buchanan MR, et al. Differential localization of von Willebrand factor, fibronectin and 13-HODE in human endothelial cell cultures. Histochemistry 1990;93:507-511
88. Forsyth KD, Levinsky RJ. Fibronectin degradation: An in-vitro model of neutrophil mediated endothelial cell damage. J Pathol 1990;161:313-319
89. Lazarchick J, Stubbs TM, Romein L, et al. Predictive value of fibronectin levels in normotensive gravid women destined to become preeclamptic. Am J Obstet Gynecol 1986;154:1050-1052
90. Letowska M, Bykowska K, Sablinski J, et al. Venostasis but not DDAVP infusion provokes the plasma fibronectin increase. Thrombos Haemostas 1990;64:294-296
91. Ogawa S, Shreeniwas R, Butura C, et al. Modulation of endothelial function by hypoxia: Perturbation of barrier and anticoagulant function, and induction of a novel factor X activator. Adv Exp Med Biol 1990;281:303-312
92. Peters JH, Sporn LA, Ginsberg MH, et al. Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1). Blood 1990;75:1801-1808
93. Lockwood CJ, Peters JH. Increased plasma levels of ED1+ cellular fibronectin precede the clinical signs of preeclampsia. Am J Obstet Gynecol 1990;162:358-362
94. Lyall F, Greer IA, Boswell F, et al. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997;104:223-228
95. Halim A, Kanayama N, el Maradny E, et al. Plasma P selectin (GMP-140) and glycocalicin are elevated in preeclampsia and eclampsia: Their significances. Am J Obstet Gynecol 1996;174:272-277
96. Krauss T, Kuhn W, Lakoma C, et al. Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk of developing preeclampsia. Am J Obstet Gynecol 1997;177:443-449
97. Rodgers GM, Taylor RN, Roberts JM. Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am J Obstet Gynecol 1988;159:908-914
98. Tsukimori K, Maeda H, Shingu M, et al. The possible role of endothelial cell in hypertensive disorders during pregnancy. Obstet Gynecol 1992;80:229-233
99. Endresen MJ, Tosti E, Lorentzen B, et al. Sera of preeclamptic women are not cytotoxic to endothelial cells in culture. Am J Obstet Gynecol 1995;172:196-201
100. Roberts JM, Edep ME, Goldfien A, et al. Sera from preeclamptic women specifically activate human umbilical vein endothelial cells in vitro: morphological and biochemical evidence. Am J Reprod Immunol 1992;27:101-108
101. Taylor RN, Musci TJ, Rodgers GM, et al. Preeclamptic sera stimulate increased platelet-derived growth factor mRNA and protein expression by cultured human endothelial cells. Am J Reprod Immunol 1991;25:105-108
102. Berk BC, Alexander RW, Brock TA, et al. Vasoconstriction: A new activity for platelet-derived growth factor. Science 1986;232:87-90
103. Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995;333:1757-1763
104. Taylor RN, Casal DC, Jones LA, et al. Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression. Am J Obstet Gynecol 1991;165:1705-1710
105. Marcus AJ, Broekman MJ, Drosopoulos JH, et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest 1997;99:1351-1360
106. Favaloro EJ. Differential expression of surface antigens on activated endothelium. Immunol Cell Biol 1993;71:571-581
107. Ahlawat S, Pati HP, Bhatla N, et al. Plasma platelet aggregating factor and platelet aggregation studies in preeclampsia. Acta Obstet Gynecol Scand 1996;75:428-431
108. Meekins JW, McLaughlin PJ, West DC, et al. Endothelial cell activation by tumour necrosis factor-alpha (TNF-alpha) and the development of pre-eclampsia. Clin Exp Immunol 1994;98:110-114
109. Kupfermine MJ, Peaceman AM, Wigton TR, et al. Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia. Am J Obstet Gynecol 1995;172:649-653
