Platelet PGI2 receptor affinity is reduced in pre-eclampsia

British Journal of Clinical Pharmacology

Volumn 41, Issue 6, 1996, Pages 616-618

  Klockenbusch, Walter ^a   Hohlfeld, Thomas ^a   Wilhelm, Michael ^a   Somville, Thierry ^a   Schrör, Karsten ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

platelets; preeclampsia; pregnancy induced hypertension; prostacyclin receptor

Indexed keywords

ILOPROST; PROSTACYCLIN; PROSTACYCLIN DERIVATIVE; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LOW BIRTH WEIGHT; MATERNAL HYPERTENSION; PREECLAMPSIA; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; RECEPTOR AFFINITY; RECEPTOR DENSITY; THROMBOCYTE ACTIVATION; THROMBOCYTE MEMBRANE; BIRTH WEIGHT; BLOOD; HYPERTENSION; METABOLISM; NEWBORN; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; PROTEIN BINDING; THROMBOCYTE;

ADULT; BIRTH WEIGHT; BLOOD PLATELETS; EPOPROSTENOL; FEMALE; HUMANS; HYPERTENSION; ILOPROST; INFANT, NEWBORN; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; PROTEIN BINDING; RECEPTORS, EPOPROSTENOL; RECEPTORS, PROSTAGLANDIN;

EID: 0029664930     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1996.40021.x     Document Type: Article

References (10)

1. Fitzgerald DJ, Entman SS, Mulloy K, FitzGerald GA. Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension. Circulation 1987; 75: 956-963.
2. Klockenbusch W, Somville T, Hafner D, Strobach H, Schrör K. Excretion of prostacyclin and thromboxane metabolites before, during, and after pregnancy-induced hypertension. Eur J Obstet Gynecol Reprod Biol 1994; 57: 47-50.
3. Kaczmarek D, Hohlfeld T, Wambach G, Schrör K. The actions of lovastatin on platelet function and platelet eicosanoid receptors in type II hypercholesterolaemia. Eur J Clin Pharmacol 1993; 45: 451-457.
4. Weber AA, Hohlfeld T, Strobach H, Schrör K. Oral naftidrofuryl prevents platelet hyperreactivity ex vivo and inhibits functional desensitization to prostacyclin in hypercholesterolemic rabbits. J Cardiovasc Pharmacol 1993; 21: 332-338.
5. Redman CWG. Platelets and the beginnings of preeclampsia. N Engl J Med 1990; 323: 478-480.
6. Hutt R, Ogunniyi SO, Sullivan MHF, Elder MG. Increased platelet volume and aggregation precede the onset of preeclampsia. Obstet Gynecol 1994; 83: 146-149.
7. Horn EH, Cooper J, Hardy E, Heptinstall S, Rubin PC. A crosssectional study of platelet cyclic AMP in healthy and hypertensive pregnant women. Clin Sci 1991; 80: 549-558.
8. Briel RC, Kieback DG, Lippert TH. Platelet sensitivity to a prostacyclin analogue in normal and pathological pregnancy. Prostaglandins Leukot Med 1984; 13: 335-340.
9. Dadak C, Kefalides A, Sinzinger H. Prostacyclin-synthesis stimulating plasma factor and platelet sensitivity in preeclampsia. Biol Res Pregnancy 1985; 6: 65-69.
10. Katsuyama M, Sugimoto Y, Namba T, et al. Cloning and expression of cDNA for the human prostacyclin receptor. FEBS Lett 1994; 344: 74-78.