110. Vince GS, Starkey PM, Austgulen R, et al. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 1995;102:20-25
111. Baykov AA, Evtushenko OA, Avaeva SM. A malachite green procedure for orthophosphate determination and its use in alkaline phosphatase-based enzyme immunoassay. Anal Biochem 1988;171:266-270
112. Gougos AS, O'Connell PJ, d'Apice AJ, et al. Identification of distinct epitopes of endoglin, an RGD-containing glycoprotein of endothelial cells, leukemic cells, and syncytiotrophoblasts. Int Immunol 1992;4:83-92
113. Lastres P, Letamendia A, Zhang H, et al. Endoglin modulates cellular responses to TGF-beta 1. J Cell Biol 1996;133: 1109-1121
114. Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab 1997;82:1582-1588
115. Bertani T, Abbate M, Zoja C, et al. Tumor necrosis factor induces glomerular damage in the rabbit. Am J Pathol 1989;134:419-430
116. Jacobson PB Schrier DJ. Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2. J Immunol 1993;151:5639-5652
117. Pfeilschifter J, Schalkwijk C, Briner VA, et al. Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells. J Clin Invest 1993;92:2516-2523
118. 2 activities in pre-eclampsia. Zentralbl Gynakol 1990;112:889-891
119. Greer IA, Lyall F, Perera T, et al. Increased concentration of cytokines interleukin-6 and imterleukin-1 receptor antagonist in plasma of women with preeclampsia: A mechanism for endothelial dysfunction? Obstet Gynecol 1994;84:937-940
120. Stallmach T, Hebisch G, Joller H, et al. Expression pattern of cytokines in the different compartments of the feto-maternal unit under various conditions. Reprod Fertil Devel 1995;7:1573-1580
121. Arbogast BW, Leeper SC, Merrick RD, et al. Which plasma factors bring about disturbance of endothelial function in pre-eclampsia? Lancet 1994;343:340-341
122. Endresen MJ, Lorentzen B, Henriksen T. Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells. Am J Obstet Gynecol 1992;167:440-447
123. Arbogast B, Leeper S, Merrick R, et al. Plasma factors that determine endothelial cell lipid toxicity in vitro correctly identify women with preeclampsia in early and late pregnancy. Hypertens Pregnancy 1996;15:263-279
124. Vigne J-L, Murai JT, Arbogast BW, et al. Elevated non-esterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin. J Clin Endocrinol Metab 1997;82:3786-3792
125. Dekker GA, van Geijn HP. Endothelial dysfunction in preeclampsia. Part I: Primary prevention. Therapeutic perspectives. J Perinat Med 1996;24:99-117
126. de Groot CJ, Davidge ST, Friedman SA, et al. Plasma from preeclamptic women increases human endothelial cell prostacyclin production without changes in cellular enzyme activity or mass. Am J Obstet Gynecol 1995;172:976-985
127. Gallery ED, Rowe J, Campbell S, et al. Secretion of prostaglandins and endothelin-1 by decidual endothelial cells from normal and preeclamptic pregnancies: Comparison with human umbilical vein endothelial cells. Am J Obstet Gynecol 1995;173:1557-1562
128. Davidge ST, Signorella AP, Hubel CA, et al. Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide or prostacyclin. Hypertension 1996;28:758-764
129. 2 receptor affinity is reduced in pre-eclampsia. Br J Clin Pharmacol 1996;41:616-618
130. North RA, Ferrier C, Gamble G, et al. Prevention of preeclampsia with heparin and antiplatelet drugs in women with renal disease. Aust NZ J Obstet Gynaecol 1995;35: 357-362
131. Collins R, Wallenburg HCS. Pharmacological prevention and treatment of hypertensive disorders in pregnancy. In: Chalmers I, Enkin M, Keirse MC (eds). Effective care in pregnancy and childbirth. Oxford: Oxford University Press, 1992:512-533
132. Hauth JC, Goldenberg RL, Parker CJ, et al. Low-dose aspirin therapy to prevent preeclampsia. Am J Obstet Gynecol 1993;168:1083-1091
133. CLASP. A randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 1994;343:619-629
134. Dekker GA, van Geijn HP. Endothelial dysfunction in preeclampsia. Part II: Reducing the adverse consequences of endothelial cell dysfunction in preeclampsia; therapeutic perspectives. J Perinat Med 1996;24:119-139
135. Smarason AK, Sargent IL, Redman CWG. Endothelial cell proliferation is suppressed by plasma but not serum from women with preeclampsia. Am J Obstet Gynecol 1996; 174:787-793
136. Cockell AP, Learmont JG, Smarason AK, et al. Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function. Br J Obstet Gynaecol 1997;104:235-240
137. Houser MT, Fish AJ, Tagatz GE, et al. Pregnancy and systemic lupus erythematosus. Am J Obstet Gynecol 1980; 138:409-413
138. Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu 1972;1:177-191
139. Robillard PY, Hulsey TC, Alexander GR, et al. Paternity patterns and risk of preeclampsia in the last pregnancy in multiparae. J Reprod Immunol 1993;24:1-12
140. Klonoff-Cohen HS, Savitz DA, Cefalo RC, et al. An epidemiologic study of contraception and preeclampsia. JAMA 1989;262:3143-3147
141. Soderstrom-Anttila V, Hovatta O. An oocyte donation program with goserelin down-regulation of voluntary donors. Acta Obstet Gynecol Scand 1995;74:288-292
142. Feeney JG, Tovey LA, Scott JS. Influence of previous blood-transfusion on incidence of pre-eclampsia. Lancet 1977;1:874-875
143. Dekker GA. Oral tolerization to paternal antigens and preeclampsia [Abstract]. Am J Obstet Gynecol 1996;174: 450
144. Robillard PY, Hulsey TC, Perianin J, et al. Association of pregnancy-induced hypertension with duration of sexual cohabitation before conception. Lancet 1994;344:973-975
145. Allen JY, Tapia-Santiago C, Kutteh WH. Antiphospholipid antibodies in patients with preeclampsia. Am J Reprod Immunol 1996;36:81-85
146. Shaarawy M, El-Mallah SY, El-Yamani AMA. The prevalence of serum antineutrophil cytoplasmic autoantibodies in preeclampsia and eclampsia. J Soc Gynecol Invest 1997;4:34-39
147. Katano K, Aoki A, Sasa H, et al. Beta 2-glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. Hum Reprod 1996;11:509-512
148. Rappaport VJ, Hirata G, Yap HK, et al. Anti-vascular endothelial cell antibodies in severe preeclampsia. Am J Obstet Gynecol 1990;162:138-146
149. Yamamoto T, Takahashi Y, Kuno S, et al. Effects of anti-endothelial cell antibody in pre-eclampsia on endothelin-1 release from cultured endothelial cells. Immunol Cell Biol 1997;75:340-344
150. Branch DW. Antiphospholipid antibodies and pregnancy: Maternal implications. Semin Perinatol 1990;14:139-146
151. Rote NS, Walter A, Lyden TW. Antiphospholipid antibodies - lobsters or red herrings? Am J Reprod Immunol 1992;28:31-37
152. Yasuda M, Takakuwa K, Tokunaga A, et al. Prospective studies of the association between anticardiolipin antibody and outcome of pregnancy. Obstet Gynecol 1995;86: 555-559
153. Carreras LO, Vermylen JG. "Lupus" anticoagulant and thrombosis: Possible role of inhibition of prostacyclin formation. Thrombos Haemostas 1982;48:38-40
154. Tannenbaum SH, Finko R, Cines DB. Antibody and immune complexes induce tissue factor production by human endothelial cells. J Immunol 1986;137:1532-1537
155. Walker TS, Triplett DA, Javed N, et al. Evaluation of lupus anticoagulants: Antiphospholipid antibodies, endothelium associated immunoglobulin, endothelial prostacyclin secretion, and antigenic protein S levels. Thrombosis Res 1988;51:267-281